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Items: 49


Biomarker-Based Therapy in Pancreatic Ductal Adenocarcinoma: An Emerging Reality?

Krantz BA, O'Reilly EM.

Clin Cancer Res. 2018 May 15;24(10):2241-2250. doi: 10.1158/1078-0432.CCR-16-3169. Epub 2017 Dec 21. Review.


Pancreas adenocarcinoma: novel therapeutics.

Krantz BA, Yu KH, O'Reilly EM.

Chin Clin Oncol. 2017 Jun;6(3):30. doi: 10.21037/cco.2017.06.14.


Reply to Yamini and Nestorovich: Alternate clamped states of the anthrax toxin protective antigen channel.

Krantz BA.

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2547. doi: 10.1073/pnas.1702212114. Epub 2017 Mar 15. No abstract available.


Uveal melanoma: epidemiology, etiology, and treatment of primary disease.

Krantz BA, Dave N, Komatsubara KM, Marr BP, Carvajal RD.

Clin Ophthalmol. 2017 Jan 31;11:279-289. doi: 10.2147/OPTH.S89591. eCollection 2017. Review.


Dynamic Phenylalanine Clamp Interactions Define Single-Channel Polypeptide Translocation through the Anthrax Toxin Protective Antigen Channel.

Ghosal K, Colby JM, Das D, Joy ST, Arora PS, Krantz BA.

J Mol Biol. 2017 Mar 24;429(6):900-910. doi: 10.1016/j.jmb.2017.02.005. Epub 2017 Feb 10.


Secondary Structure Preferences of the Anthrax Toxin Protective Antigen Translocase.

Das D, Krantz BA.

J Mol Biol. 2017 Mar 10;429(5):753-762. doi: 10.1016/j.jmb.2017.01.015. Epub 2017 Jan 20.


Laboratory evolution of artificially expanded DNA gives redesignable aptamers that target the toxic form of anthrax protective antigen.

Biondi E, Lane JD, Das D, Dasgupta S, Piccirilli JA, Hoshika S, Bradley KM, Krantz BA, Benner SA.

Nucleic Acids Res. 2016 Nov 16;44(20):9565-9577. Epub 2016 Oct 3.


Anthrax lethal toxin co-complexes are stabilized by contacts between adjacent lethal factors.

Krantz BA.

J Gen Physiol. 2016 Oct;148(4):273-5. doi: 10.1085/jgp.201611681. No abstract available.


Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis.

Jorgensen I, Zhang Y, Krantz BA, Miao EA.

J Exp Med. 2016 Sep 19;213(10):2113-28. doi: 10.1084/jem.20151613. Epub 2016 Aug 29.


Peptide- and proton-driven allosteric clamps catalyze anthrax toxin translocation across membranes.

Das D, Krantz BA.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9611-6. doi: 10.1073/pnas.1600624113. Epub 2016 Aug 9.


Peptide Probes Reveal a Hydrophobic Steric Ratchet in the Anthrax Toxin Protective Antigen Translocase.

Colby JM, Krantz BA.

J Mol Biol. 2015 Nov 6;427(22):3598-3606. doi: 10.1016/j.jmb.2015.09.007. Epub 2015 Sep 10.


Role of the α Clamp in the Protein Translocation Mechanism of Anthrax Toxin.

Brown MJ, Thoren KL, Krantz BA.

J Mol Biol. 2015 Oct 9;427(20):3340-3349. doi: 10.1016/j.jmb.2015.08.024. Epub 2015 Sep 5.


Hijacking multivesicular bodies enables long-term and exosome-mediated long-distance action of anthrax toxin.

Abrami L, Brandi L, Moayeri M, Brown MJ, Krantz BA, Leppla SH, van der Goot FG.

Cell Rep. 2013 Nov 27;5(4):986-96. doi: 10.1016/j.celrep.2013.10.019. Epub 2013 Nov 14.


Capecitabine and temozolomide (CAPTEM) for metastatic, well-differentiated neuroendocrine cancers: The Pancreas Center at Columbia University experience.

Fine RL, Gulati AP, Krantz BA, Moss RA, Schreibman S, Tsushima DA, Mowatt KB, Dinnen RD, Mao Y, Stevens PD, Schrope B, Allendorf J, Lee JA, Sherman WH, Chabot JA.

Cancer Chemother Pharmacol. 2013 Mar;71(3):663-70. doi: 10.1007/s00280-012-2055-z. Epub 2013 Jan 31.


Electrostatic ratchet in the protective antigen channel promotes anthrax toxin translocation.

Wynia-Smith SL, Brown MJ, Chirichella G, Kemalyan G, Krantz BA.

J Biol Chem. 2012 Dec 21;287(52):43753-64. doi: 10.1074/jbc.M112.419598. Epub 2012 Oct 31.


Anthrax toxin protective antigen integrates poly-γ-D-glutamate and pH signals to sense the optimal environment for channel formation.

Kintzer AF, Tang II, Schawel AK, Brown MJ, Krantz BA.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18378-83. doi: 10.1073/pnas.1208280109. Epub 2012 Oct 24.


Rapid induction of inflammatory lipid mediators by the inflammasome in vivo.

von Moltke J, Trinidad NJ, Moayeri M, Kintzer AF, Wang SB, van Rooijen N, Brown CR, Krantz BA, Leppla SH, Gronert K, Vance RE.

Nature. 2012 Oct 4;490(7418):107-11. doi: 10.1038/nature11351. Epub 2012 Aug 19.


Ratcheting up protein translocation with anthrax toxin.

Feld GK, Brown MJ, Krantz BA.

Protein Sci. 2012 May;21(5):606-24. doi: 10.1002/pro.2052. Epub 2012 Mar 30. Review.


Supercharging protein complexes from aqueous solution disrupts their native conformations.

Sterling HJ, Kintzer AF, Feld GK, Cassou CA, Krantz BA, Williams ER.

J Am Soc Mass Spectrom. 2012 Feb;23(2):191-200. doi: 10.1007/s13361-011-0301-y. Epub 2011 Dec 13.


Domain flexibility modulates the heterogeneous assembly mechanism of anthrax toxin protective antigen.

Feld GK, Kintzer AF, Tang II, Thoren KL, Krantz BA.

J Mol Biol. 2012 Jan 6;415(1):159-74. doi: 10.1016/j.jmb.2011.10.035. Epub 2011 Oct 31.


Charge requirements for proton gradient-driven translocation of anthrax toxin.

Brown MJ, Thoren KL, Krantz BA.

J Biol Chem. 2011 Jul 1;286(26):23189-99. doi: 10.1074/jbc.M111.231167. Epub 2011 Apr 20.


The unfolding story of anthrax toxin translocation.

Thoren KL, Krantz BA.

Mol Microbiol. 2011 May;80(3):588-95. doi: 10.1111/j.1365-2958.2011.07614.x. Epub 2011 Mar 28. Review.


The role of conformational flexibility on protein supercharging in native electrospray ionization.

Sterling HJ, Cassou CA, Trnka MJ, Burlingame AL, Krantz BA, Williams ER.

Phys Chem Chem Phys. 2011 Nov 7;13(41):18288-96. doi: 10.1039/c1cp20277d. Epub 2011 Mar 14.


Anthrax toxin receptor drives protective antigen oligomerization and stabilizes the heptameric and octameric oligomer by a similar mechanism.

Kintzer AF, Sterling HJ, Tang II, Williams ER, Krantz BA.

PLoS One. 2010 Nov 8;5(11):e13888. doi: 10.1371/journal.pone.0013888.


Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers.

Feld GK, Thoren KL, Kintzer AF, Sterling HJ, Tang II, Greenberg SG, Williams ER, Krantz BA.

Nat Struct Mol Biol. 2010 Nov;17(11):1383-90. doi: 10.1038/nsmb.1923. Epub 2010 Oct 31.


Effects of supercharging reagents on noncovalent complex structure in electrospray ionization from aqueous solutions.

Sterling HJ, Daly MP, Feld GK, Thoren KL, Kintzer AF, Krantz BA, Williams ER.

J Am Soc Mass Spectrom. 2010 Oct;21(10):1762-74. doi: 10.1016/j.jasms.2010.06.012. Epub 2010 Jun 25.


Role of the protective antigen octamer in the molecular mechanism of anthrax lethal toxin stabilization in plasma.

Kintzer AF, Sterling HJ, Tang II, Abdul-Gader A, Miles AJ, Wallace BA, Williams ER, Krantz BA.

J Mol Biol. 2010 Jun 25;399(5):741-58. doi: 10.1016/j.jmb.2010.04.041. Epub 2010 Apr 28.


Lethal factor unfolding is the most force-dependent step of anthrax toxin translocation.

Thoren KL, Worden EJ, Yassif JM, Krantz BA.

Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21555-60. doi: 10.1073/pnas.0905880106. Epub 2009 Nov 19.


The protective antigen component of anthrax toxin forms functional octameric complexes.

Kintzer AF, Thoren KL, Sterling HJ, Dong KC, Feld GK, Tang II, Zhang TT, Williams ER, Berger JM, Krantz BA.

J Mol Biol. 2009 Sep 25;392(3):614-29. doi: 10.1016/j.jmb.2009.07.037. Epub 2009 Jul 20.


Characterizing protein folding transition States using Psi-analysis.

Pandit AD, Krantz BA, Dothager RS, Sosnick TR.

Methods Mol Biol. 2007;350:83-104.


Characterizing the protein folding transition state using psi analysis.

Sosnick TR, Krantz BA, Dothager RS, Baxa M.

Chem Rev. 2006 May;106(5):1862-76. Review. No abstract available.


Assembly and disassembly kinetics of anthrax toxin complexes.

Christensen KA, Krantz BA, Collier RJ.

Biochemistry. 2006 Feb 21;45(7):2380-6.


Protein translocation through the anthrax toxin transmembrane pore is driven by a proton gradient.

Krantz BA, Finkelstein A, Collier RJ.

J Mol Biol. 2006 Feb 3;355(5):968-79. Epub 2005 Dec 1.


Whole-cell voltage clamp measurements of anthrax toxin pore current.

Wolfe JT, Krantz BA, Rainey GJ, Young JA, Collier RJ.

J Biol Chem. 2005 Nov 25;280(47):39417-22. Epub 2005 Sep 23.


A phenylalanine clamp catalyzes protein translocation through the anthrax toxin pore.

Krantz BA, Melnyk RA, Zhang S, Juris SJ, Lacy DB, Wu Z, Finkelstein A, Collier RJ.

Science. 2005 Jul 29;309(5735):777-81.


Interaction of the 20 kDa and 63 kDa fragments of anthrax protective antigen: kinetics and thermodynamics.

Christensen KA, Krantz BA, Melnyk RA, Collier RJ.

Biochemistry. 2005 Jan 25;44(3):1047-53.


Differences in the folding transition state of ubiquitin indicated by phi and psi analyses.

Sosnick TR, Dothager RS, Krantz BA.

Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17377-82. Epub 2004 Dec 2.


Acid-induced unfolding of the amino-terminal domains of the lethal and edema factors of anthrax toxin.

Krantz BA, Trivedi AD, Cunningham K, Christensen KA, Collier RJ.

J Mol Biol. 2004 Nov 26;344(3):739-56.


Anthrax toxin complexes: heptameric protective antigen can bind lethal factor and edema factor simultaneously.

Pimental RA, Christensen KA, Krantz BA, Collier RJ.

Biochem Biophys Res Commun. 2004 Sep 10;322(1):258-62.


Binding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigen.

Wigelsworth DJ, Krantz BA, Christensen KA, Lacy DB, Juris SJ, Collier RJ.

J Biol Chem. 2004 May 28;279(22):23349-56. Epub 2004 Mar 24.


Discerning the structure and energy of multiple transition states in protein folding using psi-analysis.

Krantz BA, Dothager RS, Sosnick TR.

J Mol Biol. 2004 Mar 19;337(2):463-75. Erratum in: J Mol Biol. 2005 Apr 15;347(5):1103.


Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding.

Krantz BA, Mayne L, Rumbley J, Englander SW, Sosnick TR.

J Mol Biol. 2002 Nov 22;324(2):359-71.


Understanding protein hydrogen bond formation with kinetic H/D amide isotope effects.

Krantz BA, Srivastava AK, Nauli S, Baker D, Sauer RT, Sosnick TR.

Nat Struct Biol. 2002 Jun;9(6):458-63.


Contribution of hydrogen bonding to protein stability estimated from isotope effects.

Shi Z, Krantz BA, Kallenbach N, Sosnick TR.

Biochemistry. 2002 Feb 19;41(7):2120-9.


Engineered metal binding sites map the heterogeneous folding landscape of a coiled coil.

Krantz BA, Sosnick TR.

Nat Struct Biol. 2001 Dec;8(12):1042-7.


Distinguishing between two-state and three-state models for ubiquitin folding.

Krantz BA, Sosnick TR.

Biochemistry. 2000 Sep 26;39(38):11696-701.


D/H amide kinetic isotope effects reveal when hydrogen bonds form during protein folding.

Krantz BA, Moran LB, Kentsis A, Sosnick TR.

Nat Struct Biol. 2000 Jan;7(1):62-71.


Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases.

Larsen CN, Krantz BA, Wilkinson KD.

Biochemistry. 1998 Mar 10;37(10):3358-68.


In vivo disassembly of free polyubiquitin chains by yeast Ubp14 modulates rates of protein degradation by the proteasome.

Amerik AYu, Swaminathan S, Krantz BA, Wilkinson KD, Hochstrasser M.

EMBO J. 1997 Aug 15;16(16):4826-38.

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