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Items: 1 to 50 of 146

1.

The p21 dependent G2 arrest of the cell cycle in epithelial tubular cells links to the early stage of renal fibrosis.

Koyano T, Namba M, Kobayashi T, Nakakuni K, Nakano D, Fukushima M, Nishiyama A, Matsuyama M.

Sci Rep. 2019 Aug 19;9(1):12059. doi: 10.1038/s41598-019-48557-8.

2.

Anatomically specific reactive oxygen species production participates in Marfan syndrome aneurysm formation.

Emrich F, Penov K, Arakawa M, Dhablania N, Burdon G, Pedroza AJ, Koyano TK, Kim YM, Raaz U, Connolly AJ, Iosef C, Fischbein MP.

J Cell Mol Med. 2019 Aug 11. doi: 10.1111/jcmm.14587. [Epub ahead of print]

3.

Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis.

Wirka RC, Wagh D, Paik DT, Pjanic M, Nguyen T, Miller CL, Kundu R, Nagao M, Coller J, Koyano TK, Fong R, Woo YJ, Liu B, Montgomery SB, Wu JC, Zhu K, Chang R, Alamprese M, Tallquist MD, Kim JB, Quertermous T.

Nat Med. 2019 Aug;25(8):1280-1289. doi: 10.1038/s41591-019-0512-5. Epub 2019 Jul 29.

PMID:
31359001
4.

Modeling conduit choice for valve-sparing aortic root replacement on biomechanics with a 3-dimensional-printed heart simulator.

Paulsen MJ, Kasinpila P, Imbrie-Moore AM, Wang H, Hironaka CE, Koyano TK, Fong R, Chiu P, Goldstone AB, Steele AN, Stapleton LM, Ma M, Woo YJ.

J Thorac Cardiovasc Surg. 2019 Aug;158(2):392-403. doi: 10.1016/j.jtcvs.2018.10.145. Epub 2018 Nov 15.

5.

Statins Reduce Thoracic Aortic Aneurysm Growth in Marfan Syndrome Mice via Inhibition of the Ras-Induced ERK (Extracellular Signal-Regulated Kinase) Signaling Pathway.

Sato T, Arakawa M, Tashima Y, Tsuboi E, Burdon G, Trojan J, Koyano T, Youn YN, Penov K, Pedroza AJ, Shabazzi M, Palmon I, Nguyen MN, Connolly AJ, Yamaguchi A, Fischbein MP.

J Am Heart Assoc. 2018 Nov 6;7(21):e008543. doi: 10.1161/JAHA.118.008543.

6.

The Notch Inhibitors Isolated from Nerium indicum.

Arai MA, Akamine R, Hayashi N, Koyano T, Kowithayakorn T, Ishibashi M.

J Nat Prod. 2018 May 25;81(5):1235-1240. doi: 10.1021/acs.jnatprod.7b01031. Epub 2018 Apr 25.

PMID:
29693393
7.

Successful production of genome-edited rats by the rGONAD method.

Kobayashi T, Namba M, Koyano T, Fukushima M, Sato M, Ohtsuka M, Matsuyama M.

BMC Biotechnol. 2018 Apr 2;18(1):19. doi: 10.1186/s12896-018-0430-5.

8.

The Notch inhibitor cowanin accelerates nicastrin degradation.

Arai MA, Akamine R, Tsuchiya A, Yoneyama T, Koyano T, Kowithayakorn T, Ishibashi M.

Sci Rep. 2018 Mar 29;8(1):5376. doi: 10.1038/s41598-018-23698-4.

9.

i-GONAD: a robust method for in situ germline genome engineering using CRISPR nucleases.

Ohtsuka M, Sato M, Miura H, Takabayashi S, Matsuyama M, Koyano T, Arifin N, Nakamura S, Wada K, Gurumurthy CB.

Genome Biol. 2018 Feb 26;19(1):25. doi: 10.1186/s13059-018-1400-x.

10.

Autophagy-mediated regulation of phytohormone metabolism during rice anther development.

Kurusu T, Koyano T, Kitahata N, Kojima M, Hanamata S, Sakakibara H, Kuchitsu K.

Plant Signal Behav. 2017 Sep 2;12(9):e1365211. doi: 10.1080/15592324.2017.1365211. Epub 2017 Sep 5.

11.

Identification of BMI1 Promoter Inhibitors from Beaumontia murtonii and Eugenia operculata.

Kaneta Y, Arai MA, Ishikawa N, Toume K, Koyano T, Kowithayakorn T, Chiba T, Iwama A, Ishibashi M.

J Nat Prod. 2017 Jun 23;80(6):1853-1859. doi: 10.1021/acs.jnatprod.7b00138. Epub 2017 Jun 9.

PMID:
28598616
12.

Long-term miR-29b suppression reduces aneurysm formation in a Marfan mouse model.

Okamura H, Emrich F, Trojan J, Chiu P, Dalal AR, Arakawa M, Sato T, Penov K, Koyano T, Pedroza A, Connolly AJ, Rabinovitch M, Alvira C, Fischbein MP.

Physiol Rep. 2017 Apr;5(8). pii: e13257. doi: 10.14814/phy2.13257. Epub 2017 Apr 28.

13.

Gene expression profiling of acute type A aortic dissection combined with in vitro assessment.

Kimura N, Futamura K, Arakawa M, Okada N, Emrich F, Okamura H, Sato T, Shudo Y, Koyano TK, Yamaguchi A, Adachi H, Matsuda A, Kawahito K, Matsumoto K, Fischbein MP.

Eur J Cardiothorac Surg. 2017 Oct 1;52(4):810-817. doi: 10.1093/ejcts/ezx095.

PMID:
28402522
14.

Boesenberols, Pimarane Diterpenes with TRAIL-Resistance-Overcoming Activity from Boesenbergia pandurata.

Karmakar UK, Ishikawa N, Arai MA, Ahmed F, Koyano T, Kowithayakorn T, Ishibashi M.

J Nat Prod. 2016 Aug 26;79(8):2075-82. doi: 10.1021/acs.jnatprod.6b00424. Epub 2016 Aug 10.

PMID:
27508308
15.

Cerasoidine, a Bis-aporphine Alkaloid Isolated from Polyalthia cerasoides during Screening for Wnt Signal Inhibitors.

Shono T, Ishikawa N, Toume K, Arai MA, Masu H, Koyano T, Kowithayakorn T, Ishibashi M.

J Nat Prod. 2016 Aug 26;79(8):2083-8. doi: 10.1021/acs.jnatprod.6b00409. Epub 2016 Aug 4.

PMID:
27490091
16.

Hes1 inhibitor isolated by target protein oriented natural products isolation (TPO-NAPI) of differentiation activators of neural stem cells.

Arai MA, Ishikawa N, Tanaka M, Uemura K, Sugimitsu N, Suganami A, Tamura Y, Koyano T, Kowithayakorn T, Ishibashi M.

Chem Sci. 2016 Feb 1;7(2):1514-1520. doi: 10.1039/c5sc03540f. Epub 2015 Dec 1.

17.

Casein kinase 1γ acts as a molecular switch for cell polarization through phosphorylation of the polarity factor Tea1 in fission yeast.

Koyano T, Barnouin K, Snijders AP, Kume K, Hirata D, Toda T.

Genes Cells. 2015 Dec;20(12):1046-58. doi: 10.1111/gtc.12309. Epub 2015 Nov 2.

18.

Hedgehog inhibitors from Artocarpus communis and Hyptis suaveolens.

Arai MA, Uchida K, Sadhu SK, Ahmed F, Koyano T, Kowithayakorn T, Ishibashi M.

Bioorg Med Chem. 2015 Aug 1;23(15):4150-4. doi: 10.1016/j.bmc.2015.06.058. Epub 2015 Jul 2.

PMID:
26178912
19.

9-Hydroxycanthin-6-one, a β-Carboline Alkaloid from Eurycoma longifolia, Is the First Wnt Signal Inhibitor through Activation of Glycogen Synthase Kinase 3β without Depending on Casein Kinase 1α.

Ohishi K, Toume K, Arai MA, Koyano T, Kowithayakorn T, Mizoguchi T, Itoh M, Ishibashi M.

J Nat Prod. 2015 May 22;78(5):1139-46. doi: 10.1021/acs.jnatprod.5b00153. Epub 2015 Apr 23.

PMID:
25905468
20.

Isolation of a spontaneous cerulenin-resistant sake yeast with both high ethyl caproate-producing ability and normal checkpoint integrity.

Tamura H, Okada H, Kume K, Koyano T, Goshima T, Nakamura R, Akao T, Shimoi H, Mizunuma M, Ohya Y, Hirata D.

Biosci Biotechnol Biochem. 2015;79(7):1191-9. doi: 10.1080/09168451.2015.1020756. Epub 2015 Mar 19.

PMID:
25787154
21.

Correction to Prenylated Flavonoids and Resveratrol Derivatives Isolated from Artocarpus communis with the Ability to Overcome TRAIL Resistance.

Toume K, Habu T, Arai MA, Koyano T, Kowithayakorn T, Ishibashi M.

J Nat Prod. 2015 Apr 24;78(4):968. doi: 10.1021/acs.jnatprod.5b00061. Epub 2015 Feb 20. No abstract available.

PMID:
25700156
22.

Casein kinase 1γ ensures monopolar growth polarity under incomplete DNA replication downstream of Cds1 and calcineurin in fission yeast.

Koyano T, Konishi M, Martin SG, Ohya Y, Hirata D, Toda T, Kume K.

Mol Cell Biol. 2015 May;35(9):1533-42. doi: 10.1128/MCB.01465-14. Epub 2015 Feb 17.

23.

Screening for a gene deletion mutant whose temperature sensitivity is suppressed by FK506 in budding yeast and its application for a positive screening for drugs inhibiting calcineurin.

Kume K, Koyano T, Takata J, Wakabayashi K, Mizunuma M, Miyakawa T, Hirata D.

Biosci Biotechnol Biochem. 2015;79(5):790-4. doi: 10.1080/09168451.2014.1003132. Epub 2015 Jan 23.

PMID:
25614218
24.

Prenylated flavonoids and resveratrol derivatives isolated from Artocarpus communis with the ability to overcome TRAIL resistance.

Toume K, Habu T, Arai MA, Koyano T, Kowithayakorn T, Ishibashi M.

J Nat Prod. 2015 Jan 23;78(1):103-10. doi: 10.1021/np500734t. Epub 2014 Dec 24. Erratum in: J Nat Prod. 2015 Apr 24;78(4):968.

PMID:
25537111
25.

Enhanced caspase activity contributes to aortic wall remodeling and early aneurysm development in a murine model of Marfan syndrome.

Emrich FC, Okamura H, Dalal AR, Penov K, Merk DR, Raaz U, Hennigs JK, Chin JT, Miller MO, Pedroza AJ, Craig JK, Koyano TK, Blankenberg FG, Connolly AJ, Mohr FW, Alvira CM, Rabinovitch M, Fischbein MP.

Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):146-54. doi: 10.1161/ATVBAHA.114.304364. Epub 2014 Oct 30.

PMID:
25359856
26.

Corrigendum to "Prenylflavonoids isolated from Artocarpus champeden with TRAIL-resistance overcoming activity" [Phytochemistry 96 (2013) 299-304].

Minakawa T, Toume K, Arai MA, Koyano T, Kowithayakorn T, Ishibashi M.

Phytochemistry. 2014 Oct;106:207. doi: 10.1016/j.phytochem.2014.06.005. Epub 2014 Jun 28. No abstract available.

PMID:
28918119
27.

Apicoaortic conduit for severe hemolytic anemia after aortic valve replacement.

Hatori K, Ohki S, Obayashi T, Koyano T, Yasuhara K, Hirai H.

Asian Cardiovasc Thorac Ann. 2015 Jun;23(5):558-60. doi: 10.1177/0218492313517702. Epub 2013 Dec 17.

PMID:
24887937
28.

OsATG7 is required for autophagy-dependent lipid metabolism in rice postmeiotic anther development.

Kurusu T, Koyano T, Hanamata S, Kubo T, Noguchi Y, Yagi C, Nagata N, Yamamoto T, Ohnishi T, Okazaki Y, Kitahata N, Ando D, Ishikawa M, Wada S, Miyao A, Hirochika H, Shimada H, Makino A, Saito K, Ishida H, Kinoshita T, Kurata N, Kuchitsu K.

Autophagy. 2014 May;10(5):878-88. doi: 10.4161/auto.28279. Epub 2014 Mar 24.

29.

Prenylflavonoids isolated from Artocarpus champeden with TRAIL-resistance overcoming activity.

Minakawa T, Toume K, Arai MA, Koyano T, Kowithayakorn T, Ishibashi M.

Phytochemistry. 2013 Dec;96:299-304. doi: 10.1016/j.phytochem.2013.08.015. Epub 2013 Sep 24. Erratum in: Phytochemistry. 2014 Oct;106:207.

PMID:
24074554
30.

Naturally occurring Ngn2 promoter activators from Butea superba.

Arai MA, Koryudzu K, Koyano T, Kowithayakorn T, Ishibashi M.

Mol Biosyst. 2013 Oct;9(10):2489-97. doi: 10.1039/c3mb70083f.

PMID:
23903453
31.

Fission yeast leucine-rich repeat protein Lrp1 is essential for cell morphogenesis as a component of the morphogenesis Orb6 network (MOR).

Kume K, Kubota S, Koyano T, Kanai M, Mizunuma M, Toda T, Hirata D.

Biosci Biotechnol Biochem. 2013;77(5):1086-91. Epub 2013 May 7.

32.

Spontaneous innominate and left common carotid artery dissection with bovine aortic arch.

Ohki S, Obayashi T, Koyano T, Yasuhara K, Hirai H, Hatori K.

Gen Thorac Cardiovasc Surg. 2014 Apr;62(4):238-40. doi: 10.1007/s11748-013-0253-1. Epub 2013 Apr 24.

PMID:
23612923
33.

β-Sitosterol and flavonoids isolated from Bauhinia malabarica found during screening for Wnt signaling inhibitory activity.

Park HY, Toume K, Arai MA, Koyano T, Kowithayakorn T, Ishibashi M.

J Nat Med. 2014 Jan;68(1):242-5. doi: 10.1007/s11418-013-0762-3. Epub 2013 Mar 21.

PMID:
23516045
34.

Long-survival case of thymic carcinoma with superior vena cava tumor thrombus.

Matsuo Y, Takama N, Yasuhara K, Koyano T, Obayashi T, Sasaki T, Kanesawa N, Kurabayashi M.

Ann Thorac Surg. 2012 Nov;94(5):1729-31. doi: 10.1016/j.athoracsur.2012.02.081.

PMID:
23098957
35.

Intracellular localization and physiological function of a rice Ca²⁺-permeable channel OsTPC1.

Kurusu T, Hamada H, Koyano T, Kuchitsu K.

Plant Signal Behav. 2012 Nov;7(11):1428-30. doi: 10.4161/psb.22086. Epub 2012 Sep 18.

36.

Cycloartane triterpenes and ingol diterpenes isolated from Euphorbia neriifolia in a screening program for death-receptor expression-enhancing activity.

Toume K, Nakazawa T, Hoque T, Ohtsuki T, Arai MA, Koyano T, Kowithayakorn T, Ishibashi M.

Planta Med. 2012 Aug;78(12):1370-7. doi: 10.1055/s-0032-1314975. Epub 2012 Jun 14.

PMID:
22700046
37.

Inhibition of lysenin-induced hemolysis by all-E-lutein derived from the plant Dalbergia latifolia.

Niwa Y, Matsui C, Sukumwang N, Iinuma H, Ikeda Y, Koyano T, Kovitayakorn T, Simizu S, Umezawa K.

Planta Med. 2012 Jun;78(10):957-61. doi: 10.1055/s-0031-1298538. Epub 2012 May 15.

PMID:
22588837
38.

Regulation of a proteinaceous elicitor-induced Ca2+ influx and production of phytoalexins by a putative voltage-gated cation channel, OsTPC1, in cultured rice cells.

Hamada H, Kurusu T, Okuma E, Nokajima H, Kiyoduka M, Koyano T, Sugiyama Y, Okada K, Koga J, Saji H, Miyao A, Hirochika H, Yamane H, Murata Y, Kuchitsu K.

J Biol Chem. 2012 Mar 23;287(13):9931-9. doi: 10.1074/jbc.M111.337659. Epub 2012 Jan 23.

39.
40.

Acoschimperoside P, 2'-acetate: a Hedgehog signaling inhibitory constituent from Vallaris glabra.

Rifai Y, Arai MA, Koyano T, Kowithayakorn T, Ishibashi M.

J Nat Med. 2011 Jul;65(3-4):629-32. doi: 10.1007/s11418-011-0530-1. Epub 2011 Apr 6.

PMID:
21625949
41.

Comprehensive studies for the crystal structures and electronic properties of the superconducting system Fe(1 + δ)Se(1 - x)Te(x) with δ is approximately equal to 0.037 and x is approximately equal to 0.55.

Onoda M, Kawasaki Y, Tsubokawa M, Koyano T.

J Phys Condens Matter. 2010 Dec 22;22(50):505702. doi: 10.1088/0953-8984/22/50/505702. Epub 2010 Nov 24.

PMID:
21406805
42.

Calcineurin ensures a link between the DNA replication checkpoint and microtubule-dependent polarized growth.

Kume K, Koyano T, Kanai M, Toda T, Hirata D.

Nat Cell Biol. 2011 Mar;13(3):234-42. doi: 10.1038/ncb2166. Epub 2011 Feb 20.

PMID:
21336311
43.

A phase II study of weekly paclitaxel and doxifluridine combination chemotherapy for advanced/recurrent gastric cancer.

Takeyoshi I, Makita F, Tanahashi Y, Iwazaki S, Ogawa T, Tomizawa N, Nakamura S, Ishikawa H, Ohya T, Kakinuma S, Nakagami K, Sato Y, Koyano T, Roppongi T, Izumi M, Kobayashi J, Kawate S, Sunose Y, Kobayashi M, Yamada T, Sakamoto I.

Anticancer Res. 2011 Jan;31(1):287-91.

PMID:
21273612
44.

Cycloartane triterpenes isolated from Combretum quadrangulare in a screening program for death-receptor expression enhancing activity.

Toume K, Nakazawa T, Ohtsuki T, Arai MA, Koyano T, Kowithayakorn T, Ishibashi M.

J Nat Prod. 2011 Feb 25;74(2):249-55. doi: 10.1021/np100784t. Epub 2011 Jan 25.

PMID:
21265555
45.

New hedgehog/GLI-signaling inhibitors from Adenium obesum.

Arai MA, Tateno C, Koyano T, Kowithayakorn T, Kawabe S, Ishibashi M.

Org Biomol Chem. 2011 Feb 21;9(4):1133-9. doi: 10.1039/c0ob00677g. Epub 2010 Dec 20.

PMID:
21170436
46.

2-methoxy-1,4-naphthoquinone isolated from Impatiens balsamina in a screening program for activity to inhibit Wnt signaling.

Mori N, Toume K, Arai MA, Koyano T, Kowithayakorn T, Ishibashi M.

J Nat Med. 2011 Jan;65(1):234-6. doi: 10.1007/s11418-010-0471-0. Epub 2010 Oct 1.

PMID:
20886301
47.

Fission yeast germinal center (GC) kinase Ppk11 interacts with Pmo25 and plays an auxiliary role in concert with the morphogenesis Orb6 network (MOR) in cell morphogenesis.

Goshima T, Kume K, Koyano T, Ohya Y, Toda T, Hirata D.

J Biol Chem. 2010 Nov 5;285(45):35196-205. doi: 10.1074/jbc.M110.176867. Epub 2010 Sep 7.

48.

Search for kinases related to transition of growth polarity in fission yeast.

Koyano T, Kume K, Konishi M, Toda T, Hirata D.

Biosci Biotechnol Biochem. 2010;74(5):1129-33.

49.

Terpenoids and a flavonoid glycoside from Acacia pennata leaves as hedgehog/GLI-mediated transcriptional inhibitors.

Rifai Y, Arai MA, Koyano T, Kowithayakorn T, Ishibashi M.

J Nat Prod. 2010 May 28;73(5):995-7. doi: 10.1021/np1000818.

PMID:
20450170
50.

A method for the rapid discovery of naturally occurring products by proteins immobilized on magnetic beads and reverse affinity chromatography.

Arai MA, Kobatake E, Koyano T, Kowithayakorn T, Kato S, Ishibashi M.

Chem Asian J. 2009 Dec 1;4(12):1802-8. doi: 10.1002/asia.200900357.

PMID:
19924763

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