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Items: 26


Attenuation of hedgehog/GLI signaling by NT1721 extends survival in pancreatic cancer.

Kowolik CM, Lin M, Xie J, Overman LE, Horne DA.

J Exp Clin Cancer Res. 2019 Oct 28;38(1):431. doi: 10.1186/s13046-019-1445-z.


SMC1A is associated with radioresistance in prostate cancer and acts by regulating epithelial-mesenchymal transition and cancer stem-like properties.

Yadav S, Kowolik CM, Lin M, Zuro D, Hui SK, Riggs AD, Horne DA.

Mol Carcinog. 2019 Jan;58(1):113-125. doi: 10.1002/mc.22913. Epub 2018 Oct 5.


Inhibition of GLO1 in Glioblastoma Multiforme Increases DNA-AGEs, Stimulates RAGE Expression, and Inhibits Brain Tumor Growth in Orthotopic Mouse Models.

Jandial R, Neman J, Lim PP, Tamae D, Kowolik CM, Wuenschell GE, Shuck SC, Ciminera AK, De Jesus LR, Ouyang C, Chen MY, Termini J.

Int J Mol Sci. 2018 Jan 30;19(2). pii: E406. doi: 10.3390/ijms19020406.


NT1721, a novel epidithiodiketopiperazine, exhibits potent in vitro and in vivo efficacy against acute myeloid leukemia.

Kowolik CM, Lin M, Xie J, Overman LE, Horne DA.

Oncotarget. 2016 Dec 27;7(52):86186-86197. doi: 10.18632/oncotarget.13364.


TLR9 signaling through NF-κB/RELA and STAT3 promotes tumor-propagating potential of prostate cancer cells.

Moreira D, Zhang Q, Hossain DM, Nechaev S, Li H, Kowolik CM, D'Apuzzo M, Forman S, Jones J, Pal SK, Kortylewski M.

Oncotarget. 2015 Jul 10;6(19):17302-13.


Baicalein upregulates DDIT4 expression which mediates mTOR inhibition and growth inhibition in cancer cells.

Wang Y, Han E, Xing Q, Yan J, Arrington A, Wang C, Tully D, Kowolik CM, Lu DM, Frankel PH, Zhai J, Wen W, Horne D, Yip MLR, Yim JH.

Cancer Lett. 2015 Mar 28;358(2):170-179. doi: 10.1016/j.canlet.2014.12.033. Epub 2014 Dec 25.


Targeting JAK1/STAT3 signaling suppresses tumor progression and metastasis in a peritoneal model of human ovarian cancer.

Wen W, Liang W, Wu J, Kowolik CM, Buettner R, Scuto A, Hsieh MY, Hong H, Brown CE, Forman SJ, Horne D, Morgan R, Wakabayashi M, Dellinger TH, Han ES, Yim JH, Jove R.

Mol Cancer Ther. 2014 Dec;13(12):3037-48. doi: 10.1158/1535-7163.MCT-14-0077. Epub 2014 Oct 15.


Human breast cancer metastases to the brain display GABAergic properties in the neural niche.

Neman J, Termini J, Wilczynski S, Vaidehi N, Choy C, Kowolik CM, Li H, Hambrecht AC, Roberts E, Jandial R.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):984-9. doi: 10.1073/pnas.1322098111. Epub 2014 Jan 6.


TLR9 signaling in the tumor microenvironment initiates cancer recurrence after radiotherapy.

Gao C, Kozlowska A, Nechaev S, Li H, Zhang Q, Hossain DM, Kowolik CM, Chu P, Swiderski P, Diamond DJ, Pal SK, Raubitschek A, Kortylewski M.

Cancer Res. 2013 Dec 15;73(24):7211-21. doi: 10.1158/0008-5472.CAN-13-1314. Epub 2013 Oct 23.


Intracellular processing of immunostimulatory CpG-siRNA: Toll-like receptor 9 facilitates siRNA dicing and endosomal escape.

Nechaev S, Gao C, Moreira D, Swiderski P, Jozwiak A, Kowolik CM, Zhou J, Armstrong B, Raubitschek A, Rossi JJ, Kortylewski M.

J Control Release. 2013 Sep 28;170(3):307-15. doi: 10.1016/j.jconrel.2013.06.007. Epub 2013 Jun 15.


Co-evolution of breast-to-brain metastasis and neural progenitor cells.

Neman J, Choy C, Kowolik CM, Anderson A, Duenas VJ, Waliany S, Chen BT, Chen MY, Jandial R.

Clin Exp Metastasis. 2013 Aug;30(6):753-68. doi: 10.1007/s10585-013-9576-7. Epub 2013 Feb 28.


TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells in vivo.

Zhang Q, Hossain DM, Nechaev S, Kozlowska A, Zhang W, Liu Y, Kowolik CM, Swiderski P, Rossi JJ, Forman S, Pal S, Bhatia R, Raubitschek A, Yu H, Kortylewski M.

Blood. 2013 Feb 21;121(8):1304-15. doi: 10.1182/blood-2012-07-442590. Epub 2013 Jan 3.


Identification of a natural compound by cell-based screening that enhances interferon regulatory factor-1 activity and causes tumor suppression.

Gao J, Wang Y, Xing Q, Yan J, Senthil M, Akmal Y, Kowolik CM, Kang J, Lu DM, Zhao M, Lin Z, Cheng CH, Yip ML, Yim JH.

Mol Cancer Ther. 2011 Oct;10(10):1774-83. doi: 10.1158/1535-7163.MCT-11-0304. Epub 2011 Aug 4.


Humanized Lewis-Y specific antibody based delivery of STAT3 siRNA.

Ma Y, Kowolik CM, Swiderski PM, Kortylewski M, Yu H, Horne DA, Jove R, Caballero OL, Simpson AJ, Lee FT, Pillay V, Scott AM.

ACS Chem Biol. 2011 Sep 16;6(9):962-70. doi: 10.1021/cb200176v. Epub 2011 Jul 26.


Differential expression patterns of capping protein, protein phosphatase 1, and casein kinase 1 may serve as diagnostic markers for malignant melanoma.

Sun D, Zhou M, Kowolik CM, Trisal V, Huang Q, Kernstine KH, Lian F, Shen B.

Melanoma Res. 2011 Aug;21(4):335-43. doi: 10.1097/CMR.0b013e328346b715.


Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels.

Kretzner L, Scuto A, Dino PM, Kowolik CM, Wu J, Ventura P, Jove R, Forman SJ, Yen Y, Kirschbaum MH.

Cancer Res. 2011 Jun 1;71(11):3912-20. doi: 10.1158/0008-5472.CAN-10-2259. Epub 2011 Apr 18.


The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors.

Hedvat M, Huszar D, Herrmann A, Gozgit JM, Schroeder A, Sheehy A, Buettner R, Proia D, Kowolik CM, Xin H, Armstrong B, Bebernitz G, Weng S, Wang L, Ye M, McEachern K, Chen H, Morosini D, Bell K, Alimzhanov M, Ioannidis S, McCoon P, Cao ZA, Yu H, Jove R, Zinda M.

Cancer Cell. 2009 Dec 8;16(6):487-97. doi: 10.1016/j.ccr.2009.10.015.


Sorafenib inhibits signal transducer and activator of transcription 3 signaling associated with growth arrest and apoptosis of medulloblastomas.

Yang F, Van Meter TE, Buettner R, Hedvat M, Liang W, Kowolik CM, Mepani N, Mirosevich J, Nam S, Chen MY, Tye G, Kirschbaum M, Jove R.

Mol Cancer Ther. 2008 Nov;7(11):3519-26. doi: 10.1158/1535-7163.MCT-08-0138.


CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells.

Kowolik CM, Topp MS, Gonzalez S, Pfeiffer T, Olivares S, Gonzalez N, Smith DD, Forman SJ, Jensen MC, Cooper LJ.

Cancer Res. 2006 Nov 15;66(22):10995-1004.


Characterization of an artificial antigen-presenting cell to propagate cytolytic CD19-specific T cells.

Numbenjapon T, Serrano LM, Singh H, Kowolik CM, Olivares S, Gonzalez N, Chang WC, Forman SJ, Jensen MC, Cooper LJ.

Leukemia. 2006 Oct;20(10):1889-92. No abstract available.


Cre-mediated reversible immortalization of human renal proximal tubular epithelial cells.

Kowolik CM, Liang S, Yu Y, Yee JK.

Oncogene. 2004 Aug 5;23(35):5950-7.


HIV vector production mediated by Rev protein transduction.

Kowolik CM, Yam P, Yu Y, Yee JK.

Mol Ther. 2003 Aug;8(2):324-31.


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