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Minimal impact of age and housing temperature on the metabolic phenotype of Acc2-/- mice.

Brandon AE, Stuart E, Leslie SJ, Hoehn KL, James DE, Kraegen EW, Turner N, Cooney GJ.

J Endocrinol. 2016 Mar;228(3):127-34. doi: 10.1530/JOE-15-0444. Epub 2015 Dec 14.


Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats.

Coughlan KA, Balon TW, Valentine RJ, Petrocelli R, Schultz V, Brandon A, Cooney GJ, Kraegen EW, Ruderman NB, Saha AK.

PLoS One. 2015 May 21;10(5):e0127388. doi: 10.1371/journal.pone.0127388. eCollection 2015.


Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance.

Brandon AE, Tid-Ang J, Wright LE, Stuart E, Suryana E, Bentley N, Turner N, Cooney GJ, Ruderman NB, Kraegen EW.

PLoS One. 2015 Mar 23;10(3):e0121959. doi: 10.1371/journal.pone.0121959. eCollection 2015.


Fatty acid metabolism, energy expenditure and insulin resistance in muscle.

Turner N, Cooney GJ, Kraegen EW, Bruce CR.

J Endocrinol. 2014 Jan 15;220(2):T61-79. doi: 10.1530/JOE-13-0397. Print 2014 Feb. Review.


Activation of AMPK by bitter melon triterpenoids involves CaMKKβ.

Iseli TJ, Turner N, Zeng XY, Cooney GJ, Kraegen EW, Yao S, Ye Y, James DE, Ye JM.

PLoS One. 2013 Apr 25;8(4):e62309. doi: 10.1371/journal.pone.0062309. Print 2013.


Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding.

Turner N, Kowalski GM, Leslie SJ, Risis S, Yang C, Lee-Young RS, Babb JR, Meikle PJ, Lancaster GI, Henstridge DC, White PJ, Kraegen EW, Marette A, Cooney GJ, Febbraio MA, Bruce CR.

Diabetologia. 2013 Jul;56(7):1638-48. doi: 10.1007/s00125-013-2913-1. Epub 2013 Apr 26.


Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity.

Patel SA, Hoehn KL, Lawrence RT, Sawbridge L, Talbot NA, Tomsig JL, Turner N, Cooney GJ, Whitehead JP, Kraegen EW, Cleasby ME.

Endocrinology. 2012 Nov;153(11):5231-46. doi: 10.1210/en.2012-1368. Epub 2012 Sep 18.


Oleanolic acid reduces hyperglycemia beyond treatment period with Akt/FoxO1-induced suppression of hepatic gluconeogenesis in type-2 diabetic mice.

Zeng XY, Wang YP, Cantley J, Iseli TJ, Molero JC, Hegarty BD, Kraegen EW, Ye Y, Ye JM.

PLoS One. 2012;7(7):e42115. doi: 10.1371/journal.pone.0042115. Epub 2012 Jul 30.


Overexpression of manganese superoxide dismutase ameliorates high-fat diet-induced insulin resistance in rat skeletal muscle.

Boden MJ, Brandon AE, Tid-Ang JD, Preston E, Wilks D, Stuart E, Cleasby ME, Turner N, Cooney GJ, Kraegen EW.

Am J Physiol Endocrinol Metab. 2012 Sep 15;303(6):E798-805. doi: 10.1152/ajpendo.00577.2011. Epub 2012 Jul 24.


Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance.

Ren LP, Chan SM, Zeng XY, Laybutt DR, Iseli TJ, Sun RQ, Kraegen EW, Cooney GJ, Turner N, Ye JM.

PLoS One. 2012;7(2):e30816. doi: 10.1371/journal.pone.0030816. Epub 2012 Feb 15.


Insulin resistance due to nutrient excess: is it a consequence of AMPK downregulation?

Saha AK, Xu XJ, Balon TW, Brandon A, Kraegen EW, Ruderman NB.

Cell Cycle. 2011 Oct 15;10(20):3447-51. doi: 10.4161/cc.10.20.17886. Review.


Central neuropeptide Y infusion and melanocortin 4 receptor antagonism inhibit thyrotropic function by divergent pathways.

Preston E, Cooney GJ, Wilks D, Baran K, Zhang L, Kraegen EW, Sainsbury A.

Neuropeptides. 2011 Dec;45(6):407-15. doi: 10.1016/j.npep.2011.07.009. Epub 2011 Aug 20.


The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway.

Cleasby ME, Lau Q, Polkinghorne E, Patel SA, Leslie SJ, Turner N, Cooney GJ, Xu A, Kraegen EW.

J Endocrinol. 2011 Jul;210(1):81-92. doi: 10.1530/JOE-11-0039. Epub 2011 May 4.


The evolution of insulin resistance in muscle of the glucose infused rat.

Brandon AE, Hoy AJ, Wright LE, Turner N, Hegarty BD, Iseli TJ, Julia Xu X, Cooney GJ, Saha AK, Ruderman NB, Kraegen EW.

Arch Biochem Biophys. 2011 May 15;509(2):133-41. doi: 10.1016/ Epub 2011 Mar 21.


PPARδ agonists have opposing effects on insulin resistance in high fat-fed rats and mice due to different metabolic responses in muscle.

Ye JM, Tid-Ang J, Turner N, Zeng XY, Li HY, Cooney GJ, Wulff EM, Sauerberg P, Kraegen EW.

Br J Pharmacol. 2011 Jun;163(3):556-66. doi: 10.1111/j.1476-5381.2011.01240.x.


Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle.

Saha AK, Xu XJ, Lawson E, Deoliveira R, Brandon AE, Kraegen EW, Ruderman NB.

Diabetes. 2010 Oct;59(10):2426-34. doi: 10.2337/db09-1870. Epub 2010 Aug 3.


Mice lacking the neuropeptide alpha-calcitonin gene-related peptide are protected against diet-induced obesity.

Walker CS, Li X, Whiting L, Glyn-Jones S, Zhang S, Hickey AJ, Sewell MA, Ruggiero K, Phillips AR, Kraegen EW, Hay DL, Cooper GJ, Loomes KM.

Endocrinology. 2010 Sep;151(9):4257-69. doi: 10.1210/en.2010-0284. Epub 2010 Jul 7.


Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity.

Hoehn KL, Turner N, Swarbrick MM, Wilks D, Preston E, Phua Y, Joshi H, Furler SM, Larance M, Hegarty BD, Leslie SJ, Pickford R, Hoy AJ, Kraegen EW, James DE, Cooney GJ.

Cell Metab. 2010 Jan;11(1):70-6. doi: 10.1016/j.cmet.2009.11.008.


Insulin resistance is a cellular antioxidant defense mechanism.

Hoehn KL, Salmon AB, Hohnen-Behrens C, Turner N, Hoy AJ, Maghzal GJ, Stocker R, Van Remmen H, Kraegen EW, Cooney GJ, Richardson AR, James DE.

Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17787-92. doi: 10.1073/pnas.0902380106. Epub 2009 Sep 30.


Enhancement of muscle mitochondrial oxidative capacity and alterations in insulin action are lipid species dependent: potent tissue-specific effects of medium-chain fatty acids.

Turner N, Hariharan K, TidAng J, Frangioudakis G, Beale SM, Wright LE, Zeng XY, Leslie SJ, Li JY, Kraegen EW, Cooney GJ, Ye JM.

Diabetes. 2009 Nov;58(11):2547-54. doi: 10.2337/db09-0784. Epub 2009 Aug 31. Erratum in: Diabetes. 2010 May;59(5):1283.


APPL1 potentiates insulin-mediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice.

Cheng KK, Iglesias MA, Lam KS, Wang Y, Sweeney G, Zhu W, Vanhoutte PM, Kraegen EW, Xu A.

Cell Metab. 2009 May;9(5):417-27. doi: 10.1016/j.cmet.2009.03.013.


Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation.

Hoy AJ, Brandon AE, Turner N, Watt MJ, Bruce CR, Cooney GJ, Kraegen EW.

Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E67-75. doi: 10.1152/ajpendo.90945.2008. Epub 2009 Apr 14.


Major urinary protein-1 increases energy expenditure and improves glucose intolerance through enhancing mitochondrial function in skeletal muscle of diabetic mice.

Hui X, Zhu W, Wang Y, Lam KS, Zhang J, Wu D, Kraegen EW, Li Y, Xu A.

J Biol Chem. 2009 May 22;284(21):14050-7. doi: 10.1074/jbc.M109.001107. Epub 2009 Mar 31.


AMP-activated protein kinase and muscle insulin resistance.

Kraegen EW, Bruce C, Hegarty BD, Ye JM, Turner N, Cooney G.

Front Biosci (Landmark Ed). 2009 Jan 1;14:4658-72. Review.


Insulin resistance and fuel homeostasis: the role of AMP-activated protein kinase.

Hegarty BD, Turner N, Cooney GJ, Kraegen EW.

Acta Physiol (Oxf). 2009 May;196(1):129-45. doi: 10.1111/j.1748-1716.2009.01968.x. Epub 2009 Feb 19. Review.


Fat partitioning and insulin sensitivity: robbing Peter to pay Paul?

Watt MJ, Kraegen EW.

Diabetes. 2009 Jan;58(1):16-7. doi: 10.2337/db08-1466. No abstract available.


Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance.

Bruce CR, Hoy AJ, Turner N, Watt MJ, Allen TL, Carpenter K, Cooney GJ, Febbraio MA, Kraegen EW.

Diabetes. 2009 Mar;58(3):550-8. doi: 10.2337/db08-1078. Epub 2008 Dec 10.


Muscle insulin resistance: a case of fat overconsumption, not mitochondrial dysfunction.

Kraegen EW, Cooney GJ, Turner N.

Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7627-8. doi: 10.1073/pnas.0803901105. Epub 2008 May 28. No abstract available.


Free fatty acids and skeletal muscle insulin resistance.

Kraegen EW, Cooney GJ.

Curr Opin Lipidol. 2008 Jun;19(3):235-41. doi: 10.1097/01.mol.0000319118.44995.9a. Review.


Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action.

Turner N, Li JY, Gosby A, To SW, Cheng Z, Miyoshi H, Taketo MM, Cooney GJ, Kraegen EW, James DE, Hu LH, Li J, Ye JM.

Diabetes. 2008 May;57(5):1414-8. doi: 10.2337/db07-1552. Epub 2008 Feb 19.


Adipose triglyceride lipase regulation of skeletal muscle lipid metabolism and insulin responsiveness.

Watt MJ, van Denderen BJ, Castelli LA, Bruce CR, Hoy AJ, Kraegen EW, Macaulay L, Kemp BE.

Mol Endocrinol. 2008 May;22(5):1200-12. doi: 10.1210/me.2007-0485. Epub 2008 Jan 17. Retraction in: Mol Endocrinol. 2010 Jun;24(6):1308.


Local activation of the IkappaK-NF-kappaB pathway in muscle does not cause insulin resistance.

Polkinghorne E, Lau Q, Cooney GJ, Kraegen EW, Cleasby ME.

Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E316-25. Epub 2007 Nov 20.


Evidence that alpha-calcitonin gene-related peptide is a neurohormone that controls systemic lipid availability and utilization.

Danaher RN, Loomes KM, Leonard BL, Whiting L, Hay DL, Xu LY, Kraegen EW, Phillips AR, Cooper GJ.

Endocrinology. 2008 Jan;149(1):154-60. Epub 2007 Oct 11.


Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation.

Hoy AJ, Bruce CR, Cederberg A, Turner N, James DE, Cooney GJ, Kraegen EW.

Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1358-64. Epub 2007 Sep 4.


Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification.

Bruce CR, Brolin C, Turner N, Cleasby ME, van der Leij FR, Cooney GJ, Kraegen EW.

Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1231-7. Epub 2006 Dec 19.


Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans.

Wang Y, Lam KS, Kraegen EW, Sweeney G, Zhang J, Tso AW, Chow WS, Wat NM, Xu JY, Hoo RL, Xu A.

Clin Chem. 2007 Jan;53(1):34-41. Epub 2006 Oct 13.


Functional studies of Akt isoform specificity in skeletal muscle in vivo; maintained insulin sensitivity despite reduced insulin receptor substrate-1 expression.

Cleasby ME, Reinten TA, Cooney GJ, James DE, Kraegen EW.

Mol Endocrinol. 2007 Jan;21(1):215-28. Epub 2006 Oct 4.


Oral administration of glucose promotes intracellular partitioning of fatty acid toward storage in white but not in red muscle.

Fosgerau K, Fledelius C, Pedersen KE, Kristensen JB, Daugaard JR, Iglesias MA, Kraegen EW, Furler SM.

J Endocrinol. 2006 Sep;190(3):651-8.


Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states.

Lee YS, Kim WS, Kim KH, Yoon MJ, Cho HJ, Shen Y, Ye JM, Lee CH, Oh WK, Kim CT, Hohnen-Behrens C, Gosby A, Kraegen EW, James DE, Kim JB.

Diabetes. 2006 Aug;55(8):2256-64.


Overexpression of acyl-CoA synthetase-1 increases lipid deposition in hepatic (HepG2) cells and rodent liver in vivo.

Parkes HA, Preston E, Wilks D, Ballesteros M, Carpenter L, Wood L, Kraegen EW, Furler SM, Cooney GJ.

Am J Physiol Endocrinol Metab. 2006 Oct;291(4):E737-44. Epub 2006 May 16.


Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats.

Kraegen EW, Saha AK, Preston E, Wilks D, Hoy AJ, Cooney GJ, Ruderman NB.

Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E471-9. Epub 2005 Oct 18.


Acute bidirectional manipulation of muscle glucose uptake by in vivo electrotransfer of constructs targeting glucose transporter genes.

Cleasby ME, Davey JR, Reinten TA, Graham MW, James DE, Kraegen EW, Cooney GJ.

Diabetes. 2005 Sep;54(9):2702-11.


Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanisms.

Cleasby ME, Dzamko N, Hegarty BD, Cooney GJ, Kraegen EW, Ye JM.

Diabetes. 2004 Dec;53(12):3258-66.


Direct demonstration of lipid sequestration as a mechanism by which rosiglitazone prevents fatty-acid-induced insulin resistance in the rat: comparison with metformin.

Ye JM, Dzamko N, Cleasby ME, Hegarty BD, Furler SM, Cooney GJ, Kraegen EW.

Diabetologia. 2004 Jul;47(7):1306-1313. doi: 10.1007/s00125-004-1436-1. Epub 2004 Jul 1.


Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo.

Saha AK, Avilucea PR, Ye JM, Assifi MM, Kraegen EW, Ruderman NB.

Biochem Biophys Res Commun. 2004 Feb 6;314(2):580-5.


Insulin action, regional fat, and myocyte lipid: altered relationships with increased adiposity.

Gan SK, Kriketos AD, Poynten AM, Furler SM, Thompson CH, Kraegen EW, Campbell LV, Chisholm DJ.

Obes Res. 2003 Nov;11(11):1295-305.


Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity.

Ruderman NB, Saha AK, Kraegen EW.

Endocrinology. 2003 Dec;144(12):5166-71. Epub 2003 Sep 18. Review.


Peripheral insulin resistance develops in transgenic rats overexpressing phosphoenolpyruvate carboxykinase in the kidney.

Lamont BJ, Andrikopoulos S, Funkat A, Favaloro J, Ye JM, Kraegen EW, Howlett KF, Zajac JD, Proietto J.

Diabetologia. 2003 Oct;46(10):1338-47. Epub 2003 Jul 29.


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