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Items: 1 to 50 of 146

1.

Endotoxin-induced immunotolerance is associated with loss of monocyte metabolic plasticity and reduction of oxidative burst.

Grondman I, Arts RJW, Koch RM, Leijte GP, Gerretsen J, Bruse N, Kempkes RWM, Ter Horst R, Kox M, Pickkers P, Netea MG, Gresnigt MS.

J Leukoc Biol. 2019 Jun 6. doi: 10.1002/JLB.5HI0119-018R. [Epub ahead of print]

PMID:
31169935
2.

Methylotetracoccus oryzae Strain C50C1 Is a Novel Type Ib Gammaproteobacterial Methanotroph Adapted to Freshwater Environments.

Ghashghavi M, Belova SE, Bodelier PLE, Dedysh SN, Kox MAR, Speth DR, Frenzel P, Jetten MSM, Lücker S, Lüke C.

mSphere. 2019 Jun 5;4(3). pii: e00631-18. doi: 10.1128/mSphere.00631-18.

3.

Characterization of the phenotype of human eosinophils and their progenitors in the bone marrow of healthy individuals.

Hassani M, van Staveren S, van Grinsven E, Bartels M, Tesselaar K, Leijte G, Kox M, Pickkers P, Vrisekoop N, Koenderman L.

Haematologica. 2019 May 17. pii: haematol.2019.219048. doi: 10.3324/haematol.2019.219048. [Epub ahead of print]

4.

Complete Genome Sequence of the Aerobic Facultative Methanotroph Methylocella tundrae Strain T4.

Kox MAR, Farhan Ul Haque M, van Alen TA, Crombie AT, Jetten MSM, Op den Camp HJM, Dedysh SN, van Kessel MAHJ, Murrell JC.

Microbiol Resour Announc. 2019 May 16;8(20). pii: e00286-19. doi: 10.1128/MRA.00286-19.

5.

Remote ischaemic preconditioning does not modulate the systemic inflammatory response or renal tubular stress biomarkers after endotoxaemia in healthy human volunteers: a single-centre, mechanistic, randomised controlled trial.

Zwaag J, Beunders R, Warlé MC, Kellum JA, Riksen NP, Pickkers P, Kox M.

Br J Anaesth. 2019 May 10. pii: S0007-0912(19)30242-9. doi: 10.1016/j.bja.2019.03.037. [Epub ahead of print]

PMID:
31084985
6.

Effect of Vasopressors on The Macro- and Microcirculation During Systemic Inflammation In Humans in vivo.

van Loon LM, Stolk RF, van der Hoeven JG, Veltink PH, Pickkers P, Lemson J, Kox M.

Shock. 2019 Apr 16. doi: 10.1097/SHK.0000000000001357. [Epub ahead of print]

PMID:
31008870
7.

Pharmacokinetics, safety and tolerability of the novel β-hCG derived immunomodulatory compound, EA-230.

van Groenendael R, Aarnoutse R, Kox M, van Eijk L, Pickkers P.

Br J Clin Pharmacol. 2019 Mar 29. doi: 10.1111/bcp.13942. [Epub ahead of print]

PMID:
30924163
8.

A randomized double-blind, placebo-controlled clinical phase IIa trial on safety, immunomodulatory effects and pharmacokinetics of EA-230 during experimental human endotoxaemia.

van Groenendael R, Kox M, Leijte G, Koeneman B, Gerretsen J, van Eijk L, Pickkers P.

Br J Clin Pharmacol. 2019 Mar 28. doi: 10.1111/bcp.13941. [Epub ahead of print]

PMID:
30919998
9.

Fever in Sepsis: Still a Hot Topic.

Leijte GP, Kox M, Pickkers P.

Am J Respir Crit Care Med. 2019 Mar 25. doi: 10.1164/rccm.201903-0484LE. [Epub ahead of print] No abstract available.

PMID:
30908926
10.

Preclinical safety evaluation of the adrenomedullin-binding antibody Adrecizumab in rodents, dogs and non-human primates.

Geven C, Kox M, Blet A, Mebazaa A, Schroedter M, Struck J, Bergmann A, Pickkers P.

Toxicol Appl Pharmacol. 2019 Apr 15;369:1-16. doi: 10.1016/j.taap.2019.02.014. Epub 2019 Feb 27.

PMID:
30822437
11.
12.

Comparison of different lots of endotoxin and evaluation of in vivo potency over time in the experimental human endotoxemia model.

Kiers D, Leijte GP, Gerretsen J, Zwaag J, Kox M, Pickkers P.

Innate Immun. 2019 Jan;25(1):34-45. doi: 10.1177/1753425918819754.

PMID:
30782041
14.

Hypoxia attenuates inflammation-induced hepcidin synthesis during experimental human endotoxemia.

Kiers D, van Eijk LT, van der Hoeven JG, Swinkels DW, Pickkers P, Kox M.

Haematologica. 2019 Jun;104(6):e230-e232. doi: 10.3324/haematol.2018.202796. Epub 2019 Jan 17. No abstract available.

15.

Mitochondrial DNA: Innocent in Plasma, but Guilty in Urine?

Leijte GP, Pickkers P, Kox M.

Shock. 2019 Feb;51(2):266. doi: 10.1097/SHK.0000000000001142. No abstract available.

PMID:
30645206
16.

Treatment With Acetylsalicylic Acid Reverses Endotoxin Tolerance in Humans In Vivo: A Randomized Placebo-Controlled Study.

Leijte GP, Kiers D, van der Heijden W, Jansen A, Gerretsen J, Boerrigter V, Netea MG, Kox M, Pickkers P.

Crit Care Med. 2019 Apr;47(4):508-516. doi: 10.1097/CCM.0000000000003630.

17.

The influence of hypoxia on platelet function and plasmatic coagulation during systemic inflammation in humans in vivo.

Kiers D, Tunjungputri RN, Borkus R, Scheffer GJ, de Groot PG, Urbanus RT, van der Ven AJ, Pickkers P, de Mast Q, Kox M.

Platelets. 2018 Dec 25:1-4. doi: 10.1080/09537104.2018.1557617. [Epub ahead of print]

PMID:
30584841
18.

New frontiers in precision medicine for sepsis-induced immunoparalysis.

Bruse N, Leijte GP, Pickkers P, Kox M.

Expert Rev Clin Immunol. 2019 Mar;15(3):251-263. doi: 10.1080/1744666X.2019.1562336. Epub 2019 Jan 7.

PMID:
30572728
19.

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity.

Domínguez-Andrés J, Novakovic B, Li Y, Scicluna BP, Gresnigt MS, Arts RJW, Oosting M, Moorlag SJCFM, Groh LA, Zwaag J, Koch RM, Ter Horst R, Joosten LAB, Wijmenga C, Michelucci A, van der Poll T, Kox M, Pickkers P, Kumar V, Stunnenberg H, Netea MG.

Cell Metab. 2019 Jan 8;29(1):211-220.e5. doi: 10.1016/j.cmet.2018.09.003. Epub 2018 Oct 4.

PMID:
30293776
20.

Precision Immunotherapy for Sepsis.

Peters van Ton AM, Kox M, Abdo WF, Pickkers P.

Front Immunol. 2018 Sep 5;9:1926. doi: 10.3389/fimmu.2018.01926. eCollection 2018. Review.

21.

Long-Term Effects of Experimental Human Endotoxemia on Immune Cell Function: Similarities and Differences With Sepsis.

Rodriguez-Rosales YA, Kox M, van Rijssen E, van Cranenbroek B, van Welie M, Pickkers P, Joosten I, Koenen HJPM.

Shock. 2019 Jun;51(6):678-689. doi: 10.1097/SHK.0000000000001222.

PMID:
30124597
22.

Short-Term Hypoxia Dampens Inflammation in vivo via Enhanced Adenosine Release and Adenosine 2B Receptor Stimulation.

Kiers D, Wielockx B, Peters E, van Eijk LT, Gerretsen J, John A, Janssen E, Groeneveld R, Peters M, Damen L, Meneses AM, Krüger A, Langereis JD, Zomer AL, Blackburn MR, Joosten LA, Netea MG, Riksen NP, van der Hoeven JG, Scheffer GJ, Eltzschig HK, Pickkers P, Kox M.

EBioMedicine. 2018 Jul;33:144-156. doi: 10.1016/j.ebiom.2018.06.021. Epub 2018 Jul 4.

23.

Immunomodulatory and Kidney-Protective Effects of the Human Chorionic Gonadotropin Derivate EA-230.

van Groenendael R, Kox M, van Eijk LT, Pickkers P.

Nephron. 2018;140(2):148-151. doi: 10.1159/000490772. Epub 2018 Jul 6.

24.

The endotoxin-induced pulmonary inflammatory response is enhanced during the acute phase of influenza infection.

Koch RM, Diavatopoulos DA, Ferwerda G, Pickkers P, de Jonge MI, Kox M.

Intensive Care Med Exp. 2018 Jul 5;6(1):15. doi: 10.1186/s40635-018-0182-5.

25.

Differential antibacterial control by neutrophil subsets.

Leliefeld PHC, Pillay J, Vrisekoop N, Heeres M, Tak T, Kox M, Rooijakkers SHM, Kuijpers TW, Pickkers P, Leenen LPH, Koenderman L.

Blood Adv. 2018 Jun 12;2(11):1344-1355. doi: 10.1182/bloodadvances.2017015578.

26.

Safety, tolerability and pharmacokinetics/pharmacodynamics of the adrenomedullin antibody adrecizumab in a first-in-human study and during experimental human endotoxaemia in healthy subjects.

Geven C, van Lier D, Blet A, Peelen R, Ten Elzen B, Mebazaa A, Kox M, Pickkers P.

Br J Clin Pharmacol. 2018 Sep;84(9):2129-2141. doi: 10.1111/bcp.13655. Epub 2018 Jul 3.

PMID:
29856470
27.

Hemorrhagic Shock.

Timmermans K, Slagt C, Kox M.

N Engl J Med. 2018 May 10;378(19):1850-1. doi: 10.1056/NEJMc1802361. No abstract available.

PMID:
29745634
28.

Moderate correlation between systemic IL-6 responses and CRP with trough concentrations of voriconazole.

Vreugdenhil B, van der Velden WJFM, Feuth T, Kox M, Pickkers P, van de Veerdonk FL, Blijlevens NMA, Brüggemann RJM.

Br J Clin Pharmacol. 2018 Sep;84(9):1980-1988. doi: 10.1111/bcp.13627. Epub 2018 Jun 19.

29.

The influence of oxygen and methane on nitrogen fixation in subarctic Sphagnum mosses.

Kox MAR, Aalto SL, Penttilä T, Ettwig KF, Jetten MSM, van Kessel MAHJ.

AMB Express. 2018 May 5;8(1):76. doi: 10.1186/s13568-018-0607-2.

30.

Increased Plasma Levels of Danger-Associated Molecular Patterns Are Associated With Immune Suppression and Postoperative Infections in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.

Leijte GP, Custers H, Gerretsen J, Heijne A, Roth J, Vogl T, Scheffer GJ, Pickkers P, Kox M.

Front Immunol. 2018 Apr 5;9:663. doi: 10.3389/fimmu.2018.00663. eCollection 2018.

31.

Adrenomedullin and Adrenomedullin-Targeted Therapy As Treatment Strategies Relevant for Sepsis.

Geven C, Kox M, Pickkers P.

Front Immunol. 2018 Feb 19;9:292. doi: 10.3389/fimmu.2018.00292. eCollection 2018. Review.

32.

Short-term repeated HRV-16 exposure results in an attenuated immune response in vivo in humans.

Koch RM, Kox M, van den Kieboom C, Ferwerda G, Gerretsen J, Ten Bruggencate S, van der Hoeven JG, de Jonge MI, Pickkers P.

PLoS One. 2018 Feb 15;13(2):e0191937. doi: 10.1371/journal.pone.0191937. eCollection 2018.

33.

Effects of the Humanized Anti-Adrenomedullin Antibody Adrecizumab (HAM8101) on Vascular Barrier Function and Survival in Rodent Models of Systemic Inflammation and Sepsis.

Geven C, Peters E, Schroedter M, Struck J, Bergmann A, McCook O, Radermacher P, Kox M, Pickkers P.

Shock. 2018 Dec;50(6):648-654. doi: 10.1097/SHK.0000000000001102.

PMID:
29324627
34.

Vascular Effects of Adrenomedullin and the Anti-Adrenomedullin Antibody Adrecizumab in Sepsis.

Geven C, Bergmann A, Kox M, Pickkers P.

Shock. 2018 Aug;50(2):132-140. doi: 10.1097/SHK.0000000000001103.

PMID:
29324626
35.

Development of Endotoxin Tolerance Does Not Influence the Response to a Challenge with the Mucosal Live-Attenuated Influenza Vaccine in Humans In Vivo.

Koch RM, Kox M, Thijs EJM, Rahamat-Langendoen JC, van de Veerdonk FL, Gerretsen J, Schloesser J, Diavatopoulos D, Rimmelzwaan GF, Netea MG, van der Hoeven JG, de Jonge MI, Pickkers P.

Front Immunol. 2017 Dec 11;8:1600. doi: 10.3389/fimmu.2017.01600. eCollection 2017.

36.

Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion.

Lebrun LJ, Lenaerts K, Kiers D, Pais de Barros JP, Le Guern N, Plesnik J, Thomas C, Bourgeois T, Dejong CHC, Kox M, Hundscheid IHR, Khan NA, Mandard S, Deckert V, Pickkers P, Drucker DJ, Lagrost L, Grober J.

Cell Rep. 2017 Oct 31;21(5):1160-1168. doi: 10.1016/j.celrep.2017.10.008.

37.

Vasopressors Do Not Influence Cerebral Critical Closing Pressure During Systemic Inflammation Evoked by Experimental Endotoxemia and Sepsis in Humans.

van den Brule JMD, Stolk R, Vinke EJ, van Loon LM, Pickkers P, van der Hoeven JG, Kox M, Hoedemaekers CWE.

Shock. 2018 May;49(5):529-535. doi: 10.1097/SHK.0000000000001003.

PMID:
28991047
38.

Spleen-derived IFN-γ induces generation of PD-L1+-suppressive neutrophils during endotoxemia.

Langereis JD, Pickkers P, de Kleijn S, Gerretsen J, de Jonge MI, Kox M.

J Leukoc Biol. 2017 Dec;102(6):1401-1409. doi: 10.1189/jlb.3A0217-051RR. Epub 2017 Oct 3.

PMID:
28974543
39.

Norepinephrine Contributes to Enterocyte Damage in Septic Shock Patients: A Prospective Cohort Study.

Habes QLM, van Ede L, Gerretsen J, Kox M, Pickkers P.

Shock. 2018 Feb;49(2):137-143. doi: 10.1097/SHK.0000000000000955.

PMID:
28786832
40.

Ethylene, an early marker of systemic inflammation in humans.

Paardekooper LM, van den Bogaart G, Kox M, Dingjan I, Neerincx AH, Bendix MB, Beest MT, Harren FJM, Risby T, Pickkers P, Marczin N, Cristescu SM.

Sci Rep. 2017 Jul 31;7(1):6889. doi: 10.1038/s41598-017-05930-9.

41.

Release of Danger-Associated Molecular Patterns following Chemotherapy Does Not Induce Immunoparalysis in Leukemia Patients.

Timmermans K, Leijte GP, Kox M, Scheffer GJ, Blijlevens NMA, Pickkers PP.

Acta Haematol. 2017;138(1):39-43. doi: 10.1159/000477530. Epub 2017 Jul 20.

PMID:
28723682
42.

A randomised trial on the effect of anti-platelet therapy on the systemic inflammatory response in human endotoxaemia.

Kiers D, van der Heijden WA, van Ede L, Gerretsen J, de Mast Q, van der Ven AJ, El Messaoudi S, Rongen GA, Gomes M, Kox M, Pickkers P, Riksen NP.

Thromb Haemost. 2017 Aug 30;117(9):1798-1807. doi: 10.1160/TH16-10-0799. Epub 2017 Jul 6.

PMID:
28692111
43.

LPS-Induced ex vivo Cytokine Production is Not Augmented in Patients with Von Hippel-Lindau Disease.

Kiers D, Timmers HJLM, Gerretsen J, Pickkers P, Kox M.

Scand J Immunol. 2017 Sep;86(3):179-180. doi: 10.1111/sji.12578. No abstract available.

44.

Reduced glial activity after surgery: A sign of immunoparalysis of the brain?

Peters van Ton AM, Kox M, Pickkers P, Abdo WF.

Ann Neurol. 2017 Jul;82(1):152. doi: 10.1002/ana.24966. No abstract available.

PMID:
28556092
45.

Markers of Intestinal Damage and their Relation to Cytokine Levels in Cardiac Surgery Patients.

Habes QLM, Linssen V, Nooijen S, Kiers D, Gerretsen J, Pickkers P, Scheffer GJ, Kox M.

Shock. 2017 Jun;47(6):709-714. doi: 10.1097/SHK.0000000000000803.

PMID:
28505628
46.

Leukocyte phosphodiesterase expression after lipopolysaccharide and during sepsis and its relationship with HLA-DR expression.

Lelubre C, Medfai H, Akl I, Leentjens J, Kox M, Pickkers P, Rousseau A, Biston P, Piagnerelli M, Vanhaeverbeek M, Uzureau P, Vincent JL, Vanhamme L, Boudjeltia KZ.

J Leukoc Biol. 2017 Jun;101(6):1419-1426. doi: 10.1189/jlb.5A0516-240R. Epub 2017 Mar 29.

PMID:
28356347
47.

Adjuvant interferon-gamma immunotherapy in a patient with progressive cerebral Nocardia abscesses.

Leentjens J, Gresnigt MS, van de Veerdonk FL, Kox M, Kullberg BJ, Pickkers P, Brouwer AE, Netea MG.

Int J Infect Dis. 2017 Jun;59:25-28. doi: 10.1016/j.ijid.2017.03.013. Epub 2017 Mar 22.

48.

Crew Resource Management in the trauma room: a prospective 3-year cohort study.

Haerkens MHTM, Kox M, Noe PM, Van Der Hoeven JG, Pickkers P.

Eur J Emerg Med. 2018 Aug;25(4):281-287. doi: 10.1097/MEJ.0000000000000458.

PMID:
28328728
49.

Mitochondrial DNA and TLR9 Signaling Is Not Involved in Mechanical Ventilation-Induced Inflammation.

Timmermans K, Kox M, Vaneker M, Pickkers P, Scheffer GJ.

Anesth Analg. 2017 Feb;124(2):531-534. doi: 10.1213/ANE.0000000000001554.

PMID:
28099322
50.

Towards precision medicine for sepsis patients.

Pickkers P, Kox M.

Crit Care. 2017 Jan 12;21(1):11. doi: 10.1186/s13054-016-1583-z. No abstract available.

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