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Diversification of the TCR β Locus Vβ Repertoire by CTCF.

Chen S, Krangel MS.

Immunohorizons. 2018 Dec;2(11):377-383. doi: 10.4049/immunohorizons.1800072.


Hierarchical assembly and disassembly of a transcriptionally active RAG locus in CD4+CD8+ thymocytes.

Naik AK, Byrd AT, Lucander ACK, Krangel MS.

J Exp Med. 2019 Jan 7;216(1):231-243. doi: 10.1084/jem.20181402. Epub 2018 Dec 13.


A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus.

Chen S, Luperchio TR, Wong X, Doan EB, Byrd AT, Roy Choudhury K, Reddy KL, Krangel MS.

Cell Rep. 2018 Nov 13;25(7):1729-1740.e6. doi: 10.1016/j.celrep.2018.10.052.


Variable Extent of Lineage-Specificity and Developmental Stage-Specificity of Cohesin and CCCTC-Binding Factor Binding Within the Immunoglobulin and T Cell Receptor Loci.

Loguercio S, Barajas-Mora EM, Shih HY, Krangel MS, Feeney AJ.

Front Immunol. 2018 Mar 8;9:425. doi: 10.3389/fimmu.2018.00425. eCollection 2018.


On the Horizon.

Berg L, Krangel M.

Immunohorizons. 2018 Jan 17;2(1):26. doi: 10.4049/immunohorizons.1800002. No abstract available.


Tcrd Rearrangement Redirects a Processive Tcra Recombination Program to Expand the Tcra Repertoire.

Carico ZM, Roy Choudhury K, Zhang B, Zhuang Y, Krangel MS.

Cell Rep. 2017 Jun 6;19(10):2157-2173. doi: 10.1016/j.celrep.2017.05.045.


An Ectopic CTCF Binding Element Inhibits Tcrd Rearrangement by Limiting Contact between Vδ and Dδ Gene Segments.

Chen L, Zhao L, Alt FW, Krangel MS.

J Immunol. 2016 Oct 15;197(8):3188-3197. Epub 2016 Sep 9.


Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development.

Zhao L, Frock RL, Du Z, Hu J, Chen L, Krangel MS, Alt FW.

J Exp Med. 2016 Aug 22;213(9):1921-36. doi: 10.1084/jem.20160670. Epub 2016 Aug 15.


Pillars Article: Identification of a Putative Second T-cell Receptor. Nature. 1986. 322: 145-149.

Brenner MB, McLean J, Dialynas DP, Strominger JL, Smith JA, Owen FL, Seidman JG, Ip S, Rosen F, Krangel MS.

J Immunol. 2016 May 1;196(9):3509-13. Epub 2016 Apr 18. No abstract available.


The Ties that Bind (the Igh Locus).

Krangel MS.

Trends Genet. 2016 May;32(5):253-255. doi: 10.1016/j.tig.2016.03.003. Epub 2016 Mar 21.


Yin Yang 1 Promotes Thymocyte Survival by Downregulating p53.

Chen L, Foreman DP, Sant'Angelo DB, Krangel MS.

J Immunol. 2016 Mar 15;196(6):2572-82. doi: 10.4049/jimmunol.1501916. Epub 2016 Feb 3.


Inactivation of nuclear GSK3β by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response.

Thornton TM, Delgado P, Chen L, Salas B, Krementsov D, Fernandez M, Vernia S, Davis RJ, Heimann R, Teuscher C, Krangel MS, Ramiro AR, Rincón M.

Nat Commun. 2016 Jan 29;7:10553. doi: 10.1038/ncomms10553.


Beyond Hypothesis: Direct Evidence That V(D)J Recombination Is Regulated by the Accessibility of Chromatin Substrates.

Krangel MS.

J Immunol. 2015 Dec 1;195(11):5103-5. doi: 10.4049/jimmunol.1502150. No abstract available.


Chromatin Dynamics and the Development of the TCRα and TCRδ Repertoires.

Carico Z, Krangel MS.

Adv Immunol. 2015;128:307-61. doi: 10.1016/ Epub 2015 Aug 15. Review.


Molecular Analysis of Mouse T Cell Receptor α and β Gene Rearrangements.

Rupp LJ, Chen L, Krangel MS, Bassing CH.

Methods Mol Biol. 2016;1323:179-202. doi: 10.1007/978-1-4939-2809-5_16.


A discrete chromatin loop in the mouse Tcra-Tcrd locus shapes the TCRδ and TCRα repertoires.

Chen L, Carico Z, Shih HY, Krangel MS.

Nat Immunol. 2015 Oct;16(10):1085-93. doi: 10.1038/ni.3232. Epub 2015 Aug 10.


An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development.

Hao B, Naik AK, Watanabe A, Tanaka H, Chen L, Richards HW, Kondo M, Taniuchi I, Kohwi Y, Kohwi-Shigematsu T, Krangel MS.

J Exp Med. 2015 May 4;212(5):809-24. doi: 10.1084/jem.20142207. Epub 2015 Apr 6.


T-cell receptor α enhancer is inactivated in αβ T lymphocytes.

del Blanco B, Angulo Ú, Krangel MS, Hernández-Munain C.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1744-53. doi: 10.1073/pnas.1406551112. Epub 2015 Mar 23.


IL-7 coordinates proliferation, differentiation and Tcra recombination during thymocyte β-selection.

Boudil A, Matei IR, Shih HY, Bogdanoski G, Yuan JS, Chang SG, Montpellier B, Kowalski PE, Voisin V, Bashir S, Bader GD, Krangel MS, Guidos CJ.

Nat Immunol. 2015 Apr;16(4):397-405. doi: 10.1038/ni.3122. Epub 2015 Mar 2.


Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element.

Majumder K, Koues OI, Chan EA, Kyle KE, Horowitz JE, Yang-Iott K, Bassing CH, Taniuchi I, Krangel MS, Oltz EM.

J Exp Med. 2015 Jan 12;212(1):107-20. doi: 10.1084/jem.20141479. Epub 2014 Dec 15.


Specification of Vδ and Vα usage by Tcra/Tcrd locus V gene segment promoters.

Naik AK, Hawwari A, Krangel MS.

J Immunol. 2015 Jan 15;194(2):790-4. doi: 10.4049/jimmunol.1402423. Epub 2014 Dec 3.


KAP-1 promotes resection of broken DNA ends not protected by γ-H2AX and 53BP1 in G₁-phase lymphocytes.

Tubbs AT, Dorsett Y, Chan E, Helmink B, Lee BS, Hung P, George R, Bredemeyer AL, Mittal A, Pappu RV, Chowdhury D, Mosammaparast N, Krangel MS, Sleckman BP.

Mol Cell Biol. 2014 Aug;34(15):2811-21. doi: 10.1128/MCB.00441-14. Epub 2014 May 19.


Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2.

Chan EA, Teng G, Corbett E, Choudhury KR, Bassing CH, Schatz DG, Krangel MS.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):E4628-37. doi: 10.1073/pnas.1310846110. Epub 2013 Nov 11.


Chromatin architecture, CCCTC-binding factor, and V(D)J recombination: managing long-distance relationships at antigen receptor loci.

Shih HY, Krangel MS.

J Immunol. 2013 May 15;190(10):4915-21. doi: 10.4049/jimmunol.1300218. Review.


Tcra gene recombination is supported by a Tcra enhancer- and CTCF-dependent chromatin hub.

Shih HY, Verma-Gaur J, Torkamani A, Feeney AJ, Galjart N, Krangel MS.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):E3493-502. doi: 10.1073/pnas.1214131109. Epub 2012 Nov 19.


The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration.

Callen E, Faryabi RB, Luckey M, Hao B, Daniel JA, Yang W, Sun HW, Dressler G, Peng W, Chi H, Ge K, Krangel MS, Park JH, Nussenzweig A.

Immunity. 2012 Dec 14;37(6):971-85. doi: 10.1016/j.immuni.2012.10.007. Epub 2012 Nov 15.


Cohesin, CTCF and lymphocyte antigen receptor locus rearrangement.

Seitan VC, Krangel MS, Merkenschlager M.

Trends Immunol. 2012 Apr;33(4):153-9. doi: 10.1016/ Epub 2012 Mar 20. Review.


Regulation of TCRβ allelic exclusion by gene segment proximity and accessibility.

Kondilis-Mangum HD, Shih HY, Mahowald G, Sleckman BP, Krangel MS.

J Immunol. 2011 Dec 15;187(12):6374-81. doi: 10.4049/jimmunol.1102611. Epub 2011 Nov 11.


A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation.

Seitan VC, Hao B, Tachibana-Konwalski K, Lavagnolli T, Mira-Bontenbal H, Brown KE, Teng G, Carroll T, Terry A, Horan K, Marks H, Adams DJ, Schatz DG, Aragon L, Fisher AG, Krangel MS, Nasmyth K, Merkenschlager M.

Nature. 2011 Aug 10;476(7361):467-71. doi: 10.1038/nature10312.


Long-distance regulation of fetal V(δ) gene segment TRDV4 by the Tcrd enhancer.

Hao B, Krangel MS.

J Immunol. 2011 Sep 1;187(5):2484-91. doi: 10.4049/jimmunol.1100468. Epub 2011 Jul 22.


A barrier-type insulator forms a boundary between active and inactive chromatin at the murine TCRβ locus.

Carabana J, Watanabe A, Hao B, Krangel MS.

J Immunol. 2011 Mar 15;186(6):3556-62. doi: 10.4049/jimmunol.1003164. Epub 2011 Feb 11.


Orchestrating T-cell receptor α gene assembly through changes in chromatin structure and organization.

Shih HY, Hao B, Krangel MS.

Immunol Res. 2011 Apr;49(1-3):192-201. doi: 10.1007/s12026-010-8181-y.


Immunology at Duke: 2011.

Krangel MS.

Immunol Res. 2011 Apr;49(1-3):1-2. doi: 10.1007/s12026-010-8198-2. No abstract available.


Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination.

Ji Y, Little AJ, Banerjee JK, Hao B, Oltz EM, Krangel MS, Schatz DG.

J Exp Med. 2010 Dec 20;207(13):2809-16. doi: 10.1084/jem.20101136. Epub 2010 Nov 29.


Distinct contracted conformations of the Tcra/Tcrd locus during Tcra and Tcrd recombination.

Shih HY, Krangel MS.

J Exp Med. 2010 Aug 30;207(9):1835-41. doi: 10.1084/jem.20100772. Epub 2010 Aug 9.


Transcription-dependent mobilization of nucleosomes at accessible TCR gene segments in vivo.

Kondilis-Mangum HD, Cobb RM, Osipovich O, Srivatsan S, Oltz EM, Krangel MS.

J Immunol. 2010 Jun 15;184(12):6970-7. doi: 10.4049/jimmunol.0903923. Epub 2010 May 17.


CD69 gene is differentially regulated in T and B cells by evolutionarily conserved promoter-distal elements.

Vazquez BN, Laguna T, Carabana J, Krangel MS, Lauzurica P.

J Immunol. 2009 Nov 15;183(10):6513-21. doi: 10.4049/jimmunol.0900839. Epub 2009 Oct 19.


Germline transcription: a key regulator of accessibility and recombination.

Abarrategui I, Krangel MS.

Adv Exp Med Biol. 2009;650:93-102. Review.


Mechanics of T cell receptor gene rearrangement.

Krangel MS.

Curr Opin Immunol. 2009 Apr;21(2):133-9. doi: 10.1016/j.coi.2009.03.009. Epub 2009 Apr 9. Review.


Initiation of allelic exclusion by stochastic interaction of Tcrb alleles with repressive nuclear compartments.

Schlimgen RJ, Reddy KL, Singh H, Krangel MS.

Nat Immunol. 2008 Jul;9(7):802-9. doi: 10.1038/ni.1624. Epub 2008 Jun 8.


Noncoding transcription controls downstream promoters to regulate T-cell receptor alpha recombination.

Abarrategui I, Krangel MS.

EMBO J. 2007 Oct 17;26(20):4380-90. Epub 2007 Sep 20.


Multiple constraints at the level of TCRalpha rearrangement impact Valpha14i NKT cell development.

Hager E, Hawwari A, Matsuda JL, Krangel MS, Gapin L.

J Immunol. 2007 Aug 15;179(4):2228-34.


T cell development: better living through chromatin.

Krangel MS.

Nat Immunol. 2007 Jul;8(7):687-94. Review.


Role for rearranged variable gene segments in directing secondary T cell receptor alpha recombination.

Hawwari A, Krangel MS.

Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):903-7. Epub 2007 Jan 8.


T-B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3zeta subunit of the T-cell antigen receptor complex.

Roberts JL, Lauritsen JP, Cooney M, Parrott RE, Sajaroff EO, Win CM, Keller MD, Carpenter JH, Carabana J, Krangel MS, Sarzotti M, Zhong XP, Wiest DL, Buckley RH.

Blood. 2007 Apr 15;109(8):3198-206. Epub 2006 Dec 14.


Regulation of T cell receptor-alpha gene recombination by transcription.

Abarrategui I, Krangel MS.

Nat Immunol. 2006 Oct;7(10):1109-15. Epub 2006 Aug 27.


A role for MAPK in feedback inhibition of Tcrb recombination.

Jackson AM, Krangel MS.

J Immunol. 2006 Jun 1;176(11):6824-30.


Some nuts are tougher to crack than others.

Krangel MS, Carabana J, Abarrategui I.

Immunity. 2006 Apr;24(4):361-3. Review.


Turning T-cell receptor beta recombination on and off: more questions than answers.

Jackson AM, Krangel MS.

Immunol Rev. 2006 Feb;209:129-41. Review.


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