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Items: 1 to 50 of 74

1.

Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation.

Zewinger S, Reiser J, Jankowski V, Alansary D, Hahm E, Triem S, Klug M, Schunk SJ, Schmit D, Kramann R, Körbel C, Ampofo E, Laschke MW, Selejan SR, Paschen A, Herter T, Schuster S, Silbernagel G, Sester M, Sester U, Aßmann G, Bals R, Kostner G, Jahnen-Dechent W, Menger MD, Rohrer L, März W, Böhm M, Jankowski J, Kopf M, Latz E, Niemeyer BA, Fliser D, Laufs U, Speer T.

Nat Immunol. 2019 Dec 9. doi: 10.1038/s41590-019-0548-1. [Epub ahead of print]

PMID:
31819254
2.

The authors reply.

Saez-Rodriguez J, Rinschen MM, Floege J, Kramann R.

Kidney Int. 2019 Dec;96(6):1422-1423. doi: 10.1016/j.kint.2019.09.011. No abstract available.

PMID:
31759488
3.

Transcriptome analysis reveals microvascular endothelial cell-dependent pericyte differentiation.

Brandt MM, van Dijk CGM, Maringanti R, Chrifi I, Kramann R, Verhaar MC, Duncker DJ, Mokry M, Cheng C.

Sci Rep. 2019 Oct 30;9(1):15586. doi: 10.1038/s41598-019-51838-x.

4.

mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans.

Puelles VG, van der Wolde JW, Wanner N, Scheppach MW, Cullen-McEwen LA, Bork T, Lindenmeyer MT, Gernhold L, Wong MN, Braun F, Cohen CD, Kett MM, Kuppe C, Kramann R, Saritas T, van Roeyen CR, Moeller MJ, Tribolet L, Rebello R, Sun YB, Li J, Müller-Newen G, Hughson MD, Hoy WE, Person F, Wiech T, Ricardo SD, Kerr PG, Denton KM, Furic L, Huber TB, Nikolic-Paterson DJ, Bertram JF.

JCI Insight. 2019 Sep 19;4(18). pii: 99271. doi: 10.1172/jci.insight.99271.

5.

Speckle Tracking Echocardiography and All-Cause and Cardiovascular Mortality Risk in Chronic Kidney Disease Patients.

Jahn L, Kramann R, Marx N, Floege J, Becker M, Schlieper G.

Kidney Blood Press Res. 2019;44(4):690-703. doi: 10.1159/000501225. Epub 2019 Aug 15.

6.

Optical Clearing and Imaging of Immunolabeled Kidney Tissue.

Saritas T, Puelles VG, Su XT, Ellison DH, Kramann R.

J Vis Exp. 2019 Jul 22;(149). doi: 10.3791/60002.

PMID:
31380853
7.

Heterogeneity and plasticity in healthy and atherosclerotic vasculature explored by single-cell sequencing.

van Kuijk K, Kuppe C, Betsholtz C, Vanlandewijck M, Kramann R, Sluimer JC.

Cardiovasc Res. 2019 Oct 1;115(12):1705-1715. doi: 10.1093/cvr/cvz185.

8.

Novel 3D analysis using optical tissue clearing documents the evolution of murine rapidly progressive glomerulonephritis.

Puelles VG, Fleck D, Ortz L, Papadouri S, Strieder T, Böhner AMC, van der Wolde JW, Vogt M, Saritas T, Kuppe C, Fuss A, Menzel S, Klinkhammer BM, Müller-Newen G, Heymann F, Decker L, Braun F, Kretz O, Huber TB, Susaki EA, Ueda HR, Boor P, Floege J, Kramann R, Kurts C, Bertram JF, Spehr M, Nikolic-Paterson DJ, Moeller MJ.

Kidney Int. 2019 Aug;96(2):505-516. doi: 10.1016/j.kint.2019.02.034. Epub 2019 Mar 15.

9.

Non-canonical HIF-1 stabilization contributes to intestinal tumorigenesis.

Rohwer N, Jumpertz S, Erdem M, Egners A, Warzecha KT, Fragoulis A, Kühl AA, Kramann R, Neuss S, Rudolph I, Endermann T, Zasada C, Apostolova I, Gerling M, Kempa S, Hughes R, Lewis CE, Brenner W, Malinowski MB, Stockmann M, Schomburg L, Faller W, Sansom OJ, Tacke F, Morkel M, Cramer T.

Oncogene. 2019 Jul;38(28):5670-5685. doi: 10.1038/s41388-019-0816-4. Epub 2019 May 1.

10.

Big science and big data in nephrology.

Saez-Rodriguez J, Rinschen MM, Floege J, Kramann R.

Kidney Int. 2019 Jun;95(6):1326-1337. doi: 10.1016/j.kint.2018.11.048. Epub 2019 Mar 5. Review.

11.

Elastin imaging enables noninvasive staging and treatment monitoring of kidney fibrosis.

Sun Q, Baues M, Klinkhammer BM, Ehling J, Djudjaj S, Drude NI, Daniel C, Amann K, Kramann R, Kim H, Saez-Rodriguez J, Weiskirchen R, Onthank DC, Botnar RM, Kiessling F, Floege J, Lammers T, Boor P.

Sci Transl Med. 2019 Apr 3;11(486). pii: eaat4865. doi: 10.1126/scitranslmed.aat4865.

PMID:
30944168
12.

Disruption of CUL3-mediated ubiquitination causes proximal tubule injury and kidney fibrosis.

Saritas T, Cuevas CA, Ferdaus MZ, Kuppe C, Kramann R, Moeller MJ, Floege J, Singer JD, McCormick JA.

Sci Rep. 2019 Mar 14;9(1):4596. doi: 10.1038/s41598-019-40795-0.

13.

Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease.

Halder M, Petsophonsakul P, Akbulut AC, Pavlic A, Bohan F, Anderson E, Maresz K, Kramann R, Schurgers L.

Int J Mol Sci. 2019 Feb 19;20(4). pii: E896. doi: 10.3390/ijms20040896. Review.

14.

Magnesium but not nicotinamide prevents vascular calcification in experimental uraemia.

Kaesler N, Goettsch C, Weis D, Schurgers L, Hellmann B, Floege J, Kramann R.

Nephrol Dial Transplant. 2019 Feb 1. doi: 10.1093/ndt/gfy410. [Epub ahead of print]

PMID:
30715488
15.

Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome.

Ribezzo F, Snoeren IAM, Ziegler S, Stoelben J, Olofsen PA, Henic A, Ferreira MV, Chen S, Stalmann USA, Buesche G, Hoogenboezem RM, Kramann R, Platzbecker U, Raaijmakers MHGP, Ebert BL, Schneider RK.

Leukemia. 2019 Jul;33(7):1759-1772. doi: 10.1038/s41375-018-0350-3. Epub 2019 Jan 16.

PMID:
30651631
16.

Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target.

Schneider RK, Mullally A, Dugourd A, Peisker F, Hoogenboezem R, Van Strien PMH, Bindels EM, Heckl D, Büsche G, Fleck D, Müller-Newen G, Wongboonsin J, Ventura Ferreira M, Puelles VG, Saez-Rodriguez J, Ebert BL, Humphreys BD, Kramann R.

Cell Stem Cell. 2018 Aug 2;23(2):308-309. doi: 10.1016/j.stem.2018.07.006. No abstract available.

17.

Parabiosis and single-cell RNA sequencing reveal a limited contribution of monocytes to myofibroblasts in kidney fibrosis.

Kramann R, Machado F, Wu H, Kusaba T, Hoeft K, Schneider RK, Humphreys BD.

JCI Insight. 2018 May 3;3(9). pii: 99561. doi: 10.1172/jci.insight.99561.

18.

Initiation and Propagation of Vascular Calcification Is Regulated by a Concert of Platelet- and Smooth Muscle Cell-Derived Extracellular Vesicles.

Schurgers LJ, Akbulut AC, Kaczor DM, Halder M, Koenen RR, Kramann R.

Front Cardiovasc Med. 2018 Apr 6;5:36. doi: 10.3389/fcvm.2018.00036. eCollection 2018.

19.

The new SFB/TRR219 Research Centre.

Noels H, Boor P, Goettsch C, Hohl M, Jahnen-Dechent W, Jankowski V, Kindermann I, Kramann R, Lehrke M, Linz D, Maack C, Niemeyer B, Roma LP, Schuett K, Speer T, Wagenpfeil S, Werner C, Zewinger S, Böhm M, Marx N, Floege J, Fliser D, Jankowski J.

Eur Heart J. 2018 Mar 21;39(12):975-977. doi: 10.1093/eurheartj/ehy083. No abstract available.

PMID:
29579229
20.

The identification of fibrosis-driving myofibroblast precursors reveals new therapeutic avenues in myelofibrosis.

Kramann R, Schneider RK.

Blood. 2018 May 10;131(19):2111-2119. doi: 10.1182/blood-2018-02-834820. Epub 2018 Mar 23. Review.

PMID:
29572380
21.

Understanding deregulated cellular and molecular dynamics in the haematopoietic stem cell niche to develop novel therapeutics for bone marrow fibrosis.

Gleitz HF, Kramann R, Schneider RK.

J Pathol. 2018 Jun;245(2):138-146. doi: 10.1002/path.5078. Epub 2018 Apr 19. Review.

22.

Single-nephron proteomes connect morphology and function in proteinuric kidney disease.

Höhne M, Frese CK, Grahammer F, Dafinger C, Ciarimboli G, Butt L, Binz J, Hackl MJ, Rahmatollahi M, Kann M, Schneider S, Altintas MM, Schermer B, Reinheckel T, Göbel H, Reiser J, Huber TB, Kramann R, Seeger-Nukpezah T, Liebau MC, Beck BB, Benzing T, Beyer A, Rinschen MM.

Kidney Int. 2018 Jun;93(6):1308-1319. doi: 10.1016/j.kint.2017.12.012. Epub 2018 Mar 9.

PMID:
29530281
23.

Sclerostin deficiency modifies the development of CKD-MBD in mice.

Kaesler N, Verhulst A, De Maré A, Deck A, Behets GJ, Hyusein A, Evenepoel P, Floege J, Marx N, Babler A, Kramer I, Kneissel M, Kramann R, Weis D, D'Haese PC, Brandenburg VM.

Bone. 2018 Feb;107:115-123. doi: 10.1016/j.bone.2017.11.015. Epub 2017 Nov 21.

PMID:
29175269
24.

Mesenchymal Stem Cells in Fibrotic Disease.

El Agha E, Kramann R, Schneider RK, Li X, Seeger W, Humphreys BD, Bellusci S.

Cell Stem Cell. 2017 Aug 3;21(2):166-177. doi: 10.1016/j.stem.2017.07.011. Review.

25.

Endothelial marker-expressing stromal cells are critical for kidney formation.

Mukherjee E, Maringer K, Papke E, Bushnell D, Schaefer C, Kramann R, Ho J, Humphreys BD, Bates C, Sims-Lucas S.

Am J Physiol Renal Physiol. 2017 Sep 1;313(3):F611-F620. doi: 10.1152/ajprenal.00136.2017. Epub 2017 May 24.

26.

Slower Progress of Aortic Valve Calcification With Vitamin K Supplementation: Results From a Prospective Interventional Proof-of-Concept Study.

Brandenburg VM, Reinartz S, Kaesler N, Krüger T, Dirrichs T, Kramann R, Peeters F, Floege J, Keszei A, Marx N, Schurgers LJ, Koos R.

Circulation. 2017 May 23;135(21):2081-2083. doi: 10.1161/CIRCULATIONAHA.116.027011. No abstract available.

PMID:
28533322
27.

Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target.

Schneider RK, Mullally A, Dugourd A, Peisker F, Hoogenboezem R, Van Strien PMH, Bindels EM, Heckl D, Büsche G, Fleck D, Müller-Newen G, Wongboonsin J, Ventura Ferreira M, Puelles VG, Saez-Rodriguez J, Ebert BL, Humphreys BD, Kramann R.

Cell Stem Cell. 2017 Jun 1;20(6):785-800.e8. doi: 10.1016/j.stem.2017.03.008. Epub 2017 Apr 27. Erratum in: Cell Stem Cell. 2018 Aug 2;23(2):308-309.

28.

[Magnesium: a kardio-renal viewpoint].

Brandenburg VM, Kaesler N, Kramann R, Floege J, Marx N.

Dtsch Med Wochenschr. 2016 Oct;141(21):1537-1542. Epub 2016 Oct 17. Review. German.

PMID:
27750340
29.

Gli1+ Pericyte Loss Induces Capillary Rarefaction and Proximal Tubular Injury.

Kramann R, Wongboonsin J, Chang-Panesso M, Machado FG, Humphreys BD.

J Am Soc Nephrol. 2017 Mar;28(3):776-784. doi: 10.1681/ASN.2016030297. Epub 2016 Sep 13.

30.

Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease.

Kramann R, Goettsch C, Wongboonsin J, Iwata H, Schneider RK, Kuppe C, Kaesler N, Chang-Panesso M, Machado FG, Gratwohl S, Madhurima K, Hutcheson JD, Jain S, Aikawa E, Humphreys BD.

Cell Stem Cell. 2016 Nov 3;19(5):628-642. doi: 10.1016/j.stem.2016.08.001. Epub 2016 Sep 8.

31.

Hedgehog Gli signalling in kidney fibrosis.

Kramann R.

Nephrol Dial Transplant. 2016 Dec;31(12):1989-1995. Epub 2016 May 26. Review.

PMID:
27229466
32.

Role of mesenchymal stem cells in kidney injury and fibrosis.

Kuppe C, Kramann R.

Curr Opin Nephrol Hypertens. 2016 Jul;25(4):372-7. doi: 10.1097/MNH.0000000000000230. Review.

PMID:
27191350
33.

Lack of evidence does not justify neglect: how can we address unmet medical needs in calciphylaxis?

Brandenburg VM, Evenepoel P, Floege J, Goldsmith D, Kramann R, Massy Z, Mazzaferro S, Schurgers LJ, Sinha S, Torregrosa V, Ureña-Torres P, Vervloet M, Cozzolino M; ERA-EDTA Working Group on CKD-MBD and EUCALNET.

Nephrol Dial Transplant. 2016 Aug;31(8):1211-9. doi: 10.1093/ndt/gfw025. Epub 2016 Mar 22.

PMID:
27005994
34.

Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.

Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E.

J Clin Invest. 2016 Apr 1;126(4):1323-36. doi: 10.1172/JCI80851. Epub 2016 Mar 7.

35.

Calcific uraemic arteriolopathy (calciphylaxis): data from a large nationwide registry.

Brandenburg VM, Kramann R, Rothe H, Kaesler N, Korbiel J, Specht P, Schmitz S, Krüger T, Floege J, Ketteler M.

Nephrol Dial Transplant. 2017 Jan 1;32(1):126-132. doi: 10.1093/ndt/gfv438.

PMID:
26908770
36.

Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9.

Schneider RK, Schenone M, Ferreira MV, Kramann R, Joyce CE, Hartigan C, Beier F, Brümmendorf TH, Germing U, Platzbecker U, Büsche G, Knüchel R, Chen MC, Waters CS, Chen E, Chu LP, Novina CD, Lindsley RC, Carr SA, Ebert BL.

Nat Med. 2016 Mar;22(3):288-97. doi: 10.1038/nm.4047. Epub 2016 Feb 15.

37.

An engineered multicomponent bone marrow niche for the recapitulation of hematopoiesis at ectopic transplantation sites.

Ventura Ferreira MS, Bergmann C, Bodensiek I, Peukert K, Abert J, Kramann R, Kachel P, Rath B, Rütten S, Knuchel R, Ebert BL, Fischer H, Brümmendorf TH, Schneider RK.

J Hematol Oncol. 2016 Jan 25;9:4. doi: 10.1186/s13045-016-0234-9.

38.

Epicardial adipose tissue in long-term hemodialysis patients: its association with vascular calcification and long-term development.

Barros X, Dirrichs T, Koos R, Reinartz S, Kaesler N, Kramann R, Gladziwa U, Ketteler M, Floege J, Marx N, Torregrosa JV, Keszei A, Brandenburg VM.

J Nephrol. 2016 Apr;29(2):241-250. doi: 10.1007/s40620-015-0221-1. Epub 2015 Aug 8.

PMID:
26253562
39.

Paracrine Wnt1 Drives Interstitial Fibrosis without Inflammation by Tubulointerstitial Cross-Talk.

Maarouf OH, Aravamudhan A, Rangarajan D, Kusaba T, Zhang V, Welborn J, Gauvin D, Hou X, Kramann R, Humphreys BD.

J Am Soc Nephrol. 2016 Mar;27(3):781-90. doi: 10.1681/ASN.2014121188. Epub 2015 Jul 23.

40.

Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis.

Kramann R, Fleig SV, Schneider RK, Fabian SL, DiRocco DP, Maarouf O, Wongboonsin J, Ikeda Y, Heckl D, Chang SL, Rennke HG, Waikar SS, Humphreys BD.

J Clin Invest. 2015 Aug 3;125(8):2935-51. doi: 10.1172/JCI74929. Epub 2015 Jul 20.

41.

Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis.

Kramann R, Schneider RK, DiRocco DP, Machado F, Fleig S, Bondzie PA, Henderson JM, Ebert BL, Humphreys BD.

Cell Stem Cell. 2015 Jan 8;16(1):51-66. doi: 10.1016/j.stem.2014.11.004. Epub 2014 Nov 20.

42.

Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS.

Schneider RK, Ademà V, Heckl D, Järås M, Mallo M, Lord AM, Chu LP, McConkey ME, Kramann R, Mullally A, Bejar R, Solé F, Ebert BL.

Cancer Cell. 2014 Oct 13;26(4):509-20. doi: 10.1016/j.ccr.2014.08.001. Epub 2014 Sep 18.

43.

Kidney pericytes: roles in regeneration and fibrosis.

Kramann R, Humphreys BD.

Semin Nephrol. 2014 Jul;34(4):374-83. doi: 10.1016/j.semnephrol.2014.06.004. Epub 2014 Jun 13. Review.

44.

Who regenerates the kidney tubule?

Kramann R, Kusaba T, Humphreys BD.

Nephrol Dial Transplant. 2015 Jun;30(6):903-10. doi: 10.1093/ndt/gfu281. Epub 2014 Aug 25. Review.

45.

Speckle tracking echocardiography detects uremic cardiomyopathy early and predicts cardiovascular mortality in ESRD.

Kramann R, Erpenbeck J, Schneider RK, Röhl AB, Hein M, Brandenburg VM, van Diepen M, Dekker F, Marx N, Floege J, Becker M, Schlieper G.

J Am Soc Nephrol. 2014 Oct;25(10):2351-65. doi: 10.1681/ASN.2013070734. Epub 2014 Apr 3.

46.

Mesenchymal stem cells from rats with chronic kidney disease exhibit premature senescence and loss of regenerative potential.

Klinkhammer BM, Kramann R, Mallau M, Makowska A, van Roeyen CR, Rong S, Buecher EB, Boor P, Kovacova K, Zok S, Denecke B, Stuettgen E, Otten S, Floege J, Kunter U.

PLoS One. 2014 Mar 25;9(3):e92115. doi: 10.1371/journal.pone.0092115. eCollection 2014.

47.

Fluorescence microangiography for quantitative assessment of peritubular capillary changes after AKI in mice.

Kramann R, Tanaka M, Humphreys BD.

J Am Soc Nephrol. 2014 Sep;25(9):1924-31. doi: 10.1681/ASN.2013101121. Epub 2014 Mar 20.

48.

Matrix Producing Cells in Chronic Kidney Disease: Origin, Regulation, and Activation.

Kramann R, Dirocco DP, Maarouf OH, Humphreys BD.

Curr Pathobiol Rep. 2013 Dec;1(4). doi: 10.1007/s40139-013-0026-7.

49.

Sclerostin as a potential novel biomarker for aortic valve calcification: an in-vivo and ex-vivo study.

Koos R, Brandenburg V, Mahnken AH, Schneider R, Dohmen G, Autschbach R, Marx N, Kramann R.

J Heart Valve Dis. 2013 May;22(3):317-25.

PMID:
24151757
50.

Differentiated kidney epithelial cells repair injured proximal tubule.

Kusaba T, Lalli M, Kramann R, Kobayashi A, Humphreys BD.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1527-32. doi: 10.1073/pnas.1310653110. Epub 2013 Oct 14. Erratum in: Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5754.

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