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Items: 35


Dormant pathogenic CD4+ T cells are prevalent in the peripheral repertoire of healthy mice.

Cebula A, Kuczma M, Szurek E, Pietrzak M, Savage N, Elhefnawy WR, Rempala G, Kraj P, Ignatowicz L.

Nat Commun. 2019 Oct 25;10(1):4882. doi: 10.1038/s41467-019-12820-3.


Cell-based high throughput screening identified a novel compound that promotes regulatory T cells and prevents autoimmune colitis.

Mao R, Liu H, Yi B, Purohit S, Kuczma M, Kraj P, She JX.

Biochem Pharmacol. 2019 Nov;169:113618. doi: 10.1016/j.bcp.2019.08.020. Epub 2019 Aug 23.


TGF-β-mediated enhancement of TH17 cell generation is inhibited by bone morphogenetic protein receptor 1α signaling.

Browning LM, Pietrzak M, Kuczma M, Simms CP, Kurczewska A, Refugia JM, Lowery DJ, Rempala G, Gutkin D, Ignatowicz L, Muranski P, Kraj P.

Sci Signal. 2018 Aug 28;11(545). pii: eaar2125. doi: 10.1126/scisignal.aar2125.


The mechanisms shaping the repertoire of CD4+  Foxp3+ regulatory T cells.

Kraj P, Ignatowicz L.

Immunology. 2018 Mar;153(3):290-296. doi: 10.1111/imm.12859. Epub 2017 Nov 22. Review.


Coordination of different ligands to copper(II) and cobalt(III) metal centers enhances Zika virus and dengue virus loads in both arthropod cells and human keratinocytes.

Dutta S, Celestine MJ, Khanal S, Huddleston A, Simms C, Arca JF, Mitra A, Heller L, Kraj PJ, Ledizet M, Anderson JF, Neelakanta G, Holder AA, Sultana H.

Biochim Biophys Acta Gen Subj. 2018 Jan;1862(1):40-50. doi: 10.1016/j.bbagen.2017.10.004. Epub 2017 Oct 13.


Iron Oxide and Titanium Dioxide Nanoparticle Effects on Plant Performance and Root Associated Microbes.

Burke DJ, Pietrasiak N, Situ SF, Abenojar EC, Porche M, Kraj P, Lakliang Y, Samia AC.

Int J Mol Sci. 2015 Oct 5;16(10):23630-50. doi: 10.3390/ijms161023630.


Bone Morphogenetic Protein Signaling Regulates Development and Activation of CD4(+) T Cells.

Kuczma M, Kraj P.

Vitam Horm. 2015;99:171-93. doi: 10.1016/bs.vh.2015.05.001. Epub 2015 Jun 27. Review.


Cx3cr1 deficiency in mice attenuates hepatic granuloma formation during acute schistosomiasis by enhancing the M2-type polarization of macrophages.

Ran L, Yu Q, Zhang S, Xiong F, Cheng J, Yang P, Xu JF, Nie H, Zhong Q, Yang X, Yang F, Gong Q, Kuczma M, Kraj P, Gu W, Ren BX, Wang CY.

Dis Model Mech. 2015 Jul 1;8(7):691-700. doi: 10.1242/dmm.018242. Epub 2015 Apr 21.


Altered connexin 43 expression underlies age-dependent decrease of regulatory T cell suppressor function in nonobese diabetic mice.

Kuczma M, Wang CY, Ignatowicz L, Gourdie R, Kraj P.

J Immunol. 2015 Jun 1;194(11):5261-71. doi: 10.4049/jimmunol.1400887. Epub 2015 Apr 24.


MBD2 regulates TH17 differentiation and experimental autoimmune encephalomyelitis by controlling the homeostasis of T-bet/Hlx axis.

Zhong J, Yu Q, Yang P, Rao X, He L, Fang J, Tu Y, Zhang Z, Lai Q, Zhang S, Kuczma M, Kraj P, Xu JF, Gong F, Zhou J, Wen L, Eizirik DL, Du J, Wang W, Wang CY.

J Autoimmun. 2014 Sep;53:95-104. doi: 10.1016/j.jaut.2014.05.006. Epub 2014 Jun 14.


Modulation of bone morphogenic protein signaling in T-cells for cancer immunotherapy.

Kuczma M, Kurczewska A, Kraj P.

J Immunotoxicol. 2014 Oct;11(4):319-27. doi: 10.3109/1547691X.2013.864736. Epub 2013 Dec 19.


SUMO1 regulates endothelial function by modulating the overall signals in favor of angiogenesis and homeostatic responses.

Yang P, Zhang Y, Xu J, Zhang S, Yu Q, Pang J, Rao X, Kuczma M, Marrero MB, Fulton D, Kraj P, Su Y, Wang CY.

Am J Transl Res. 2013 May 24;5(4):427-40. Print 2013.


Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota.

Cebula A, Seweryn M, Rempala GA, Pabla SS, McIndoe RA, Denning TL, Bry L, Kraj P, Kisielow P, Ignatowicz L.

Nature. 2013 May 9;497(7448):258-62. doi: 10.1038/nature12079. Epub 2013 Apr 28.


Systematic evaluation of 640 FDA drugs for their effect on CD4⁺Foxp3⁺ regulatory T cells using a novel cell-based high throughput screening assay.

Mao R, Xiao W, Liu H, Chen B, Yi B, Kraj P, She JX.

Biochem Pharmacol. 2013 May 15;85(10):1513-24. doi: 10.1016/j.bcp.2013.03.013. Epub 2013 Mar 26.


Connexin 43 signaling enhances the generation of Foxp3+ regulatory T cells.

Kuczma M, Lee JR, Kraj P.

J Immunol. 2011 Jul 1;187(1):248-57. doi: 10.4049/jimmunol.1003785. Epub 2011 Jun 3.


Intratumoral convergence of the TCR repertoires of effector and Foxp3+ CD4+ T cells.

Kuczma M, Kopij M, Pawlikowska I, Wang CY, Rempala GA, Kraj P.

PLoS One. 2010 Oct 26;5(10):e13623. doi: 10.1371/journal.pone.0013623.


Foxp3-deficient regulatory T cells do not revert into conventional effector CD4+ T cells but constitute a unique cell subset.

Kuczma M, Podolsky R, Garge N, Daniely D, Pacholczyk R, Ignatowicz L, Kraj P.

J Immunol. 2009 Sep 15;183(6):3731-41. doi: 10.4049/jimmunol.0800601. Epub 2009 Aug 26.


TCR repertoire and Foxp3 expression define functionally distinct subsets of CD4+ regulatory T cells.

Kuczma M, Pawlikowska I, Kopij M, Podolsky R, Rempala GA, Kraj P.

J Immunol. 2009 Sep 1;183(5):3118-29. doi: 10.4049/jimmunol.0900514. Epub 2009 Jul 31.


ParaKMeans: Implementation of a parallelized K-means algorithm suitable for general laboratory use.

Kraj P, Sharma A, Garge N, Podolsky R, McIndoe RA.

BMC Bioinformatics. 2008 Apr 16;9:200. doi: 10.1186/1471-2105-9-200.


Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells.

Pacholczyk R, Kern J, Singh N, Iwashima M, Kraj P, Ignatowicz L.

Immunity. 2007 Sep;27(3):493-504.


Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cells.

Pacholczyk R, Ignatowicz H, Kraj P, Ignatowicz L.

Immunity. 2006 Aug;25(2):249-59. Epub 2006 Aug 3.


Presentation of antagonist peptides to naive CD4+ T cells abrogates spatial reorganization of class II MHC peptide complexes on the surface of dendritic cells.

Chmielowski B, Pacholczyk R, Kraj P, Kisielow P, Ignatowicz L.

Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15012-7. Epub 2002 Oct 31.


Positive selection of a Qa-1-restricted T cell receptor with specificity for insulin.

Sullivan BA, Kraj P, Weber DA, Ignatowicz L, Jensen PE.

Immunity. 2002 Jul;17(1):95-105.


Peptide specificity of thymic selection of CD4+CD25+ T cells.

Pacholczyk R, Kraj P, Ignatowicz L.

J Immunol. 2002 Jan 15;168(2):613-20.


Positive selection of CD4(+) T cells is induced in vivo by agonist and inhibited by antagonist peptides.

Kraj P, Pacholczyk R, Ignatowicz H, Kisielow P, Jensen P, Ignatowicz L.

J Exp Med. 2001 Aug 20;194(4):407-16.


Altered selection of CD4+ T cells by class II MHC bound with dominant and low abundance self-peptides.

Gaszewska-Mastalarz A, Muranski P, Chmielowski B, Kraj P, Ignatowicz L.

J Immunol. 2000 Dec 1;165(11):6099-106.


The human heavy chain Ig V region gene repertoire is biased at all stages of B cell ontogeny, including early pre-B cells.

Kraj P, Rao SP, Glas AM, Hardy RR, Milner EC, Silberstein LE.

J Immunol. 1997 Jun 15;158(12):5824-32.


Factors influencing the preimmune antibody repertoire.

Kraj P.

Folia Biol (Praha). 1997;43(2):53-61. Review.


VH4.21 expression in the normal human B-cell repertoire.

Friedman DF, Kraj P, Silberstein LE.

Ann N Y Acad Sci. 1995 Sep 29;764:285-92. No abstract available.


Evidence for the overexpression of the VH4-34 (VH4.21) Ig gene segment in the normal adult human peripheral blood B cell repertoire.

Kraj P, Friedman DF, Stevenson F, Silberstein LE.

J Immunol. 1995 Jun 15;154(12):6406-20.


[Repertoire of rearranged immunoglobulin genes of human peripheral lymphocytes].

Kraj P.

Postepy Hig Med Dosw. 1995;49(1):9-22. Review. Polish.


Immunoglobulin gene sequence analysis to further assess B-cell origin of multiple myeloma.

Biggs DD, Kraj P, Goldman J, Jefferies L, Carchidi C, Anderson K, Silberstein LE.

Clin Diagn Lab Immunol. 1995 Jan;2(1):44-52.

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