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Items: 1 to 50 of 185

1.

Localizing proton-mediated inhibitory feedback at the retinal horizontal cell-cone synapse with genetically-encoded pH probes.

Beckwith-Cohen B, Holzhausen LC, Wang TM, Rajappa R, Kramer RH.

J Neurosci. 2018 Nov 30. pii: 1541-18. doi: 10.1523/JNEUROSCI.1541-18.2018. [Epub ahead of print]

PMID:
30504272
2.

Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors.

Durand-de Cuttoli R, Mondoloni S, Marti F, Lemoine D, Nguyen C, Naudé J, d'Izarny-Gargas T, Pons S, Maskos U, Trauner D, Kramer RH, Faure P, Mourot A.

Elife. 2018 Sep 4;7. pii: e37487. doi: 10.7554/eLife.37487.

3.

Design of a Highly Bistable Photoswitchable Tethered Ligand for Rapid and Sustained Manipulation of Neurotransmission.

Lin WC, Tsai MC, Rajappa R, Kramer RH.

J Am Chem Soc. 2018 Jun 20;140(24):7445-7448. doi: 10.1021/jacs.8b03942. Epub 2018 Jun 6.

PMID:
29874068
4.

Restoring Vision to the Blind with Chemical Photoswitches.

Tochitsky I, Kienzler MA, Isacoff E, Kramer RH.

Chem Rev. 2018 Nov 14;118(21):10748-10773. doi: 10.1021/acs.chemrev.7b00723. Epub 2018 Jun 6.

PMID:
29874052
5.

Author Correction: Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor.

Berry MH, Holt A, Levitz J, Broichhagen J, Gaub BM, Visel M, Stanley C, Aghi K, Kim YJ, Cao K, Kramer RH, Trauner D, Flannery J, Isacoff EY.

Nat Commun. 2018 Mar 13;9(1):1112. doi: 10.1038/s41467-018-03585-2.

6.

Light-Switchable Ion Channels and Receptors for Optogenetic Interrogation of Neuronal Signaling.

Lin WC, Kramer RH.

Bioconjug Chem. 2018 Apr 18;29(4):861-869. doi: 10.1021/acs.bioconjchem.7b00803. Epub 2018 Feb 21.

PMID:
29465988
7.

Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor.

Berry MH, Holt A, Levitz J, Broichhagen J, Gaub BM, Visel M, Stanley C, Aghi K, Kim YJ, Cao K, Kramer RH, Trauner D, Flannery J, Isacoff EY.

Nat Commun. 2017 Nov 30;8(1):1862. doi: 10.1038/s41467-017-01990-7. Erratum in: Nat Commun. 2018 Mar 13;9(1):1112.

8.

Understanding and improving photo-control of ion channels in nociceptors with azobenzene photo-switches.

Mourot A, Herold C, Kienzler MA, Kramer RH.

Br J Pharmacol. 2018 Jun;175(12):2296-2311. doi: 10.1111/bph.13923. Epub 2017 Jul 27.

PMID:
28635081
9.

Photopharmacological control of bipolar cells restores visual function in blind mice.

Laprell L, Tochitsky I, Kaur K, Manookin MB, Stein M, Barber DM, Schön C, Michalakis S, Biel M, Kramer RH, Sumser MP, Trauner D, Van Gelder RN.

J Clin Invest. 2017 Jun 30;127(7):2598-2611. doi: 10.1172/JCI92156. Epub 2017 Jun 5.

10.

Restoring visual function to the blind retina with a potent, safe and long-lasting photoswitch.

Tochitsky I, Trautman J, Gallerani N, Malis JG, Kramer RH.

Sci Rep. 2017 Apr 13;7:45487. doi: 10.1038/srep45487.

11.

How Azobenzene Photoswitches Restore Visual Responses to the Blind Retina.

Tochitsky I, Helft Z, Meseguer V, Fletcher RB, Vessey KA, Telias M, Denlinger B, Malis J, Fletcher EL, Kramer RH.

Neuron. 2016 Oct 5;92(1):100-113. doi: 10.1016/j.neuron.2016.08.038. Epub 2016 Sep 22.

12.

Serotonin modulates spike probability in the axon initial segment through HCN channels.

Ko KW, Rasband MN, Meseguer V, Kramer RH, Golding NL.

Nat Neurosci. 2016 Jun;19(6):826-34. doi: 10.1038/nn.4293. Epub 2016 Apr 25.

13.

Lateral Inhibition in the Vertebrate Retina: The Case of the Missing Neurotransmitter.

Kramer RH, Davenport CM.

PLoS Biol. 2015 Dec 10;13(12):e1002322. doi: 10.1371/journal.pbio.1002322. eCollection 2015 Dec.

14.

A Comprehensive Optogenetic Pharmacology Toolkit for In Vivo Control of GABA(A) Receptors and Synaptic Inhibition.

Lin WC, Tsai MC, Davenport CM, Smith CM, Veit J, Wilson NM, Adesnik H, Kramer RH.

Neuron. 2015 Dec 2;88(5):879-891. doi: 10.1016/j.neuron.2015.10.026. Epub 2015 Nov 19.

15.

Controlled release of photoswitch drugs by degradable polymer microspheres.

Groynom R, Shoffstall E, Wu LS, Kramer RH, Lavik EB.

J Drug Target. 2015;23(7-8):710-5. doi: 10.3109/1061186X.2015.1060978.

16.

ErbB3 upregulation by the HNSCC 3D microenvironment modulates cell survival and growth.

Humtsoe JO, Pham E, Louie RJ, Chan DA, Kramer RH.

Oncogene. 2016 Mar 24;35(12):1554-64. doi: 10.1038/onc.2015.220. Epub 2015 Jun 15.

PMID:
26073080
17.

Optogenetics in Developmental Biology: using light to control ion flux-dependent signals in Xenopus embryos.

Spencer Adams D, Lemire JM, Kramer RH, Levin M.

Int J Dev Biol. 2014;58(10-12):851-61. doi: 10.1387/ijdb.140207ml.

18.

Optopharmacological tools for restoring visual function in degenerative retinal diseases.

Tochitsky I, Kramer RH.

Curr Opin Neurobiol. 2015 Oct;34:74-8. doi: 10.1016/j.conb.2015.01.018. Epub 2015 Feb 22. Review.

19.

Engineering a light-regulated GABAA receptor for optical control of neural inhibition.

Lin WC, Davenport CM, Mourot A, Vytla D, Smith CM, Medeiros KA, Chambers JJ, Kramer RH.

ACS Chem Biol. 2014 Jul 18;9(7):1414-9. doi: 10.1021/cb500167u. Epub 2014 May 22.

20.

Differentiation of human skeletal muscle stem cells into odontoblasts is dependent on induction of α1 integrin expression.

Ozeki N, Mogi M, Yamaguchi H, Hiyama T, Kawai R, Hase N, Nakata K, Nakamura H, Kramer RH.

J Biol Chem. 2014 May 16;289(20):14380-91. doi: 10.1074/jbc.M113.526772. Epub 2014 Apr 1.

21.

Restoring visual function to blind mice with a photoswitch that exploits electrophysiological remodeling of retinal ganglion cells.

Tochitsky I, Polosukhina A, Degtyar VE, Gallerani N, Smith CM, Friedman A, Van Gelder RN, Trauner D, Kaufer D, Kramer RH.

Neuron. 2014 Feb 19;81(4):800-13. doi: 10.1016/j.neuron.2014.01.003.

22.

Imaging an optogenetic pH sensor reveals that protons mediate lateral inhibition in the retina.

Wang TM, Holzhausen LC, Kramer RH.

Nat Neurosci. 2014 Feb;17(2):262-8. doi: 10.1038/nn.3627. Epub 2014 Jan 19.

23.

Optogenetic pharmacology for control of native neuronal signaling proteins.

Kramer RH, Mourot A, Adesnik H.

Nat Neurosci. 2013 Jul;16(7):816-23. doi: 10.1038/nn.3424. Epub 2013 Jun 25. Review.

24.

Light at the end of the channel: optical manipulation of intrinsic neuronal excitability with chemical photoswitches.

Mourot A, Tochitsky I, Kramer RH.

Front Mol Neurosci. 2013 Mar 21;6:5. doi: 10.3389/fnmol.2013.00005. eCollection 2013.

25.

Photochromic potassium channel blockers: design and electrophysiological characterization.

Mourot A, Fehrentz T, Kramer RH.

Methods Mol Biol. 2013;995:89-105. doi: 10.1007/978-1-62703-345-9_7.

26.

Tuning photochromic ion channel blockers.

Mourot A, Kienzler MA, Banghart MR, Fehrentz T, Huber FM, Stein M, Kramer RH, Trauner D.

ACS Chem Neurosci. 2011 Sep 21;2(9):536-43. doi: 10.1021/cn200037p. Epub 2011 Jun 9.

27.

Photochemical restoration of visual responses in blind mice.

Polosukhina A, Litt J, Tochitsky I, Nemargut J, Sychev Y, De Kouchkovsky I, Huang T, Borges K, Trauner D, Van Gelder RN, Kramer RH.

Neuron. 2012 Jul 26;75(2):271-82. doi: 10.1016/j.neuron.2012.05.022.

28.

Optical control of endogenous proteins with a photoswitchable conditional subunit reveals a role for TREK1 in GABA(B) signaling.

Sandoz G, Levitz J, Kramer RH, Isacoff EY.

Neuron. 2012 Jun 21;74(6):1005-14. doi: 10.1016/j.neuron.2012.04.026.

29.

Rab3A mediates vesicle delivery at photoreceptor ribbon synapses.

Tian M, Xu CS, Montpetit R, Kramer RH.

J Neurosci. 2012 May 16;32(20):6931-6. doi: 10.1523/JNEUROSCI.0265-12.2012.

30.

Rapid optical control of nociception with an ion-channel photoswitch.

Mourot A, Fehrentz T, Le Feuvre Y, Smith CM, Herold C, Dalkara D, Nagy F, Trauner D, Kramer RH.

Nat Methods. 2012 Feb 19;9(4):396-402. doi: 10.1038/nmeth.1897.

31.

Optochemical control of genetically engineered neuronal nicotinic acetylcholine receptors.

Tochitsky I, Banghart MR, Mourot A, Yao JZ, Gaub B, Kramer RH, Trauner D.

Nat Chem. 2012 Jan 10;4(2):105-11. doi: 10.1038/nchem.1234.

32.

Water-soluble, donor-acceptor biphenyl derivatives in the 2-(o-nitrophenyl)propyl series: highly efficient two-photon uncaging of the neurotransmitter γ-aminobutyric acid at λ = 800 nm.

Donato L, Mourot A, Davenport CM, Herbivo C, Warther D, Léonard J, Bolze F, Nicoud JF, Kramer RH, Goeldner M, Specht A.

Angew Chem Int Ed Engl. 2012 Feb 20;51(8):1840-3. doi: 10.1002/anie.201106559. Epub 2012 Jan 11. No abstract available.

33.

Transcriptional profiling identifies upregulated genes following induction of epithelial-mesenchymal transition in squamous carcinoma cells.

Humtsoe JO, Koya E, Pham E, Aramoto T, Zuo J, Ishikawa T, Kramer RH.

Exp Cell Res. 2012 Feb 15;318(4):379-90. doi: 10.1016/j.yexcr.2011.11.011. Epub 2011 Nov 29.

PMID:
22154512
34.

Release from the cone ribbon synapse under bright light conditions can be controlled by the opening of only a few Ca(2+) channels.

Bartoletti TM, Jackman SL, Babai N, Mercer AJ, Kramer RH, Thoreson WB.

J Neurophysiol. 2011 Dec;106(6):2922-35. doi: 10.1152/jn.00634.2011. Epub 2011 Aug 31.

35.

Engineering light-regulated ion channels.

Fortin DL, Dunn TW, Kramer RH.

Cold Spring Harb Protoc. 2011 Jun 1;2011(6):579-85. doi: 10.1101/pdb.top112. No abstract available.

PMID:
21632787
36.

A positive feedback synapse from retinal horizontal cells to cone photoreceptors.

Jackman SL, Babai N, Chambers JJ, Thoreson WB, Kramer RH.

PLoS Biol. 2011 May;9(5):e1001057. doi: 10.1371/journal.pbio.1001057. Epub 2011 May 3.

37.

Optogenetic photochemical control of designer K+ channels in mammalian neurons.

Fortin DL, Dunn TW, Fedorchak A, Allen D, Montpetit R, Banghart MR, Trauner D, Adelman JP, Kramer RH.

J Neurophysiol. 2011 Jul;106(1):488-96. doi: 10.1152/jn.00251.2011. Epub 2011 Apr 27.

38.

Bcl-2 overexpression induces a partial epithelial to mesenchymal transition and promotes squamous carcinoma cell invasion and metastasis.

Zuo J, Ishikawa T, Boutros S, Xiao Z, Humtsoe JO, Kramer RH.

Mol Cancer Res. 2010 Feb;8(2):170-82. doi: 10.1158/1541-7786.MCR-09-0354. Epub 2010 Feb 9.

39.

Sdc1 negatively modulates carcinoma cell motility and invasion.

Ishikawa T, Kramer RH.

Exp Cell Res. 2010 Apr 1;316(6):951-65. doi: 10.1016/j.yexcr.2009.12.013. Epub 2009 Dec 28.

40.

Differential epidermal growth factor receptor signaling regulates anchorage-independent growth by modulation of the PI3K/AKT pathway.

Humtsoe JO, Kramer RH.

Oncogene. 2010 Feb 25;29(8):1214-26. doi: 10.1038/onc.2009.419. Epub 2009 Nov 23.

41.

Photochromic blockers of voltage-gated potassium channels.

Banghart MR, Mourot A, Fortin DL, Yao JZ, Kramer RH, Trauner D.

Angew Chem Int Ed Engl. 2009;48(48):9097-101. doi: 10.1002/anie.200904504. No abstract available.

42.

New photochemical tools for controlling neuronal activity.

Kramer RH, Fortin DL, Trauner D.

Curr Opin Neurobiol. 2009 Oct;19(5):544-52. doi: 10.1016/j.conb.2009.09.004. Epub 2009 Oct 12. Review.

43.

Role of the synaptic ribbon in transmitting the cone light response.

Jackman SL, Choi SY, Thoreson WB, Rabl K, Bartoletti TM, Kramer RH.

Nat Neurosci. 2009 Mar;12(3):303-10. doi: 10.1038/nn.2267. Epub 2009 Feb 15.

44.

Light-activated ion channels for remote control of neural activity.

Chambers JJ, Kramer RH.

Methods Cell Biol. 2008;90:217-32. doi: 10.1016/S0091-679X(08)00811-X.

45.

Light regulation of Ca2+ in the cone photoreceptor synaptic terminal.

Choi SY, Jackman S, Thoreson WB, Kramer RH.

Vis Neurosci. 2008 Sep-Dec;25(5-6):693-700.

46.
47.

Photochemical control of endogenous ion channels and cellular excitability.

Fortin DL, Banghart MR, Dunn TW, Borges K, Wagenaar DA, Gaudry Q, Karakossian MH, Otis TS, Kristan WB, Trauner D, Kramer RH.

Nat Methods. 2008 Apr;5(4):331-8. doi: 10.1038/nmeth.1187. Epub 2008 Mar 2.

48.

STAT3 signaling is induced by intercellular adhesion in squamous cell carcinoma cells.

Onishi A, Chen Q, Humtsoe JO, Kramer RH.

Exp Cell Res. 2008 Jan 15;314(2):377-86. Epub 2007 Sep 29.

49.
50.

Remote control of neuronal activity with a light-gated glutamate receptor.

Szobota S, Gorostiza P, Del Bene F, Wyart C, Fortin DL, Kolstad KD, Tulyathan O, Volgraf M, Numano R, Aaron HL, Scott EK, Kramer RH, Flannery J, Baier H, Trauner D, Isacoff EY.

Neuron. 2007 May 24;54(4):535-45.

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