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Items: 1 to 50 of 120


Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance.

Guerra C, Navarro P, Valverde AM, Arribas M, Brüning J, Kozak LP, Kahn CR, Benito M.

J Clin Invest. 2019 Jan 2;129(1):437. doi: 10.1172/JCI126191. Epub 2019 Jan 2. No abstract available.


Isolation and identification of endogenous RFamide-related peptides 1 and 3 in the mouse hypothalamus.

Gospodarska E, Kozak LP, Jaroslawska J.

J Neuroendocrinol. 2019 Jan;31(1):e12668. doi: 10.1111/jne.12668. Epub 2019 Jan 2.


Diet-induced adipose tissue expansion is mitigated in mice with a targeted inactivation of mesoderm specific transcript (Mest).

Anunciado-Koza RP, Manuel J, Mynatt RL, Zhang J, Kozak LP, Koza RA.

PLoS One. 2017 Jun 22;12(6):e0179879. doi: 10.1371/journal.pone.0179879. eCollection 2017.


C57BL/6J mice as a polygenic developmental model of diet-induced obesity.

Chu DT, Malinowska E, Jura M, Kozak LP.

Physiol Rep. 2017 Apr;5(7). pii: e13093. doi: 10.14814/phy2.13093.


Neotenic phenomenon in gene expression in the skin of Foxn1- deficient (nude) mice - a projection for regenerative skin wound healing.

Kur-Piotrowska A, Kopcewicz M, Kozak LP, Sachadyn P, Grabowska A, Gawronska-Kozak B.

BMC Genomics. 2017 Jan 9;18(1):56. doi: 10.1186/s12864-016-3401-z.


Brown fat thermogenesis: Stability of developmental programming and transient effects of temperature and gut microbiota in adults.

Ziętak M, Chabowska-Kita A, Kozak LP.

Biochimie. 2017 Mar;134:93-98. doi: 10.1016/j.biochi.2016.12.006. Epub 2016 Dec 11. Review.


Altered Microbiota Contributes to Reduced Diet-Induced Obesity upon Cold Exposure.

Ziętak M, Kovatcheva-Datchary P, Markiewicz LH, Ståhlman M, Kozak LP, Bäckhed F.

Cell Metab. 2016 Jun 14;23(6):1216-1223. doi: 10.1016/j.cmet.2016.05.001.


Lactation undernutrition leads to multigenerational molecular programming of hypothalamic gene networks controlling reproduction.

Kaczmarek MM, Mendoza T, Kozak LP.

BMC Genomics. 2016 May 4;17:333. doi: 10.1186/s12864-016-2615-4.


Obesity and related consequences to ageing.

Jura M, Kozak LP.

Age (Dordr). 2016 Feb;38(1):23. doi: 10.1007/s11357-016-9884-3. Epub 2016 Feb 4. Review.


The critical period for brown adipocyte development: Genetic and environmental influences.

Chabowska-Kita A, Kozak LP.

Obesity (Silver Spring). 2016 Feb;24(2):283-90. doi: 10.1002/oby.21376. Epub 2016 Jan 6. Review.


Bile acids induce uncoupling protein 1-dependent thermogenesis and stimulate energy expenditure at thermoneutrality in mice.

Zietak M, Kozak LP.

Am J Physiol Endocrinol Metab. 2016 Mar 1;310(5):E346-54. doi: 10.1152/ajpendo.00485.2015. Epub 2015 Dec 29.


Correction: Npvf: Hypothalamic Biomarker of Ambient Temperature Independent of Nutritional Status.

Jaroslawska J, Chabowska-Kita A, Kaczmarek MM, Kozak LP.

PLoS Genet. 2015 Sep 17;11(9):e1005431. doi: 10.1371/journal.pgen.1005431. eCollection 2015 Sep. No abstract available.


Npvf: Hypothalamic Biomarker of Ambient Temperature Independent of Nutritional Status.

Jaroslawska J, Chabowska-Kita A, Kaczmarek MM, Kozak LP.

PLoS Genet. 2015 Jun 12;11(6):e1005287. doi: 10.1371/journal.pgen.1005287. eCollection 2015 Jun. Erratum in: PLoS Genet. 2015 Sep;11(9):e1005431.


Mest and Sfrp5 are biomarkers for healthy adipose tissue.

Jura M, Jarosławska J, Chu DT, Kozak LP.

Biochimie. 2016 May;124:124-133. doi: 10.1016/j.biochi.2015.05.006. Epub 2015 May 20.


Low ambient temperature during early postnatal development fails to cause a permanent induction of brown adipocytes.

Chabowska-Kita A, Trabczynska A, Korytko A, Kaczmarek MM, Kozak LP.

FASEB J. 2015 Aug;29(8):3238-52. doi: 10.1096/fj.15-271395. Epub 2015 Apr 20.


Uncoupling Protein 1 and Sarcolipin Are Required to Maintain Optimal Thermogenesis, and Loss of Both Systems Compromises Survival of Mice under Cold Stress.

Rowland LA, Bal NC, Kozak LP, Periasamy M.

J Biol Chem. 2015 May 8;290(19):12282-9. doi: 10.1074/jbc.M115.637603. Epub 2015 Mar 30.


Mitochondrial turnover: a phenotype distinguishing brown adipocytes from interscapular brown adipose tissue and white adipose tissue.

Gospodarska E, Nowialis P, Kozak LP.

J Biol Chem. 2015 Mar 27;290(13):8243-55. doi: 10.1074/jbc.M115.637785. Epub 2015 Feb 1.


Expression of adipocyte biomarkers in a primary cell culture models reflects preweaning adipobiology.

Chu DT, Malinowska E, Gawronska-Kozak B, Kozak LP.

J Biol Chem. 2014 Jun 27;289(26):18478-88. doi: 10.1074/jbc.M114.555821. Epub 2014 May 7. Erratum in: J Biol Chem. 2014 Aug 22;289(34):23330.


Genetic variation in brown fat activity and body weight regulation in mice: lessons for human studies.

Kozak LP.

Biochim Biophys Acta. 2014 Mar;1842(3):370-6. doi: 10.1016/j.bbadis.2013.04.025. Epub 2013 May 2. Review.


Heat from calcium cycling melts fat.

Kozak LP, Young ME.

Nat Med. 2012 Oct;18(10):1458-9. doi: 10.1038/nm.2956. No abstract available.


Inherent plasticity of brown adipogenesis in white fat of mice allows for recovery from effects of post-natal malnutrition.

Kozak LP, Koza RA, Anunciado-Koza R, Mendoza T, Newman S.

PLoS One. 2012;7(2):e30392. doi: 10.1371/journal.pone.0030392. Epub 2012 Feb 24.


Inactivation of the mitochondrial carrier SLC25A25 (ATP-Mg2+/Pi transporter) reduces physical endurance and metabolic efficiency in mice.

Anunciado-Koza RP, Zhang J, Ukropec J, Bajpeyi S, Koza RA, Rogers RC, Cefalu WT, Mynatt RL, Kozak LP.

J Biol Chem. 2011 Apr 1;286(13):11659-71. doi: 10.1074/jbc.M110.203000. Epub 2011 Feb 4.


The genetics of brown adipocyte induction in white fat depots.

Kozak LP.

Front Endocrinol (Lausanne). 2011 Oct 31;2:64. doi: 10.3389/fendo.2011.00064. eCollection 2011.


The genetics of brown adipose tissue.

Kozak LP, Koza RA.

Prog Mol Biol Transl Sci. 2010;94:75-123. doi: 10.1016/S1877-1173(10)94004-0. Review.


Brown fat thermogenesis and body weight regulation in mice: relevance to humans.

Kozak LP, Koza RA, Anunciado-Koza R.

Int J Obes (Lond). 2010 Oct;34 Suppl 1:S23-7. doi: 10.1038/ijo.2010.179. Review.


The early nutritional environment of mice determines the capacity for adipose tissue expansion by modulating genes of caveolae structure.

Kozak LP, Newman S, Chao PM, Mendoza T, Koza RA.

PLoS One. 2010 Jun 21;5(6):e11015. doi: 10.1371/journal.pone.0011015.


Brown fat and the myth of diet-induced thermogenesis.

Kozak LP.

Cell Metab. 2010 Apr 7;11(4):263-7. doi: 10.1016/j.cmet.2010.03.009. Review.


A recurring problem with the analysis of energy expenditure in genetic models expressing lean and obese phenotypes.

Butler AA, Kozak LP.

Diabetes. 2010 Feb;59(2):323-9. doi: 10.2337/db09-1471. Review. No abstract available.


Have we entered the brown adipose tissue renaissance?

Ravussin E, Kozak LP.

Obes Rev. 2009 May;10(3):265-8. doi: 10.1111/j.1467-789X.2008.00559.x. Epub 2009 Jan 19. Review.


UCP1: its involvement and utility in obesity.

Kozak LP, Anunciado-Koza R.

Int J Obes (Lond). 2008 Dec;32 Suppl 7:S32-8. doi: 10.1038/ijo.2008.236. Review.


Inactivation of UCP1 and the glycerol phosphate cycle synergistically increases energy expenditure to resist diet-induced obesity.

Anunciado-Koza R, Ukropec J, Koza RA, Kozak LP.

J Biol Chem. 2008 Oct 10;283(41):27688-97. doi: 10.1074/jbc.M804268200. Epub 2008 Aug 4.


Mesoderm-specific transcript is associated with fat mass expansion in response to a positive energy balance.

Nikonova L, Koza RA, Mendoza T, Chao PM, Curley JP, Kozak LP.

FASEB J. 2008 Nov;22(11):3925-37. doi: 10.1096/fj.08-108266. Epub 2008 Jul 21.


Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat.

Xue B, Rim JS, Hogan JC, Coulter AA, Koza RA, Kozak LP.

J Lipid Res. 2007 Jan;48(1):41-51. Epub 2006 Oct 14.


UCP1-independent thermogenesis in white adipose tissue of cold-acclimated Ucp1-/- mice.

Ukropec J, Anunciado RP, Ravussin Y, Hulver MW, Kozak LP.

J Biol Chem. 2006 Oct 20;281(42):31894-908. Epub 2006 Aug 16.


Changes in gene expression foreshadow diet-induced obesity in genetically identical mice.

Koza RA, Nikonova L, Hogan J, Rim JS, Mendoza T, Faulk C, Skaf J, Kozak LP.

PLoS Genet. 2006 May;2(5):e81. Epub 2006 May 26.


Leptin is required for uncoupling protein-1-independent thermogenesis during cold stress.

Ukropec J, Anunciado RV, Ravussin Y, Kozak LP.

Endocrinology. 2006 May;147(5):2468-80. Epub 2006 Feb 9.


Uncoupling proteins: current status and therapeutic prospects.

Nedergaard J, Ricquier D, Kozak LP.

EMBO Rep. 2005 Oct;6(10):917-21. No abstract available.


Transcriptional synergy and the regulation of Ucp1 during brown adipocyte induction in white fat depots.

Xue B, Coulter A, Rim JS, Koza RA, Kozak LP.

Mol Cell Biol. 2005 Sep;25(18):8311-22.


Contributions of dysregulated energy metabolism to type 2 diabetes development in NZO/H1Lt mice with polygenic obesity.

Koza RA, Flurkey K, Graunke DM, Braun C, Pan HJ, Reifsnyder PC, Kozak LP, Leiter EH.

Metabolism. 2004 Jun;53(6):799-808.


Sequestration of thermogenic transcription factors in the cytoplasm during development of brown adipose tissue.

Rim JS, Xue B, Gawronska-Kozak B, Kozak LP.

J Biol Chem. 2004 Jun 11;279(24):25916-26. Epub 2004 Apr 8.


Uncoupling protein 2, but not uncoupling protein 1, is expressed in the female mouse reproductive tract.

Rousset S, Alves-Guerra MC, Ouadghiri-Bencherif S, Kozak LP, Miroux B, Richard D, Bouillaud F, Ricquier D, Cassard-Doulcier AM.

J Biol Chem. 2003 Nov 14;278(46):45843-7. Epub 2003 Aug 26.


Variation in type 2 diabetes--related traits in mouse strains susceptible to diet-induced obesity.

Rossmeisl M, Rim JS, Koza RA, Kozak LP.

Diabetes. 2003 Aug;52(8):1958-66.


Dietary fat interacts with QTLs controlling induction of Pgc-1 alpha and Ucp1 during conversion of white to brown fat.

Coulter AA, Bearden CM, Liu X, Koza RA, Kozak LP.

Physiol Genomics. 2003 Jul 7;14(2):139-47.


[The role of oxidative metabolism in development of adaptation effect after exposure to ethanol and pulsed hypoxic training].

Kozak LP, Terlets'ka OI, Koval'chuk SM.

Fiziol Zh. 2002;48(6):74-9. Ukrainian.


Paradoxical resistance to diet-induced obesity in UCP1-deficient mice.

Liu X, Rossmeisl M, McClaine J, Riachi M, Harper ME, Kozak LP.

J Clin Invest. 2003 Feb;111(3):399-407. Erratum in: J Clin Invest. 2003 Mar;111(5):759.


Lethal hypoglycemic ketosis and glyceroluria in mice lacking both the mitochondrial and the cytosolic glycerol phosphate dehydrogenases.

Brown LJ, Koza RA, Marshall L, Kozak LP, MacDonald MJ.

J Biol Chem. 2002 Sep 6;277(36):32899-904. Epub 2002 Jul 1.


Normal thyroid thermogenesis but reduced viability and adiposity in mice lacking the mitochondrial glycerol phosphate dehydrogenase.

Brown LJ, Koza RA, Everett C, Reitman ML, Marshall L, Fahien LA, Kozak LP, MacDonald MJ.

J Biol Chem. 2002 Sep 6;277(36):32892-8. Epub 2002 Jul 1.

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