Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 24

1.

The In Vitro Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1.

Schadt S, Husser C, Staack RF, Ekiciler A, Qiu NH, Fowler S, Funk C, Kratochwil NA.

Sci Rep. 2019 Mar 11;9(1):4074. doi: 10.1038/s41598-019-40542-5.

2.

Nanotracing and cavity-ring down spectroscopy: A new ultrasensitive approach in large molecule drug disposition studies.

Kratochwil NA, Dueker SR, Muri D, Senn C, Yoon H, Yu BY, Lee GH, Dong F, Otteneder MB.

PLoS One. 2018 Oct 17;13(10):e0205435. doi: 10.1371/journal.pone.0205435. eCollection 2018.

3.

Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor.

Kratochwil NA, Triyatni M, Mueller MB, Klammers F, Leonard B, Turley D, Schmaler J, Ekiciler A, Molitor B, Walter I, Gonsard PA, Tournillac CA, Durrwell A, Marschmann M, Jones R, Ullah M, Boess F, Ottaviani G, Jin Y, Parrott NJ, Fowler S.

J Pharmacol Exp Ther. 2018 May;365(2):237-248. doi: 10.1124/jpet.117.245712. Epub 2018 Feb 16.

PMID:
29453199
4.

Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects Modeling.

Kratochwil NA, Meille C, Fowler S, Klammers F, Ekiciler A, Molitor B, Simon S, Walter I, McGinnis C, Walther J, Leonard B, Triyatni M, Javanbakht H, Funk C, Schuler F, Lavé T, Parrott NJ.

AAPS J. 2017 Mar;19(2):534-550. doi: 10.1208/s12248-016-0019-7. Epub 2017 Jan 3.

PMID:
28050713
5.

Effect of Partially Fluorinated N-Alkyl-Substituted Piperidine-2-carboxamides on Pharmacologically Relevant Properties.

Vorberg R, Trapp N, Zimmerli D, Wagner B, Fischer H, Kratochwil NA, Kansy M, Carreira EM, Müller K.

ChemMedChem. 2016 Oct 6;11(19):2216-2239. doi: 10.1002/cmdc.201600325. Epub 2016 Sep 15.

PMID:
27629993
6.

Functional analysis and transcriptional output of the Göttingen minipig genome.

Heckel T, Schmucki R, Berrera M, Ringshandl S, Badi L, Steiner G, Ravon M, Küng E, Kuhn B, Kratochwil NA, Schmitt G, Kiialainen A, Nowaczyk C, Daff H, Khan AP, Lekolool I, Pelle R, Okoth E, Bishop R, Daubenberger C, Ebeling M, Certa U.

BMC Genomics. 2015 Nov 14;16:932. doi: 10.1186/s12864-015-2119-7.

7.

Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery.

Huchet QA, Kuhn B, Wagner B, Kratochwil NA, Fischer H, Kansy M, Zimmerli D, Carreira EM, Müller K.

J Med Chem. 2015 Nov 25;58(22):9041-60. doi: 10.1021/acs.jmedchem.5b01455. Epub 2015 Nov 17.

PMID:
26523333
8.

G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey.

Kratochwil NA, Gatti-McArthur S, Hoener MC, Lindemann L, Christ AD, Green LG, Guba W, Martin RE, Malherbe P, Porter RH, Slack JP, Winnig M, Dehmlow H, Grether U, Hertel C, Narquizian R, Panousis CG, Kolczewski S, Steward L.

Curr Top Med Chem. 2011;11(15):1902-24.

PMID:
21470172
9.

Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: optimization of in vitro activity.

Peters JU, Kühne H, Dehmlow H, Grether U, Conte A, Hainzl D, Hertel C, Kratochwil NA, Otteneder M, Narquizian R, Panousis CG, Ricklin F, Röver S.

Bioorg Med Chem Lett. 2010 Sep 15;20(18):5426-30. doi: 10.1016/j.bmcl.2010.07.108. Epub 2010 Jul 29.

PMID:
20724150
10.

The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor.

Winnig M, Bufe B, Kratochwil NA, Slack JP, Meyerhof W.

BMC Struct Biol. 2007 Oct 12;7:66.

11.

An automated system for the analysis of G protein-coupled receptor transmembrane binding pockets: alignment, receptor-based pharmacophores, and their application.

Kratochwil NA, Malherbe P, Lindemann L, Ebeling M, Hoener MC, Mühlemann A, Porter RH, Stahl M, Gerber PR.

J Chem Inf Model. 2005 Sep-Oct;45(5):1324-36.

PMID:
16180909
12.

Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors.

Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC.

Genomics. 2005 Mar;85(3):372-85.

PMID:
15718104
13.

Predicting plasma protein binding of drugs--revisited.

Kratochwil NA, Huber W, Müller F, Kansy M, Gerber PR.

Curr Opin Drug Discov Devel. 2004 Jul;7(4):507-12. Review.

PMID:
15338960
14.

Nucleotide cross-linking induced by photoreactions of platinum(IV)-azide complexes.

Müller P, Schröder B, Parkinson JA, Kratochwil NA, Coxall RA, Parkin A, Parsons S, Sadler PJ.

Angew Chem Int Ed Engl. 2003 Jan 20;42(3):335-9. No abstract available.

PMID:
12548693
15.

Predicting plasma protein binding of drugs: a new approach.

Kratochwil NA, Huber W, Müller F, Kansy M, Gerber PR.

Biochem Pharmacol. 2002 Nov 1;64(9):1355-74.

PMID:
12392818
16.

A Novel Dinuclear Diaminoplatinum(II) Glutathione Macrochelate.

del Socorro Murdoch P, Kratochwil NA, Parkinson JA, Patriarca M, Sadler PJ.

Angew Chem Int Ed Engl. 1999 Oct 4;38(19):2949-2951.

PMID:
10540403
17.

Effect of thiols exported by cancer cells on the stability and growth-inhibitory activity of Pt(IV) complexes.

Kratochwil NA, Bednarski PJ.

J Cancer Res Clin Oncol. 1999 Dec;125(12):690-6.

PMID:
10592102
18.
19.

Nucleotide Platination Induced by Visible Light.

Kratochwil NA, Parkinson JA, Bednarski PJ, Sadler PJ.

Angew Chem Int Ed Engl. 1999 May 17;38(10):1460-1463. doi: 10.1002/(SICI)1521-3773(19990517)38:10<1460::AID-ANIE1460>3.0.CO;2-Z.

PMID:
29711587
21.

Photolysis of an iodoplatinum(IV) diamine complex to cytotoxic species by visible light.

Kratochwil NA, Bednarski PJ, Mrozek H, Vogler A, Nagle JK.

Anticancer Drug Des. 1996 Mar;11(2):155-71.

PMID:
8630187
22.
23.
24.

Supplemental Content

Loading ...
Support Center