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Items: 26

1.

Gata2 as a Crucial Regulator of Stem Cells in Adult Hematopoiesis and Acute Myeloid Leukemia.

Menendez-Gonzalez JB, Vukovic M, Abdelfattah A, Saleh L, Almotiri A, Thomas LA, Agirre-Lizaso A, Azevedo A, Menezes AC, Tornillo G, Edkins S, Kong K, Giles P, Anjos-Afonso F, Tonks A, Boyd AS, Kranc KR, Rodrigues NP.

Stem Cell Reports. 2019 Aug 13;13(2):291-306. doi: 10.1016/j.stemcr.2019.07.005. Epub 2019 Aug 1.

PMID:
31378673
2.

Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia.

Paris J, Morgan M, Campos J, Spencer GJ, Shmakova A, Ivanova I, Mapperley C, Lawson H, Wotherspoon DA, Sepulveda C, Vukovic M, Allen L, Sarapuu A, Tavosanis A, Guitart AV, Villacreces A, Much C, Choe J, Azar A, van de Lagemaat LN, Vernimmen D, Nehme A, Mazurier F, Somervaille TCP, Gregory RI, O'Carroll D, Kranc KR.

Cell Stem Cell. 2019 Jul 3;25(1):137-148.e6. doi: 10.1016/j.stem.2019.03.021. Epub 2019 Apr 25.

3.

CpG binding protein (CFP1) occupies open chromatin regions of active genes, including enhancers and non-CpG islands.

van de Lagemaat LN, Flenley M, Lynch MD, Garrick D, Tomlinson SR, Kranc KR, Vernimmen D.

Epigenetics Chromatin. 2018 Oct 6;11(1):59. doi: 10.1186/s13072-018-0230-0.

4.

Ca2+tapulting HSCs into action.

Guitart AV, Finch AJ, Kranc KR.

J Exp Med. 2018 Aug 6;215(8):1971-1973. doi: 10.1084/jem.20181097. Epub 2018 Jul 12.

5.

hsa-mir183/EGR1-mediated regulation of E2F1 is required for CML stem/progenitor cell survival.

Pellicano F, Park L, Hopcroft LEM, Shah MM, Jackson L, Scott MT, Clarke CJ, Sinclair A, Abraham SA, Hair A, Helgason GV, Aspinall-O'Dea M, Bhatia R, Leone G, Kranc KR, Whetton AD, Holyoake TL.

Blood. 2018 Apr 5;131(14):1532-1544. doi: 10.1182/blood-2017-05-783845. Epub 2018 Feb 5.

6.

Machine Learning Enables Live Label-Free Phenotypic Screening in Three Dimensions.

O'Duibhir E, Paris J, Lawson H, Sepulveda C, Shenton DD, Carragher NO, Kranc KR.

Assay Drug Dev Technol. 2018 Jan;16(1):51-63. doi: 10.1089/adt.2017.819.

PMID:
29345979
7.

Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions.

Guitart AV, Panagopoulou TI, Villacreces A, Vukovic M, Sepulveda C, Allen L, Carter RN, van de Lagemaat LN, Morgan M, Giles P, Sas Z, Gonzalez MV, Lawson H, Paris J, Edwards-Hicks J, Schaak K, Subramani C, Gezer D, Armesilla-Diaz A, Wills J, Easterbrook A, Coman D, So CW, O'Carroll D, Vernimmen D, Rodrigues NP, Pollard PJ, Morton NM, Finch A, Kranc KR.

J Exp Med. 2017 Mar 6;214(3):719-735. doi: 10.1084/jem.20161087. Epub 2017 Feb 15.

8.

Condensin II mutation causes T-cell lymphoma through tissue-specific genome instability.

Woodward J, Taylor GC, Soares DC, Boyle S, Sie D, Read D, Chathoth K, Vukovic M, Tarrats N, Jamieson D, Campbell KJ, Blyth K, Acosta JC, Ylstra B, Arends MJ, Kranc KR, Jackson AP, Bickmore WA, Wood AJ.

Genes Dev. 2016 Oct 1;30(19):2173-2186. Epub 2016 Oct 13.

9.

CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells.

Sinclair A, Park L, Shah M, Drotar M, Calaminus S, Hopcroft LE, Kinstrie R, Guitart AV, Dunn K, Abraham SA, Sansom O, Michie AM, Machesky L, Kranc KR, Graham GJ, Pellicano F, Holyoake TL.

Blood. 2016 Jul 21;128(3):371-83. doi: 10.1182/blood-2015-08-661785. Epub 2016 May 24.

10.

ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells.

Karvela M, Baquero P, Kuntz EM, Mukhopadhyay A, Mitchell R, Allan EK, Chan E, Kranc KR, Calabretta B, Salomoni P, Gottlieb E, Holyoake TL, Helgason GV.

Autophagy. 2016 Jun 2;12(6):936-48. doi: 10.1080/15548627.2016.1162359. Epub 2016 May 11.

11.

Adult hematopoietic stem cells lacking Hif-1α self-renew normally.

Vukovic M, Sepulveda C, Subramani C, Guitart AV, Mohr J, Allen L, Panagopoulou TI, Paris J, Lawson H, Villacreces A, Armesilla-Diaz A, Gezer D, Holyoake TL, Ratcliffe PJ, Kranc KR.

Blood. 2016 Jun 9;127(23):2841-6. doi: 10.1182/blood-2015-10-677138. Epub 2016 Apr 8.

12.

Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance.

Vukovic M, Guitart AV, Sepulveda C, Villacreces A, O'Duibhir E, Panagopoulou TI, Ivens A, Menendez-Gonzalez J, Iglesias JM, Allen L, Glykofrydis F, Subramani C, Armesilla-Diaz A, Post AE, Schaak K, Gezer D, So CW, Holyoake TL, Wood A, O'Carroll D, Ratcliffe PJ, Kranc KR.

J Exp Med. 2015 Dec 14;212(13):2223-34. doi: 10.1084/jem.20150452. Epub 2015 Dec 7.

13.

Relieving oxidative stress in immune cells.

Kranc KR, Dzierzak E.

J Exp Med. 2015 Jul 27;212(8):1140. doi: 10.1084/jem.2128insight1. No abstract available.

14.

Acute loss of Cited2 impairs Nanog expression and decreases self-renewal of mouse embryonic stem cells.

Kranc KR, Oliveira DV, Armesilla-Diaz A, Pacheco-Leyva I, Catarina Matias A, Luisa Escapa A, Subramani C, Wheadon H, Trindade M, Nichols J, Kaji K, Enver T, Bragança J.

Stem Cells. 2015 Mar;33(3):699-712. doi: 10.1002/stem.1889.

15.

Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism.

Yang M, Su H, Soga T, Kranc KR, Pollard PJ.

Hypoxia (Auckl). 2014 Aug 30;2:127-142. eCollection 2014. Review.

16.

Concise review: genetic dissection of hypoxia signaling pathways in normal and leukemic stem cells.

Gezer D, Vukovic M, Soga T, Pollard PJ, Kranc KR.

Stem Cells. 2014 Jun;32(6):1390-7. doi: 10.1002/stem.1657. Review.

17.

Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance.

Guitart AV, Subramani C, Armesilla-Diaz A, Smith G, Sepulveda C, Gezer D, Vukovic M, Dunn K, Pollard P, Holyoake TL, Enver T, Ratcliffe PJ, Kranc KR.

Blood. 2013 Sep 5;122(10):1741-5. doi: 10.1182/blood-2013-02-484923. Epub 2013 Jul 26.

18.

Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny.

Calaminus SD, Guitart AV, Sinclair A, Schachtner H, Watson SP, Holyoake TL, Kranc KR, Machesky LM.

PLoS One. 2012;7(12):e51361. doi: 10.1371/journal.pone.0051361. Epub 2012 Dec 27. Erratum in: PLoS One. 2013;8(5). doi:10.1371/annotation/4c610387-c7f0-4330-b772-30ed52a07547. Guitart, Amelie [corrected to Guitart, Amelie V].

19.

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance.

Mortensen M, Soilleux EJ, Djordjevic G, Tripp R, Lutteropp M, Sadighi-Akha E, Stranks AJ, Glanville J, Knight S, Jacobsen SE, Kranc KR, Simon AK.

J Exp Med. 2011 Mar 14;208(3):455-67. doi: 10.1084/jem.20101145. Epub 2011 Feb 21.

20.

Hypoxia signaling in hematopoietic stem cells: a double-edged sword.

Pollard PJ, Kranc KR.

Cell Stem Cell. 2010 Sep 3;7(3):276-8. doi: 10.1016/j.stem.2010.08.006. No abstract available.

21.

Cited2 is an essential regulator of adult hematopoietic stem cells.

Kranc KR, Schepers H, Rodrigues NP, Bamforth S, Villadsen E, Ferry H, Bouriez-Jones T, Sigvardsson M, Bhattacharya S, Jacobsen SE, Enver T.

Cell Stem Cell. 2009 Dec 4;5(6):659-65. doi: 10.1016/j.stem.2009.11.001.

22.

Functional epistasis on a common MHC haplotype associated with multiple sclerosis.

Gregersen JW, Kranc KR, Ke X, Svendsen P, Madsen LS, Thomsen AR, Cardon LR, Bell JI, Fugger L.

Nature. 2006 Oct 5;443(7111):574-7. Epub 2006 Sep 27.

PMID:
17006452
23.

Control of autoimmunity by "epitope theft".

Kranc KR, Taylor AM, Willcox N, Fugger L.

Trends Mol Med. 2005 Jan;11(1):1-4. Review.

PMID:
15649815
24.

Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF.

Kranc KR, Bamforth SD, Bragança J, Norbury C, van Lohuizen M, Bhattacharya S.

Mol Cell Biol. 2003 Nov;23(21):7658-66.

25.

Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator.

Bamforth SD, Bragança J, Eloranta JJ, Murdoch JN, Marques FI, Kranc KR, Farza H, Henderson DJ, Hurst HC, Bhattacharya S.

Nat Genet. 2001 Dec;29(4):469-74.

PMID:
11694877
26.

Oxidative degradation of bilirubin produces vasoactive compounds.

Kranc KR, Pyne GJ, Tao L, Claridge TD, Harris DA, Cadoux-Hudson TA, Turnbull JJ, Schofield CJ, Clark JF.

Eur J Biochem. 2000 Dec;267(24):7094-101.

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