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Items: 1 to 50 of 204

1.

The Molecular and Cellular Mechanisms of Axon Guidance in Mossy Fiber Sprouting.

Koyama R, Ikegaya Y.

Front Neurol. 2018 May 29;9:382. doi: 10.3389/fneur.2018.00382. eCollection 2018. Review.

2.

Cholesterol Unbound RORγt Protein Enables a Sensitive Inverse Agonist Screening.

Koyama R, Fukuda Y, Kamada Y, Nakagawa H, Witmer D, Ambrus-Aikelin G, Sang BC, Nakayama M, Iwata H.

Assay Drug Dev Technol. 2018 May/Jun;16(4):194-204. doi: 10.1089/adt.2018.852. Epub 2018 Jun 6.

PMID:
29874096
3.

Ischemic Brain Injury Leads to Brain Edema via Hyperthermia-Induced TRPV4 Activation.

Hoshi Y, Okabe K, Shibasaki K, Funatsu T, Matsuki N, Ikegaya Y, Koyama R.

J Neurosci. 2018 Jun 20;38(25):5700-5709. doi: 10.1523/JNEUROSCI.2888-17.2018. Epub 2018 May 23.

PMID:
29793978
4.

Neonatal Seizure Models to Study Epileptogenesis.

Kasahara Y, Ikegaya Y, Koyama R.

Front Pharmacol. 2018 Apr 18;9:385. doi: 10.3389/fphar.2018.00385. eCollection 2018. Review.

5.

Exogenous Abscisic Acid Promotes Anthocyanin Biosynthesis and Increased Expression of Flavonoid Synthesis Genes in Vitis vinifera × Vitis labrusca Table Grapes in a Subtropical Region.

Koyama R, Roberto SR, de Souza RT, Borges WFS, Anderson M, Waterhouse AL, Cantu D, Fidelibus MW, Blanco-Ulate B.

Front Plant Sci. 2018 Mar 26;9:323. doi: 10.3389/fpls.2018.00323. eCollection 2018.

6.

Microglia after Seizures and in Epilepsy.

Hiragi T, Ikegaya Y, Koyama R.

Cells. 2018 Mar 28;7(4). pii: E26. doi: 10.3390/cells7040026. Review.

7.

Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation.

Ohoka N, Morita Y, Nagai K, Shimokawa K, Ujikawa O, Fujimori I, Ito M, Hayase Y, Okuhira K, Shibata N, Hattori T, Sameshima T, Sano O, Koyama R, Imaeda Y, Nara H, Cho N, Naito M.

J Biol Chem. 2018 May 4;293(18):6776-6790. doi: 10.1074/jbc.RA117.001091. Epub 2018 Mar 15.

PMID:
29545311
8.

Identification of Small-Molecule Inhibitors of Human Golgi Mannosidase via a Drug Repositioning Screen.

Koyama R, Hakamata W, Hirano T, Nishio T.

Chem Pharm Bull (Tokyo). 2018 Jun 1;66(6):678-681. doi: 10.1248/cpb.c17-01009. Epub 2018 Mar 13.

9.

GH directly stimulates UCP3 expression.

Hayashi M, Futawaka K, Matsushita M, Koyama R, Fun Y, Fukuda Y, Nushida A, Nezu S, Tagami T, Moriyama K.

Growth Horm IGF Res. 2018 Jun;40:44-54. doi: 10.1016/j.ghir.2018.01.002. Epub 2018 Jan 31.

PMID:
29398371
10.

Identification of novel quinazolinedione derivatives as RORγt inverse agonist.

Fukase Y, Sato A, Tomata Y, Ochida A, Kono M, Yonemori K, Koga K, Okui T, Yamasaki M, Fujitani Y, Nakagawa H, Koyama R, Nakayama M, Skene R, Sang BC, Hoffman I, Shirai J, Yamamoto S.

Bioorg Med Chem. 2018 Feb 1;26(3):721-736. doi: 10.1016/j.bmc.2017.12.039. Epub 2017 Dec 28.

PMID:
29342416
11.

Correction: CT Chest and pulmonary functional changes in patients with HTLV-associated myelopathy in the Eastern Brazilian Amazon.

Magno Falcão LF, Falcão ASC, Medeiros Sousa RC, Vieira WB, de Oliveira RTM, Normando VMF, da Silva Dias GA, de Souza Santos MC, Rocha RSB, Yoshikawa GT, Koyama RVL, Fujihara S, Corrêa VAC, Fuzii HT, Quaresma JAS.

PLoS One. 2017 Dec 27;12(12):e0190436. doi: 10.1371/journal.pone.0190436. eCollection 2017.

12.

Discovery of orally efficacious RORγt inverse agonists, part 1: Identification of novel phenylglycinamides as lead scaffolds.

Shirai J, Tomata Y, Kono M, Ochida A, Fukase Y, Sato A, Masada S, Kawamoto T, Yonemori K, Koyama R, Nakagawa H, Nakayama M, Uga K, Shibata A, Koga K, Okui T, Shirasaki M, Skene R, Sang B, Hoffman I, Lane W, Fujitani Y, Yamasaki M, Yamamoto S.

Bioorg Med Chem. 2018 Jan 15;26(2):483-500. doi: 10.1016/j.bmc.2017.12.006. Epub 2017 Dec 9.

PMID:
29262987
13.

[Mouse model of febrile seizures].

Kasahara Y, Ikegaya Y, Koyama R.

Nihon Yakurigaku Zasshi. 2017;150(5):240-245. doi: 10.1254/fpj.150.240. Japanese. No abstract available.

PMID:
29118287
14.

Effects of growth hormone on uncoupling protein 1 in white adipose tissues in obese mice.

Hayashi M, Futawaka K, Koyama R, Fan Y, Matsushita M, Hirao A, Fukuda Y, Nushida A, Nezu S, Tagami T, Moriyama K.

Growth Horm IGF Res. 2017 Dec;37:31-39. doi: 10.1016/j.ghir.2017.10.006. Epub 2017 Oct 24.

PMID:
29111497
15.

CT Chest and pulmonary functional changes in patients with HTLV-associated myelopathy in the Eastern Brazilian Amazon.

Magno Falcão LF, Falcão ASC, Medeiros Sousa RC, Vieira WB, de Oliveira RTM, Normando VMF, Dias GADS, Santos MCS, Rocha RSB, Yoshikawa GT, Koyama RVL, Fujihara S, Corrêa VAC, Fuzii HT, Quaresma JAS.

PLoS One. 2017 Nov 2;12(11):e0186055. doi: 10.1371/journal.pone.0186055. eCollection 2017. Erratum in: PLoS One. 2017 Dec 27;12 (12 ):e0190436.

16.

Identification and characterization of a metastatic suppressor BRMS1L as a target gene of p53.

Koyama R, Tamura M, Nakagaki T, Ohashi T, Idogawa M, Suzuki H, Tokino T, Sasaki Y.

Cancer Sci. 2017 Dec;108(12):2413-2421. doi: 10.1111/cas.13420. Epub 2017 Nov 6.

17.

Profiling cancer-related gene mutations in oral squamous cell carcinoma from Japanese patients by targeted amplicon sequencing.

Nakagaki T, Tamura M, Kobashi K, Koyama R, Fukushima H, Ohashi T, Idogawa M, Ogi K, Hiratsuka H, Tokino T, Sasaki Y.

Oncotarget. 2017 Jul 15;8(35):59113-59122. doi: 10.18632/oncotarget.19262. eCollection 2017 Aug 29.

18.

Effectiveness of computer-aided diagnosis of colorectal lesions using novel software for magnifying narrow-band imaging: a pilot study.

Tamai N, Saito Y, Sakamoto T, Nakajima T, Matsuda T, Sumiyama K, Tajiri H, Koyama R, Kido S.

Endosc Int Open. 2017 Aug;5(8):E690-E694. doi: 10.1055/s-0043-105490. Epub 2017 Aug 3.

19.

Rho kinase-dependent desensitization of GPR39; a unique mechanism of GPCR downregulation.

Shimizu Y, Koyama R, Kawamoto T.

Biochem Pharmacol. 2017 Sep 15;140:105-114. doi: 10.1016/j.bcp.2017.06.115. Epub 2017 Jun 12.

PMID:
28619258
20.

Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands.

Shibata N, Nagai K, Morita Y, Ujikawa O, Ohoka N, Hattori T, Koyama R, Sano O, Imaeda Y, Nara H, Cho N, Naito M.

J Med Chem. 2018 Jan 25;61(2):543-575. doi: 10.1021/acs.jmedchem.7b00168. Epub 2017 Jun 23.

PMID:
28594553
21.

Differentiation of Human Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons in Mouse Hippocampal Slice Cultures.

Hiragi T, Andoh M, Araki T, Shirakawa T, Ono T, Koyama R, Ikegaya Y.

Front Cell Neurosci. 2017 May 17;11:143. doi: 10.3389/fncel.2017.00143. eCollection 2017.

22.

Hypomyopathic dermatomyositis associated with interstitial lung disease and good response to mycophenolate mofetil: case-based review.

Koyama RVL, Braga TKK, da Silva Dias GA, Fujihara S, Fuzii HT, Yoshikawa GT.

Clin Rheumatol. 2017 Aug;36(8):1919-1926. doi: 10.1007/s10067-017-3671-0. Epub 2017 May 9. Review.

PMID:
28488124
23.

Surfactant protein-D predicts prognosis of interstitial lung disease induced by anticancer agents in advanced lung cancer: a case control study.

Nakamura K, Kato M, Shukuya T, Mori K, Sekimoto Y, Ihara H, Kanemaru R, Ko R, Shibayama R, Tajima K, Koyama R, Shimada N, Nagashima O, Takahashi F, Sasaki S, Takahashi K.

BMC Cancer. 2017 May 2;17(1):302. doi: 10.1186/s12885-017-3285-6.

24.

Glycogen synthase kinase-3 inhibitors suppress the AR-V7-mediated transcription and selectively inhibit cell growth in AR-V7-positive prostate cancer cells.

Nakata D, Koyama R, Nakayama K, Kitazawa S, Watanabe T, Hara T.

Prostate. 2017 Jun;77(9):955-961. doi: 10.1002/pros.23351. Epub 2017 Apr 10.

PMID:
28397338
25.

Red blotch disease alters grape berry development and metabolism by interfering with the transcriptional and hormonal regulation of ripening.

Blanco-Ulate B, Hopfer H, Figueroa-Balderas R, Ye Z, Rivero RM, Albacete A, Pérez-Alfocea F, Koyama R, Anderson MM, Smith RJ, Ebeler SE, Cantu D.

J Exp Bot. 2017 Feb 1;68(5):1225-1238. doi: 10.1093/jxb/erw506.

26.

Parallel fluorescent probe synthesis based on the large-scale preparation of BODIPY FL propionic acid.

Katoh T, Yoshikawa M, Yamamoto T, Arai R, Nii N, Tomata Y, Suzuki S, Koyama R, Negoro N, Yogo T.

Bioorg Med Chem Lett. 2017 Mar 1;27(5):1145-1148. doi: 10.1016/j.bmcl.2017.01.076. Epub 2017 Jan 28.

PMID:
28174108
27.

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs).

Ohoka N, Okuhira K, Ito M, Nagai K, Shibata N, Hattori T, Ujikawa O, Shimokawa K, Sano O, Koyama R, Fujita H, Teratani M, Matsumoto H, Imaeda Y, Nara H, Cho N, Naito M.

J Biol Chem. 2017 Mar 17;292(11):4556-4570. doi: 10.1074/jbc.M116.768853. Epub 2017 Feb 2.

28.

Phase I/II study of docetaxel combined with resminostat, an oral hydroxamic acid HDAC inhibitor, for advanced non-small cell lung cancer in patients previously treated with platinum-based chemotherapy.

Tambo Y, Hosomi Y, Sakai H, Nogami N, Atagi S, Sasaki Y, Kato T, Takahashi T, Seto T, Maemondo M, Nokihara H, Koyama R, Nakagawa K, Kawaguchi T, Okamura Y, Nakamura O, Nishio M, Tamura T.

Invest New Drugs. 2017 Apr;35(2):217-226. doi: 10.1007/s10637-017-0435-2. Epub 2017 Jan 30.

PMID:
28138828
29.

Novel DOCK2-selective inhibitory peptide that suppresses B-cell line migration.

Sakamoto K, Adachi Y, Komoike Y, Kamada Y, Koyama R, Fukuda Y, Kadotani A, Asami T, Sakamoto JI.

Biochem Biophys Res Commun. 2017 Jan 29;483(1):183-190. doi: 10.1016/j.bbrc.2016.12.170. Epub 2016 Dec 27.

PMID:
28039053
30.

Microglia and neurogenesis in the epileptic dentate gyrus.

Luo C, Ikegaya Y, Koyama R.

Neurogenesis (Austin). 2016 Sep 26;3(1):e1235525. eCollection 2016.

31.

DNase γ, DNase I and caspase-activated DNase cooperate to degrade dead cells.

Koyama R, Arai T, Kijima M, Sato S, Miura S, Yuasa M, Kitamura D, Mizuta R.

Genes Cells. 2016 Nov;21(11):1150-1163. doi: 10.1111/gtc.12433. Epub 2016 Sep 22.

32.

Acrolein scavengers, cysteamine and N-benzylhydroxylamine, reduces the mouse liver damage after acetaminophen overdose.

Koyama R, Mizuta R.

J Vet Med Sci. 2017 Jan 10;78(12):1903-1905. doi: 10.1292/jvms.16-0325. Epub 2016 Sep 5.

33.

Successful treatment with weekly high-dose erlotinib against meningeal metastases from epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma.

Kanemaru R, Morio Y, Takekawa H, Jo H, Kasuga F, Koyama R, Shiota S, Nagaoka T, Takahashi K.

Respir Investig. 2016 Sep;54(5):372-5. doi: 10.1016/j.resinv.2016.04.001. Epub 2016 Jun 6. No abstract available.

PMID:
27566387
34.

Identification and characterization of the intercellular adhesion molecule-2 gene as a novel p53 target.

Sasaki Y, Tamura M, Takeda K, Ogi K, Nakagaki T, Koyama R, Idogawa M, Hiratsuka H, Tokino T.

Oncotarget. 2016 Sep 20;7(38):61426-61437. doi: 10.18632/oncotarget.11366.

35.

Nitric Oxide-induced Activation of the Type 1 Ryanodine Receptor Is Critical for Epileptic Seizure-induced Neuronal Cell Death.

Mikami Y, Kanemaru K, Okubo Y, Nakaune T, Suzuki J, Shibata K, Sugiyama H, Koyama R, Murayama T, Ito A, Yamazawa T, Ikegaya Y, Sakurai T, Saito N, Kakizawa S, Iino M.

EBioMedicine. 2016 Sep;11:253-261. doi: 10.1016/j.ebiom.2016.08.020. Epub 2016 Aug 13.

36.

Treatment of biliary tract stones after gastrectomy in the era of laparoscopic cholecystectomy.

Hashimoto M, Imamura T, Tamura T, Koyama R, Koizumi Y, Makuuchi M, Matsuda M, Watanabe G.

J Hepatobiliary Pancreat Sci. 2016 Nov;23(11):703-707. doi: 10.1002/jhbp.393. Epub 2016 Sep 19.

PMID:
27526946
37.

Autism spectrum disorders and epilepsy.

Andoh M, Ikegaya Y, Koyama R.

Nihon Yakurigaku Zasshi. 2016 Aug;148(2):121-2. doi: 10.1254/fpj.148.121. Review. Japanese. No abstract available.

PMID:
27478051
38.

Vitamin D3/VDR resists diet-induced obesity by modulating UCP3 expression in muscles.

Fan Y, Futawaka K, Koyama R, Fukuda Y, Hayashi M, Imamoto M, Miyawaki T, Kasahara M, Tagami T, Moriyama K.

J Biomed Sci. 2016 Jul 29;23(1):56. doi: 10.1186/s12929-016-0271-2.

39.

Microglia engulf viable newborn cells in the epileptic dentate gyrus.

Luo C, Koyama R, Ikegaya Y.

Glia. 2016 Sep;64(9):1508-17. doi: 10.1002/glia.23018. Epub 2016 Jun 15.

PMID:
27301702
40.

Dentate Circuitry as a Model to Study Epileptogenesis.

Koyama R.

Biol Pharm Bull. 2016;39(6):891-6. doi: 10.1248/bpb.b16-00125. Review.

41.

Structural insight into photoactivation of an adenylate cyclase from a photosynthetic cyanobacterium.

Ohki M, Sugiyama K, Kawai F, Tanaka H, Nihei Y, Unzai S, Takebe M, Matsunaga S, Adachi S, Shibayama N, Zhou Z, Koyama R, Ikegaya Y, Takahashi T, Tame JR, Iseki M, Park SY.

Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):6659-64. doi: 10.1073/pnas.1517520113. Epub 2016 May 31.

42.

Depth and time-dependent heterogeneity of microglia in mouse hippocampal slice cultures.

Kasahara Y, Koyama R, Ikegaya Y.

Neurosci Res. 2016 Oct;111:64-9. doi: 10.1016/j.neures.2016.05.001. Epub 2016 May 17.

PMID:
27211829
43.

Transcriptional activation of the wild-type and mutant vitamin D receptors by vitamin D3 analogs.

Futawaka K, Tagami T, Fukuda Y, Koyama R, Nushida A, Nezu S, Yamamoto H, Imamoto M, Kasahara M, Moriyama K.

J Mol Endocrinol. 2016 Jul;57(1):23-32. doi: 10.1530/JME-16-0048. Epub 2016 May 6.

PMID:
27154546
44.

Growth hormone regulates the expression of UCP2 in myocytes.

Futawaka K, Tagami T, Fukuda Y, Koyama R, Nushida A, Nezu S, Imamoto M, Kasahara M, Moriyama K.

Growth Horm IGF Res. 2016 Aug;29:57-62. doi: 10.1016/j.ghir.2016.04.005. Epub 2016 Apr 15.

PMID:
27150070
45.

Scaffold protein enigma homolog 1 overcomes the repression of myogenesis activation by inhibitor of DNA binding 2.

Nakatani M, Ito J, Koyama R, Iijima M, Yoshimoto N, Niimi T, Kuroda S, Maturana AD.

Biochem Biophys Res Commun. 2016 May 27;474(2):413-420. doi: 10.1016/j.bbrc.2016.04.119. Epub 2016 Apr 23.

PMID:
27114303
46.

Bevacizumab-induced chronic interstitial pneumonia during maintenance therapy in non-small cell lung cancer.

Sekimoto Y, Kato M, Shukuya T, Koyama R, Nagaoka T, Takahashi K.

Respirol Case Rep. 2016 Mar 31;4(2):e00151. doi: 10.1002/rcr2.151. eCollection 2016 Apr. Erratum in: Respirol Case Rep. 2016 Jul;4(4):e00166.

47.

Cerebral infarction in advanced non-small cell lung cancer: a case control study.

Kato M, Shukuya T, Mori K, Kanemaru R, Honma Y, Nanjo Y, Muraki K, Shibayama R, Koyama R, Shimada N, Takahashi F, Takahashi K.

BMC Cancer. 2016 Mar 10;16:203. doi: 10.1186/s12885-016-2233-1.

48.

Genomic characterization of esophageal squamous cell carcinoma: Insights from next-generation sequencing.

Sasaki Y, Tamura M, Koyama R, Nakagaki T, Adachi Y, Tokino T.

World J Gastroenterol. 2016 Feb 21;22(7):2284-93. doi: 10.3748/wjg.v22.i7.2284. Review.

49.

Photoactivated adenylyl cyclase (PAC) reveals novel mechanisms underlying cAMP-dependent axonal morphogenesis.

Zhou Z, Tanaka KF, Matsunaga S, Iseki M, Watanabe M, Matsuki N, Ikegaya Y, Koyama R.

Sci Rep. 2016 Jan 22;5:19679. doi: 10.1038/srep19679.

50.

Experimental febrile seizures induce age-dependent structural plasticity and improve memory in mice.

Tao K, Ichikawa J, Matsuki N, Ikegaya Y, Koyama R.

Neuroscience. 2016 Mar 24;318:34-44. doi: 10.1016/j.neuroscience.2016.01.011. Epub 2016 Jan 12.

PMID:
26794590

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