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Items: 24

1.

Treatment of type 2 diabetes with the designer cytokine IC7Fc.

Findeisen M, Allen TL, Henstridge DC, Kammoun H, Brandon AE, Baggio LL, Watt KI, Pal M, Cron L, Estevez E, Yang C, Kowalski GM, O'Reilly L, Egan C, Sun E, Thai LM, Krippner G, Adams TE, Lee RS, Grötzinger J, Garbers C, Risis S, Kraakman MJ, Mellet NA, Sligar J, Kimber ET, Young RL, Cowley MA, Bruce CR, Meikle PJ, Baldock PA, Gregorevic P, Biden TJ, Cooney GJ, Keating DJ, Drucker DJ, Rose-John S, Febbraio MA.

Nature. 2019 Oct;574(7776):63-68. doi: 10.1038/s41586-019-1601-9. Epub 2019 Sep 25.

PMID:
31554967
2.

Identification of C2CD4A as a human diabetes susceptibility gene with a role in β cell insulin secretion.

Kuo T, Kraakman MJ, Damle M, Gill R, Lazar MA, Accili D.

Proc Natl Acad Sci U S A. 2019 Oct 1;116(40):20033-20042. doi: 10.1073/pnas.1904311116. Epub 2019 Sep 16.

PMID:
31527256
3.

CD137 deficiency causes immune dysregulation with predisposition to lymphomagenesis.

Somekh I, Thian M, Medgyesi D, Gülez N, Magg T, Gallón Duque A, Stauber T, Lev A, Genel F, Unal E, Simon AJ, Lee YN, Kalinichenko A, Dmytrus J, Kraakman MJ, Schiby G, Rohlfs M, Jacobson JM, Özer E, Akcal Ö, Conca R, Patiroglu T, Karakukcu M, Ozcan A, Shahin T, Appella E, Tatematsu M, Martinez-Jaramillo C, Chinn IK, Orange JS, Trujillo-Vargas CM, Franco JL, Hauck F, Somech R, Klein C, Boztug K.

Blood. 2019 Sep 9. pii: blood.2019000644. doi: 10.1182/blood.2019000644. [Epub ahead of print]

PMID:
31501153
4.

The depot-specific and essential roles of CBP/p300 in regulating adipose plasticity.

Namwanje M, Liu L, Chan M, Aaron N, Kraakman MJ, Qiang L.

J Endocrinol. 2019 Feb 1;240(2):257-269. doi: 10.1530/JOE-18-0361.

PMID:
30530904
5.

Chronic sympathetic driven hypertension promotes atherosclerosis by enhancing hematopoiesis.

Al-Sharea A, Lee MKS, Whillas A, Michell DL, Shihata WA, Nicholls AJ, Cooney OD, Kraakman MJ, Veiga CB, Jefferis AM, Jackson K, Nagareddy PR, Lambert G, Wong CHY, Andrews KL, Head GA, Chin-Dusting J, Murphy AJ.

Haematologica. 2019 Mar;104(3):456-467. doi: 10.3324/haematol.2018.192898. Epub 2018 Oct 25.

6.

Evidence for a Non-leptin System that Defends against Weight Gain in Overfeeding.

Ravussin Y, Edwin E, Gallop M, Xu L, Bartolomé A, Kraakman MJ, LeDuc CA, Ferrante AW Jr.

Cell Metab. 2018 Aug 7;28(2):289-299.e5. doi: 10.1016/j.cmet.2018.05.029. Epub 2018 Jun 21.

7.

Defective cholesterol metabolism in haematopoietic stem cells promotes monocyte-driven atherosclerosis in rheumatoid arthritis.

Dragoljevic D, Kraakman MJ, Nagareddy PR, Ngo D, Shihata W, Kammoun HL, Whillas A, Lee MKS, Al-Sharea A, Pernes G, Flynn MC, Lancaster GI, Febbraio MA, Chin-Dusting J, Hanaoka BY, Wicks IP, Murphy AJ.

Eur Heart J. 2018 Jun 14;39(23):2158-2167. doi: 10.1093/eurheartj/ehy119.

8.

PPARγ deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects.

Kraakman MJ, Liu Q, Postigo-Fernandez J, Ji R, Kon N, Larrea D, Namwanje M, Fan L, Chan M, Area-Gomez E, Fu W, Creusot RJ, Qiang L.

J Clin Invest. 2018 Jun 1;128(6):2600-2612. doi: 10.1172/JCI98709. Epub 2018 May 14.

9.

Leptin-deficient obesity prolongs survival in a murine model of myelodysplastic syndrome.

Kraakman MJ, Kammoun HL, Dragoljevic D, Al-Sharea A, Lee MKS, Flynn MC, Stolz CJ, Guirguis AA, Lancaster GI, Chin-Dusting J, Curtis DJ, Murphy AJ.

Haematologica. 2018 Apr;103(4):597-606. doi: 10.3324/haematol.2017.181958. Epub 2018 Jan 25.

10.

Over-expressing the soluble gp130-Fc does not ameliorate methionine and choline deficient diet-induced non alcoholic steatohepatitis in mice.

Kammoun HL, Allen TL, Henstridge DC, Kraakman MJ, Peijs L, Rose-John S, Febbraio MA.

PLoS One. 2017 Jun 20;12(6):e0179099. doi: 10.1371/journal.pone.0179099. eCollection 2017.

11.

Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes.

Kraakman MJ, Lee MK, Al-Sharea A, Dragoljevic D, Barrett TJ, Montenont E, Basu D, Heywood S, Kammoun HL, Flynn M, Whillas A, Hanssen NM, Febbraio MA, Westein E, Fisher EA, Chin-Dusting J, Cooper ME, Berger JS, Goldberg IJ, Nagareddy PR, Murphy AJ.

J Clin Invest. 2017 Jun 1;127(6):2133-2147. doi: 10.1172/JCI92450. Epub 2017 May 15.

12.

Resolution of glucose intolerance in long-term high-fat, high-sucrose-fed mice.

Kowalski GM, Kraakman MJ, Mason SA, Murphy AJ, Bruce CR.

J Endocrinol. 2017 Jun;233(3):269-279. doi: 10.1530/JOE-17-0004. Epub 2017 Mar 30.

PMID:
28360081
13.

Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle.

Lee-Young RS, Hoffman NJ, Murphy KT, Henstridge DC, Samocha-Bonet D, Siebel AL, Iliades P, Zivanovic B, Hong YH, Colgan TD, Kraakman MJ, Bruce CR, Gregorevic P, McConell GK, Lynch GS, Drummond GR, Kingwell BA, Greenfield JR, Febbraio MA.

Mol Metab. 2016 Sep 9;5(11):1083-1091. doi: 10.1016/j.molmet.2016.09.002. eCollection 2016 Nov.

14.

Is the risk of cardiovascular disease altered with anti-inflammatory therapies? Insights from rheumatoid arthritis.

Kraakman MJ, Dragoljevic D, Kammoun HL, Murphy AJ.

Clin Transl Immunology. 2016 May 20;5(5):e84. doi: 10.1038/cti.2016.31. eCollection 2016 May. Review.

15.

PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications.

Lancaster GI, Kammoun HL, Kraakman MJ, Kowalski GM, Bruce CR, Febbraio MA.

Nat Commun. 2016 Feb 3;7:10626. doi: 10.1038/ncomms10626.

16.

IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome.

Murphy AJ, Kraakman MJ, Kammoun HL, Dragoljevic D, Lee MK, Lawlor KE, Wentworth JM, Vasanthakumar A, Gerlic M, Whitehead LW, DiRago L, Cengia L, Lane RM, Metcalf D, Vince JE, Harrison LC, Kallies A, Kile BT, Croker BA, Febbraio MA, Masters SL.

Cell Metab. 2016 Jan 12;23(1):155-64. doi: 10.1016/j.cmet.2015.09.024. Epub 2015 Oct 22.

17.

Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism.

Meex RC, Hoy AJ, Morris A, Brown RD, Lo JC, Burke M, Goode RJ, Kingwell BA, Kraakman MJ, Febbraio MA, Greve JW, Rensen SS, Molloy MP, Lancaster GI, Bruce CR, Watt MJ.

Cell Metab. 2015 Dec 1;22(6):1078-89. doi: 10.1016/j.cmet.2015.09.023. Epub 2015 Oct 22.

18.

Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance.

Kraakman MJ, Kammoun HL, Allen TL, Deswaerte V, Henstridge DC, Estevez E, Matthews VB, Neill B, White DA, Murphy AJ, Peijs L, Yang C, Risis S, Bruce CR, Du XJ, Bobik A, Lee-Young RS, Kingwell BA, Vasanthakumar A, Shi W, Kallies A, Lancaster GI, Rose-John S, Febbraio MA.

Cell Metab. 2015 Mar 3;21(3):403-16. doi: 10.1016/j.cmet.2015.02.006. Erratum in: Cell Metab. 2016 Mar 8;23(3):563.

19.

Analysis of the liver lipidome reveals insights into the protective effect of exercise on high-fat diet-induced hepatosteatosis in mice.

Jordy AB, Kraakman MJ, Gardner T, Estevez E, Kammoun HL, Weir JM, Kiens B, Meikle PJ, Febbraio MA, Henstridge DC.

Am J Physiol Endocrinol Metab. 2015 May 1;308(9):E778-91. doi: 10.1152/ajpendo.00547.2014. Epub 2015 Feb 24.

20.

The dual-specificity phosphatase 2 (DUSP2) does not regulate obesity-associated inflammation or insulin resistance in mice.

Lancaster GI, Kraakman MJ, Kammoun HL, Langley KG, Estevez E, Banerjee A, Grumont RJ, Febbraio MA, Gerondakis S.

PLoS One. 2014 Nov 6;9(11):e111524. doi: 10.1371/journal.pone.0111524. eCollection 2014.

21.

Macrophage polarization in obesity and type 2 diabetes: weighing down our understanding of macrophage function?

Kraakman MJ, Murphy AJ, Jandeleit-Dahm K, Kammoun HL.

Front Immunol. 2014 Sep 26;5:470. doi: 10.3389/fimmu.2014.00470. eCollection 2014. Review.

22.

Adipose tissue inflammation in glucose metabolism.

Kammoun HL, Kraakman MJ, Febbraio MA.

Rev Endocr Metab Disord. 2014 Mar;15(1):31-44. doi: 10.1007/s11154-013-9274-4. Review.

PMID:
24048715
23.

Targeting gp130 to prevent inflammation and promote insulin action.

Kraakman MJ, Allen TL, Whitham M, Iliades P, Kammoun HL, Estevez E, Lancaster GI, Febbraio MA.

Diabetes Obes Metab. 2013 Sep;15 Suppl 3:170-5. doi: 10.1111/dom.12170. Review.

PMID:
24003934
24.

Tumor progression locus 2 (Tpl2) deficiency does not protect against obesity-induced metabolic disease.

Lancaster GI, Kowalski GM, Estevez E, Kraakman MJ, Grigoriadis G, Febbraio MA, Gerondakis S, Banerjee A.

PLoS One. 2012;7(6):e39100. doi: 10.1371/journal.pone.0039100. Epub 2012 Jun 11.

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