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Combined inhibition of Bcl-2 and NFκB synergistically induces cell death in cutaneous T-cell lymphoma.

Froehlich TC, Müller-Decker K, Braun JD, Albrecht T, Schroeder A, Gülow K, Goerdt S, Krammer PH, Nicolay JP.

Blood. 2019 Aug 1;134(5):445-455. doi: 10.1182/blood.2019001545. Epub 2019 Jun 5.


Enhanced expression of thioredoxin-interacting-protein regulates oxidative DNA damage and aging.

Oberacker T, Bajorat J, Ziola S, Schroeder A, Röth D, Kastl L, Edgar BA, Wagner W, Gülow K, Krammer PH.

FEBS Lett. 2018 Jul;592(13):2297-2307. doi: 10.1002/1873-3468.13156. Epub 2018 Jun 27.


Neutralization of CD95 ligand protects the liver against ischemia-reperfusion injury and prevents acute liver failure.

Al-Saeedi M, Steinebrunner N, Kudsi H, Halama N, Mogler C, Büchler MW, Krammer PH, Schemmer P, Müller M.

Cell Death Dis. 2018 Jan 26;9(2):132. doi: 10.1038/s41419-017-0150-0.


Tumor necrosis factor receptor signaling is a driver of chronic lymphocytic leukemia that can be therapeutically targeted by the flavonoid wogonin.

Dürr C, Hanna BS, Schulz A, Lucas F, Zucknick M, Benner A, Clear A, Ohl S, Öztürk S, Zenz T, Stilgenbauer S, Li-Weber M, Krammer PH, Gribben JG, Lichter P, Seiffert M.

Haematologica. 2018 Apr;103(4):688-697. doi: 10.3324/haematol.2017.177808. Epub 2018 Jan 11.


Two-Step Coimmunoprecipitation (TIP) Enables Efficient and Highly Selective Isolation of Native Protein Complexes.

Sciuto MR, Warnken U, Schnölzer M, Valvo C, Brunetto L, Boe A, Biffoni M, Krammer PH, De Maria R, Haas TL.

Mol Cell Proteomics. 2018 May;17(5):993-1009. doi: 10.1074/mcp.O116.065920. Epub 2017 Dec 7.


NRAS mutations in cutaneous T cell lymphoma (CTCL) sensitize tumors towards treatment with the multikinase inhibitor Sorafenib.

Kießling MK, Nicolay JP, Schlör T, Klemke CD, Süss D, Krammer PH, Gülow K.

Oncotarget. 2017 Jul 11;8(28):45687-45697. doi: 10.18632/oncotarget.17669.


Targeting Thioredoxin-1 by dimethyl fumarate induces ripoptosome-mediated cell death.

Schroeder A, Warnken U, Röth D, Klika KD, Vobis D, Barnert A, Bujupi F, Oberacker T, Schnölzer M, Nicolay JP, Krammer PH, Gülow K.

Sci Rep. 2017 Feb 24;7:43168. doi: 10.1038/srep43168.


Analysis of FOXP3+ regulatory T cell subpopulations in peripheral blood and tissue of patients with systemic lupus erythematosus.

Schmidt A, Rieger CC, Venigalla RK, Éliás S, Max R, Lorenz HM, Gröne HJ, Krammer PH, Kuhn A.

Immunol Res. 2017 Apr;65(2):551-563. doi: 10.1007/s12026-017-8904-4.


Life, death and tolerance.

Krammer PH, Weyd H.

Biochem Biophys Res Commun. 2017 Jan 15;482(3):470-472. doi: 10.1016/j.bbrc.2016.10.123. Epub 2017 Feb 3. Review. No abstract available.


Rocaglamide breaks TRAIL-resistance in human multiple myeloma and acute T-cell leukemia in vivo in a mouse xenogtraft model.

Wu Y, Giaisi M, Köhler R, Chen WM, Krammer PH, Li-Weber M.

Cancer Lett. 2017 Mar 28;389:70-77. doi: 10.1016/j.canlet.2016.12.010. Epub 2016 Dec 18.


The anticancer phytochemical rocaglamide inhibits Rho GTPase activity and cancer cell migration.

Becker MS, Müller PM, Bajorat J, Schroeder A, Giaisi M, Amin E, Ahmadian MR, Rocks O, Köhler R, Krammer PH, Li-Weber M.

Oncotarget. 2016 Aug 9;7(32):51908-51921. doi: 10.18632/oncotarget.10188.


Dimethyl fumarate restores apoptosis sensitivity and inhibits tumor growth and metastasis in CTCL by targeting NF-κB.

Nicolay JP, Müller-Decker K, Schroeder A, Brechmann M, Möbs M, Géraud C, Assaf C, Goerdt S, Krammer PH, Gülow K.

Blood. 2016 Aug 11;128(6):805-15. doi: 10.1182/blood-2016-01-694117. Epub 2016 Jun 6.


A Recombinant Bispecific CD20×CD95 Antibody With Superior Activity Against Normal and Malignant B-cells.

Nalivaiko K, Hofmann M, Kober K, Teichweyde N, Krammer PH, Rammensee HG, Grosse-Hovest L, Jung G.

Mol Ther. 2016 Feb;24(2):298-305. doi: 10.1038/mt.2015.209. Epub 2015 Nov 19.


Molecular architecture of the DED chains at the DISC: regulation of procaspase-8 activation by short DED proteins c-FLIP and procaspase-8 prodomain.

Schleich K, Buchbinder JH, Pietkiewicz S, Kähne T, Warnken U, Öztürk S, Schnölzer M, Naumann M, Krammer PH, Lavrik IN.

Cell Death Differ. 2016 Apr;23(4):681-94. doi: 10.1038/cdd.2015.137. Epub 2015 Oct 23.


AF-1 a novel regulator of the redox equilibrium during aging.

Bajorat J, Oberacker T, Ziola S, Edgar BA, Gülow K, Krammer PH.

Free Radic Biol Med. 2014 Oct;75 Suppl 1:S22-3. doi: 10.1016/j.freeradbiomed.2014.10.737. Epub 2014 Dec 10.


Combinatorial treatment of CD95L and gemcitabine in pancreatic cancer cells induces apoptotic and RIP1-mediated necroptotic cell death network.

Pietkiewicz S, Eils R, Krammer PH, Giese N, Lavrik IN.

Exp Cell Res. 2015 Nov 15;339(1):1-9. doi: 10.1016/j.yexcr.2015.10.005. Epub 2015 Oct 8.


High-resolution analysis of the human T-cell receptor repertoire.

Ruggiero E, Nicolay JP, Fronza R, Arens A, Paruzynski A, Nowrouzi A, Ürenden G, Lulay C, Schneider S, Goerdt S, Glimm H, Krammer PH, Schmidt M, von Kalle C.

Nat Commun. 2015 Sep 1;6:8081. doi: 10.1038/ncomms9081.


HTLV-1-associated adult T cell leukemia is highly susceptible to Navitoclax due to enhanced Bax expression.

Witzens-Harig M, Giaisi M, Köhler R, Krammer PH, Li-Weber M.

Int J Cancer. 2016 Jan 15;138(2):507-14. doi: 10.1002/ijc.29726. Epub 2015 Aug 27.


Induction of apoptosis by IFNγ in human neuroblastoma cell lines through the CD95/CD95L autocrine circuit.

Bernassola F, Scheuerpflug C, Herr I, Krammer PH, Debatin KM, Melino G.

Cell Death Differ. 2015 Sep;22(9):1562. doi: 10.1038/cdd.2015.89. No abstract available.


Mangrove dolabrane-type of diterpenes tagalsins suppresses tumor growth via ROS-mediated apoptosis and ATM/ATR-Chk1/Chk2-regulated cell cycle arrest.

Neumann J, Yang Y, Köhler R, Giaisi M, Witzens-Harig M, Liu D, Krammer PH, Lin W, Li-Weber M.

Int J Cancer. 2015 Dec 1;137(11):2739-48. doi: 10.1002/ijc.29629. Epub 2015 Jun 30.


The tolerogenic function of annexins on apoptotic cells is mediated by the annexin core domain.

Linke B, Abeler-Dörner L, Jahndel V, Kurz A, Mahr A, Pfrang S, Linke L, Krammer PH, Weyd H.

J Immunol. 2015 Jun 1;194(11):5233-42. doi: 10.4049/jimmunol.1401299. Epub 2015 Apr 27.


Tax contributes apoptosis resistance to HTLV-1-infected T cells via suppression of Bid and Bim expression.

Mühleisen A, Giaisi M, Köhler R, Krammer PH, Li-Weber M.

Cell Death Dis. 2014 Dec 18;5:e1575. doi: 10.1038/cddis.2014.536.


Targeting CDK9 by wogonin and related natural flavones potentiates the anti-cancer efficacy of the Bcl-2 family inhibitor ABT-263.

Polier G, Giaisi M, Köhler R, Müller WW, Lutz C, Buss EC, Krammer PH, Li-Weber M.

Int J Cancer. 2015 Feb 1;136(3):688-98. doi: 10.1002/ijc.29009. Epub 2014 Jun 13.


The protein phosphatase 2A regulatory subunit B56γ mediates suppression of T cell receptor (TCR)-induced nuclear factor-κB (NF-κB) activity.

Breuer R, Becker MS, Brechmann M, Mock T, Arnold R, Krammer PH.

J Biol Chem. 2014 May 23;289(21):14996-5004. doi: 10.1074/jbc.M113.533547. Epub 2014 Apr 9.


Dynamin related protein 1-dependent mitochondrial fission regulates oxidative signalling in T cells.

Röth D, Krammer PH, Gülow K.

FEBS Lett. 2014 May 2;588(9):1749-54. doi: 10.1016/j.febslet.2014.03.029. Epub 2014 Mar 26.


The traditional Chinese medical compound Rocaglamide protects nonmalignant primary cells from DNA damage-induced toxicity by inhibition of p53 expression.

Becker MS, Schmezer P, Breuer R, Haas SF, Essers MA, Krammer PH, Li-Weber M.

Cell Death Dis. 2014 Jan 16;5:e1000. doi: 10.1038/cddis.2013.528.


TNF-α mediates mitochondrial uncoupling and enhances ROS-dependent cell migration via NF-κB activation in liver cells.

Kastl L, Sauer SW, Ruppert T, Beissbarth T, Becker MS, Süss D, Krammer PH, Gülow K.

FEBS Lett. 2014 Jan 3;588(1):175-83. doi: 10.1016/j.febslet.2013.11.033. Epub 2013 Dec 4.


The natural anticancer compound rocaglamide selectively inhibits the G1-S-phase transition in cancer cells through the ATM/ATR-mediated Chk1/2 cell cycle checkpoints.

Neumann J, Boerries M, Köhler R, Giaisi M, Krammer PH, Busch H, Li-Weber M.

Int J Cancer. 2014 Apr 15;134(8):1991-2002. doi: 10.1002/ijc.28521. Epub 2013 Oct 21.


Apoptotic signal molecules in skin biopsies of cutaneous lupus erythematosus: analysis using tissue microarray.

Toberer F, Sykora J, Göttel D, Hartschuh W, Werchau S, Enk A, Joos S, Krammer PH, Kuhn A.

Exp Dermatol. 2013 Oct;22(10):656-9. doi: 10.1111/exd.12216.


Interferon-α abrogates the suppressive effect of apoptotic cells on dendritic cells in an in vitro model of systemic lupus erythematosus pathogenesis.

Abeler-Dörner L, Rieger CC, Berger B, Weyd H, Gräf D, Pfrang S, Tarner IH, Schwarting A, Lorenz HM, Müller-Ladner U, Krammer PH, Kuhn A.

J Rheumatol. 2013 Oct;40(10):1683-96. doi: 10.3899/jrheum.121299. Epub 2013 Sep 15.


The Wilms' tumor suppressor WT1 enhances CD95L expression and promotes activation-induced cell death in leukemic T cells.

Bourkoula K, Englert C, Giaisi M, Köhler R, Krammer PH, Li-Weber M.

Int J Cancer. 2014 Jan 15;134(2):291-300. doi: 10.1002/ijc.28379. Epub 2013 Aug 9.


Mitochondria as oxidative signaling organelles in T-cell activation: physiological role and pathological implications.

Kamiński MM, Röth D, Krammer PH, Gülow K.

Arch Immunol Ther Exp (Warsz). 2013 Oct;61(5):367-84. doi: 10.1007/s00005-013-0235-0. Epub 2013 Jun 9. Review.


Annexin A1 on the surface of early apoptotic cells suppresses CD8+ T cell immunity.

Weyd H, Abeler-Dörner L, Linke B, Mahr A, Jahndel V, Pfrang S, Schnölzer M, Falk CS, Krammer PH.

PLoS One. 2013 Apr 30;8(4):e62449. doi: 10.1371/journal.pone.0062449. Print 2013.


Targeting the IL-4/IL-13 signaling pathway sensitizes Hodgkin lymphoma cells to chemotherapeutic drugs.

Natoli A, Lüpertz R, Merz C, Müller WW, Köhler R, Krammer PH, Li-Weber M.

Int J Cancer. 2013 Oct 15;133(8):1945-54. doi: 10.1002/ijc.28189. Epub 2013 Apr 25.


Pillars article: T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells. J. Exp. Med. 1982. 155: 734-748.

Isakson PC, Puré E, Vitetta ES, Krammer PH.

J Immunol. 2013 Feb 1;190(3):849-63. No abstract available.


The chains of death: a new view on caspase-8 activation at the DISC.

Schleich K, Krammer PH, Lavrik IN.

Cell Cycle. 2013 Jan 15;12(2):193-4. doi: 10.4161/cc.23464. Epub 2012 Jan 15. No abstract available.


2-Methoxyestradiol inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation.

Duncan GS, Brenner D, Tusche MW, Brüstle A, Knobbe CB, Elia AJ, Mock T, Bray MR, Krammer PH, Mak TW.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21034-9. doi: 10.1073/pnas.1215558110. Epub 2012 Dec 3.


T cell activation is driven by an ADP-dependent glucokinase linking enhanced glycolysis with mitochondrial reactive oxygen species generation.

Kamiński MM, Sauer SW, Kamiński M, Opp S, Ruppert T, Grigaravičius P, Grudnik P, Gröne HJ, Krammer PH, Gülow K.

Cell Rep. 2012 Nov 29;2(5):1300-15. doi: 10.1016/j.celrep.2012.10.009. Epub 2012 Nov 15.


A PP4 holoenzyme balances physiological and oncogenic nuclear factor-kappa B signaling in T lymphocytes.

Brechmann M, Mock T, Nickles D, Kiessling M, Weit N, Breuer R, Müller W, Wabnitz G, Frey F, Nicolay JP, Booken N, Samstag Y, Klemke CD, Herling M, Boutros M, Krammer PH, Arnold R.

Immunity. 2012 Oct 19;37(4):697-708. doi: 10.1016/j.immuni.2012.07.014.


The natural anticancer compounds rocaglamides inhibit the Raf-MEK-ERK pathway by targeting prohibitin 1 and 2.

Polier G, Neumann J, Thuaud F, Ribeiro N, Gelhaus C, Schmidt H, Giaisi M, Köhler R, Müller WW, Proksch P, Leippe M, Janssen O, Désaubry L, Krammer PH, Li-Weber M.

Chem Biol. 2012 Sep 21;19(9):1093-104. doi: 10.1016/j.chembiol.2012.07.012.


Stoichiometry of the CD95 death-inducing signaling complex: experimental and modeling evidence for a death effector domain chain model.

Schleich K, Warnken U, Fricker N, Oztürk S, Richter P, Kammerer K, Schnölzer M, Krammer PH, Lavrik IN.

Mol Cell. 2012 Jul 27;47(2):306-19. doi: 10.1016/j.molcel.2012.05.006. Epub 2012 Jun 7.


Molecular mechanisms of treg-mediated T cell suppression.

Schmidt A, Oberle N, Krammer PH.

Front Immunol. 2012 Mar 21;3:51. doi: 10.3389/fimmu.2012.00051. eCollection 2012.


Manganese superoxide dismutase: a regulator of T cell activation-induced oxidative signaling and cell death.

Kamiński MM, Röth D, Sass S, Sauer SW, Krammer PH, Gülow K.

Biochim Biophys Acta. 2012 May;1823(5):1041-52. doi: 10.1016/j.bbamcr.2012.03.003. Epub 2012 Mar 9.


Human regulatory T cells rapidly suppress T cell receptor-induced Ca(2+), NF-κB, and NFAT signaling in conventional T cells.

Schmidt A, Oberle N, Weiss EM, Vobis D, Frischbutter S, Baumgrass R, Falk CS, Haag M, Brügger B, Lin H, Mayr GW, Reichardt P, Gunzer M, Suri-Payer E, Krammer PH.

Sci Signal. 2011 Dec 20;4(204):ra90. doi: 10.1126/scisignal.2002179.


Curcumin suppresses T cell activation by blocking Ca2+ mobilization and nuclear factor of activated T cells (NFAT) activation.

Kliem C, Merling A, Giaisi M, Köhler R, Krammer PH, Li-Weber M.

J Biol Chem. 2012 Mar 23;287(13):10200-9. doi: 10.1074/jbc.M111.318733. Epub 2012 Feb 2.


Regulation of CD95/Fas signaling at the DISC.

Lavrik IN, Krammer PH.

Cell Death Differ. 2012 Jan;19(1):36-41. doi: 10.1038/cdd.2011.155. Epub 2011 Nov 11. Review.


Caspase-8 activity has an essential role in CD95/Fas-mediated MAPK activation.

Kober AM, Legewie S, Pforr C, Fricker N, Eils R, Krammer PH, Lavrik IN.

Cell Death Dis. 2011 Oct 6;2:e212. doi: 10.1038/cddis.2011.93.


Rocaglamide and a XIAP inhibitor cooperatively sensitize TRAIL-mediated apoptosis in Hodgkin's lymphomas.

Giaisi M, Köhler R, Fulda S, Krammer PH, Li-Weber M.

Int J Cancer. 2012 Aug 15;131(4):1003-8. doi: 10.1002/ijc.26458. Epub 2011 Nov 8.


Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1.

Polier G, Ding J, Konkimalla BV, Eick D, Ribeiro N, Köhler R, Giaisi M, Efferth T, Desaubry L, Krammer PH, Li-Weber M.

Cell Death Dis. 2011 Jul 21;2:e182. doi: 10.1038/cddis.2011.66.

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