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Items: 34


p53 Signaling Pathway Polymorphisms Associated With Emphysematous Changes in Patients With COPD.

Mizuno S, Ishizaki T, Kadowaki M, Akai M, Shiozaki K, Iguchi M, Oikawa T, Nakagawa K, Osanai K, Toga H, Gomez-Arroyo J, Kraskauskas D, Cool CD, Bogaard HJ, Voelkel NF.

Chest. 2017 Jul;152(1):58-69. doi: 10.1016/j.chest.2017.03.012. Epub 2017 Mar 15.


Vitamin C promotes wound healing through novel pleiotropic mechanisms.

Mohammed BM, Fisher BJ, Kraskauskas D, Ward S, Wayne JS, Brophy DF, Fowler AA 3rd, Yager DR, Natarajan R.

Int Wound J. 2016 Aug;13(4):572-84. doi: 10.1111/iwj.12484. Epub 2015 Aug 20.


A high-sugar and high-fat diet impairs cardiac systolic and diastolic function in mice.

Carbone S, Mauro AG, Mezzaroma E, Kraskauskas D, Marchetti C, Buzzetti R, Van Tassell BW, Abbate A, Toldo S.

Int J Cardiol. 2015 Nov 1;198:66-9. doi: 10.1016/j.ijcard.2015.06.136. Epub 2015 Jul 2.


Vascular endothelial growth factor receptor 3 signaling contributes to angioobliterative pulmonary hypertension.

Al-Husseini A, Kraskauskas D, Mezzaroma E, Nordio A, Farkas D, Drake JI, Abbate A, Felty Q, Voelkel NF.

Pulm Circ. 2015 Mar;5(1):101-16. doi: 10.1086/679704.


Increased eicosanoid levels in the Sugen/chronic hypoxia model of severe pulmonary hypertension.

Al-Husseini A, Wijesinghe DS, Farkas L, Kraskauskas D, Drake JI, Van Tassel B, Abbate A, Chalfant CE, Voelkel NF.

PLoS One. 2015 Mar 18;10(3):e0120157. doi: 10.1371/journal.pone.0120157. eCollection 2015.


Iloprost reverses established fibrosis in experimental right ventricular failure.

Gomez-Arroyo J, Sakagami M, Syed AA, Farkas L, Van Tassell B, Kraskauskas D, Mizuno S, Abbate A, Bogaard HJ, Byron PR, Voelkel NF.

Eur Respir J. 2015 Feb;45(2):449-62. doi: 10.1183/09031936.00188013. Epub 2014 Sep 26.


Nuclear factor κB inhibition reduces lung vascular lumen obliteration in severe pulmonary hypertension in rats.

Farkas D, Alhussaini AA, Kraskauskas D, Kraskauskiene V, Cool CD, Nicolls MR, Natarajan R, Farkas L.

Am J Respir Cell Mol Biol. 2014 Sep;51(3):413-25. doi: 10.1165/rcmb.2013-0355OC.


CXCR4 inhibition ameliorates severe obliterative pulmonary hypertension and accumulation of C-kit⁺ cells in rats.

Farkas D, Kraskauskas D, Drake JI, Alhussaini AA, Kraskauskiene V, Bogaard HJ, Cool CD, Voelkel NF, Farkas L.

PLoS One. 2014 Feb 24;9(2):e89810. doi: 10.1371/journal.pone.0089810. eCollection 2014.


Vitamin C: a novel regulator of neutrophil extracellular trap formation.

Mohammed BM, Fisher BJ, Kraskauskas D, Farkas D, Brophy DF, Fowler AA 3rd, Natarajan R.

Nutrients. 2013 Aug 9;5(8):3131-51. doi: 10.3390/nu5083131.


Attenuation of sepsis-induced organ injury in mice by vitamin C.

Fisher BJ, Kraskauskas D, Martin EJ, Farkas D, Puri P, Massey HD, Idowu MO, Brophy DF, Voelkel NF, Fowler AA 3rd, Natarajan R.

JPEN J Parenter Enteral Nutr. 2014 Sep;38(7):825-39. doi: 10.1177/0148607113497760. Epub 2013 Aug 5.


Chronic carvedilol treatment partially reverses the right ventricular failure transcriptional profile in experimental pulmonary hypertension.

Drake JI, Gomez-Arroyo J, Dumur CI, Kraskauskas D, Natarajan R, Bogaard HJ, Fawcett P, Voelkel NF.

Physiol Genomics. 2013 Jun 17;45(12):449-61. doi: 10.1152/physiolgenomics.00166.2012. Epub 2013 Apr 30.


Fenretinide causes emphysema, which is prevented by sphingosine 1-phoshate.

Yasuo M, Mizuno S, Allegood J, Kraskauskas D, Bogaard HJ, Spiegel S, Voelkel NF.

PLoS One. 2013;8(1):e53927. doi: 10.1371/journal.pone.0053927. Epub 2013 Jan 11.


Metabolic gene remodeling and mitochondrial dysfunction in failing right ventricular hypertrophy secondary to pulmonary arterial hypertension.

Gomez-Arroyo J, Mizuno S, Szczepanek K, Van Tassell B, Natarajan R, dos Remedios CG, Drake JI, Farkas L, Kraskauskas D, Wijesinghe DS, Chalfant CE, Bigbee J, Abbate A, Lesnefsky EJ, Bogaard HJ, Voelkel NF.

Circ Heart Fail. 2013 Jan;6(1):136-44. doi: 10.1161/CIRCHEARTFAILURE.111.966127. Epub 2012 Nov 14.


Severe pulmonary arterial hypertension induced by SU5416 and ovalbumin immunization.

Mizuno S, Farkas L, Al Husseini A, Farkas D, Gomez-Arroyo J, Kraskauskas D, Nicolls MR, Cool CD, Bogaard HJ, Voelkel NF.

Am J Respir Cell Mol Biol. 2012 Nov;47(5):679-87. doi: 10.1165/rcmb.2012-0077OC. Epub 2012 Jul 27.


Thyroid hormone is highly permissive in angioproliferative pulmonary hypertension in rats.

Al Husseini A, Bagnato G, Farkas L, Gomez-Arroyo J, Farkas D, Mizuno S, Kraskauskas D, Abbate A, Van Tassel B, Voelkel NF, Bogaard HJ.

Eur Respir J. 2013 Jan;41(1):104-14. doi: 10.1183/09031936.00196511. Epub 2012 Jul 26.


Acrolein induces endoplasmic reticulum stress and causes airspace enlargement.

Kitaguchi Y, Taraseviciene-Stewart L, Hanaoka M, Natarajan R, Kraskauskas D, Voelkel NF.

PLoS One. 2012;7(5):e38038. doi: 10.1371/journal.pone.0038038. Epub 2012 May 31.


Mechanisms of attenuation of abdominal sepsis induced acute lung injury by ascorbic acid.

Fisher BJ, Kraskauskas D, Martin EJ, Farkas D, Wegelin JA, Brophy D, Ward KR, Voelkel NF, Fowler AA 3rd, Natarajan R.

Am J Physiol Lung Cell Mol Physiol. 2012 Jul 1;303(1):L20-32. doi: 10.1152/ajplung.00300.2011. Epub 2012 Apr 20.


MicroRNA-199a-5p is associated with hypoxia-inducible factor-1α expression in lungs from patients with COPD.

Mizuno S, Bogaard HJ, Gomez-Arroyo J, Alhussaini A, Kraskauskas D, Cool CD, Voelkel NF.

Chest. 2012 Sep;142(3):663-672. doi: 10.1378/chest.11-2746.


A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects.

Gomez-Arroyo J, Saleem SJ, Mizuno S, Syed AA, Bogaard HJ, Abbate A, Taraseviciene-Stewart L, Sung Y, Kraskauskas D, Farkas D, Conrad DH, Nicolls MR, Voelkel NF.

Am J Physiol Lung Cell Mol Physiol. 2012 May 15;302(10):L977-91. doi: 10.1152/ajplung.00362.2011. Epub 2012 Feb 3. Review.


Copper deficiency induced emphysema is associated with focal adhesion kinase inactivation.

Mizuno S, Yasuo M, Bogaard HJ, Kraskauskas D, Alhussaini A, Gomez-Arroyo J, Farkas D, Farkas L, Voelkel NF.

PLoS One. 2012;7(1):e30678. doi: 10.1371/journal.pone.0030678. Epub 2012 Jan 20.


Copper dependence of angioproliferation in pulmonary arterial hypertension in rats and humans.

Bogaard HJ, Mizuno S, Guignabert C, Al Hussaini AA, Farkas D, Ruiter G, Kraskauskas D, Fadel E, Allegood JC, Humbert M, Vonk Noordegraaf A, Spiegel S, Farkas L, Voelkel NF.

Am J Respir Cell Mol Biol. 2012 May;46(5):582-91. doi: 10.1165/rcmb.2011-0296OC. Epub 2011 Dec 28.


Imbalance of apoptosis and cell proliferation contributes to the development and persistence of emphysema.

Lee JH, Hanaoka M, Kitaguchi Y, Kraskauskas D, Shapiro L, Voelkel NF, Taraseviciene-Stewart L.

Lung. 2012 Feb;190(1):69-82. doi: 10.1007/s00408-011-9326-z. Epub 2011 Oct 21.


The monocrotaline model of pulmonary hypertension in perspective.

Gomez-Arroyo JG, Farkas L, Alhussaini AA, Farkas D, Kraskauskas D, Voelkel NF, Bogaard HJ.

Am J Physiol Lung Cell Mol Physiol. 2012 Feb 15;302(4):L363-9. doi: 10.1152/ajplung.00212.2011. Epub 2011 Sep 30. Review.


Ascorbic acid attenuates lipopolysaccharide-induced acute lung injury.

Fisher BJ, Seropian IM, Kraskauskas D, Thakkar JN, Voelkel NF, Fowler AA 3rd, Natarajan R.

Crit Care Med. 2011 Jun;39(6):1454-60. doi: 10.1097/CCM.0b013e3182120cb8. Erratum in: Crit Care Med. 2011 Aug;39(8):2022.


p53 Gene deficiency promotes hypoxia-induced pulmonary hypertension and vascular remodeling in mice.

Mizuno S, Bogaard HJ, Kraskauskas D, Alhussaini A, Gomez-Arroyo J, Voelkel NF, Ishizaki T.

Am J Physiol Lung Cell Mol Physiol. 2011 May;300(5):L753-61. doi: 10.1152/ajplung.00286.2010. Epub 2011 Feb 18.


Suppression of histone deacetylases worsens right ventricular dysfunction after pulmonary artery banding in rats.

Bogaard HJ, Mizuno S, Hussaini AA, Toldo S, Abbate A, Kraskauskas D, Kasper M, Natarajan R, Voelkel NF.

Am J Respir Crit Care Med. 2011 May 15;183(10):1402-10. doi: 10.1164/rccm.201007-1106OC. Epub 2011 Feb 4.


Inhibition of histone deacetylase causes emphysema.

Mizuno S, Yasuo M, Bogaard HJ, Kraskauskas D, Natarajan R, Voelkel NF.

Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L402-13. doi: 10.1152/ajplung.00207.2010. Epub 2010 Dec 17.


Immunomodulatory strategies prevent the development of autoimmune emphysema.

Hanaoka M, Nicolls MR, Fontenot AP, Kraskauskas D, Mack DG, Kratzer A, Salys J, Kraskauskiene V, Burns N, Voelkel NF, Taraseviciene-Stewart L.

Respir Res. 2010 Dec 16;11:179. doi: 10.1186/1465-9921-11-179.


Hypoxia inducible factor-1α in human emphysema lung tissue.

Yasuo M, Mizuno S, Kraskauskas D, Bogaard HJ, Natarajan R, Cool CD, Zamora M, Voelkel NF.

Eur Respir J. 2011 Apr;37(4):775-83. doi: 10.1183/09031936.00022910. Epub 2010 Jun 18.


Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats.

Bogaard HJ, Natarajan R, Mizuno S, Abbate A, Chang PJ, Chau VQ, Hoke NN, Kraskauskas D, Kasper M, Salloum FN, Voelkel NF.

Am J Respir Crit Care Med. 2010 Sep 1;182(5):652-60. doi: 10.1164/rccm.201003-0335OC. Epub 2010 May 27.


Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure.

Bogaard HJ, Natarajan R, Henderson SC, Long CS, Kraskauskas D, Smithson L, Ockaili R, McCord JM, Voelkel NF.

Circulation. 2009 Nov 17;120(20):1951-60. doi: 10.1161/CIRCULATIONAHA.109.883843. Epub 2009 Nov 2.


Absence of T cells confers increased pulmonary arterial hypertension and vascular remodeling.

Taraseviciene-Stewart L, Nicolls MR, Kraskauskas D, Scerbavicius R, Burns N, Cool C, Wood K, Parr JE, Boackle SA, Voelkel NF.

Am J Respir Crit Care Med. 2007 Jun 15;175(12):1280-9. Epub 2007 Apr 5.


Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats.

Oka M, Homma N, Taraseviciene-Stewart L, Morris KG, Kraskauskas D, Burns N, Voelkel NF, McMurtry IF.

Circ Res. 2007 Mar 30;100(6):923-9. Epub 2007 Mar 1.


Mechanisms of autoimmune emphysema.

Taraseviciene-Stewart L, Burns N, Kraskauskas D, Nicolls MR, Tuder RM, Voelkel NF.

Proc Am Thorac Soc. 2006 Aug;3(6):486-7. No abstract available.

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