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Items: 47


Cardiac Radiation Dose, Cardiac Disease, and Mortality in Patients With Lung Cancer.

Atkins KM, Rawal B, Chaunzwa TL, Lamba N, Bitterman DS, Williams CL, Kozono DE, Baldini EH, Chen AB, Nguyen PL, D'Amico AV, Nohria A, Hoffmann U, Aerts HJWL, Mak RH.

J Am Coll Cardiol. 2019 Jun 18;73(23):2976-2987. doi: 10.1016/j.jacc.2019.03.500.


Lipopolysaccharide-Binding Protein Is an Early Biomarker of Cardiac Function After Radiation Therapy for Breast Cancer.

Chalubinska-Fendler J, Graczyk L, Piotrowski G, Wyka K, Nowicka Z, Tomasik B, Fijuth J, Kozono D, Fendler W.

Int J Radiat Oncol Biol Phys. 2019 Aug 1;104(5):1074-1083. doi: 10.1016/j.ijrobp.2019.04.002. Epub 2019 Apr 13.


USP1 Is Required for Replication Fork Protection in BRCA1-Deficient Tumors.

Lim KS, Li H, Roberts EA, Gaudiano EF, Clairmont C, Sambel LA, Ponnienselvan K, Liu JC, Yang C, Kozono D, Parmar K, Yusufzai T, Zheng N, D'Andrea AD.

Mol Cell. 2018 Dec 20;72(6):925-941.e4. doi: 10.1016/j.molcel.2018.10.045.


Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade.

Ishizuka JJ, Manguso RT, Cheruiyot CK, Bi K, Panda A, Iracheta-Vellve A, Miller BC, Du PP, Yates KB, Dubrot J, Buchumenski I, Comstock DE, Brown FD, Ayer A, Kohnle IC, Pope HW, Zimmer MD, Sen DR, Lane-Reticker SK, Robitschek EJ, Griffin GK, Collins NB, Long AH, Doench JG, Kozono D, Levanon EY, Haining WN.

Nature. 2019 Jan;565(7737):43-48. doi: 10.1038/s41586-018-0768-9. Epub 2018 Dec 17.


Dual HDAC and PI3K Inhibition Abrogates NFκB- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas.

Pal S, Kozono D, Yang X, Fendler W, Fitts W, Ni J, Alberta JA, Zhao J, Liu KX, Bian J, Truffaux N, Weiss WA, Resnick AC, Bandopadhayay P, Ligon KL, DuBois SG, Mueller S, Chowdhury D, Haas-Kogan DA.

Cancer Res. 2018 Jul 15;78(14):4007-4021. doi: 10.1158/0008-5472.CAN-17-3691. Epub 2018 May 14.


NF-κB inhibition by dimethylaminoparthenolide radiosensitizes non-small-cell lung carcinoma by blocking DNA double-strand break repair.

Deraska PV, O'Leary C, Reavis HD, Labe S, Dinh TK, Lazaro JB, Sweeney C, D'Andrea AD, Kozono D.

Cell Death Discov. 2018 Feb 7;4:10. doi: 10.1038/s41420-017-0008-3. eCollection 2018 Dec.


Radiation toxicity in patients with collagen vascular disease and intrathoracic malignancy treated with modern radiation techniques.

Diao K, Chen YH, Catalano PJ, Lee S, Milani N, Killoran JH, Baldini EH, Chen AB, Kozono DE, Mak RH.

Radiother Oncol. 2017 Nov;125(2):301-309. doi: 10.1016/j.radonc.2017.10.002. Epub 2017 Nov 5.


Use of frailty to predict survival in elderly patients with early stage non-small-cell lung cancer treated with stereotactic body radiation therapy.

Franco I, Chen YH, Chipidza F, Agrawal V, Romano J, Baldini E, Chen A, Colson Y, Hou Y, Kozono D, Wee J, Mak R.

J Geriatr Oncol. 2018 Mar;9(2):130-137. doi: 10.1016/j.jgo.2017.09.002. Epub 2017 Sep 21.


Lymph node volume predicts survival but not nodal clearance in Stage IIIA-IIIB NSCLC.

Agrawal V, Coroller TP, Hou Y, Lee SW, Romano JL, Baldini EH, Chen AB, Kozono D, Swanson SJ, Wee JO, Aerts HJWL, Mak RH.

PLoS One. 2017 Apr 20;12(4):e0174268. doi: 10.1371/journal.pone.0174268. eCollection 2017.


Systemic Immune Response to Vaccination on FDG-PET/CT.

Mingos M, Howard S, Giacalone N, Kozono D, Jacene H.

Nucl Med Mol Imaging. 2016 Dec;50(4):358-361. Epub 2015 Dec 9.


Radiologic-pathologic correlation of response to chemoradiation in resectable locally advanced NSCLC.

Agrawal V, Coroller TP, Hou Y, Lee SW, Romano JL, Baldini EH, Chen AB, Jackman DM, Kozono D, Swanson SJ, Wee JO, Aerts HJ, Mak RH.

Lung Cancer. 2016 Dec;102:1-8. doi: 10.1016/j.lungcan.2016.10.002. Epub 2016 Oct 14.


Clinical Outcomes After Lung Stereotactic Body Radiation Therapy in Patients With or Without a Prior Lung Resection.

Hou Y, Hermann G, Lewis JH, Aerts HJ, Baldini EH, Chen AB, Colson YL, Hacker FL, Killoran JH, Kozono DE, Wagar M, Wee JO, Mak RH.

Am J Clin Oncol. 2018 Jul;41(7):695-701. doi: 10.1097/COC.0000000000000344.


Inter-scan and inter-observer tumour volume delineation variability on cone beam computed tomography in patients treated with stereotactic body radiation therapy for early-stage non-small cell lung cancer.

Hou Y, Lee S, Agrawal V, Romano J, Baldini EH, Chen AB, Kozono DE, Killoran JH, Wagar M, Hacker FL, Aerts HJ, Lewis JH, Mak RH.

J Med Imaging Radiat Oncol. 2017 Feb;61(1):93-98. doi: 10.1111/1754-9485.12537. Epub 2016 Oct 5.


FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair.

Kais Z, Rondinelli B, Holmes A, O'Leary C, Kozono D, D'Andrea AD, Ceccaldi R.

Cell Rep. 2016 Jun 14;15(11):2488-99. doi: 10.1016/j.celrep.2016.05.031. Epub 2016 Jun 2.


Advanced nodal stage predicts venous thromboembolism in patients with locally advanced non-small cell lung cancer.

Li R, Hermann G, Baldini E, Chen A, Jackman D, Kozono D, Nguyen P, Nohria A, Powell G, Mak R.

Lung Cancer. 2016 Jun;96:41-7. doi: 10.1016/j.lungcan.2016.03.004. Epub 2016 Mar 16.


Circulating miR-29a and miR-150 correlate with delivered dose during thoracic radiation therapy for non-small cell lung cancer.

Dinh TK, Fendler W, Chałubińska-Fendler J, Acharya SS, O'Leary C, Deraska PV, D'Andrea AD, Chowdhury D, Kozono D.

Radiat Oncol. 2016 Apr 27;11:61. doi: 10.1186/s13014-016-0636-4.


TGF-β Inhibition Rescues Hematopoietic Stem Cell Defects and Bone Marrow Failure in Fanconi Anemia.

Zhang H, Kozono DE, O'Connor KW, Vidal-Cardenas S, Rousseau A, Hamilton A, Moreau L, Gaudiano EF, Greenberger J, Bagby G, Soulier J, Grompe M, Parmar K, D'Andrea AD.

Cell Stem Cell. 2016 May 5;18(5):668-81. doi: 10.1016/j.stem.2016.03.002. Epub 2016 Mar 24.


Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression.

Kozono D, Li J, Nitta M, Sampetrean O, Gonda D, Kushwaha DS, Merzon D, Ramakrishnan V, Zhu S, Zhu K, Matsui H, Harismendy O, Hua W, Mao Y, Kwon CH, Saya H, Nakano I, Pizzo DP, VandenBerg SR, Chen CC.

Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4055-64. doi: 10.1073/pnas.1501967112. Epub 2015 Jul 9.


Updated patterns of failure after multimodality therapy for malignant pleural mesothelioma.

Baldini EH, Richards WG, Gill RR, Goodman BM, Winfrey OK, Eisen HM, Mak RH, Chen AB, Kozono DE, Bueno R, Sugarbaker DJ.

J Thorac Cardiovasc Surg. 2015 May;149(5):1374-81. doi: 10.1016/j.jtcvs.2014.10.128. Epub 2015 Feb 7.


USP9X inhibition promotes radiation-induced apoptosis in non-small cell lung cancer cells expressing mid-to-high MCL1.

Kushwaha D, O'Leary C, Cron KR, Deraska P, Zhu K, D'Andrea AD, Kozono D.

Cancer Biol Ther. 2015;16(3):392-401. doi: 10.1080/15384047.2014.1002358.


Image-guided radiotherapy platform using single nodule conditional lung cancer mouse models.

Herter-Sprie GS, Korideck H, Christensen CL, Herter JM, Rhee K, Berbeco RI, Bennett DG, Akbay EA, Kozono D, Mak RH, Mike Makrigiorgos G, Kimmelman AC, Wong KK.

Nat Commun. 2014 Dec 18;5:5870. doi: 10.1038/ncomms6870.


Outcomes by tumor histology and KRAS mutation status after lung stereotactic body radiation therapy for early-stage non-small-cell lung cancer.

Mak RH, Hermann G, Lewis JH, Aerts HJ, Baldini EH, Chen AB, Colson YL, Hacker FH, Kozono D, Wee JO, Chen YH, Catalano PJ, Wong KK, Sher DJ.

Clin Lung Cancer. 2015 Jan;16(1):24-32. doi: 10.1016/j.cllc.2014.09.005. Epub 2014 Sep 30.


Aggressive therapy for patients with non-small cell lung carcinoma and synchronous brain-only oligometastatic disease is associated with long-term survival.

Gray PJ, Mak RH, Yeap BY, Cryer SK, Pinnell NE, Christianson LW, Sher DJ, Arvold ND, Baldini EH, Chen AB, Kozono DE, Swanson SJ, Jackman DM, Alexander BM.

Lung Cancer. 2014 Aug;85(2):239-44. doi: 10.1016/j.lungcan.2014.06.001. Epub 2014 Jun 6.


Definitive primary therapy in patients presenting with oligometastatic non-small cell lung cancer.

Parikh RB, Cronin AM, Kozono DE, Oxnard GR, Mak RH, Jackman DM, Lo PC, Baldini EH, Johnson BE, Chen AB.

Int J Radiat Oncol Biol Phys. 2014 Jul 15;89(4):880-7. doi: 10.1016/j.ijrobp.2014.04.007. Epub 2014 May 24.


Low incidence of chest wall pain with a risk-adapted lung stereotactic body radiation therapy approach using three or five fractions based on chest wall dosimetry.

Coroller TP, Mak RH, Lewis JH, Baldini EH, Chen AB, Colson YL, Hacker FL, Hermann G, Kozono D, Mannarino E, Molodowitch C, Wee JO, Sher DJ, Killoran JH.

PLoS One. 2014 Apr 11;9(4):e94859. doi: 10.1371/journal.pone.0094859. eCollection 2014.


Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma.

Li J, Zhu S, Kozono D, Ng K, Futalan D, Shen Y, Akers JC, Steed T, Kushwaha D, Schlabach M, Carter BS, Kwon CH, Furnari F, Cavenee W, Elledge S, Chen CC.

Oncotarget. 2014 Feb 28;5(4):882-93.


Comparison of once and twice daily radiotherapy for limited stage small-cell lung cancer.

Gazula A, Baldini EH, Chen A, Kozono D.

Lung. 2014 Feb;192(1):151-8. doi: 10.1007/s00408-013-9518-9. Epub 2013 Oct 27.


Proteasome inhibitors block DNA repair and radiosensitize non-small cell lung cancer.

Cron KR, Zhu K, Kushwaha DS, Hsieh G, Merzon D, Rameseder J, Chen CC, D'Andrea AD, Kozono D.

PLoS One. 2013 Sep 5;8(9):e73710. doi: 10.1371/journal.pone.0073710. eCollection 2013.


Cutaneous radiation-associated angiosarcoma of the breast: poor prognosis in a rare secondary malignancy.

Morgan EA, Kozono DE, Wang Q, Mery CM, Butrynski JE, Baldini EH, George S, Nascimento AF, Raut CP.

Ann Surg Oncol. 2012 Nov;19(12):3801-8. doi: 10.1245/s10434-012-2563-4. Epub 2012 Aug 14.


TU-E-BRB-02: A Decision Support Tool for SBRT Planning Using a Searchable DVH Database.

Lewis J, Mak R, Molodowitch C, Mannarino E, Baldini E, Chen A, Kozono D, Sher D, Hacker F, Killoran J.

Med Phys. 2012 Jun;39(6Part24):3908. doi: 10.1118/1.4735951.


A DNA repair pathway-focused score for prediction of outcomes in ovarian cancer treated with platinum-based chemotherapy.

Kang J, D'Andrea AD, Kozono D.

J Natl Cancer Inst. 2012 May 2;104(9):670-81. doi: 10.1093/jnci/djs177. Epub 2012 Apr 13.


Necroptosis is a novel mechanism of radiation-induced cell death in anaplastic thyroid and adrenocortical cancers.

Nehs MA, Lin CI, Kozono DE, Whang EE, Cho NL, Zhu K, Moalem J, Moore FD Jr, Ruan DT.

Surgery. 2011 Dec;150(6):1032-9. doi: 10.1016/j.surg.2011.09.012.


Src homology domain-containing phosphatase 2 suppresses cellular senescence in glioblastoma.

Sturla LM, Zinn PO, Ng K, Nitta M, Kozono D, Chen CC, Kasper EM.

Br J Cancer. 2011 Oct 11;105(8):1235-43. doi: 10.1038/bjc.2011.345. Epub 2011 Sep 20.


Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy.

Nitta M, Kozono D, Kennedy R, Stommel J, Ng K, Zinn PO, Kushwaha D, Kesari S, Inda MM, Wykosky J, Furnari F, Hoadley KA, Chin L, DePinho RA, Cavenee WK, D'Andrea A, Chen CC.

PLoS One. 2010 May 24;5(5):e10767. doi: 10.1371/journal.pone.0010767. Erratum in: PLoS One. 2011;6(4). doi:10.1371/annotation/9b9cc4ae-ad56-464f-ab97-59f096b5c0eb. Inda, Maria-del-Mar [added]; Wykosky, Jill [added].


Functional genomics to explore cancer cell vulnerabilities.

Kahle KT, Kozono D, Ng K, Hsieh G, Zinn PO, Nitta M, Chen CC.

Neurosurg Focus. 2010 Jan;28(1):E5. doi: 10.3171/2009.10.FOCUS09212.


Structural basis for conductance by the archaeal aquaporin AqpM at 1.68 A.

Lee JK, Kozono D, Remis J, Kitagawa Y, Agre P, Stroud RM.

Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18932-7. Epub 2005 Dec 16.


Co-axial association of recombinant eye lens aquaporin-0 observed in loosely packed 3D crystals.

Palanivelu DV, Kozono DE, Engel A, Suda K, Lustig A, Agre P, Schirmer T.

J Mol Biol. 2006 Jan 27;355(4):605-11. Epub 2005 Nov 8.


Conversion of aquaporin 6 from an anion channel to a water-selective channel by a single amino acid substitution.

Liu K, Kozono D, Kato Y, Agre P, Hazama A, Yasui M.

Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2192-7. Epub 2005 Jan 25.


From structure to disease: the evolving tale of aquaporin biology.

King LS, Kozono D, Agre P.

Nat Rev Mol Cell Biol. 2004 Sep;5(9):687-98. Review.


Aquaporin water channels: molecular mechanisms for human diseases.

Agre P, Kozono D.

FEBS Lett. 2003 Nov 27;555(1):72-8. Review.


Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver.

Carbrey JM, Gorelick-Feldman DA, Kozono D, Praetorius J, Nielsen S, Agre P.

Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2945-50. Epub 2003 Feb 19.


Functional expression and characterization of an archaeal aquaporin. AqpM from methanothermobacter marburgensis.

Kozono D, Ding X, Iwasaki I, Meng X, Kamagata Y, Agre P, Kitagawa Y.

J Biol Chem. 2003 Mar 21;278(12):10649-56. Epub 2003 Jan 7.


Characterization of aquaporin-6 as a nitrate channel in mammalian cells. Requirement of pore-lining residue threonine 63.

Ikeda M, Beitz E, Kozono D, Guggino WB, Agre P, Yasui M.

J Biol Chem. 2002 Oct 18;277(42):39873-9. Epub 2002 Aug 9.


Aquaporin water channels: atomic structure molecular dynamics meet clinical medicine.

Kozono D, Yasui M, King LS, Agre P.

J Clin Invest. 2002 Jun;109(11):1395-9. Review. No abstract available.


Ion permeation of AQP6 water channel protein. Single channel recordings after Hg2+ activation.

Hazama A, Kozono D, Guggino WB, Agre P, Yasui M.

J Biol Chem. 2002 Aug 9;277(32):29224-30. Epub 2002 May 28.


Water and ion permeation of aquaporin-1 in planar lipid bilayers. Major differences in structural determinants and stoichiometry.

Saparov SM, Kozono D, Rothe U, Agre P, Pohl P.

J Biol Chem. 2001 Aug 24;276(34):31515-20. Epub 2001 Jun 15.


Functional reconstitution and characterization of AqpZ, the E. coli water channel protein.

Borgnia MJ, Kozono D, Calamita G, Maloney PC, Agre P.

J Mol Biol. 1999 Sep 3;291(5):1169-79.


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