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Items: 1 to 50 of 129

1.

Commentary: The Influence of Proton Pump Inhibitors on the Fecal Microbiome of Infants with Gastroesophageal Reflux-A Prospective Longitudinal Interventional Study.

Drall KM, Tun HM, Kozyrskyj AL.

Front Cell Infect Microbiol. 2018 Dec 14;8:430. doi: 10.3389/fcimb.2018.00430. eCollection 2018. No abstract available.

2.

Maternal Metabolic Complications in Pregnancy and Offspring Behavior Problems at 2 Years of Age.

Krzeczkowski JE, Lau A, Fitzpatrick J, Tamana S, Smithson L, de Souza R, Kozyrskyj AL, Lefebvre D, Becker AB, Subbarao P, Turvey SE, Pei J, Schmidt LA, Sears MR, Van Lieshout RJ, Mandhane PJ; CHILD Study Investigators.

Matern Child Health J. 2019 Jan 2. doi: 10.1007/s10995-018-2691-y. [Epub ahead of print]

PMID:
30600520
3.

Microbiota be nimble.

Kozyrskyj AL, Bourque SL, Ospina MB.

EBioMedicine. 2019 Jan;39:21-22. doi: 10.1016/j.ebiom.2018.11.058. Epub 2018 Dec 1. No abstract available.

4.

Worldwide Variation in Human Milk Metabolome: Indicators of Breast Physiology and Maternal Lifestyle?

Gay MCL, Koleva PT, Slupsky CM, Toit ED, Eggesbo M, Johnson CC, Wegienka G, Shimojo N, Campbell DE, Prescott SL, Munblit D, Geddes DT, Kozyrskyj AL; InVIVO LactoActive Study Investigators.

Nutrients. 2018 Aug 23;10(9). pii: E1151. doi: 10.3390/nu10091151.

5.

Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations.

Ho NT, Li F, Lee-Sarwar KA, Tun HM, Brown BP, Pannaraj PS, Bender JM, Azad MB, Thompson AL, Weiss ST, Azcarate-Peril MA, Litonjua AA, Kozyrskyj AL, Jaspan HB, Aldrovandi GM, Kuhn L.

Nat Commun. 2018 Oct 9;9(1):4169. doi: 10.1038/s41467-018-06473-x.

6.

Postnatal exposure to household disinfectants, infant gut microbiota and subsequent risk of overweight in children.

Tun MH, Tun HM, Mahoney JJ, Konya TB, Guttman DS, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Brook JR, Lou W, Takaro TK, Scott JA, Kozyrskyj AL; CHILD Study Investigators.

CMAJ. 2018 Sep 17;190(37):E1097-E1107. doi: 10.1503/cmaj.170809. Erratum in: CMAJ. 2018 Nov 12;190(45):E1341.

7.

The association between early life antibiotic use and allergic disease in young children: recent insights and their implications.

Obiakor CV, Tun HM, Bridgman SL, Arrieta MC, Kozyrskyj AL.

Expert Rev Clin Immunol. 2018 Oct;14(10):841-855. doi: 10.1080/1744666X.2018.1521271. Epub 2018 Sep 29.

PMID:
30198345
8.

Risk for Maternal Depressive Symptoms and Perceived Stress by Ethnicities in Canada: From Pregnancy Through the Preschool Years.

Dharma C, Lefebvre DL, Lu Z, Lou WYW, Becker AB, Mandhane PJ, Turvey SE, Moraes TJ, Azad MB, Chen E, Elliott SJ, Kozyrskyj AL, Sears MR, Subbarao P.

Can J Psychiatry. 2019 Mar;64(3):190-198. doi: 10.1177/0706743718792190. Epub 2018 Aug 1.

PMID:
30068224
9.

Regional Caesarean Delivery Practices, the Maternal-Infant Microbiome, and Risk for Asthma.

Entz R, Rai U, Rycroft J, Chari RS, Kozyrskyj AL.

J Obstet Gynaecol Can. 2018 Aug;40(8):1061-1065. doi: 10.1016/j.jogc.2018.01.025. Epub 2018 Jun 7. No abstract available.

PMID:
29887361
10.

Association of Exposure to Formula in the Hospital and Subsequent Infant Feeding Practices With Gut Microbiota and Risk of Overweight in the First Year of Life.

Forbes JD, Azad MB, Vehling L, Tun HM, Konya TB, Guttman DS, Field CJ, Lefebvre D, Sears MR, Becker AB, Mandhane PJ, Turvey SE, Moraes TJ, Subbarao P, Scott JA, Kozyrskyj AL; Canadian Healthy Infant Longitudinal Development (CHILD) Study Investigators.

JAMA Pediatr. 2018 Jul 2;172(7):e181161. doi: 10.1001/jamapediatrics.2018.1161. Epub 2018 Jul 2.

PMID:
29868719
11.

Impact of maternal pre-pregnancy overweight on infant overweight at 1 year of age: associations and sex-specific differences.

Bridgman SL, Azad MB, Persaud RR, Chari RS, Becker AB, Sears MR, Mandhane PJ, Turvey SE, Subbarao P, Haqq AM, Kozyrskyj AL.

Pediatr Obes. 2018 Oct;13(10):579-589. doi: 10.1111/ijpo.12291. Epub 2018 May 25.

PMID:
29797797
12.

Atopic dermatitis: Interaction between genetic variants of GSTP1, TNF, TLR2, and TLR4 and air pollution in early life.

Hüls A, Klümper C, MacIntyre EA, Brauer M, Melén E, Bauer M, Berdel D, Bergström A, Brunekreef B, Chan-Yeung M, Fuertes E, Gehring U, Gref A, Heinrich J, Standl M, Lehmann I, Kerkhof M, Koppelman GH, Kozyrskyj AL, Pershagen G, Carlsten C, Krämer U, Schikowski T; TAG Study Group.

Pediatr Allergy Immunol. 2018 Sep;29(6):596-605. doi: 10.1111/pai.12903. Epub 2018 May 7.

PMID:
29624745
13.

Long-term Non-Invasive Ventilation in Infants: A Systematic Review and Meta-Analysis.

Bedi PK, Castro-Codesal ML, Featherstone R, AlBalawi MM, Alkhaledi B, Kozyrskyj AL, Flores-Mir C, MacLean JE.

Front Pediatr. 2018 Feb 12;6:13. doi: 10.3389/fped.2018.00013. eCollection 2018.

14.

Roles of Birth Mode and Infant Gut Microbiota in Intergenerational Transmission of Overweight and Obesity From Mother to Offspring.

Tun HM, Bridgman SL, Chari R, Field CJ, Guttman DS, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Scott JA, Kozyrskyj AL; Canadian Healthy Infant Longitudinal Development (CHILD) Study Investigators.

JAMA Pediatr. 2018 Apr 1;172(4):368-377. doi: 10.1001/jamapediatrics.2017.5535.

15.

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

Demenais F, Margaritte-Jeannin P, Barnes KC, Cookson WOC, Altmüller J, Ang W, Barr RG, Beaty TH, Becker AB, Beilby J, Bisgaard H, Bjornsdottir US, Bleecker E, Bønnelykke K, Boomsma DI, Bouzigon E, Brightling CE, Brossard M, Brusselle GG, Burchard E, Burkart KM, Bush A, Chan-Yeung M, Chung KF, Couto Alves A, Curtin JA, Custovic A, Daley D, de Jongste JC, Del-Rio-Navarro BE, Donohue KM, Duijts L, Eng C, Eriksson JG, Farrall M, Fedorova Y, Feenstra B, Ferreira MA; Australian Asthma Genetics Consortium (AAGC) collaborators, Freidin MB, Gajdos Z, Gauderman J, Gehring U, Geller F, Genuneit J, Gharib SA, Gilliland F, Granell R, Graves PE, Gudbjartsson DF, Haahtela T, Heckbert SR, Heederik D, Heinrich J, Heliövaara M, Henderson J, Himes BE, Hirose H, Hirschhorn JN, Hofman A, Holt P, Hottenga J, Hudson TJ, Hui J, Imboden M, Ivanov V, Jaddoe VWV, James A, Janson C, Jarvelin MR, Jarvis D, Jones G, Jonsdottir I, Jousilahti P, Kabesch M, Kähönen M, Kantor DB, Karunas AS, Khusnutdinova E, Koppelman GH, Kozyrskyj AL, Kreiner E, Kubo M, Kumar R, Kumar A, Kuokkanen M, Lahousse L, Laitinen T, Laprise C, Lathrop M, Lau S, Lee YA, Lehtimäki T, Letort S, Levin AM, Li G, Liang L, Loehr LR, London SJ, Loth DW, Manichaikul A, Marenholz I, Martinez FJ, Matheson MC, Mathias RA, Matsumoto K, Mbarek H, McArdle WL, Melbye M, Melén E, Meyers D, Michel S, Mohamdi H, Musk AW, Myers RA, Nieuwenhuis MAE, Noguchi E, O'Connor GT, Ogorodova LM, Palmer CD, Palotie A, Park JE, Pennell CE, Pershagen G, Polonikov A, Postma DS, Probst-Hensch N, Puzyrev VP, Raby BA, Raitakari OT, Ramasamy A, Rich SS, Robertson CF, Romieu I, Salam MT, Salomaa V, Schlünssen V, Scott R, Selivanova PA, Sigsgaard T, Simpson A, Siroux V, Smith LJ, Solodilova M, Standl M, Stefansson K, Strachan DP, Stricker BH, Takahashi A, Thompson PJ, Thorleifsson G, Thorsteinsdottir U, Tiesler CMT, Torgerson DG, Tsunoda T, Uitterlinden AG, van der Valk RJP, Vaysse A, Vedantam S, von Berg A, von Mutius E, Vonk JM, Waage J, Wareham NJ, Weiss ST, White WB, Wickman M, Widén E, Willemsen G, Williams LK, Wouters IM, Yang JJ, Zhao JH, Moffatt MF, Ober C, Nicolae DL.

Nat Genet. 2018 Jan;50(1):42-53. doi: 10.1038/s41588-017-0014-7. Epub 2017 Dec 22.

16.

Sex-specific impact of asthma during pregnancy on infant gut microbiota.

Koleva PT, Tun HM, Konya T, Guttman DS, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Scott JA, Kozyrskyj AL; CHILD Study Investigators.

Eur Respir J. 2017 Nov 22;50(5). pii: 1700280. doi: 10.1183/13993003.00280-2017. Print 2017 Nov.

17.

The Kynurenine Pathway As a Novel Link between Allergy and the Gut Microbiome.

Van der Leek AP, Yanishevsky Y, Kozyrskyj AL.

Front Immunol. 2017 Nov 6;8:1374. doi: 10.3389/fimmu.2017.01374. eCollection 2017. Review.

18.

Maternal depressive symptoms linked to reduced fecal Immunoglobulin A concentrations in infants.

Kang LJ, Koleva PT, Field CJ, Giesbrecht GF, Wine E, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Scott JA, Kozyrskyj AL; CHILD Study Investigators.

Brain Behav Immun. 2018 Feb;68:123-131. doi: 10.1016/j.bbi.2017.10.007. Epub 2017 Oct 12.

PMID:
29032226
19.

Cesarean Section, Formula Feeding, and Infant Antibiotic Exposure: Separate and Combined Impacts on Gut Microbial Changes in Later Infancy.

Yasmin F, Tun HM, Konya TB, Guttman DS, Chari RS, Field CJ, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR; CHILD Study Investigators, Scott JA, Dinu I, Kozyrskyj AL.

Front Pediatr. 2017 Sep 26;5:200. doi: 10.3389/fped.2017.00200. eCollection 2017.

20.

Human Milk and Allergic Diseases: An Unsolved Puzzle.

Munblit D, Peroni DG, Boix-Amorós A, Hsu PS, Van't Land B, Gay MCL, Kolotilina A, Skevaki C, Boyle RJ, Collado MC, Garssen J, Geddes DT, Nanan R, Slupsky C, Wegienka G, Kozyrskyj AL, Warner JO.

Nutrients. 2017 Aug 17;9(8). pii: E894. doi: 10.3390/nu9080894. Review.

21.

Sex-Specific Differences in the Association Between Childhood Adversity and Cardiovascular Disease in Adulthood: Evidence From a National Cohort Study.

Garad Y, Maximova K, MacKinnon N, McGrath JJ, Kozyrskyj AL, Colman I.

Can J Cardiol. 2017 Aug;33(8):1013-1019. doi: 10.1016/j.cjca.2017.05.008. Epub 2017 May 19.

PMID:
28754386
22.

Maternal sensitivity and social support protect against childhood atopic dermatitis.

Letourneau NL, Kozyrskyj AL, Cosic N, Ntanda HN, Anis L, Hart MJ, Campbell TS, Giesbrecht GF; APrON Team.

Allergy Asthma Clin Immunol. 2017 May 26;13:26. doi: 10.1186/s13223-017-0199-4. eCollection 2017.

23.

Fecal Short-Chain Fatty Acid Variations by Breastfeeding Status in Infants at 4 Months: Differences in Relative versus Absolute Concentrations.

Bridgman SL, Azad MB, Field CJ, Haqq AM, Becker AB, Mandhane PJ, Subbarao P, Turvey SE, Sears MR, Scott JA, Wishart DS, Kozyrskyj AL; CHILD Study Investigators.

Front Nutr. 2017 Apr 10;4:11. doi: 10.3389/fnut.2017.00011. eCollection 2017.

24.

Exposure to household furry pets influences the gut microbiota of infant at 3-4 months following various birth scenarios.

Tun HM, Konya T, Takaro TK, Brook JR, Chari R, Field CJ, Guttman DS, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Scott JA, Kozyrskyj AL; CHILD Study Investigators.

Microbiome. 2017 Apr 6;5(1):40. doi: 10.1186/s40168-017-0254-x.

25.

Genome-Wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up.

Gref A, Merid SK, Gruzieva O, Ballereau S, Becker A, Bellander T, Bergström A, Bossé Y, Bottai M, Chan-Yeung M, Fuertes E, Ierodiakonou D, Jiang R, Joly S, Jones M, Kobor MS, Korek M, Kozyrskyj AL, Kumar A, Lemonnier N, MacIntyre E, Ménard C, Nickle D, Obeidat M, Pellet J, Standl M, Sääf A, Söderhäll C, Tiesler CMT, van den Berge M, Vonk JM, Vora H, Xu CJ, Antó JM, Auffray C, Brauer M, Bousquet J, Brunekreef B, Gauderman WJ, Heinrich J, Kere J, Koppelman GH, Postma D, Carlsten C, Pershagen G, Melén E.

Am J Respir Crit Care Med. 2017 May 15;195(10):1373-1383. doi: 10.1164/rccm.201605-1026OC.

26.

Gut microbial metabolism defines host metabolism: an emerging perspective in obesity and allergic inflammation.

Kumari M, Kozyrskyj AL.

Obes Rev. 2017 Jan;18(1):18-31. doi: 10.1111/obr.12484. Epub 2016 Nov 11. Review.

PMID:
27862824
27.

Associations between postpartum depressive symptoms and childhood asthma diminish with child age.

Kozyrskyj AL, Letourneau NL, Kang LJ, Salmani M.

Clin Exp Allergy. 2017 Mar;47(3):324-330. doi: 10.1111/cea.12837. Epub 2016 Nov 28.

PMID:
27770463
28.

High fecal IgA is associated with reduced Clostridium difficile colonization in infants.

Bridgman SL, Konya T, Azad MB, Guttman DS, Sears MR, Becker AB, Turvey SE, Mandhane PJ, Subbarao P; CHILD Study Investigators, Scott JA, Field CJ, Kozyrskyj AL.

Microbes Infect. 2016 Sep;18(9):543-9. doi: 10.1016/j.micinf.2016.05.001. Epub 2016 May 24.

PMID:
27235197
29.

Perinatal programming of gut microbiota and immunity.

Kozyrskyj AL, Sloboda DM.

J Dev Orig Health Dis. 2016 Feb;7(1):2-4. No abstract available.

PMID:
27073823
30.

Wheezing Patterns in Early Childhood and the Risk of Respiratory and Allergic Disease in Adolescence.

Azad MB, Chan-Yeung M, Chan ES, Dytnerski AM, Kozyrskyj AL, Ramsey C, Becker AB.

JAMA Pediatr. 2016 Apr;170(4):393-5. doi: 10.1001/jamapediatrics.2015.4127. No abstract available.

PMID:
26857593
31.

Probiotics for treatment and primary prevention of allergic diseases and asthma: looking back and moving forward.

West CE, Jenmalm MC, Kozyrskyj AL, Prescott SL.

Expert Rev Clin Immunol. 2016 Jun;12(6):625-39. doi: 10.1586/1744666X.2016.1147955. Epub 2016 Mar 4. Review.

32.

Gut microbiota and allergic disease in children.

Bridgman SL, Kozyrskyj AL, Scott JA, Becker AB, Azad MB.

Ann Allergy Asthma Immunol. 2016 Feb;116(2):99-105. doi: 10.1016/j.anai.2015.10.001. Review. No abstract available.

PMID:
26815703
33.

Infant gut immunity: a preliminary study of IgA associations with breastfeeding.

Bridgman SL, Konya T, Azad MB, Sears MR, Becker AB, Turvey SE, Mandhane PJ, Subbarao P; CHILD Study Investigators, Scott JA, Field CJ, Kozyrskyj AL.

J Dev Orig Health Dis. 2016 Feb;7(1):68-72. doi: 10.1017/S2040174415007862.

PMID:
26690933
34.

Microbial programming of health and disease starts during fetal life.

Koleva PT, Kim JS, Scott JA, Kozyrskyj AL.

Birth Defects Res C Embryo Today. 2015 Dec;105(4):265-77. doi: 10.1002/bdrc.21117. Epub 2015 Dec 10. Review.

PMID:
26663884
35.

Can we predict future allergies from our infant gut microbiota?

Kozyrskyj AL.

Expert Rev Respir Med. 2015;9(6):667-70. doi: 10.1586/17476348.2015.1098538. Epub 2015 Oct 21. No abstract available.

PMID:
26488391
36.

Postpartum depression, a direct and mediating risk factor for preschool wheeze in girls.

Alton ME, Zeng Y, Tough SC, Mandhane PJ, Kozyrskyj AL.

Pediatr Pulmonol. 2016 Apr;51(4):349-57. doi: 10.1002/ppul.23308. Epub 2015 Oct 8.

PMID:
26448278
37.

Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: a prospective cohort study.

Azad MB, Konya T, Persaud RR, Guttman DS, Chari RS, Field CJ, Sears MR, Mandhane PJ, Turvey SE, Subbarao P, Becker AB, Scott JA, Kozyrskyj AL; CHILD Study Investigators.

BJOG. 2016 May;123(6):983-93. doi: 10.1111/1471-0528.13601. Epub 2015 Sep 28.

38.

Fetal programming of overweight through the microbiome: boys are disproportionately affected.

Kozyrskyj AL, Kalu R, Koleva PT, Bridgman SL.

J Dev Orig Health Dis. 2016 Feb;7(1):25-34. doi: 10.1017/S2040174415001269. Epub 2015 Jun 29. Review.

PMID:
26118444
39.

The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma.

Subbarao P, Anand SS, Becker AB, Befus AD, Brauer M, Brook JR, Denburg JA, HayGlass KT, Kobor MS, Kollmann TR, Kozyrskyj AL, Lou WY, Mandhane PJ, Miller GE, Moraes TJ, Pare PD, Scott JA, Takaro TK, Turvey SE, Duncan JM, Lefebvre DL, Sears MR; CHILD Study investigators.

Thorax. 2015 Oct;70(10):998-1000. doi: 10.1136/thoraxjnl-2015-207246. Epub 2015 Jun 11.

PMID:
26069286
40.

The infant gut microbiome: evidence for obesity risk and dietary intervention.

Koleva PT, Bridgman SL, Kozyrskyj AL.

Nutrients. 2015 Mar 31;7(4):2237-60. doi: 10.3390/nu7042237. Review.

41.

Infant gut microbiota and food sensitization: associations in the first year of life.

Azad MB, Konya T, Guttman DS, Field CJ, Sears MR, HayGlass KT, Mandhane PJ, Turvey SE, Subbarao P, Becker AB, Scott JA, Kozyrskyj AL; CHILD Study Investigators.

Clin Exp Allergy. 2015 Mar;45(3):632-43. doi: 10.1111/cea.12487.

PMID:
25599982
42.

The gut microbiota and inflammatory noncommunicable diseases: associations and potentials for gut microbiota therapies.

West CE, Renz H, Jenmalm MC, Kozyrskyj AL, Allen KJ, Vuillermin P, Prescott SL; in-FLAME Microbiome Interest Group.

J Allergy Clin Immunol. 2015 Jan;135(1):3-13; quiz 14. doi: 10.1016/j.jaci.2014.11.012. Review.

43.

Atypical antipsychotic drug use and falls among nursing home residents in Winnipeg, Canada.

Bozat-Emre S, Doupe M, Kozyrskyj AL, Grymonpre R, Mahmud SM.

Int J Geriatr Psychiatry. 2015 Aug;30(8):842-50. doi: 10.1002/gps.4223. Epub 2014 Nov 3.

PMID:
25363460
44.

Maternal perspectives on the use of probiotics in infants: a cross-sectional survey.

Bridgman SL, Azad MB, Field CJ, Letourneau N, Johnston DW, Kaplan BJ, Kozyrskyj AL.

BMC Complement Altern Med. 2014 Sep 29;14:366. doi: 10.1186/1472-6882-14-366.

45.

Associations between the 17q21 region and allergic rhinitis in 5 birth cohorts.

Fuertes E, Söderhäll C, Acevedo N, Becker A, Brauer M, Chan-Yeung M, Dijk FN, Heinrich J, de Jongste J, Koppelman GH, Postma DS, Kere J, Kozyrskyj AL, Pershagen G, Sandford A, Standl M, Tiesler CM, Waldenberger M, Westman M, Carlsten C, Melén E.

J Allergy Clin Immunol. 2015 Feb;135(2):573-6. doi: 10.1016/j.jaci.2014.08.016. Epub 2014 Sep 26. No abstract available.

46.

Insulin resistance, puberty, and nonatopic asthma in adolescent girls.

Kozyrskyj AL, Zeng Y, Saurek-Aleksandrovska N, Sellers EA, Ramsey CD, Becker AB.

Am J Respir Crit Care Med. 2014 Aug 15;190(4):474-7. doi: 10.1164/rccm.201403-0426LE. No abstract available.

PMID:
25127308
47.

Perinatal antibiotic exposure of neonates in Canada and associated risk factors: a population-based study.

Persaud RR, Azad MB, Chari RS, Sears MR, Becker AB, Kozyrskyj AL; CHILD Study Investigators.

J Matern Fetal Neonatal Med. 2015 Jul;28(10):1190-5. doi: 10.3109/14767058.2014.947578. Epub 2014 Aug 14.

PMID:
25053193
48.

Impact of the 2008 economic and financial crisis on child health: a systematic review.

Rajmil L, Fernandez de Sanmamed MJ, Choonara I, Faresjö T, Hjern A, Kozyrskyj AL, Lucas PJ, Raat H, Séguin L, Spencer N, Taylor-Robinson D; International Network for Research in Inequalities in Child Health (INRICH).

Int J Environ Res Public Health. 2014 Jun;11(6):6528-46. Review.

49.

Infant antibiotic exposure and the development of childhood overweight and central adiposity.

Azad MB, Bridgman SL, Becker AB, Kozyrskyj AL.

Int J Obes (Lond). 2014 Oct;38(10):1290-8. doi: 10.1038/ijo.2014.119. Epub 2014 Jul 11.

PMID:
25012772
50.

Exposure to Beta-(1,3)-D-glucan in house dust at age 7-10 is associated with airway hyperresponsiveness and atopic asthma by age 11-14.

Maheswaran D, Zeng Y, Chan-Yeung M, Scott J, Osornio-Vargas A, Becker AB, Kozyrskyj AL.

PLoS One. 2014 Jun 6;9(6):e98878. doi: 10.1371/journal.pone.0098878. eCollection 2014.

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