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Items: 1 to 50 of 134

2.

Hypoxia attenuates inflammation-induced hepcidin production during experimental human endotoxaemia.

Kiers D, van Eijk LT, van der Hoeven JG, Swinkels DW, Pickkers P, Kox M.

Haematologica. 2019 Jan 17. pii: haematol.2018.202796. doi: 10.3324/haematol.2018.202796. [Epub ahead of print]

3.

Mitochondrial DNA: Innocent in Plasma, but Guilty in Urine?

Leijte GP, Pickkers P, Kox M.

Shock. 2019 Feb;51(2):266. doi: 10.1097/SHK.0000000000001142. No abstract available.

PMID:
30645206
4.

Treatment With Acetylsalicylic Acid Reverses Endotoxin Tolerance in Humans In Vivo: A Randomized Placebo-Controlled Study.

Leijte GP, Kiers D, van der Heijden W, Jansen A, Gerretsen J, Boerrigter V, Netea MG, Kox M, Pickkers P.

Crit Care Med. 2018 Dec 21. doi: 10.1097/CCM.0000000000003630. [Epub ahead of print]

PMID:
30585832
5.

The influence of hypoxia on platelet function and plasmatic coagulation during systemic inflammation in humans in vivo.

Kiers D, Tunjungputri RN, Borkus R, Scheffer GJ, de Groot PG, Urbanus RT, van der Ven AJ, Pickkers P, de Mast Q, Kox M.

Platelets. 2018 Dec 25:1-4. doi: 10.1080/09537104.2018.1557617. [Epub ahead of print]

PMID:
30584841
6.

New frontiers in precision medicine for sepsis-induced immunoparalysis.

Bruse N, Leijte GP, Pickkers P, Kox M.

Expert Rev Clin Immunol. 2019 Mar;15(3):251-263. doi: 10.1080/1744666X.2019.1562336. Epub 2019 Jan 7.

PMID:
30572728
7.

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity.

Domínguez-Andrés J, Novakovic B, Li Y, Scicluna BP, Gresnigt MS, Arts RJW, Oosting M, Moorlag SJCFM, Groh LA, Zwaag J, Koch RM, Ter Horst R, Joosten LAB, Wijmenga C, Michelucci A, van der Poll T, Kox M, Pickkers P, Kumar V, Stunnenberg H, Netea MG.

Cell Metab. 2019 Jan 8;29(1):211-220.e5. doi: 10.1016/j.cmet.2018.09.003. Epub 2018 Oct 4.

PMID:
30293776
8.

Precision Immunotherapy for Sepsis.

Peters van Ton AM, Kox M, Abdo WF, Pickkers P.

Front Immunol. 2018 Sep 5;9:1926. doi: 10.3389/fimmu.2018.01926. eCollection 2018. Review.

9.

Long-Term Effects of Experimental Human Endotoxemia on Immune Cell Function: Similarities and Differences with Sepsis.

Rodriguez-Rosales YA, Kox M, van Rijssen E, van Cranenbroek B, van Welie M, Pickkers P, Joosten I, Koenen H.

Shock. 2018 Aug 17. doi: 10.1097/SHK.0000000000001222. [Epub ahead of print]

PMID:
30124597
10.

Short-Term Hypoxia Dampens Inflammation in vivo via Enhanced Adenosine Release and Adenosine 2B Receptor Stimulation.

Kiers D, Wielockx B, Peters E, van Eijk LT, Gerretsen J, John A, Janssen E, Groeneveld R, Peters M, Damen L, Meneses AM, Krüger A, Langereis JD, Zomer AL, Blackburn MR, Joosten LA, Netea MG, Riksen NP, van der Hoeven JG, Scheffer GJ, Eltzschig HK, Pickkers P, Kox M.

EBioMedicine. 2018 Jul;33:144-156. doi: 10.1016/j.ebiom.2018.06.021. Epub 2018 Jul 4.

11.

Immunomodulatory and Kidney-Protective Effects of the Human Chorionic Gonadotropin Derivate EA-230.

van Groenendael R, Kox M, van Eijk LT, Pickkers P.

Nephron. 2018;140(2):148-151. doi: 10.1159/000490772. Epub 2018 Jul 6.

12.

The endotoxin-induced pulmonary inflammatory response is enhanced during the acute phase of influenza infection.

Koch RM, Diavatopoulos DA, Ferwerda G, Pickkers P, de Jonge MI, Kox M.

Intensive Care Med Exp. 2018 Jul 5;6(1):15. doi: 10.1186/s40635-018-0182-5.

13.

Differential antibacterial control by neutrophil subsets.

Leliefeld PHC, Pillay J, Vrisekoop N, Heeres M, Tak T, Kox M, Rooijakkers SHM, Kuijpers TW, Pickkers P, Leenen LPH, Koenderman L.

Blood Adv. 2018 Jun 12;2(11):1344-1355. doi: 10.1182/bloodadvances.2017015578.

14.

Safety, tolerability and pharmacokinetics/pharmacodynamics of the adrenomedullin antibody adrecizumab in a first-in-human study and during experimental human endotoxaemia in healthy subjects.

Geven C, van Lier D, Blet A, Peelen R, Ten Elzen B, Mebazaa A, Kox M, Pickkers P.

Br J Clin Pharmacol. 2018 Sep;84(9):2129-2141. doi: 10.1111/bcp.13655. Epub 2018 Jul 3.

PMID:
29856470
15.

Hemorrhagic Shock.

Timmermans K, Slagt C, Kox M.

N Engl J Med. 2018 May 10;378(19):1850-1. doi: 10.1056/NEJMc1802361. No abstract available.

PMID:
29745634
16.

Moderate correlation between systemic IL-6 responses and CRP with trough concentrations of voriconazole.

Vreugdenhil B, van der Velden WJFM, Feuth T, Kox M, Pickkers P, van de Veerdonk FL, Blijlevens NMA, Brüggemann RJM.

Br J Clin Pharmacol. 2018 Sep;84(9):1980-1988. doi: 10.1111/bcp.13627. Epub 2018 Jun 19.

17.

The influence of oxygen and methane on nitrogen fixation in subarctic Sphagnum mosses.

Kox MAR, Aalto SL, Penttilä T, Ettwig KF, Jetten MSM, van Kessel MAHJ.

AMB Express. 2018 May 5;8(1):76. doi: 10.1186/s13568-018-0607-2.

18.

Increased Plasma Levels of Danger-Associated Molecular Patterns Are Associated With Immune Suppression and Postoperative Infections in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.

Leijte GP, Custers H, Gerretsen J, Heijne A, Roth J, Vogl T, Scheffer GJ, Pickkers P, Kox M.

Front Immunol. 2018 Apr 5;9:663. doi: 10.3389/fimmu.2018.00663. eCollection 2018.

19.

Adrenomedullin and Adrenomedullin-Targeted Therapy As Treatment Strategies Relevant for Sepsis.

Geven C, Kox M, Pickkers P.

Front Immunol. 2018 Feb 19;9:292. doi: 10.3389/fimmu.2018.00292. eCollection 2018. Review.

20.

Short-term repeated HRV-16 exposure results in an attenuated immune response in vivo in humans.

Koch RM, Kox M, van den Kieboom C, Ferwerda G, Gerretsen J, Ten Bruggencate S, van der Hoeven JG, de Jonge MI, Pickkers P.

PLoS One. 2018 Feb 15;13(2):e0191937. doi: 10.1371/journal.pone.0191937. eCollection 2018.

21.

Effects of the Humanized Anti-Adrenomedullin Antibody Adrecizumab (HAM8101) on Vascular Barrier Function and Survival in Rodent Models of Systemic Inflammation and Sepsis.

Geven C, Peters E, Schroedter M, Struck J, Bergmann A, McCook O, Radermacher P, Kox M, Pickkers P.

Shock. 2018 Dec;50(6):648-654. doi: 10.1097/SHK.0000000000001102.

PMID:
29324627
22.

Vascular Effects of Adrenomedullin and the Anti-Adrenomedullin Antibody Adrecizumab in Sepsis.

Geven C, Bergmann A, Kox M, Pickkers P.

Shock. 2018 Aug;50(2):132-140. doi: 10.1097/SHK.0000000000001103.

PMID:
29324626
23.

Development of Endotoxin Tolerance Does Not Influence the Response to a Challenge with the Mucosal Live-Attenuated Influenza Vaccine in Humans In Vivo.

Koch RM, Kox M, Thijs EJM, Rahamat-Langendoen JC, van de Veerdonk FL, Gerretsen J, Schloesser J, Diavatopoulos D, Rimmelzwaan GF, Netea MG, van der Hoeven JG, de Jonge MI, Pickkers P.

Front Immunol. 2017 Dec 11;8:1600. doi: 10.3389/fimmu.2017.01600. eCollection 2017.

24.

Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion.

Lebrun LJ, Lenaerts K, Kiers D, Pais de Barros JP, Le Guern N, Plesnik J, Thomas C, Bourgeois T, Dejong CHC, Kox M, Hundscheid IHR, Khan NA, Mandard S, Deckert V, Pickkers P, Drucker DJ, Lagrost L, Grober J.

Cell Rep. 2017 Oct 31;21(5):1160-1168. doi: 10.1016/j.celrep.2017.10.008.

25.

Vasopressors Do Not Influence Cerebral Critical Closing Pressure During Systemic Inflammation Evoked by Experimental Endotoxemia and Sepsis in Humans.

van den Brule JMD, Stolk R, Vinke EJ, van Loon LM, Pickkers P, van der Hoeven JG, Kox M, Hoedemaekers CWE.

Shock. 2018 May;49(5):529-535. doi: 10.1097/SHK.0000000000001003.

PMID:
28991047
26.

Spleen-derived IFN-γ induces generation of PD-L1+-suppressive neutrophils during endotoxemia.

Langereis JD, Pickkers P, de Kleijn S, Gerretsen J, de Jonge MI, Kox M.

J Leukoc Biol. 2017 Dec;102(6):1401-1409. doi: 10.1189/jlb.3A0217-051RR. Epub 2017 Oct 3.

PMID:
28974543
27.

Norepinephrine Contributes to Enterocyte Damage in Septic Shock Patients: A Prospective Cohort Study.

Habes QLM, van Ede L, Gerretsen J, Kox M, Pickkers P.

Shock. 2018 Feb;49(2):137-143. doi: 10.1097/SHK.0000000000000955.

PMID:
28786832
28.

Ethylene, an early marker of systemic inflammation in humans.

Paardekooper LM, van den Bogaart G, Kox M, Dingjan I, Neerincx AH, Bendix MB, Beest MT, Harren FJM, Risby T, Pickkers P, Marczin N, Cristescu SM.

Sci Rep. 2017 Jul 31;7(1):6889. doi: 10.1038/s41598-017-05930-9.

29.

Release of Danger-Associated Molecular Patterns following Chemotherapy Does Not Induce Immunoparalysis in Leukemia Patients.

Timmermans K, Leijte GP, Kox M, Scheffer GJ, Blijlevens NMA, Pickkers PP.

Acta Haematol. 2017;138(1):39-43. doi: 10.1159/000477530. Epub 2017 Jul 20.

PMID:
28723682
30.

A randomised trial on the effect of anti-platelet therapy on the systemic inflammatory response in human endotoxaemia.

Kiers D, van der Heijden WA, van Ede L, Gerretsen J, de Mast Q, van der Ven AJ, El Messaoudi S, Rongen GA, Gomes M, Kox M, Pickkers P, Riksen NP.

Thromb Haemost. 2017 Aug 30;117(9):1798-1807. doi: 10.1160/TH16-10-0799. Epub 2017 Jul 6.

PMID:
28692111
31.

LPS-Induced ex vivo Cytokine Production is Not Augmented in Patients with Von Hippel-Lindau Disease.

Kiers D, Timmers HJLM, Gerretsen J, Pickkers P, Kox M.

Scand J Immunol. 2017 Sep;86(3):179-180. doi: 10.1111/sji.12578. No abstract available.

32.

Reduced glial activity after surgery: A sign of immunoparalysis of the brain?

Peters van Ton AM, Kox M, Pickkers P, Abdo WF.

Ann Neurol. 2017 Jul;82(1):152. doi: 10.1002/ana.24966. No abstract available.

PMID:
28556092
33.

Markers of Intestinal Damage and their Relation to Cytokine Levels in Cardiac Surgery Patients.

Habes QLM, Linssen V, Nooijen S, Kiers D, Gerretsen J, Pickkers P, Scheffer GJ, Kox M.

Shock. 2017 Jun;47(6):709-714. doi: 10.1097/SHK.0000000000000803.

PMID:
28505628
34.

Leukocyte phosphodiesterase expression after lipopolysaccharide and during sepsis and its relationship with HLA-DR expression.

Lelubre C, Medfai H, Akl I, Leentjens J, Kox M, Pickkers P, Rousseau A, Biston P, Piagnerelli M, Vanhaeverbeek M, Uzureau P, Vincent JL, Vanhamme L, Boudjeltia KZ.

J Leukoc Biol. 2017 Jun;101(6):1419-1426. doi: 10.1189/jlb.5A0516-240R. Epub 2017 Mar 29.

PMID:
28356347
35.

Adjuvant interferon-gamma immunotherapy in a patient with progressive cerebral Nocardia abscesses.

Leentjens J, Gresnigt MS, van de Veerdonk FL, Kox M, Kullberg BJ, Pickkers P, Brouwer AE, Netea MG.

Int J Infect Dis. 2017 Jun;59:25-28. doi: 10.1016/j.ijid.2017.03.013. Epub 2017 Mar 22.

36.

Crew Resource Management in the trauma room: a prospective 3-year cohort study.

Haerkens MHTM, Kox M, Noe PM, Van Der Hoeven JG, Pickkers P.

Eur J Emerg Med. 2018 Aug;25(4):281-287. doi: 10.1097/MEJ.0000000000000458.

PMID:
28328728
37.

Mitochondrial DNA and TLR9 Signaling Is Not Involved in Mechanical Ventilation-Induced Inflammation.

Timmermans K, Kox M, Vaneker M, Pickkers P, Scheffer GJ.

Anesth Analg. 2017 Feb;124(2):531-534. doi: 10.1213/ANE.0000000000001554.

PMID:
28099322
38.

Towards precision medicine for sepsis patients.

Pickkers P, Kox M.

Crit Care. 2017 Jan 12;21(1):11. doi: 10.1186/s13054-016-1583-z. No abstract available.

39.

Characterization of a model of systemic inflammation in humans in vivo elicited by continuous infusion of endotoxin.

Kiers D, Koch RM, Hamers L, Gerretsen J, Thijs EJ, van Ede L, Riksen NP, Kox M, Pickkers P.

Sci Rep. 2017 Jan 5;7:40149. doi: 10.1038/srep40149.

40.

β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance.

Novakovic B, Habibi E, Wang SY, Arts RJW, Davar R, Megchelenbrink W, Kim B, Kuznetsova T, Kox M, Zwaag J, Matarese F, van Heeringen SJ, Janssen-Megens EM, Sharifi N, Wang C, Keramati F, Schoonenberg V, Flicek P, Clarke L, Pickkers P, Heath S, Gut I, Netea MG, Martens JHA, Logie C, Stunnenberg HG.

Cell. 2016 Nov 17;167(5):1354-1368.e14. doi: 10.1016/j.cell.2016.09.034.

41.

Increased risk for secondary infections in trauma patients with viral reactivation.

Koch RM, Kox M, Rahamat-Langendoen JC, Timmermans K, van der Hoeven JG, Pickkers P.

Intensive Care Med. 2016 Nov;42(11):1828-1829. Epub 2016 Aug 8. No abstract available.

PMID:
27502508
42.

Preoperative use of anxiolytic-sedative agents; are we on the right track?

Bucx MJ, Krijtenburg P, Kox M.

J Clin Anesth. 2016 Sep;33:135-40. doi: 10.1016/j.jclinane.2016.03.025. Epub 2016 Apr 29.

PMID:
27555147
43.

Patterns in Bacterial- and Viral-Induced Immunosuppression and Secondary Infections in the ICU.

Koch RM, Kox M, de Jonge MI, van der Hoeven JG, Ferwerda G, Pickkers P.

Shock. 2017 Jan;47(1):5-12. Review.

PMID:
27517143
44.

Potentially Inadvertent Immunomodulation: Norepinephrine Use in Sepsis.

Stolk RF, van der Poll T, Angus DC, van der Hoeven JG, Pickkers P, Kox M.

Am J Respir Crit Care Med. 2016 Sep 1;194(5):550-8. doi: 10.1164/rccm.201604-0862CP.

PMID:
27398737
45.

Effects of serostatus and gender on the HRV-16-induced local immune response.

Koch RM, Kox M, Pickkers P, de Jonge MI; Radboudumc Immunoforce group.

Vaccine. 2016 Jul 29;34(35):4087-4091. doi: 10.1016/j.vaccine.2016.06.076. Epub 2016 Jul 4.

PMID:
27389172
46.

Immunologic Consequences of Hypoxia during Critical Illness.

Kiers HD, Scheffer GJ, van der Hoeven JG, Eltzschig HK, Pickkers P, Kox M.

Anesthesiology. 2016 Jul;125(1):237-49. doi: 10.1097/ALN.0000000000001163.

47.

Metagenomic analysis of nitrogen and methane cycling in the Arabian Sea oxygen minimum zone.

Lüke C, Speth DR, Kox MAR, Villanueva L, Jetten MSM.

PeerJ. 2016 Apr 7;4:e1924. doi: 10.7717/peerj.1924. eCollection 2016.

48.

Aspirin may improve outcome in sepsis by augmentation of the inflammatory response.

Kiers HD, Kox M, van der Heijden WA, Riksen NP, Pickkers P.

Intensive Care Med. 2016 Jun;42(6):1096. doi: 10.1007/s00134-016-4264-0. Epub 2016 Apr 4. No abstract available.

PMID:
27043236
49.

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis.

Cheng SC, Scicluna BP, Arts RJ, Gresnigt MS, Lachmandas E, Giamarellos-Bourboulis EJ, Kox M, Manjeri GR, Wagenaars JA, Cremer OL, Leentjens J, van der Meer AJ, van de Veerdonk FL, Bonten MJ, Schultz MJ, Willems PH, Pickkers P, Joosten LA, van der Poll T, Netea MG.

Nat Immunol. 2016 Apr;17(4):406-13. doi: 10.1038/ni.3398. Epub 2016 Mar 7.

PMID:
26950237
50.

Plasma levels of danger-associated molecular patterns are associated with immune suppression in trauma patients.

Timmermans K, Kox M, Vaneker M, van den Berg M, John A, van Laarhoven A, van der Hoeven H, Scheffer GJ, Pickkers P.

Intensive Care Med. 2016 Apr;42(4):551-561. doi: 10.1007/s00134-015-4205-3. Epub 2016 Feb 24.

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