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Items: 37


Biofilms of Mycobacterium abscessus complex can be sensitized to antibiotics by disaggregation and oxygenation.

Kolpen M, Jensen PØ, Qvist T, Kragh KN, Ravnholt C, Fritz BG, Johansen UR, Bjarnsholt T, Høiby N.

Antimicrob Agents Chemother. 2019 Nov 18. pii: AAC.01212-19. doi: 10.1128/AAC.01212-19. [Epub ahead of print]


In Situ Monitoring of the Antibacterial Activity of a Copper-Silver Alloy Using Confocal Laser Scanning Microscopy and pH Microsensors.

Ciacotich N, Kragh KN, Lichtenberg M, Tesdorpf JE, Bjarnsholt T, Gram L.

Glob Chall. 2019 Jul 15;3(11):1900044. doi: 10.1002/gch2.201900044. eCollection 2019 Nov.


Oxygen Restriction Generates Difficult-to-Culture P. aeruginosa.

Kvich L, Fritz B, Crone S, Kragh KN, Kolpen M, Sønderholm M, Andersson M, Koch A, Jensen PØ, Bjarnsholt T.

Front Microbiol. 2019 Aug 29;10:1992. doi: 10.3389/fmicb.2019.01992. eCollection 2019.


Is pseudarthrosis after spinal instrumentation caused by a chronic infection?

Ohrt-Nissen S, Fritz B, Valentin L, Kragh KN, Manniche C, Dahl B, Bjarnsholt T.

Eur Spine J. 2019 Dec;28(12):2996-3002. doi: 10.1007/s00586-019-06004-2. Epub 2019 May 13.


Hyperbaric oxygen treatment increases killing of aggregating Pseudomonas aeruginosa isolates from cystic fibrosis patients.

Møller SA, Jensen PØ, Høiby N, Ciofu O, Kragh KN, Bjarnsholt T, Kolpen M.

J Cyst Fibros. 2019 Sep;18(5):657-664. doi: 10.1016/j.jcf.2019.01.005. Epub 2019 Jan 31.


In Vivo Gentamicin Susceptibility Test for Prevention of Bacterial Biofilms in Bone Tissue and on Implants.

Jensen LK, Bjarnsholt T, Kragh KN, Aalbæk B, Henriksen NL, Blirup SA, Pankoke K, Petersen A, Jensen HE.

Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01889-18. doi: 10.1128/AAC.01889-18. Print 2019 Feb.


[Interaction between microbiota and immune system in colorectal cancer].

Raskov H, Bjarnsholt T, Alamili M, Kragh KN, Gögenur I.

Ugeskr Laeger. 2018 Nov 5;180(45). pii: V04180253. Danish.


UV light assisted antibiotics for eradication of in vitro biofilms.

Argyraki A, Markvart M, Stavnsbjerg C, Kragh KN, Ou Y, Bjørndal L, Bjarnsholt T, Petersen PM.

Sci Rep. 2018 Nov 5;8(1):16360. doi: 10.1038/s41598-018-34340-8.


Bacterial biofilm formation inside colonic crypts may accelerate colorectal carcinogenesis.

Raskov H, Kragh KN, Bjarnsholt T, Alamili M, Gögenur I.

Clin Transl Med. 2018 Sep 17;7(1):30. doi: 10.1186/s40169-018-0209-2.


Bacterial biofilms: a possible mechanism for chronic infection in patients with lumbar disc herniation - a prospective proof-of-concept study using fluorescence in situ hybridization.

Ohrt-Nissen S, Fritz BG, Walbom J, Kragh KN, Bjarnsholt T, Dahl B, Manniche C.

APMIS. 2018 May;126(5):440-447. doi: 10.1111/apm.12841.


Bacterial Aggregates Establish at the Edges of Acute Epidermal Wounds.

Bay L, Kragh KN, Eickhardt SR, Poulsen SS, Gjerdrum LMR, Ghathian K, Calum H, Ågren MS, Bjarnsholt T.

Adv Wound Care (New Rochelle). 2018 Apr 1;7(4):105-113. doi: 10.1089/wound.2017.0770.


Combined Staining Techniques for Demonstration of Staphylococcus aureus Biofilm in Routine Histopathology.

Jensen LK, Henriksen NL, Bjarnsholt T, Kragh KN, Jensen HE.

J Bone Jt Infect. 2018 Feb 20;3(1):27-36. doi: 10.7150/jbji.22799. eCollection 2018.


Tools for studying growth patterns and chemical dynamics of aggregated Pseudomonas aeruginosa exposed to different electron acceptors in an alginate bead model.

Sønderholm M, Koren K, Wangpraseurt D, Jensen PØ, Kolpen M, Kragh KN, Bjarnsholt T, Kühl M.

NPJ Biofilms Microbiomes. 2018 Feb 19;4:3. doi: 10.1038/s41522-018-0047-4. eCollection 2018.


The Inoculation Method Could Impact the Outcome of Microbiological Experiments.

Kragh KN, Alhede M, Rybtke M, Stavnsberg C, Jensen PØ, Tolker-Nielsen T, Whiteley M, Bjarnsholt T.

Appl Environ Microbiol. 2018 Feb 14;84(5). pii: e02264-17. doi: 10.1128/AEM.02264-17. Print 2018 Mar 1.


The Consequences of Being in an Infectious Biofilm: Microenvironmental Conditions Governing Antibiotic Tolerance.

Sønderholm M, Bjarnsholt T, Alhede M, Kolpen M, Jensen PØ, Kühl M, Kragh KN.

Int J Mol Sci. 2017 Dec 12;18(12). pii: E2688. doi: 10.3390/ijms18122688. Review.


Hyperbaric Oxygen Sensitizes Anoxic Pseudomonas aeruginosa Biofilm to Ciprofloxacin.

Kolpen M, Lerche CJ, Kragh KN, Sams T, Koren K, Jensen AS, Line L, Bjarnsholt T, Ciofu O, Moser C, Kühl M, Høiby N, Jensen PØ.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01024-17. doi: 10.1128/AAC.01024-17. Print 2017 Nov.


The Pseudomonas aeruginosa PSL Polysaccharide Is a Social but Noncheatable Trait in Biofilms.

Irie Y, Roberts AEL, Kragh KN, Gordon VD, Hutchison J, Allen RJ, Melaugh G, Bjarnsholt T, West SA, Diggle SP.

MBio. 2017 Jun 20;8(3). pii: e00374-17. doi: 10.1128/mBio.00374-17.


Microenvironmental characteristics and physiology of biofilms in chronic infections of CF patients are strongly affected by the host immune response.

Jensen PØ, Kolpen M, Kragh KN, Kühl M.

APMIS. 2017 Apr;125(4):276-288. doi: 10.1111/apm.12668. Review.


Phage Inhibit Pathogen Dissemination by Targeting Bacterial Migrants in a Chronic Infection Model.

Darch SE, Kragh KN, Abbott EA, Bjarnsholt T, Bull JJ, Whiteley M.

MBio. 2017 Apr 4;8(2). pii: e00240-17. doi: 10.1128/mBio.00240-17.


Pseudomonas aeruginosa Aggregate Formation in an Alginate Bead Model System Exhibits In Vivo-Like Characteristics.

Sønderholm M, Kragh KN, Koren K, Jakobsen TH, Darch SE, Alhede M, Jensen PØ, Whiteley M, Kühl M, Bjarnsholt T.

Appl Environ Microbiol. 2017 Apr 17;83(9). pii: e00113-17. doi: 10.1128/AEM.00113-17. Print 2017 May 1.


Real-Time Monitoring of nfxB Mutant Occurrence and Dynamics in Pseudomonas aeruginosa Biofilm Exposed to Subinhibitory Concentrations of Ciprofloxacin.

Zaborskyte G, Andersen JB, Kragh KN, Ciofu O.

Antimicrob Agents Chemother. 2017 Feb 23;61(3). pii: e02292-16. doi: 10.1128/AAC.02292-16. Print 2017 Mar.


Novel porcine model of implant-associated osteomyelitis: A comprehensive analysis of local, regional, and systemic response.

Jensen LK, Koch J, Dich-Jorgensen K, Aalbaek B, Petersen A, Fuursted K, Bjarnsholt T, Kragh KN, Tøtterup M, Bue M, Hanberg P, Søballe K, Heegaard PMH, Jensen HE.

J Orthop Res. 2017 Oct;35(10):2211-2221. doi: 10.1002/jor.23505. Epub 2017 Jan 15.


Early implant-associated osteomyelitis results in a peri-implanted bacterial reservoir.

Jensen LK, Koch J, Aalbaek B, Moodley A, Bjarnsholt T, Kragh KN, Petersen A, Jensen HE.

APMIS. 2017 Jan;125(1):38-45. doi: 10.1111/apm.12597. Epub 2016 Oct 5.


Phenotypic shift in Pseudomonas aeruginosa populations from cystic fibrosis lungs after 2-week antipseudomonal treatment.

Fernández-Barat L, Ciofu O, Kragh KN, Pressler T, Johansen U, Motos A, Torres A, Hoiby N.

J Cyst Fibros. 2017 Mar;16(2):222-229. doi: 10.1016/j.jcf.2016.08.005. Epub 2016 Sep 17.


Role of Multicellular Aggregates in Biofilm Formation.

Kragh KN, Hutchison JB, Melaugh G, Rodesney C, Roberts AE, Irie Y, Jensen PØ, Diggle SP, Allen RJ, Gordon V, Bjarnsholt T.

MBio. 2016 Mar 22;7(2):e00237. doi: 10.1128/mBio.00237-16.


Shaping the Growth Behaviour of Biofilms Initiated from Bacterial Aggregates.

Melaugh G, Hutchison J, Kragh KN, Irie Y, Roberts A, Bjarnsholt T, Diggle SP, Gordon VD, Allen RJ.

PLoS One. 2016 Mar 2;11(3):e0149683. doi: 10.1371/journal.pone.0149683. eCollection 2016. Erratum in: PLoS One. 2016;11(4):e0154637.


Chronic pulmonary disease with Mycobacterium abscessus complex is a biofilm infection.

Qvist T, Eickhardt S, Kragh KN, Andersen CB, Iversen M, Høiby N, Bjarnsholt T.

Eur Respir J. 2015 Dec;46(6):1823-6. doi: 10.1183/13993003.01102-2015. Epub 2015 Oct 22. No abstract available.


Increased bactericidal activity of colistin on Pseudomonas aeruginosa biofilms in anaerobic conditions.

Kolpen M, Appeldorff CF, Brandt S, Mousavi N, Kragh KN, Aydogan S, Uppal HA, Bjarnsholt T, Ciofu O, Høiby N, Jensen PØ.

Pathog Dis. 2016 Feb;74(1):ftv086. doi: 10.1093/femspd/ftv086. Epub 2015 Oct 12.


The Limitations of In Vitro Experimentation in Understanding Biofilms and Chronic Infection.

Roberts AE, Kragh KN, Bjarnsholt T, Diggle SP.

J Mol Biol. 2015 Nov 20;427(23):3646-61. doi: 10.1016/j.jmb.2015.09.002. Epub 2015 Sep 5. Review.


Autofluorescence in samples obtained from chronic biofilm infections--"all that glitters is not gold".

Eickhardt S, Kragh KN, Schrøder S, Poulsen SS, Sillesen H, Givskov M, Høiby N, Bjarnsholt T, Alhede M.

Pathog Dis. 2015 Jun;73(4). pii: ftv012. doi: 10.1093/femspd/ftv012. Epub 2015 Feb 5.


Denitrification by cystic fibrosis pathogens - Stenotrophomonas maltophilia is dormant in sputum.

Kolpen M, Kragh KN, Bjarnsholt T, Line L, Hansen CR, Dalbøge CS, Hansen N, Kühl M, Høiby N, Jensen PØ.

Int J Med Microbiol. 2015 Jan;305(1):1-10. doi: 10.1016/j.ijmm.2014.07.002. Epub 2014 Aug 10.


Rapid identification of Stenotrophomonas maltophilia by peptide nucleic acid fluorescence in situ hybridization.

Hansen N, Rasmussen AK, Fiandaca MJ, Kragh KN, Bjarnsholt T, Høiby N, Stender H, Guardabassi L.

New Microbes New Infect. 2014 May;2(3):79-81. doi: 10.1002/nmi2.38. Epub 2014 Mar 25.


Polymorphonuclear leukocytes restrict growth of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients.

Kragh KN, Alhede M, Jensen PØ, Moser C, Scheike T, Jacobsen CS, Seier Poulsen S, Eickhardt-Sørensen SR, Trøstrup H, Christoffersen L, Hougen HP, Rickelt LF, Kühl M, Høiby N, Bjarnsholt T.

Infect Immun. 2014 Nov;82(11):4477-86. doi: 10.1128/IAI.01969-14. Epub 2014 Aug 11.


Formation of hydroxyl radicals contributes to the bactericidal activity of ciprofloxacin against Pseudomonas aeruginosa biofilms.

Jensen PØ, Briales A, Brochmann RP, Wang H, Kragh KN, Kolpen M, Hempel C, Bjarnsholt T, Høiby N, Ciofu O.

Pathog Dis. 2014 Apr;70(3):440-3. doi: 10.1111/2049-632X.12120. Epub 2014 Feb 10.


The microorganisms in chronically infected end-stage and non-end-stage cystic fibrosis patients.

Rudkjøbing VB, Thomsen TR, Alhede M, Kragh KN, Nielsen PH, Johansen UR, Givskov M, Høiby N, Bjarnsholt T.

FEMS Immunol Med Microbiol. 2012 Jul;65(2):236-44. doi: 10.1111/j.1574-695X.2011.00925.x. Epub 2012 Jan 23.


Phenotypes of non-attached Pseudomonas aeruginosa aggregates resemble surface attached biofilm.

Alhede M, Kragh KN, Qvortrup K, Allesen-Holm M, van Gennip M, Christensen LD, Jensen PØ, Nielsen AK, Parsek M, Wozniak D, Molin S, Tolker-Nielsen T, Høiby N, Givskov M, Bjarnsholt T.

PLoS One. 2011;6(11):e27943. doi: 10.1371/journal.pone.0027943. Epub 2011 Nov 21.


True microbiota involved in chronic lung infection of cystic fibrosis patients found by culturing and 16S rRNA gene analysis.

Rudkjøbing VB, Thomsen TR, Alhede M, Kragh KN, Nielsen PH, Johansen UR, Givskov M, Høiby N, Bjarnsholt T.

J Clin Microbiol. 2011 Dec;49(12):4352-5. doi: 10.1128/JCM.06092-11. Epub 2011 Oct 19.

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