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Items: 1 to 50 of 165

1.

ULK1/2 Restricts the Formation of Inducible SINT-Speckles, Membraneless Organelles Controlling the Threshold of TBK1 Activation.

Saul VV, Seibert M, Krüger M, Jeratsch S, Kracht M, Schmitz ML.

iScience. 2019 Sep 27;19:527-544. doi: 10.1016/j.isci.2019.08.001. Epub 2019 Aug 6.

2.

Single-Cell Analysis of Multiple Steps of Dynamic NF-κB Regulation in Interleukin-1α-Triggered Tumor Cells Using Proximity Ligation Assays.

Mayr-Buro C, Schlereth E, Beuerlein K, Tenekeci U, Meier-Soelch J, Schmitz ML, Kracht M.

Cancers (Basel). 2019 Aug 16;11(8). pii: E1199. doi: 10.3390/cancers11081199.

3.

Chemotherapeutic Drugs Inhibiting Topoisomerase 1 Activity Impede Cytokine-Induced and NF-κB p65-Regulated Gene Expression.

Riedlinger T, Bartkuhn M, Zimmermann T, Hake SB, Nist A, Stiewe T, Kracht M, Schmitz ML.

Cancers (Basel). 2019 Jun 25;11(6). pii: E883. doi: 10.3390/cancers11060883.

4.

Phosphoproteome Analysis of Cells Infected with Adapted and Nonadapted Influenza A Virus Reveals Novel Pro- and Antiviral Signaling Networks.

Weber A, Dam S, Saul VV, Kuznetsova I, Müller C, Fritz-Wolf K, Becker K, Linne U, Gu H, Stokes MP, Pleschka S, Kracht M, Schmitz ML.

J Virol. 2019 Jun 14;93(13). pii: e00528-19. doi: 10.1128/JVI.00528-19. Print 2019 Jul 1.

PMID:
30996098
5.

A paper-based, cell-free biosensor system for the detection of heavy metals and date rape drugs.

Gräwe A, Dreyer A, Vornholt T, Barteczko U, Buchholz L, Drews G, Ho UL, Jackowski ME, Kracht M, Lüders J, Bleckwehl T, Rositzka L, Ruwe M, Wittchen M, Lutter P, Müller K, Kalinowski J.

PLoS One. 2019 Mar 6;14(3):e0210940. doi: 10.1371/journal.pone.0210940. eCollection 2019.

6.

CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation.

Seibert M, Krüger M, Watson NA, Sen O, Daum JR, Slotman JA, Braun T, Houtsmuller AB, Gorbsky GJ, Jacob R, Kracht M, Higgins JMG, Schmitz ML.

J Cell Biol. 2019 Apr 1;218(4):1164-1181. doi: 10.1083/jcb.201806057. Epub 2019 Feb 14.

7.

Bioluminescent reporter assay for monitoring ER stress in human beta cells.

Kracht MJL, de Koning EJP, Hoeben RC, Roep BO, Zaldumbide A.

Sci Rep. 2018 Dec 10;8(1):17738. doi: 10.1038/s41598-018-36142-4.

8.

NF-κB p65 dimerization and DNA-binding is important for inflammatory gene expression.

Riedlinger T, Liefke R, Meier-Soelch J, Jurida L, Nist A, Stiewe T, Kracht M, Schmitz ML.

FASEB J. 2019 Mar;33(3):4188-4202. doi: 10.1096/fj.201801638R. Epub 2018 Dec 7.

9.

Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.

Weith M, Seiler J, van den Boom J, Kracht M, Hülsmann J, Primorac I, Del Pino Garcia J, Kaschani F, Kaiser M, Musacchio A, Bollen M, Meyer H.

Mol Cell. 2018 Nov 15;72(4):766-777.e6. doi: 10.1016/j.molcel.2018.09.020. Epub 2018 Oct 18.

PMID:
30344098
10.

The Crosstalk of Endoplasmic Reticulum (ER) Stress Pathways with NF-κB: Complex Mechanisms Relevant for Cancer, Inflammation and Infection.

Schmitz ML, Shaban MS, Albert BV, Gökçen A, Kracht M.

Biomedicines. 2018 May 16;6(2). pii: E58. doi: 10.3390/biomedicines6020058. Review.

11.

Correction: Riedlinger, T. et al. The Direct and Indirect Roles of NF-κB in Cancer: Lessons from Oncogenic Fusion Proteins and Knock-In Mice. Biomedicines, 2018, 6, 36.

Riedlinger T, Haas J, Busch J, van de Sluis B, Kracht M, Schmitz ML.

Biomedicines. 2018 May 16;6(2). pii: E57. doi: 10.3390/biomedicines6020057. No abstract available.

12.

RNAi-Based Identification of Gene-Specific Nuclear Cofactor Networks Regulating Interleukin-1 Target Genes.

Meier-Soelch J, Jurida L, Weber A, Newel D, Kim J, Braun T, Schmitz ML, Kracht M.

Front Immunol. 2018 Apr 27;9:775. doi: 10.3389/fimmu.2018.00775. eCollection 2018.

13.

The Direct and Indirect Roles of NF-κB in Cancer: Lessons from Oncogenic Fusion Proteins and Knock-in Mice.

Riedlinger T, Haas J, Busch J, van de Sluis B, Kracht M, Schmitz ML.

Biomedicines. 2018 Mar 19;6(1). pii: E36. doi: 10.3390/biomedicines6010036. Review. Erratum in: Biomedicines. 2018 May 16;6(2):.

14.

PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFα.

Dopeso H, Jiao HK, Cuesta AM, Henze AT, Jurida L, Kracht M, Acker-Palmer A, Garvalov BK, Acker T.

Cancer Res. 2018 Apr 1;78(7):1805-1819. doi: 10.1158/0008-5472.CAN-17-1346. Epub 2018 Jan 16.

15.

The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription.

Rodríguez-Gil A, Ritter O, Saul VV, Wilhelm J, Yang CY, Grosschedl R, Imai Y, Kuba K, Kracht M, Schmitz ML.

Sci Rep. 2017 Jun 14;7(1):3547. doi: 10.1038/s41598-017-03708-7.

16.

The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells.

Poppe M, Wittig S, Jurida L, Bartkuhn M, Wilhelm J, Müller H, Beuerlein K, Karl N, Bhuju S, Ziebuhr J, Schmitz ML, Kracht M.

PLoS Pathog. 2017 Mar 29;13(3):e1006286. doi: 10.1371/journal.ppat.1006286. eCollection 2017 Mar.

17.

Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes.

Kracht MJ, van Lummel M, Nikolic T, Joosten AM, Laban S, van der Slik AR, van Veelen PA, Carlotti F, de Koning EJ, Hoeben RC, Zaldumbide A, Roep BO.

Nat Med. 2017 Apr;23(4):501-507. doi: 10.1038/nm.4289. Epub 2017 Feb 27.

PMID:
28263308
18.

Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse.

Stauber M, Weidemann M, Dittrich-Breiholz O, Lobschat K, Alten L, Mai M, Beckers A, Kracht M, Gossler A.

Dev Biol. 2017 Mar 15;423(2):170-188. doi: 10.1016/j.ydbio.2016.11.019. Epub 2016 Dec 1.

19.

IL-1-induced post-transcriptional mechanisms target overlapping translational silencing and destabilizing elements in IκBζ mRNA.

Dhamija S, Doerrie A, Winzen R, Dittrich-Breiholz O, Taghipour A, Kuehne N, Kracht M, Holtmann H.

J Biol Chem. 2016 Nov 18;291(47):24801. No abstract available.

20.

Proliferation status defines functional properties of endothelial cells.

Lipps C, Badar M, Butueva M, Dubich T, Singh VV, Rau S, Weber A, Kracht M, Köster M, May T, Schulz TF, Hauser H, Wirth D.

Cell Mol Life Sci. 2017 Apr;74(7):1319-1333. doi: 10.1007/s00018-016-2417-5. Epub 2016 Nov 16.

PMID:
27853834
21.

K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping.

Tenekeci U, Poppe M, Beuerlein K, Buro C, Müller H, Weiser H, Kettner-Buhrow D, Porada K, Newel D, Xu M, Chen ZJ, Busch J, Schmitz ML, Kracht M.

Mol Cell. 2016 Aug 4;63(3):540. doi: 10.1016/j.molcel.2016.07.009. Epub 2016 Aug 4. No abstract available.

22.

Testing the Effects of SIAH Ubiquitin E3 Ligases on Lysine Acetyl Transferases.

Hagenbucher J, Stekman H, Rodriguez-Gil A, Kracht M, Schmitz ML.

Methods Mol Biol. 2017;1510:297-312.

PMID:
27761830
23.

A roadmap of the generation of neoantigens as targets of the immune system in type 1 diabetes.

Roep BO, Kracht MJ, van Lummel M, Zaldumbide A.

Curr Opin Immunol. 2016 Dec;43:67-73. doi: 10.1016/j.coi.2016.09.007. Epub 2016 Oct 7. Review.

24.

The Influenza A Virus Genotype Determines the Antiviral Function of NF-κB.

Dam S, Kracht M, Pleschka S, Schmitz ML.

J Virol. 2016 Aug 12;90(17):7980-90. doi: 10.1128/JVI.00946-16. Print 2016 Sep 1.

25.

K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping.

Tenekeci U, Poppe M, Beuerlein K, Buro C, Müller H, Weiser H, Kettner-Buhrow D, Porada K, Newel D, Xu M, Chen ZJ, Busch J, Schmitz ML, Kracht M.

Mol Cell. 2016 Jun 16;62(6):943-957. doi: 10.1016/j.molcel.2016.05.017. Erratum in: Mol Cell. 2016 Aug 4;63(3):540.

26.

HIPK family kinases bind and regulate the function of the CCR4-NOT complex.

Rodriguez-Gil A, Ritter O, Hornung J, Stekman H, Krüger M, Braun T, Kremmer E, Kracht M, Schmitz ML.

Mol Biol Cell. 2016 Jun 15;27(12):1969-80. doi: 10.1091/mbc.E15-09-0629. Epub 2016 Apr 27.

27.

Neoantigens and Microenvironment in Type 1 Diabetes: Lessons from Antitumor Immunity.

Kracht MJL, Zaldumbide A, Roep BO.

Trends Endocrinol Metab. 2016 Jun;27(6):353-362. doi: 10.1016/j.tem.2016.03.013. Epub 2016 Apr 16. Review.

PMID:
27094501
28.

Cyclin-Dependent Kinases as Coregulators of Inflammatory Gene Expression.

Schmitz ML, Kracht M.

Trends Pharmacol Sci. 2016 Feb;37(2):101-113. doi: 10.1016/j.tips.2015.10.004. Epub 2015 Dec 22. Review.

PMID:
26719217
29.

C/EBPβ is a transcriptional key regulator of IL-36α in murine macrophages.

Nerlich A, Ruangkiattikul N, Laarmann K, Janze N, Dittrich-Breiholz O, Kracht M, Goethe R.

Biochim Biophys Acta. 2015 Aug;1849(8):966-78. doi: 10.1016/j.bbagrm.2015.06.002. Epub 2015 Jun 8.

PMID:
26066982
30.

The Activation of IL-1-Induced Enhancers Depends on TAK1 Kinase Activity and NF-κB p65.

Jurida L, Soelch J, Bartkuhn M, Handschick K, Müller H, Newel D, Weber A, Dittrich-Breiholz O, Schneider H, Bhuju S, Saul VV, Schmitz ML, Kracht M.

Cell Rep. 2015 Feb 10;10(5):726-739. doi: 10.1016/j.celrep.2015.01.001. Epub 2015 Feb 5.

31.

The intricate interplay between RNA viruses and NF-κB.

Schmitz ML, Kracht M, Saul VV.

Biochim Biophys Acta. 2014 Nov;1843(11):2754-2764. doi: 10.1016/j.bbamcr.2014.08.004. Epub 2014 Aug 10. Review.

32.

Copper metabolism domain-containing 1 represses genes that promote inflammation and protects mice from colitis and colitis-associated cancer.

Li H, Chan L, Bartuzi P, Melton SD, Weber A, Ben-Shlomo S, Varol C, Raetz M, Mao X, Starokadomskyy P, van Sommeren S, Mokadem M, Schneider H, Weisberg R, Westra HJ, Esko T, Metspalu A, Kumar V, Faubion WA, Yarovinsky F, Hofker M, Wijmenga C, Kracht M, Franke L, Aguirre V, Weersma RK, Gluck N, van de Sluis B, Burstein E.

Gastroenterology. 2014 Jul;147(1):184-195.e3. doi: 10.1053/j.gastro.2014.04.007. Epub 2014 Apr 13.

33.

Identification of two forms of TNF tolerance in human monocytes: differential inhibition of NF-κB/AP-1- and PP1-associated signaling.

Günther J, Vogt N, Hampel K, Bikker R, Page S, Müller B, Kandemir J, Kracht M, Dittrich-Breiholz O, Huber R, Brand K.

J Immunol. 2014 Apr 1;192(7):3143-55. doi: 10.4049/jimmunol.1301610. Epub 2014 Feb 26.

34.

MKK7 mediates miR-493-dependent suppression of liver metastasis of colon cancer cells.

Sakai H, Sato A, Aihara Y, Ikarashi Y, Midorikawa Y, Kracht M, Nakagama H, Okamoto K.

Cancer Sci. 2014 Apr;105(4):425-30. doi: 10.1111/cas.12380. Epub 2014 Mar 24.

35.

An environmental bacterial taxon with a large and distinct metabolic repertoire.

Wilson MC, Mori T, Rückert C, Uria AR, Helf MJ, Takada K, Gernert C, Steffens UA, Heycke N, Schmitt S, Rinke C, Helfrich EJ, Brachmann AO, Gurgui C, Wakimoto T, Kracht M, Crüsemann M, Hentschel U, Abe I, Matsunaga S, Kalinowski J, Takeyama H, Piel J.

Nature. 2014 Feb 6;506(7486):58-62. doi: 10.1038/nature12959. Epub 2014 Jan 29. Erratum in: Nature. 2014 Mar 13;507(7491):262.

PMID:
24476823
36.

Cyclin-dependent kinase 6 is a chromatin-bound cofactor for NF-κB-dependent gene expression.

Handschick K, Beuerlein K, Jurida L, Bartkuhn M, Müller H, Soelch J, Weber A, Dittrich-Breiholz O, Schneider H, Scharfe M, Jarek M, Stellzig J, Schmitz ML, Kracht M.

Mol Cell. 2014 Jan 23;53(2):193-208. doi: 10.1016/j.molcel.2013.12.002. Epub 2014 Jan 2. Erratum in: Mol Cell. 2014 Feb 20;53(4):682.

37.

The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells.

Haas DA, Bala K, Büsche G, Weidner-Glunde M, Santag S, Kati S, Gramolelli S, Damas M, Dittrich-Breiholz O, Kracht M, Rückert J, Varga Z, Keri G, Schulz TF.

PLoS Pathog. 2013;9(11):e1003737. doi: 10.1371/journal.ppat.1003737. Epub 2013 Nov 7.

38.

The cytokine-induced conformational switch of nuclear factor κB p65 is mediated by p65 phosphorylation.

Milanovic M, Kracht M, Schmitz ML.

Biochem J. 2014 Feb 1;457(3):401-13. doi: 10.1042/BJ20130780.

PMID:
24175631
39.

Transcriptional regulation of immediate-early gene response by THOC5, a member of mRNA export complex, contributes to the M-CSF-induced macrophage differentiation.

Tran DD, Saran S, Dittrich-Breiholz O, Williamson AJ, Klebba-Färber S, Koch A, Kracht M, Whetton AD, Tamura T.

Cell Death Dis. 2013 Oct 24;4:e879. doi: 10.1038/cddis.2013.409.

40.

Interleukin-17 (IL-17) and IL-1 activate translation of overlapping sets of mRNAs, including that of the negative regulator of inflammation, MCPIP1.

Dhamija S, Winzen R, Doerrie A, Behrens G, Kuehne N, Schauerte C, Neumann E, Dittrich-Breiholz O, Kracht M, Holtmann H.

J Biol Chem. 2013 Jun 28;288(26):19250-9. doi: 10.1074/jbc.M113.452649. Epub 2013 May 8.

41.

Regulation of TAK1/TAB1-mediated IL-1β signaling by cytoplasmic PPARβ/δ.

Stockert J, Wolf A, Kaddatz K, Schnitzer E, Finkernagel F, Meissner W, Müller-Brüsselbach S, Kracht M, Müller R.

PLoS One. 2013 Apr 30;8(4):e63011. doi: 10.1371/journal.pone.0063011. Print 2013.

42.

Intravenous delivery of HIV-based lentiviral vectors preferentially transduces F4/80+ and Ly-6C+ cells in spleen, important target cells in autoimmune arthritis.

van den Brand BT, Vermeij EA, Waterborg CE, Arntz OJ, Kracht M, Bennink MB, van den Berg WB, van de Loo FA.

PLoS One. 2013;8(2):e55356. doi: 10.1371/journal.pone.0055356. Epub 2013 Feb 4.

43.

Cyclin-dependent kinase 6 phosphorylates NF-κB P65 at serine 536 and contributes to the regulation of inflammatory gene expression.

Buss H, Handschick K, Jurrmann N, Pekkonen P, Beuerlein K, Müller H, Wait R, Saklatvala J, Ojala PM, Schmitz ML, Naumann M, Kracht M.

PLoS One. 2012;7(12):e51847. doi: 10.1371/journal.pone.0051847. Epub 2012 Dec 26.

44.

The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB.

Ziesché E, Kettner-Buhrow D, Weber A, Wittwer T, Jurida L, Soelch J, Müller H, Newel D, Kronich P, Schneider H, Dittrich-Breiholz O, Bhaskara S, Hiebert SW, Hottiger MO, Li H, Burstein E, Schmitz ML, Kracht M.

Nucleic Acids Res. 2013 Jan 7;41(1):90-109. doi: 10.1093/nar/gks916. Epub 2012 Oct 19.

45.

Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCγ1 and activating NFAT1-dependent RCAN1 expression.

Bala K, Bosco R, Gramolelli S, Haas DA, Kati S, Pietrek M, Hävemeier A, Yakushko Y, Singh VV, Dittrich-Breiholz O, Kracht M, Schulz TF.

PLoS Pathog. 2012 Sep;8(9):e1002927. doi: 10.1371/journal.ppat.1002927. Epub 2012 Sep 27.

46.

Regulation of NF-κB-dependent gene expression by ligand-induced endocytosis of the interleukin-1 receptor.

Hansen B, Dittrich-Breiholz O, Kracht M, Windheim M.

Cell Signal. 2013 Jan;25(1):214-28. doi: 10.1016/j.cellsig.2012.09.028. Epub 2012 Sep 28.

PMID:
23022958
47.

NF-κB-dependent IL-8 induction by prostaglandin E(2) receptors EP(1) and EP(4).

Neuschäfer-Rube F, Pathe-Neuschäfer-Rube A, Hippenstiel S, Kracht M, Püschel GP.

Br J Pharmacol. 2013 Feb;168(3):704-17. doi: 10.1111/j.1476-5381.2012.02182.x.

48.

Induction of a broad spectrum of inflammation-related genes by Coxsackievirus B3 requires Interleukin-1 signaling.

Rehren F, Ritter B, Dittrich-Breiholz O, Henke A, Lam E, Kati S, Kracht M, Heim A.

Med Microbiol Immunol. 2013 Feb;202(1):11-23. doi: 10.1007/s00430-012-0245-2. Epub 2012 Jun 3.

PMID:
22661216
49.

Human primary keratinocytes show restricted ability to up-regulate suppressor of cytokine signaling (SOCS)3 protein compared with autologous macrophages.

Zeitvogel J, Dalpke A, Eiz-Vesper B, Kracht M, Dittrich-Breiholz O, Werfel T, Wittmann M.

J Biol Chem. 2012 Mar 23;287(13):9923-30. doi: 10.1074/jbc.M111.280370. Epub 2012 Jan 31.

50.

Identification and functional characterization of novel phosphorylation sites in TAK1-binding protein (TAB) 1.

Wolf A, Beuerlein K, Eckart C, Weiser H, Dickkopf B, Müller H, Sakurai H, Kracht M.

PLoS One. 2011;6(12):e29256. doi: 10.1371/journal.pone.0029256. Epub 2011 Dec 22.

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