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An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes.

Futch HS, McFarland KN, Moore BD, Kuhn MZ, Giasson BI, Ladd TB, Scott KA, Shapiro MR, Nosacka RL, Goodwin MS, Ran Y, Cruz PE, Ryu DH, Croft CL, Levites Y, Janus C, Chakrabarty P, Judge AR, Brusko TM, de Kloet AD, Krause EG, Golde TE.

J Exp Med. 2019 Aug 29. pii: jem.20190430. doi: 10.1084/jem.20190430. [Epub ahead of print]


Oxytocin Receptors Are Expressed by Glutamatergic Prefrontal Cortical Neurons That Selectively Modulate Social Recognition.

Tan Y, Singhal SM, Harden SW, Cahill KM, Nguyen DM, Colon-Perez LM, Sahagian TJ, Thinschmidt JS, de Kloet AD, Febo M, Frazier CJ, Krause EG.

J Neurosci. 2019 Apr 24;39(17):3249-3263. doi: 10.1523/JNEUROSCI.2944-18.2019. Epub 2019 Feb 25.


A novel rat model of comorbid PTSD and addiction reveals intersections between stress susceptibility and enhanced cocaine seeking with a role for mGlu5 receptors.

Schwendt M, Shallcross J, Hadad NA, Namba MD, Hiller H, Wu L, Krause EG, Knackstedt LA.

Transl Psychiatry. 2018 Oct 5;8(1):209. doi: 10.1038/s41398-018-0265-9.


Stress-induced corticosterone secretion covaries with working memory in aging.

McQuail JA, Krause EG, Setlow B, Scheuer DA, Bizon JL.

Neurobiol Aging. 2018 Nov;71:156-160. doi: 10.1016/j.neurobiolaging.2018.07.015. Epub 2018 Jul 30.


Macrophage angiotensin II type 2 receptor triggers neuropathic pain.

Shepherd AJ, Mickle AD, Golden JP, Mack MR, Halabi CM, de Kloet AD, Samineni VK, Kim BS, Krause EG, Gereau RW 4th, Mohapatra DP.

Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E8057-E8066. doi: 10.1073/pnas.1721815115. Epub 2018 Aug 6.


Angiotensin II Triggers Peripheral Macrophage-to-Sensory Neuron Redox Crosstalk to Elicit Pain.

Shepherd AJ, Copits BA, Mickle AD, Karlsson P, Kadunganattil S, Haroutounian S, Tadinada SM, de Kloet AD, Valtcheva MV, McIlvried LA, Sheahan TD, Jain S, Ray PR, Usachev YM, Dussor G, Krause EG, Price TJ, Gereau RW 4th, Mohapatra DP.

J Neurosci. 2018 Aug 8;38(32):7032-7057. doi: 10.1523/JNEUROSCI.3542-17.2018. Epub 2018 Jul 5.


Coupling corticotropin-releasing-hormone and angiotensin converting enzyme 2 dampens stress responsiveness in male mice.

Wang LA, de Kloet AD, Smeltzer MD, Cahill KM, Hiller H, Bruce EB, Pioquinto DJ, Ludin JA, Katovich MJ, Raizada MK, Krause EG.

Neuropharmacology. 2018 May 1;133:85-93. doi: 10.1016/j.neuropharm.2018.01.025.


A Single Angiotensin II Hypertensive Stimulus Is Associated with Prolonged Neuronal and Immune System Activation in Wistar-Kyoto Rats.

Zubcevic J, Santisteban MM, Perez PD, Arocha R, Hiller H, Malphurs WL, Colon-Perez LM, Sharma RK, de Kloet A, Krause EG, Febo M, Raizada MK.

Front Physiol. 2017 Aug 31;8:592. doi: 10.3389/fphys.2017.00592. eCollection 2017.


Post-stroke angiotensin II type 2 receptor activation provides long-term neuroprotection in aged rats.

Bennion DM, Isenberg JD, Harmel AT, DeMars K, Dang AN, Jones CH, Pignataro ME, Graham JT, Steckelings UM, Alexander JC, Febo M, Krause EG, de Kloet AD, Candelario-Jalil E, Sumners C.

PLoS One. 2017 Jul 3;12(7):e0180738. doi: 10.1371/journal.pone.0180738. eCollection 2017.


Ischemia-responsive protein 94 is a key mediator of ischemic neuronal injury-induced microglial activation.

Tikamdas R, Singhal S, Zhang P, Smith JA, Krause EG, Stevens SM Jr, Song S, Liu B.

J Neurochem. 2017 Sep;142(6):908-919. doi: 10.1111/jnc.14111. Epub 2017 Jul 31.


Targeting psychologic stress signaling pathways in Alzheimer's disease.

Futch HS, Croft CL, Truong VQ, Krause EG, Golde TE.

Mol Neurodegener. 2017 Jun 21;12(1):49. doi: 10.1186/s13024-017-0190-z. Review.



Krause EG, Reagan LP, Tamashiro KL.

Physiol Behav. 2017 Sep 1;178:1. doi: 10.1016/j.physbeh.2017.04.025. Epub 2017 May 2. No abstract available.


Chronic salt-loading reduces basal excitatory input to CRH neurons in the paraventricular nucleus and accelerates recovery from restraint stress in male mice.

Krause EG, Pati D, Frazier CJ.

Physiol Behav. 2017 Jul 1;176:189-194. doi: 10.1016/j.physbeh.2017.03.038. Epub 2017 Mar 27.


Susceptibility or resilience? Prenatal stress predisposes male rats to social subordination, but facilitates adaptation to subordinate status.

Scott KA, de Kloet AD, Smeltzer MD, Krause EG, Flak JN, Melhorn SJ, Foster MT, Tamashiro KLK, Sakai RR.

Physiol Behav. 2017 Sep 1;178:117-125. doi: 10.1016/j.physbeh.2017.03.006. Epub 2017 Mar 8.


A Unique "Angiotensin-Sensitive" Neuronal Population Coordinates Neuroendocrine, Cardiovascular, and Behavioral Responses to Stress.

de Kloet AD, Wang L, Pitra S, Hiller H, Smith JA, Tan Y, Nguyen D, Cahill KM, Sumners C, Stern JE, Krause EG.

J Neurosci. 2017 Mar 29;37(13):3478-3490. doi: 10.1523/JNEUROSCI.3674-16.2017. Epub 2017 Feb 20.


Oxytocin receptors are expressed on dopamine and glutamate neurons in the mouse ventral tegmental area that project to nucleus accumbens and other mesolimbic targets.

Peris J, MacFadyen K, Smith JA, de Kloet AD, Wang L, Krause EG.

J Comp Neurol. 2017 Apr 1;525(5):1094-1108. doi: 10.1002/cne.24116. Epub 2016 Sep 27.


Angiotensin type 1a receptors in the paraventricular nucleus of the hypothalamus control cardiovascular reactivity and anxiety-like behavior in male mice.

Wang L, Hiller H, Smith JA, de Kloet AD, Krause EG.

Physiol Genomics. 2016 Sep 1;48(9):667-76. doi: 10.1152/physiolgenomics.00029.2016. Epub 2016 Jul 28.


Angiotensin Type-2 Receptors Influence the Activity of Vasopressin Neurons in the Paraventricular Nucleus of the Hypothalamus in Male Mice.

de Kloet AD, Pitra S, Wang L, Hiller H, Pioquinto DJ, Smith JA, Sumners C, Stern JE, Krause EG.

Endocrinology. 2016 Aug;157(8):3167-80. doi: 10.1210/en.2016-1131. Epub 2016 Jun 6.


Conditioned stress prevents cue-primed cocaine reinstatement only in stress-responsive rats.

Hadad NA, Wu L, Hiller H, Krause EG, Schwendt M, Knackstedt LA.

Stress. 2016 Jul;19(4):406-18. doi: 10.1080/10253890.2016.1189898. Epub 2016 Jun 3.


Increasing brain angiotensin converting enzyme 2 activity decreases anxiety-like behavior in male mice by activating central Mas receptors.

Wang L, de Kloet AD, Pati D, Hiller H, Smith JA, Pioquinto DJ, Ludin JA, Oh SP, Katovich MJ, Frazier CJ, Raizada MK, Krause EG.

Neuropharmacology. 2016 Jun;105:114-123. doi: 10.1016/j.neuropharm.2015.12.026. Epub 2016 Jan 6.


Cross talk between AT1 receptors and Toll-like receptor 4 in microglia contributes to angiotensin II-derived ROS production in the hypothalamic paraventricular nucleus.

Biancardi VC, Stranahan AM, Krause EG, de Kloet AD, Stern JE.

Am J Physiol Heart Circ Physiol. 2016 Feb 1;310(3):H404-15. doi: 10.1152/ajpheart.00247.2015. Epub 2015 Dec 4.


Role of neurons and glia in the CNS actions of the renin-angiotensin system in cardiovascular control.

de Kloet AD, Liu M, Rodríguez V, Krause EG, Sumners C.

Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R444-58. doi: 10.1152/ajpregu.00078.2015. Epub 2015 Jun 17. Review.


Neuroendocrine Function After Hypothalamic Depletion of Glucocorticoid Receptors in Male and Female Mice.

Solomon MB, Loftspring M, de Kloet AD, Ghosal S, Jankord R, Flak JN, Wulsin AC, Krause EG, Zhang R, Rice T, McKlveen J, Myers B, Tasker JG, Herman JP.

Endocrinology. 2015 Aug;156(8):2843-53. doi: 10.1210/en.2015-1276. Epub 2015 Jun 5.


Hydration and beyond: neuropeptides as mediators of hydromineral balance, anxiety and stress-responsiveness.

Smith JA, Pati D, Wang L, de Kloet AD, Frazier CJ, Krause EG.

Front Syst Neurosci. 2015 Mar 31;9:46. doi: 10.3389/fnsys.2015.00046. eCollection 2015. Review.


Adipocyte glucocorticoid receptors mediate fat-to-brain signaling.

de Kloet AD, Krause EG, Solomon MB, Flak JN, Scott KA, Kim DH, Myers B, Ulrich-Lai YM, Woods SC, Seeley RJ, Herman JP.

Psychoneuroendocrinology. 2015 Jun;56:110-9. doi: 10.1016/j.psyneuen.2015.03.008. Epub 2015 Mar 12.


Angiotensin type 2 receptors: blood pressure regulation and end organ damage.

Sumners C, de Kloet AD, Krause EG, Unger T, Steckelings UM.

Curr Opin Pharmacol. 2015 Apr;21:115-21. doi: 10.1016/j.coph.2015.01.004. Epub 2015 Feb 9. Review.


Reporter mouse strain provides a novel look at angiotensin type-2 receptor distribution in the central nervous system.

de Kloet AD, Wang L, Ludin JA, Smith JA, Pioquinto DJ, Hiller H, Steckelings UM, Scheuer DA, Sumners C, Krause EG.

Brain Struct Funct. 2016 Mar;221(2):891-912. doi: 10.1007/s00429-014-0943-1. Epub 2014 Nov 27.


Role of paraventricular nucleus-projecting norepinephrine/epinephrine neurons in acute and chronic stress.

Flak JN, Myers B, Solomon MB, McKlveen JM, Krause EG, Herman JP.

Eur J Neurosci. 2014 Jun;39(11):1903-11. doi: 10.1111/ejn.12587. Epub 2014 Apr 26.


Acute hypernatremia promotes anxiolysis and attenuates stress-induced activation of the hypothalamic-pituitary-adrenal axis in male mice.

Smith JA, Wang L, Hiller H, Taylor CT, de Kloet AD, Krause EG.

Physiol Behav. 2014 Sep;136:91-6. doi: 10.1016/j.physbeh.2014.03.027. Epub 2014 Apr 2.


Smooth muscle LDL receptor-related protein-1 deletion induces aortic insufficiency and promotes vascular cardiomyopathy in mice.

Basford JE, Koch S, Anjak A, Singh VP, Krause EG, Robbins N, Weintraub NL, Hui DY, Rubinstein J.

PLoS One. 2013 Nov 29;8(11):e82026. doi: 10.1371/journal.pone.0082026. eCollection 2013.


Acute hypernatremia exerts an inhibitory oxytocinergic tone that is associated with anxiolytic mood in male rats.

Frazier CJ, Pati D, Hiller H, Nguyen D, Wang L, Smith JA, MacFadyen K, de Kloet AD, Krause EG.

Endocrinology. 2013 Jul;154(7):2457-67. doi: 10.1210/en.2013-1049. Epub 2013 May 7.


Angiotensin type 1a receptors in the paraventricular nucleus of the hypothalamus protect against diet-induced obesity.

de Kloet AD, Pati D, Wang L, Hiller H, Sumners C, Frazier CJ, Seeley RJ, Herman JP, Woods SC, Krause EG.

J Neurosci. 2013 Mar 13;33(11):4825-33. doi: 10.1523/JNEUROSCI.3806-12.2013.


Neuroimmune communication in hypertension and obesity: a new therapeutic angle?

de Kloet AD, Krause EG, Shi PD, Zubcevic J, Raizada MK, Sumners C.

Pharmacol Ther. 2013 Jun;138(3):428-40. doi: 10.1016/j.pharmthera.2013.02.005. Epub 2013 Feb 28. Review.


Identification of chronic stress-activated regions reveals a potential recruited circuit in rat brain.

Flak JN, Solomon MB, Jankord R, Krause EG, Herman JP.

Eur J Neurosci. 2012 Aug;36(4):2547-55. doi: 10.1111/j.1460-9568.2012.08161.x. Epub 2012 Jul 12.


Blood-borne angiotensin II acts in the brain to influence behavioral and endocrine responses to psychogenic stress.

Krause EG, de Kloet AD, Scott KA, Flak JN, Jones K, Smeltzer MD, Ulrich-Lai YM, Woods SC, Wilson SP, Reagan LP, Herman JP, Sakai RR.

J Neurosci. 2011 Oct 19;31(42):15009-15. doi: 10.1523/JNEUROSCI.0892-11.2011.


Central angiotensin II has catabolic action at white and brown adipose tissue.

de Kloet AD, Krause EG, Scott KA, Foster MT, Herman JP, Sakai RR, Seeley RJ, Woods SC.

Am J Physiol Endocrinol Metab. 2011 Dec;301(6):E1081-91. doi: 10.1152/ajpendo.00307.2011. Epub 2011 Aug 23.


Hydration state controls stress responsiveness and social behavior.

Krause EG, de Kloet AD, Flak JN, Smeltzer MD, Solomon MB, Evanson NK, Woods SC, Sakai RR, Herman JP.

J Neurosci. 2011 Apr 6;31(14):5470-6. doi: 10.1523/JNEUROSCI.6078-10.2011.


Opposing effects of chronic stress and weight restriction on cardiovascular, neuroendocrine and metabolic function.

Flak JN, Jankord R, Solomon MB, Krause EG, Herman JP.

Physiol Behav. 2011 Aug 3;104(2):228-34. doi: 10.1016/j.physbeh.2011.03.002. Epub 2011 Mar 15.


Central melanocortins modulate mesocorticolimbic activity and food seeking behavior in the rat.

Davis JF, Choi DL, Shurdak JD, Krause EG, Fitzgerald MF, Lipton JW, Sakai RR, Benoit SC.

Physiol Behav. 2011 Mar 28;102(5):491-5. doi: 10.1016/j.physbeh.2010.12.017. Epub 2010 Dec 21.


Pleasurable behaviors reduce stress via brain reward pathways.

Ulrich-Lai YM, Christiansen AM, Ostrander MM, Jones AA, Jones KR, Choi DC, Krause EG, Evanson NK, Furay AR, Davis JF, Solomon MB, de Kloet AD, Tamashiro KL, Sakai RR, Seeley RJ, Woods SC, Herman JP.

Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20529-34. doi: 10.1073/pnas.1007740107. Epub 2010 Nov 8.


Meal patterns and hypothalamic NPY expression during chronic social stress and recovery.

Melhorn SJ, Krause EG, Scott KA, Mooney MR, Johnson JD, Woods SC, Sakai RR.

Am J Physiol Regul Integr Comp Physiol. 2010 Sep;299(3):R813-22. doi: 10.1152/ajpregu.00820.2009. Epub 2010 Jul 7.


Glucose parameters are altered in mouse offspring produced by assisted reproductive technologies and somatic cell nuclear transfer.

Scott KA, Yamazaki Y, Yamamoto M, Lin Y, Melhorn SJ, Krause EG, Woods SC, Yanagimachi R, Sakai RR, Tamashiro KL.

Biol Reprod. 2010 Aug 1;83(2):220-7. doi: 10.1095/biolreprod.109.082826. Epub 2010 May 5.


The renin angiotensin system and the metabolic syndrome.

de Kloet AD, Krause EG, Woods SC.

Physiol Behav. 2010 Jul 14;100(5):525-34. doi: 10.1016/j.physbeh.2010.03.018. Epub 2010 Apr 8. Review.


Nongenomic actions of adrenal steroids in the central nervous system.

Evanson NK, Herman JP, Sakai RR, Krause EG.

J Neuroendocrinol. 2010 Aug;22(8):846-61. doi: 10.1111/j.1365-2826.2010.02000.x. Epub 2010 Mar 27. Review.


Post-ingestive signals and satiation of water and sodium intake of male rats.

Krause EG, de Kloet AD, Sakai RR.

Physiol Behav. 2010 Apr 19;99(5):657-62. doi: 10.1016/j.physbeh.2010.01.030. Epub 2010 Feb 4.


Acute exposure to a high-fat diet alters meal patterns and body composition.

Melhorn SJ, Krause EG, Scott KA, Mooney MR, Johnson JD, Woods SC, Sakai RR.

Physiol Behav. 2010 Jan 12;99(1):33-9. doi: 10.1016/j.physbeh.2009.10.004.


The effect of angiotensin-converting enzyme inhibition using captopril on energy balance and glucose homeostasis.

de Kloet AD, Krause EG, Kim DH, Sakai RR, Seeley RJ, Woods SC.

Endocrinology. 2009 Sep;150(9):4114-23. doi: 10.1210/en.2009-0065. Epub 2009 Jun 4.


Dominant rats are natural risk takers and display increased motivation for food reward.

Davis JF, Krause EG, Melhorn SJ, Sakai RR, Benoit SC.

Neuroscience. 2009 Aug 4;162(1):23-30. doi: 10.1016/j.neuroscience.2009.04.039. Epub 2009 Apr 22.


Sex differences in physiology and behavior: focus on central actions of ovarian hormones.

Curtis KS, Krause EG.

Physiol Behav. 2009 May 25;97(2):141-2. doi: 10.1016/j.physbeh.2009.02.026. Epub 2009 Mar 4. No abstract available.


Angiotensin type 1 receptors in the subfornical organ mediate the drinking and hypothalamic-pituitary-adrenal response to systemic isoproterenol.

Krause EG, Melhorn SJ, Davis JF, Scott KA, Ma LY, de Kloet AD, Benoit SC, Woods SC, Sakai RR.

Endocrinology. 2008 Dec;149(12):6416-24. doi: 10.1210/en.2008-0477. Epub 2008 Aug 7.

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