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Items: 34

1.

cGAS and CD-NTase enzymes: structure, mechanism, and evolution.

Kranzusch PJ.

Curr Opin Struct Biol. 2019 Dec;59:178-187. doi: 10.1016/j.sbi.2019.08.003. Epub 2019 Oct 6. Review.

2.

Analysis of human cGAS activity and structure.

Zhou W, Whiteley AT, Kranzusch PJ.

Methods Enzymol. 2019;625:13-40. doi: 10.1016/bs.mie.2019.04.012. Epub 2019 May 2.

PMID:
31455523
3.

Publisher Correction: Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling.

Eaglesham JB, Pan Y, Kupper TS, Kranzusch PJ.

Nature. 2019 May;569(7758):E12. doi: 10.1038/s41586-019-1207-2.

PMID:
31081500
4.

Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation.

de Oliveira Mann CC, Orzalli MH, King DS, Kagan JC, Lee ASY, Kranzusch PJ.

Cell Rep. 2019 Apr 23;27(4):1165-1175.e5. doi: 10.1016/j.celrep.2019.03.098.

5.

Structure and mechanism of a Hypr GGDEF enzyme that activates cGAMP signaling to control extracellular metal respiration.

Hallberg ZF, Chan CH, Wright TA, Kranzusch PJ, Doxzen KW, Park JJ, Bond DR, Hammond MC.

Elife. 2019 Apr 9;8. pii: e43959. doi: 10.7554/eLife.43959.

6.

Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA.

Barnett KC, Coronas-Serna JM, Zhou W, Ernandes MJ, Cao A, Kranzusch PJ, Kagan JC.

Cell. 2019 Mar 7;176(6):1432-1446.e11. doi: 10.1016/j.cell.2019.01.049. Epub 2019 Feb 28.

PMID:
30827685
7.

Bacterial cGAS-like enzymes synthesize diverse nucleotide signals.

Whiteley AT, Eaglesham JB, de Oliveira Mann CC, Morehouse BR, Lowey B, Nieminen EA, Danilchanka O, King DS, Lee ASY, Mekalanos JJ, Kranzusch PJ.

Nature. 2019 Mar;567(7747):194-199. doi: 10.1038/s41586-019-0953-5. Epub 2019 Feb 20.

8.

Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling.

Eaglesham JB, Pan Y, Kupper TS, Kranzusch PJ.

Nature. 2019 Feb;566(7743):259-263. doi: 10.1038/s41586-019-0928-6. Epub 2019 Feb 6. Erratum in: Nature. 2019 May 13;:.

9.

Recurrent Loss-of-Function Mutations Reveal Costs to OAS1 Antiviral Activity in Primates.

Carey CM, Govande AA, Cooper JM, Hartley MK, Kranzusch PJ, Elde NC.

Cell Host Microbe. 2019 Feb 13;25(2):336-343.e4. doi: 10.1016/j.chom.2019.01.001. Epub 2019 Jan 31.

10.

Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance.

Zhou W, Whiteley AT, de Oliveira Mann CC, Morehouse BR, Nowak RP, Fischer ES, Gray NS, Mekalanos JJ, Kranzusch PJ.

Cell. 2018 Jul 12;174(2):300-311.e11. doi: 10.1016/j.cell.2018.06.026.

11.

cGAS Conducts Micronuclei DNA Surveillance.

de Oliveira Mann CC, Kranzusch PJ.

Trends Cell Biol. 2017 Oct;27(10):697-698. doi: 10.1016/j.tcb.2017.08.007. Epub 2017 Sep 4.

PMID:
28882413
12.

Dynamic Control of X Chromosome Conformation and Repression by a Histone H4K20 Demethylase.

Brejc K, Bian Q, Uzawa S, Wheeler BS, Anderson EC, King DS, Kranzusch PJ, Preston CG, Meyer BJ.

Cell. 2017 Sep 21;171(1):85-102.e23. doi: 10.1016/j.cell.2017.07.041. Epub 2017 Aug 31.

13.

A Broad-Spectrum Inhibitor of CRISPR-Cas9.

Harrington LB, Doxzen KW, Ma E, Liu JJ, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, Doudna JA.

Cell. 2017 Sep 7;170(6):1224-1233.e15. doi: 10.1016/j.cell.2017.07.037. Epub 2017 Aug 24.

14.

eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.

Lee AS, Kranzusch PJ, Doudna JA, Cate JH.

Nature. 2016 Aug 4;536(7614):96-9. Epub 2016 Jul 27.

15.

A bacterial Argonaute with noncanonical guide RNA specificity.

Kaya E, Doxzen KW, Knoll KR, Wilson RC, Strutt SC, Kranzusch PJ, Doudna JA.

Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4057-62. doi: 10.1073/pnas.1524385113. Epub 2016 Mar 30.

16.

Foreign DNA capture during CRISPR-Cas adaptive immunity.

Nuñez JK, Harrington LB, Kranzusch PJ, Engelman AN, Doudna JA.

Nature. 2015 Nov 26;527(7579):535-8. doi: 10.1038/nature15760. Epub 2015 Oct 21.

17.

Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.

Kranzusch PJ, Wilson SC, Lee AS, Berger JM, Doudna JA, Vance RE.

Mol Cell. 2015 Sep 17;59(6):891-903. doi: 10.1016/j.molcel.2015.07.022. Epub 2015 Aug 20.

18.

eIF3 targets cell-proliferation messenger RNAs for translational activation or repression.

Lee AS, Kranzusch PJ, Cate JH.

Nature. 2015 Jun 4;522(7554):111-4. doi: 10.1038/nature14267. Epub 2015 Apr 6.

19.

Structure-guided reprogramming of human cGAS dinucleotide linkage specificity.

Kranzusch PJ, Lee ASY, Wilson SC, Solovykh MS, Vance RE, Berger JM, Doudna JA.

Cell. 2014 Aug 28;158(5):1011-1021. doi: 10.1016/j.cell.2014.07.028. Epub 2014 Aug 14.

20.

Cas1-Cas2 complex formation mediates spacer acquisition during CRISPR-Cas adaptive immunity.

Nuñez JK, Kranzusch PJ, Noeske J, Wright AV, Davies CW, Doudna JA.

Nat Struct Mol Biol. 2014 Jun;21(6):528-34. doi: 10.1038/nsmb.2820. Epub 2014 May 4.

21.

African origin of the malaria parasite Plasmodium vivax.

Liu W, Li Y, Shaw KS, Learn GH, Plenderleith LJ, Malenke JA, Sundararaman SA, Ramirez MA, Crystal PA, Smith AG, Bibollet-Ruche F, Ayouba A, Locatelli S, Esteban A, Mouacha F, Guichet E, Butel C, Ahuka-Mundeke S, Inogwabini BI, Ndjango JB, Speede S, Sanz CM, Morgan DB, Gonder MK, Kranzusch PJ, Walsh PD, Georgiev AV, Muller MN, Piel AK, Stewart FA, Wilson ML, Pusey AE, Cui L, Wang Z, Färnert A, Sutherland CJ, Nolder D, Hart JA, Hart TB, Bertolani P, Gillis A, LeBreton M, Tafon B, Kiyang J, Djoko CF, Schneider BS, Wolfe ND, Mpoudi-Ngole E, Delaporte E, Carter R, Culleton RL, Shaw GM, Rayner JC, Peeters M, Hahn BH, Sharp PM.

Nat Commun. 2014;5:3346. doi: 10.1038/ncomms4346.

22.

cGAS dimerization entangles DNA recognition.

Kranzusch PJ, Vance RE.

Immunity. 2013 Dec 12;39(6):992-4. doi: 10.1016/j.immuni.2013.11.012.

23.

Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity.

Kranzusch PJ, Lee AS, Berger JM, Doudna JA.

Cell Rep. 2013 May 30;3(5):1362-8. doi: 10.1016/j.celrep.2013.05.008. Epub 2013 May 23.

24.

The polymerase of negative-stranded RNA viruses.

Morin B, Kranzusch PJ, Rahmeh AA, Whelan SP.

Curr Opin Virol. 2013 Apr;3(2):103-10. doi: 10.1016/j.coviro.2013.03.008. Epub 2013 Apr 18. Review.

25.

Architecture and regulation of negative-strand viral enzymatic machinery.

Kranzusch PJ, Whelan SP.

RNA Biol. 2012 Jul;9(7):941-8. doi: 10.4161/rna.20345. Epub 2012 Jul 1.

26.

Arenavirus Z protein controls viral RNA synthesis by locking a polymerase-promoter complex.

Kranzusch PJ, Whelan SP.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19743-8. doi: 10.1073/pnas.1112742108. Epub 2011 Nov 21.

27.

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1.

Carette JE, Raaben M, Wong AC, Herbert AS, Obernosterer G, Mulherkar N, Kuehne AI, Kranzusch PJ, Griffin AM, Ruthel G, Dal Cin P, Dye JM, Whelan SP, Chandran K, Brummelkamp TR.

Nature. 2011 Aug 24;477(7364):340-3. doi: 10.1038/nature10348.

28.

Ebolavirus delta-peptide immunoadhesins inhibit marburgvirus and ebolavirus cell entry.

Radoshitzky SR, Warfield KL, Chi X, Dong L, Kota K, Bradfute SB, Gearhart JD, Retterer C, Kranzusch PJ, Misasi JN, Hogenbirk MA, Wahl-Jensen V, Volchkov VE, Cunningham JM, Jahrling PB, Aman MJ, Bavari S, Farzan M, Kuhn JH.

J Virol. 2011 Sep;85(17):8502-13. doi: 10.1128/JVI.02600-10. Epub 2011 Jun 22.

29.

Molecular architecture of the vesicular stomatitis virus RNA polymerase.

Rahmeh AA, Schenk AD, Danek EI, Kranzusch PJ, Liang B, Walz T, Whelan SP.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20075-80. doi: 10.1073/pnas.1013559107. Epub 2010 Nov 1.

30.

Assembly of a functional Machupo virus polymerase complex.

Kranzusch PJ, Schenk AD, Rahmeh AA, Radoshitzky SR, Bavari S, Walz T, Whelan SP.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20069-74. doi: 10.1073/pnas.1007152107. Epub 2010 Oct 26.

31.

Origin of the human malaria parasite Plasmodium falciparum in gorillas.

Liu W, Li Y, Learn GH, Rudicell RS, Robertson JD, Keele BF, Ndjango JB, Sanz CM, Morgan DB, Locatelli S, Gonder MK, Kranzusch PJ, Walsh PD, Delaporte E, Mpoudi-Ngole E, Georgiev AV, Muller MN, Shaw GM, Peeters M, Sharp PM, Rayner JC, Hahn BH.

Nature. 2010 Sep 23;467(7314):420-5. doi: 10.1038/nature09442.

32.

Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin.

Radoshitzky SR, Dong L, Chi X, Clester JC, Retterer C, Spurgers K, Kuhn JH, Sandwick S, Ruthel G, Kota K, Boltz D, Warren T, Kranzusch PJ, Whelan SP, Bavari S.

J Virol. 2010 Oct;84(20):10569-80. doi: 10.1128/JVI.00103-10. Epub 2010 Aug 4.

33.

Molecular epidemiology of simian immunodeficiency virus infection in wild-living gorillas.

Neel C, Etienne L, Li Y, Takehisa J, Rudicell RS, Bass IN, Moudindo J, Mebenga A, Esteban A, Van Heuverswyn F, Liegeois F, Kranzusch PJ, Walsh PD, Sanz CM, Morgan DB, Ndjango JB, Plantier JC, Locatelli S, Gonder MK, Leendertz FH, Boesch C, Todd A, Delaporte E, Mpoudi-Ngole E, Hahn BH, Peeters M.

J Virol. 2010 Feb;84(3):1464-76. doi: 10.1128/JVI.02129-09. Epub 2009 Nov 11.

34.

Ribose 2'-O methylation of the vesicular stomatitis virus mRNA cap precedes and facilitates subsequent guanine-N-7 methylation by the large polymerase protein.

Rahmeh AA, Li J, Kranzusch PJ, Whelan SP.

J Virol. 2009 Nov;83(21):11043-50. doi: 10.1128/JVI.01426-09. Epub 2009 Aug 26.

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