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Items: 1 to 50 of 227

1.

Uncapping the N-terminus of a ubiquitous His-tag peptide enhances its Cu2+ binding affinity.

Wątły J, Hecel A, Wieczorek R, Swiątek-Kozłowska J, Kozłowski H, Rowińska-Żyrek M.

Dalton Trans. 2019 Jul 16. doi: 10.1039/c9dt01635j. [Epub ahead of print]

PMID:
31309219
2.

Coexpression of ABCB1 and ABCG2 in a Cell Line Model Reveals Both Independent and Additive Transporter Function.

Robinson AN, Tebase BG, Francone SC, Huff LM, Kozlowski H, Cossari D, Lee JM, Esposito D, Robey RW, Gottesman MM.

Drug Metab Dispos. 2019 Jul;47(7):715-723. doi: 10.1124/dmd.118.086181. Epub 2019 May 2.

3.

Copper(II)-Induced Restructuring of ZnuD, a Zinc(II) Transporter from Neisseria meningitidis.

Hecel A, Rowińska-Żyrek M, Kozłowski H.

Inorg Chem. 2019 May 6;58(9):5932-5942. doi: 10.1021/acs.inorgchem.9b00265. Epub 2019 Apr 15.

PMID:
30986048
4.

Structural analysis of copper(I) interaction with amyloid β peptide.

De Gregorio G, Biasotto F, Hecel A, Luczkowski M, Kozlowski H, Valensin D.

J Inorg Biochem. 2019 Jun;195:31-38. doi: 10.1016/j.jinorgbio.2019.03.006. Epub 2019 Mar 7.

PMID:
30884319
5.

Targeting mitochondrial hexokinases increases efficacy of histone deacetylase inhibitors in solid tumor models.

McDonald AJ, Curt KM, Patel RP, Kozlowski H, Sackett DL, Robey RW, Gottesman MM, Bates SE.

Exp Cell Res. 2019 Feb 15;375(2):106-112. doi: 10.1016/j.yexcr.2018.12.012. Epub 2018 Dec 21.

PMID:
30579954
6.

How copper ions and membrane environment influence the structure of the human and chicken tandem repeats domain?

Hecel A, Valensin D, Kozłowski H.

J Inorg Biochem. 2019 Feb;191:143-153. doi: 10.1016/j.jinorgbio.2018.11.012. Epub 2018 Nov 23.

PMID:
30529722
7.

Pneumococcal histidine triads - involved not only in Zn2+, but also Ni2+ binding?

Miller A, Dudek D, Potocki S, Czapor-Irzabek H, Kozłowski H, Rowińska-Żyrek M.

Metallomics. 2018 Nov 14;10(11):1631-1637. doi: 10.1039/c8mt00275d.

PMID:
30334560
8.

Glycogen synthase kinase-3 (GSK-3) activity regulates mRNA methylation in mouse embryonic stem cells.

Faulds KJ, Egelston JN, Sedivy LJ, Mitchell MK, Garimella S, Kozlowski H, D'Alessandro A, Hansen KC, Balsbaugh JL, Phiel CJ.

J Biol Chem. 2018 Jul 6;293(27):10731-10743. doi: 10.1074/jbc.RA117.001298. Epub 2018 May 18.

9.

Histidine tracts in human transcription factors: insight into metal ion coordination ability.

Hecel A, Wątły J, Rowińska-Żyrek M, Świątek-Kozłowska J, Kozłowski H.

J Biol Inorg Chem. 2018 Jan;23(1):81-90. doi: 10.1007/s00775-017-1512-x. Epub 2017 Dec 7.

10.

Ag+ Complexes as Potential Therapeutic Agents in Medicine and Pharmacy.

Hecel A, Kolkowska P, Krzywoszynska K, Szebesczyk A, Rowinska-Zyrek M, Kozlowski H.

Curr Med Chem. 2019;26(4):624-647. doi: 10.2174/0929867324666170920125943.

PMID:
28933286
11.

The effect of a membrane-mimicking environment on the interactions of Cu2+ with an amyloidogenic fragment of chicken prion protein.

Hecel A, Draghi S, Valensin D, Kozlowski H.

Dalton Trans. 2017 Jun 20;46(24):7758-7769. doi: 10.1039/c7dt01069a.

PMID:
28589973
12.

Poly-Xaa Sequences in Proteins - Biological Role and Interactions with Metal Ions: Chemical and Medical Aspects.

Watly J, Hecel A, Kolkowska P, Kozlowski H, Rowinska-Zyrek M.

Curr Med Chem. 2018;25(1):22-48. doi: 10.2174/0929867324666170428104928. Review.

PMID:
28462711
13.

Preface.

Kozłowski H, Gumienna-Kontecka E, Rowińska-Żyrek M.

J Inorg Biochem. 2016 Oct;163:229. doi: 10.1016/j.jinorgbio.2016.09.018. No abstract available.

PMID:
27810061
14.

Coordination and redox properties of copper interaction with α-synuclein.

Valensin D, Dell'Acqua S, Kozlowski H, Casella L.

J Inorg Biochem. 2016 Oct;163:292-300. doi: 10.1016/j.jinorgbio.2016.04.012. Epub 2016 Apr 11. Review.

PMID:
27112900
15.

AGHLDDLPGALSAL: A hemoglobin fragment potentially competing with albumin to bind transition metal ions.

Zamariola G, Watly J, Gallerani E, Gavioli R, Guerrini R, Kozlowski H, Remelli M.

J Inorg Biochem. 2016 Oct;163:301-310. doi: 10.1016/j.jinorgbio.2016.04.001. Epub 2016 Apr 8.

PMID:
27087285
16.

DOES hemopressin bind metal ions in vivo?

Remelli M, Ceciliato C, Guerrini R, Kolkowska P, Krzywoszynska K, Salvadori S, Valensin D, Watly J, Kozlowski H.

Dalton Trans. 2016 Nov 15;45(45):18267-18280.

PMID:
27801457
17.

The Eighth Central European Conference "Chemistry towards Biology": Snapshot.

Perczel A, Atanasov AG, Sklenář V, Nováček J, Papoušková V, Kadeřávek P, Žídek L, Kozłowski H, Wątły J, Hecel A, Kołkowska P, Koča J, Svobodová-Vařeková R, Pravda L, Sehnal D, Horský V, Geidl S, Enriz RD, Matějka P, Jeništová A, Dendisová M, Kokaislová A, Weissig V, Olsen M, Coffey A, Ajuebor J, Keary R, Sanz-Gaitero M, van Raaij MJ, McAuliffe O, Waltenberger B, Mocan A, Šmejkal K, Heiss EH, Diederich M, Musioł R, Košmrlj J, Polański J, Jampílek J.

Molecules. 2016 Oct 17;21(10). pii: E1381.

18.

Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras.

Bahr JC, Robey RW, Luchenko V, Basseville A, Chakraborty AR, Kozlowski H, Pauly GT, Patel P, Schneider JP, Gottesman MM, Bates SE.

Oncotarget. 2016 Oct 25;7(43):69804-69815. doi: 10.18632/oncotarget.12001.

19.

Extracellular histones identified in crocodile blood inhibit in-vitro HIV-1 infection.

Kozlowski HN, Lai ET, Havugimana PC, White C, Emili A, Sakac D, Binnington B, Neschadim A, McCarthy SD, Branch DR.

AIDS. 2016 Aug 24;30(13):2043-52. doi: 10.1097/QAD.0000000000001159.

PMID:
27191975
20.

The unusual metal ion binding ability of histidyl tags and their mutated derivatives.

Brasili D, Watly J, Simonovsky E, Guerrini R, Barbosa NA, Wieczorek R, Remelli M, Kozlowski H, Miller Y.

Dalton Trans. 2016 Apr 7;45(13):5629-39. doi: 10.1039/c5dt04747a. Epub 2016 Feb 29.

PMID:
26923149
21.

A Rapid Screening Assay Identifies Monotherapy with Interferon-ß and Combination Therapies with Nucleoside Analogs as Effective Inhibitors of Ebola Virus.

McCarthy SD, Majchrzak-Kita B, Racine T, Kozlowski HN, Baker DP, Hoenen T, Kobinger GP, Fish EN, Branch DR.

PLoS Negl Trop Dis. 2016 Jan 11;10(1):e0004364. doi: 10.1371/journal.pntd.0004364. eCollection 2016 Jan.

22.

Specific binding modes of Cu(I) and Ag(I) with neurotoxic domain of the human prion protein.

Valensin D, Padula EM, Hecel A, Luczkowski M, Kozlowski H.

J Inorg Biochem. 2016 Feb;155:26-35. doi: 10.1016/j.jinorgbio.2015.11.015. Epub 2015 Nov 11.

PMID:
26606290
23.

Biomimetic ferrichrome: structural motifs for switching between narrow- and broad-spectrum activities in P. putida and E. coli.

Olshvang E, Szebesczyk A, Kozłowski H, Hadar Y, Gumienna-Kontecka E, Shanzer A.

Dalton Trans. 2015 Dec 28;44(48):20850-8. doi: 10.1039/c5dt02685g. Epub 2015 Oct 13.

PMID:
26459799
24.

African Viper Poly-His Tag Peptide Fragment Efficiently Binds Metal Ions and Is Folded into an α-Helical Structure.

Watly J, Simonovsky E, Barbosa N, Spodzieja M, Wieczorek R, Rodziewicz-Motowidlo S, Miller Y, Kozlowski H.

Inorg Chem. 2015 Aug 17;54(16):7692-702. doi: 10.1021/acs.inorgchem.5b01029. Epub 2015 Jul 27.

PMID:
26214303
25.

Impact of SDS surfactant on the interactions of Cu(2+) ions with the amyloidogenic region of human prion protein.

Hecel A, Migliorini C, Valensin D, Luczkowski M, Kozlowski H.

Dalton Trans. 2015 Aug 7;44(29):13125-32. doi: 10.1039/c5dt01488c.

PMID:
26107283
26.

Specificity of the Zn(2+), Cd(2+) and Ni(2+) ion binding sites in the loop domain of the HypA protein.

Kolkowska P, Krzywoszynska K, Potocki S, Chetana PR, Spodzieja M, Rodziewicz-Motowidlo S, Kozlowski H.

Dalton Trans. 2015 Jun 7;44(21):9887-900. doi: 10.1039/c5dt01005e.

PMID:
25945782
27.

The unusual binding mechanism of Cu(II) ions to the poly-histidyl domain of a peptide found in the venom of an African viper.

Pontecchiani F, Simonovsky E, Wieczorek R, Barbosa N, Rowinska-Zyrek M, Potocki S, Remelli M, Miller Y, Kozlowski H.

Dalton Trans. 2014 Nov 28;43(44):16680-9. doi: 10.1039/c4dt02257b.

PMID:
25266233
28.

Specific binding of Zn2+, Cd2+ and Ni2+ ions by a cyclic four-cysteinyl peptide.

Krzywoszynska K, Kozlowski H.

Dalton Trans. 2014 Nov 21;43(43):16207-12. doi: 10.1039/c4dt01614a.

PMID:
25051461
29.

General aspects of metal toxicity.

Kozlowski H, Kolkowska P, Watly J, Krzywoszynska K, Potocki S.

Curr Med Chem. 2014;21(33):3721-40.

PMID:
25039781
30.

Insight into the coordination and the binding sites of Cu(2+) by the histidyl-6-tag using experimental and computational tools.

Watly J, Simonovsky E, Wieczorek R, Barbosa N, Miller Y, Kozlowski H.

Inorg Chem. 2014 Jul 7;53(13):6675-83. doi: 10.1021/ic500387u. Epub 2014 Jun 6.

PMID:
24905906
31.

The specificity of interaction of Zn(2+), Ni(2+) and Cu(2+) ions with the histidine-rich domain of the TjZNT1 ZIP family transporter.

Potocki S, Valensin D, Kozlowski H.

Dalton Trans. 2014 Jul 14;43(26):10215-23. doi: 10.1039/c4dt00903g. Epub 2014 May 30.

PMID:
24874820
32.

Ni²⁺ chemistry in pathogens--a possible target for eradication.

Rowinska-Zyrek M, Zakrzewska-Czerwinska J, Zawilak-Pawlik A, Kozlowski H.

Dalton Trans. 2014 Jun 28;43(24):8976-89. doi: 10.1039/c4dt00421c. Erratum in: Dalton Trans. 2014 Nov 28;43(44):16943.

PMID:
24781528
33.

Copper-induced structural propensities of the amyloidogenic region of human prion protein.

Migliorini C, Sinicropi A, Kozlowski H, Luczkowski M, Valensin D.

J Biol Inorg Chem. 2014 Jun;19(4-5):635-45. doi: 10.1007/s00775-014-1132-7. Epub 2014 Apr 16.

PMID:
24737041
34.

Ni(II) binding to the 429-460 peptide fragment from human Toll like receptor (hTLR4): a crucial role for nickel-induced contact allergy?

Zoroddu MA, Peana M, Medici S, Potocki S, Kozlowski H.

Dalton Trans. 2014 Feb 21;43(7):2764-71. doi: 10.1039/c3dt52187g.

PMID:
24169691
35.

The extracellular loop of IRT1 ZIP protein--the chosen one for zinc?

Potocki S, Valensin D, Camponeschi F, Kozlowski H.

J Inorg Biochem. 2013 Oct;127:246-52. doi: 10.1016/j.jinorgbio.2013.05.003. Epub 2013 May 6.

PMID:
23706761
36.

Unexpected impact of the number of glutamine residues on metal complex stability.

Chiera NM, Rowinska-Zyrek M, Wieczorek R, Guerrini R, Witkowska D, Remelli M, Kozlowski H.

Metallomics. 2013 Mar;5(3):214-21. doi: 10.1039/c3mt20166j.

PMID:
23370132
37.

The zinc-binding fragment of HypA from Helicobacter pylori: a tempting site also for nickel ions.

Rowinska-Zyrek M, Potocki S, Witkowska D, Valensin D, Kozlowski H.

Dalton Trans. 2013 May 7;42(17):6012-20. doi: 10.1039/c2dt32195e.

PMID:
23338727
38.

The unusual stabilization of the Ni2+ and Cu2+ complexes with NSFRY.

Janicka-Klos A, Porciatti E, Valensin D, Conato C, Remelli M, Oldziej S, Valensin G, Kozlowski H.

Dalton Trans. 2013 Jan 14;42(2):448-58. doi: 10.1039/c2dt31959d. Epub 2012 Oct 22.

PMID:
23085940
39.

NMR metabolomic investigation of astrocytes interacted with Aβ₄₂ or its complexes with either copper(II) or zinc(II).

Rocchi A, Valensin D, Aldinucci C, Giani G, Barbucci R, Gaggelli E, Kozlowski H, Valensin G.

J Inorg Biochem. 2012 Dec;117:326-33. doi: 10.1016/j.jinorgbio.2012.08.021. Epub 2012 Sep 8.

PMID:
23062696
40.

The coordination of NiII and Cu(II) ions to the polyhistidyl motif of Hpn protein: is it as strong as we think?

Witkowska D, Politano R, Rowinska-Zyrek M, Guerrini R, Remelli M, Kozlowski H.

Chemistry. 2012 Aug 27;18(35):11088-99. doi: 10.1002/chem.201200780. Epub 2012 Jul 24.

PMID:
22829429
41.

Thermodynamic and spectroscopic investigation on the role of Met residues in Cu(II) binding to the non-octarepeat site of the human prion protein.

Remelli M, Valensin D, Toso L, Gralka E, Guerrini R, Marzola E, Kozłowski H.

Metallomics. 2012 Aug;4(8):794-806. doi: 10.1039/c2mt20060k. Epub 2012 Jul 13.

PMID:
22791135
42.

Gonadoliberin (GnRH) and its copper complex (Cu-GnRH) enzymatic degradation in hypothalamic and pituitary tissue in vitro.

Herman A, Kozlowski H, Czauderna M, Kochman K, Kulon K, Gajewska A.

J Physiol Pharmacol. 2012 Feb;63(1):69-75.

43.

Metal transport and homeostasis within the human body: toxicity associated with transport abnormalities.

Potocki S, Rowinska-Zyrek M, Witkowska D, Pyrkosz M, Szebesczyk A, Krzywoszynska K, Kozlowski H.

Curr Med Chem. 2012;19(17):2738-59. Review.

PMID:
22455583
44.

Coordination of Ni2+ and Cu2+ to metal ion binding domains of E. coli SlyD protein.

Witkowska D, Valensin D, Rowinska-Zyrek M, Karafova A, Kamysz W, Kozlowski H.

J Inorg Biochem. 2012 Feb;107(1):73-81. doi: 10.1016/j.jinorgbio.2011.11.012. Epub 2011 Nov 29.

PMID:
22178668
45.

Polythiol binding to biologically relevant metal ions.

Krzywoszynska K, Rowinska-Zyrek M, Witkowska D, Potocki S, Luczkowski M, Kozlowski H.

Dalton Trans. 2011 Oct 28;40(40):10434-9. doi: 10.1039/c1dt10562k. Epub 2011 Jul 8.

PMID:
21743911
46.

Exploring the reactions of β-amyloid (Aβ) peptide 1-28 with Al(III) and Fe(III) ions.

Valensin D, Migliorini C, Valensin G, Gaggelli E, La Penna G, Kozlowski H, Gabbiani C, Messori L.

Inorg Chem. 2011 Aug 1;50(15):6865-7. doi: 10.1021/ic201069v. Epub 2011 Jun 30.

PMID:
21718030
47.

Metal binding ability of cysteine-rich peptide domain of ZIP13 Zn2+ ions transporter.

Potocki S, Rowinska-Zyrek M, Valensin D, Krzywoszynska K, Witkowska D, Luczkowski M, Kozlowski H.

Inorg Chem. 2011 Jul 4;50(13):6135-45. doi: 10.1021/ic200270p. Epub 2011 Jun 1.

PMID:
21630642
48.

The -Cys-Cys- motif in Helicobacter pylori's Hpn and HspA proteins is an essential anchoring site for metal ions.

Rowinska-Zyrek M, Witkowska D, Bielinska S, Kamysz W, Kozlowski H.

Dalton Trans. 2011 May 28;40(20):5604-10. doi: 10.1039/c1dt10187k. Epub 2011 Apr 18.

PMID:
21503353
49.

Stability and structure of mixed-ligand metal ion complexes that contain Ni2+, Cu2+, or Zn2+, and Histamine, as well as adenosine 5'-triphosphate (ATP4-) or uridine 5'-triphosphate (UTP(4-): an intricate network of equilibria.

Knobloch B, Mucha A, Operschall BP, Sigel H, Jeżowska-Bojczuk M, Kozłowski H, Sigel RK.

Chemistry. 2011 May 2;17(19):5393-403. doi: 10.1002/chem.201001931. Epub 2011 Apr 4.

PMID:
21465580
50.

The role of His-50 of α-synuclein in binding Cu(II): pH dependence, speciation, thermodynamics and structure.

Valensin D, Camponeschi F, Luczkowski M, Baratto MC, Remelli M, Valensin G, Kozlowski H.

Metallomics. 2011 Mar;3(3):292-302. doi: 10.1039/c0mt00068j. Epub 2011 Jan 6.

PMID:
21212878

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