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Structure-Function Analysis of the Bifunctional CcsBA Heme Exporter and Cytochrome c Synthetase.

Sutherland MC, Tran NL, Tillman DE, Jarodsky JM, Yuan J, Kranz RG.

MBio. 2018 Dec 18;9(6). pii: e02134-18. doi: 10.1128/mBio.02134-18.


Structurally Mapping Endogenous Heme in the CcmCDE Membrane Complex for Cytochrome c Biogenesis.

Sutherland MC, Jarodsky JM, Ovchinnikov S, Baker D, Kranz RG.

J Mol Biol. 2018 Apr 13;430(8):1065-1080. doi: 10.1016/j.jmb.2018.01.022. Epub 2018 Mar 5.


Biosynthesis of Single Thioether c-Type Cytochromes Provides Insight into Mechanisms Intrinsic to Holocytochrome c Synthase (HCCS).

Babbitt SE, Hsu J, Mendez DL, Kranz RG.

Biochemistry. 2017 Jul 5;56(26):3337-3346. doi: 10.1021/acs.biochem.7b00286. Epub 2017 Jun 26.


Oxidized or Reduced Cytochrome c and Axial Ligand Variants All Form the Apoptosome in Vitro.

Mendez DL, Akey IV, Akey CW, Kranz RG.

Biochemistry. 2017 Jun 6;56(22):2766-2769. doi: 10.1021/acs.biochem.7b00309. Epub 2017 May 19.


Engineered holocytochrome c synthases that biosynthesize new cytochromes c.

Mendez DL, Babbitt SE, King JD, D'Alessandro J, Watson MB, Blankenship RE, Mirica LM, Kranz RG.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2235-2240. doi: 10.1073/pnas.1615929114. Epub 2017 Feb 14.


Molecular Basis Behind Inability of Mitochondrial Holocytochrome c Synthase to Mature Bacterial Cytochromes: DEFINING A CRITICAL ROLE FOR CYTOCHROME c α HELIX-1.

Babbitt SE, Hsu J, Kranz RG.

J Biol Chem. 2016 Aug 19;291(34):17523-34. doi: 10.1074/jbc.M116.741231. Epub 2016 Jul 6.


Heme Trafficking and Modifications during System I Cytochrome c Biogenesis: Insights from Heme Redox Potentials of Ccm Proteins.

Sutherland MC, Rankin JA, Kranz RG.

Biochemistry. 2016 Jun 7;55(22):3150-6. doi: 10.1021/acs.biochem.6b00427. Epub 2016 May 26.


Mitochondrial cytochrome c biogenesis: no longer an enigma.

Babbitt SE, Sutherland MC, San Francisco B, Mendez DL, Kranz RG.

Trends Biochem Sci. 2015 Aug;40(8):446-55. doi: 10.1016/j.tibs.2015.05.006. Epub 2015 Jun 11. Review.


Mechanisms of mitochondrial holocytochrome c synthase and the key roles played by cysteines and histidine of the heme attachment site, Cys-XX-Cys-His.

Babbitt SE, San Francisco B, Mendez DL, Lukat-Rodgers GS, Rodgers KR, Bretsnyder EC, Kranz RG.

J Biol Chem. 2014 Oct 17;289(42):28795-807. doi: 10.1074/jbc.M114.593509. Epub 2014 Aug 28.


Conserved residues of the human mitochondrial holocytochrome c synthase mediate interactions with heme.

Babbitt SE, San Francisco B, Bretsnyder EC, Kranz RG.

Biochemistry. 2014 Aug 19;53(32):5261-71. doi: 10.1021/bi500704p. Epub 2014 Aug 6.


Interaction of holoCcmE with CcmF in heme trafficking and cytochrome c biosynthesis.

San Francisco B, Kranz RG.

J Mol Biol. 2014 Feb 6;426(3):570-85.


The CcmFH complex is the system I holocytochrome c synthetase: engineering cytochrome c maturation independent of CcmABCDE.

San Francisco B, Sutherland MC, Kranz RG.

Mol Microbiol. 2014 Mar;91(5):996-1008. doi: 10.1111/mmi.12510. Epub 2014 Jan 27.


Human mitochondrial holocytochrome c synthase's heme binding, maturation determinants, and complex formation with cytochrome c.

San Francisco B, Bretsnyder EC, Kranz RG.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):E788-97. doi: 10.1073/pnas.1213897109. Epub 2012 Nov 12.


A nitrogen-regulated glutamine amidotransferase (GAT1_2.1) represses shoot branching in Arabidopsis.

Zhu H, Kranz RG.

Plant Physiol. 2012 Dec;160(4):1770-80. doi: 10.1104/pp.112.199364. Epub 2012 Aug 10.


Heme ligand identification and redox properties of the cytochrome c synthetase, CcmF.

San Francisco B, Bretsnyder EC, Rodgers KR, Kranz RG.

Biochemistry. 2011 Dec 20;50(50):10974-85. doi: 10.1021/bi201508t. Epub 2011 Nov 21.


Thiol redox requirements and substrate specificities of recombinant cytochrome c assembly systems II and III.

Richard-Fogal CL, San Francisco B, Frawley ER, Kranz RG.

Biochim Biophys Acta. 2012 Jun;1817(6):911-9. doi: 10.1016/j.bbabio.2011.09.008. Epub 2011 Sep 16.


Essential histidine pairs indicate conserved haem binding in epsilonproteobacterial cytochrome c haem lyases.

Kern M, Scheithauer J, Kranz RG, Simon J.

Microbiology. 2010 Dec;156(Pt 12):3773-81. doi: 10.1099/mic.0.042838-0. Epub 2010 Aug 12.


The CcmC:heme:CcmE complex in heme trafficking and cytochrome c biosynthesis.

Richard-Fogal C, Kranz RG.

J Mol Biol. 2010 Aug 20;401(3):350-62. doi: 10.1016/j.jmb.2010.06.041. Epub 2010 Jun 25.


Substrate specificity of three cytochrome c haem lyase isoenzymes from Wolinella succinogenes: unconventional haem c binding motifs are not sufficient for haem c attachment by NrfI and CcsA1.

Kern M, Eisel F, Scheithauer J, Kranz RG, Simon J.

Mol Microbiol. 2010 Jan;75(1):122-37. doi: 10.1111/j.1365-2958.2009.06965.x. Epub 2009 Nov 17.


CPC, a single-repeat R3 MYB, is a negative regulator of anthocyanin biosynthesis in Arabidopsis.

Zhu HF, Fitzsimmons K, Khandelwal A, Kranz RG.

Mol Plant. 2009 Jul;2(4):790-802. doi: 10.1093/mp/ssp030. Epub 2009 Jun 2.


Cytochrome c biogenesis: mechanisms for covalent modifications and trafficking of heme and for heme-iron redox control.

Kranz RG, Richard-Fogal C, Taylor JS, Frawley ER.

Microbiol Mol Biol Rev. 2009 Sep;73(3):510-28, Table of Contents. doi: 10.1128/MMBR.00001-09. Review.


A conserved haem redox and trafficking pathway for cofactor attachment.

Richard-Fogal CL, Frawley ER, Bonner ER, Zhu H, San Francisco B, Kranz RG.

EMBO J. 2009 Aug 19;28(16):2349-59. doi: 10.1038/emboj.2009.189. Epub 2009 Jul 23.


CcsBA is a cytochrome c synthetase that also functions in heme transport.

Frawley ER, Kranz RG.

Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10201-6. doi: 10.1073/pnas.0903132106. Epub 2009 Jun 9.


The cytochrome c maturation components CcmF, CcmH, and CcmI form a membrane-integral multisubunit heme ligation complex.

Sanders C, Turkarslan S, Lee DW, Onder O, Kranz RG, Daldal F.

J Biol Chem. 2008 Oct 31;283(44):29715-22. doi: 10.1074/jbc.M805413200. Epub 2008 Aug 27.


Topology and function of CcmD in cytochrome c maturation.

Richard-Fogal CL, Frawley ER, Kranz RG.

J Bacteriol. 2008 May;190(10):3489-93. doi: 10.1128/JB.00146-08. Epub 2008 Mar 7.


Heme concentration dependence and metalloporphyrin inhibition of the system I and II cytochrome c assembly pathways.

Richard-Fogal CL, Frawley ER, Feissner RE, Kranz RG.

J Bacteriol. 2007 Jan;189(2):455-63. Epub 2006 Nov 3.


ABC transporter-mediated release of a haem chaperone allows cytochrome c biogenesis.

Feissner RE, Richard-Fogal CL, Frawley ER, Kranz RG.

Mol Microbiol. 2006 Jul;61(1):219-31.


Recombinant cytochromes c biogenesis systems I and II and analysis of haem delivery pathways in Escherichia coli.

Feissner RE, Richard-Fogal CL, Frawley ER, Loughman JA, Earley KW, Kranz RG.

Mol Microbiol. 2006 May;60(3):563-77.


Development and evaluation of a Gal4-mediated LUC/GFP/GUS enhancer trap system in Arabidopsis.

Engineer CB, Fitzsimmons KC, Schmuke JJ, Dotson SB, Kranz RG.

BMC Plant Biol. 2005 Jun 7;5:9.


Mutations in cytochrome assembly and periplasmic redox pathways in Bordetella pertussis.

Feissner RE, Beckett CS, Loughman JA, Kranz RG.

J Bacteriol. 2005 Jun;187(12):3941-9.


RNA polymerase subunit requirements for activation by the enhancer-binding protein Rhodobacter capsulatus NtrC.

Richard CL, Tandon A, Sloan NR, Kranz RG.

J Biol Chem. 2003 Aug 22;278(34):31701-8. Epub 2003 Jun 6.


Chemiluminescent-based methods to detect subpicomole levels of c-type cytochromes.

Feissner R, Xiang Y, Kranz RG.

Anal Biochem. 2003 Apr 1;315(1):90-4.


Overexpression of ccl1-2 can bypass the need for the putative apocytochrome chaperone CycH during the biogenesis of c-type cytochromes.

Deshmukh M, May M, Zhang Y, Gabbert KK, Karberg KA, Kranz RG, Daldal F.

Mol Microbiol. 2002 Nov;46(4):1069-80.


ABC transporters associated with cytochrome c biogenesis.

Goldman BS, Kranz RG.

Res Microbiol. 2001 Apr-May;152(3-4):323-9. Review.


Urea utilization in the phototrophic bacterium Rhodobacter capsulatus is regulated by the transcriptional activator NtrC.

Masepohl B, Kaiser B, Isakovic N, Richard CL, Kranz RG, Klipp W.

J Bacteriol. 2001 Jan;183(2):637-43.


Four genes are required for the system II cytochrome c biogenesis pathway in Bordetella pertussis, a unique bacterial model.

Beckett CS, Loughman JA, Karberg KA, Donato GM, Goldman WE, Kranz RG.

Mol Microbiol. 2000 Nov;38(3):465-81.


Oxidation-reduction properties of disulfide-containing proteins of the Rhodobacter capsulatus cytochrome c biogenesis system.

Setterdahl AT, Goldman BS, Hirasawa M, Jacquot P, Smith AJ, Kranz RG, Knaff DB.

Biochemistry. 2000 Aug 22;39(33):10172-6.


In vitro activation and repression of photosynthesis gene transcription in Rhodobacter capsulatus.

Bowman WC, Du S, Bauer CE, Kranz RG.

Mol Microbiol. 1999 Jul;33(2):429-37.


Translational activation by an NtrC enhancer-binding protein.

Cullen PJ, Bowman WC, Hartnett DF, Reilly SC, Kranz RG.

J Mol Biol. 1998 May 22;278(5):903-14.


Transmembrane heme delivery systems.

Goldman BS, Beck DL, Monika EM, Kranz RG.

Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5003-8.


Analysis of the fnrL gene and its function in Rhodobacter capsulatus.

Zeilstra-Ryalls JH, Gabbert K, Mouncey NJ, Kaplan S, Kranz RG.

J Bacteriol. 1997 Dec;179(23):7264-73.


A thioreduction pathway tethered to the membrane for periplasmic cytochromes c biogenesis; in vitro and in vivo studies.

Monika EM, Goldman BS, Beckman DL, Kranz RG.

J Mol Biol. 1997 Sep 5;271(5):679-92.


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