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Items: 45


Attenuation of hedgehog/GLI signaling by NT1721 extends survival in pancreatic cancer.

Kowolik CM, Lin M, Xie J, Overman LE, Horne DA.

J Exp Clin Cancer Res. 2019 Oct 28;38(1):431. doi: 10.1186/s13046-019-1445-z.


TRAF6 mediates human DNA2 polyubiquitination and nuclear localization to maintain nuclear genome integrity.

Meng Y, Liu C, Shen L, Zhou M, Liu W, Kowolik C, Campbell JL, Zheng L, Shen B.

Nucleic Acids Res. 2019 Aug 22;47(14):7564-7579. doi: 10.1093/nar/gkz537.


8-chloro-adenosine activity in FLT3-ITD acute myeloid leukemia.

Buettner R, Nguyen LXT, Kumar B, Morales C, Liu C, Chen LS, Pemovska T, Synold TW, Palmer J, Thompson R, Li L, Hoang DH, Zhang B, Ghoda L, Kowolik C, Kontro M, Leitch C, Wennerberg K, Yu X, Chen CC, Horne D, Gandhi V, Pullarkat V, Marcucci G, Rosen ST.

J Cell Physiol. 2019 Feb 15. doi: 10.1002/jcp.28294. [Epub ahead of print]


SMC1A is associated with radioresistance in prostate cancer and acts by regulating epithelial-mesenchymal transition and cancer stem-like properties.

Yadav S, Kowolik CM, Lin M, Zuro D, Hui SK, Riggs AD, Horne DA.

Mol Carcinog. 2019 Jan;58(1):113-125. doi: 10.1002/mc.22913. Epub 2018 Oct 5.


Inhibition of GLO1 in Glioblastoma Multiforme Increases DNA-AGEs, Stimulates RAGE Expression, and Inhibits Brain Tumor Growth in Orthotopic Mouse Models.

Jandial R, Neman J, Lim PP, Tamae D, Kowolik CM, Wuenschell GE, Shuck SC, Ciminera AK, De Jesus LR, Ouyang C, Chen MY, Termini J.

Int J Mol Sci. 2018 Jan 30;19(2). pii: E406. doi: 10.3390/ijms19020406.


NT1721, a novel epidithiodiketopiperazine, exhibits potent in vitro and in vivo efficacy against acute myeloid leukemia.

Kowolik CM, Lin M, Xie J, Overman LE, Horne DA.

Oncotarget. 2016 Dec 27;7(52):86186-86197. doi: 10.18632/oncotarget.13364.


Protein Kinase C-α is a Critical Protein for Antisense Oligonucleotide-mediated Silencing in Mammalian Cells.

Castanotto D, Lin M, Kowolik C, Koch T, Hansen BR, Oerum H, Stein CA.

Mol Ther. 2016 Jun;24(6):1117-1125. doi: 10.1038/mt.2016.54. Epub 2016 Mar 10.


A cytoplasmic pathway for gapmer antisense oligonucleotide-mediated gene silencing in mammalian cells.

Castanotto D, Lin M, Kowolik C, Wang L, Ren XQ, Soifer HS, Koch T, Hansen BR, Oerum H, Armstrong B, Wang Z, Bauer P, Rossi J, Stein CA.

Nucleic Acids Res. 2015 Oct 30;43(19):9350-61. doi: 10.1093/nar/gkv964. Epub 2015 Oct 3.


TLR9 signaling through NF-κB/RELA and STAT3 promotes tumor-propagating potential of prostate cancer cells.

Moreira D, Zhang Q, Hossain DM, Nechaev S, Li H, Kowolik CM, D'Apuzzo M, Forman S, Jones J, Pal SK, Kortylewski M.

Oncotarget. 2015 Jul 10;6(19):17302-13.


CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells.

Herrmann A, Priceman SJ, Swiderski P, Kujawski M, Xin H, Cherryholmes GA, Zhang W, Zhang C, Lahtz C, Kowolik C, Forman SJ, Kortylewski M, Yu H.

J Clin Invest. 2015 Jun;125(6):2547. doi: 10.1172/JCI82555. Epub 2015 Jun 1. No abstract available.


Baicalein upregulates DDIT4 expression which mediates mTOR inhibition and growth inhibition in cancer cells.

Wang Y, Han E, Xing Q, Yan J, Arrington A, Wang C, Tully D, Kowolik CM, Lu DM, Frankel PH, Zhai J, Wen W, Horne D, Yip MLR, Yim JH.

Cancer Lett. 2015 Mar 28;358(2):170-179. doi: 10.1016/j.canlet.2014.12.033. Epub 2014 Dec 25.


Targeting JAK1/STAT3 signaling suppresses tumor progression and metastasis in a peritoneal model of human ovarian cancer.

Wen W, Liang W, Wu J, Kowolik CM, Buettner R, Scuto A, Hsieh MY, Hong H, Brown CE, Forman SJ, Horne D, Morgan R, Wakabayashi M, Dellinger TH, Han ES, Yim JH, Jove R.

Mol Cancer Ther. 2014 Dec;13(12):3037-48. doi: 10.1158/1535-7163.MCT-14-0077. Epub 2014 Oct 15.


TLR9 is critical for glioma stem cell maintenance and targeting.

Herrmann A, Cherryholmes G, Schroeder A, Phallen J, Alizadeh D, Xin H, Wang T, Lee H, Lahtz C, Swiderski P, Armstrong B, Kowolik C, Gallia GL, Lim M, Brown C, Badie B, Forman S, Kortylewski M, Jove R, Yu H.

Cancer Res. 2014 Sep 15;74(18):5218-28. doi: 10.1158/0008-5472.CAN-14-1151. Epub 2014 Jul 21.


CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells.

Herrmann A, Priceman SJ, Swiderski P, Kujawski M, Xin H, Cherryholmes GA, Zhang W, Zhang C, Lahtz C, Kowolik C, Forman SJ, Kortylewski M, Yu H.

J Clin Invest. 2014 Jul;124(7):2977-87. doi: 10.1172/JCI73174. Epub 2014 Jun 2. Erratum in: J Clin Invest. 2015 Jun;125(6):2547. Swiderski, Piotr [Added].


Human breast cancer metastases to the brain display GABAergic properties in the neural niche.

Neman J, Termini J, Wilczynski S, Vaidehi N, Choy C, Kowolik CM, Li H, Hambrecht AC, Roberts E, Jandial R.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):984-9. doi: 10.1073/pnas.1322098111. Epub 2014 Jan 6.


Loss of androgen receptor expression promotes a stem-like cell phenotype in prostate cancer through STAT3 signaling.

Schroeder A, Herrmann A, Cherryholmes G, Kowolik C, Buettner R, Pal S, Yu H, Müller-Newen G, Jove R.

Cancer Res. 2014 Feb 15;74(4):1227-37. doi: 10.1158/0008-5472.CAN-13-0594. Epub 2013 Oct 31.


TLR9 signaling in the tumor microenvironment initiates cancer recurrence after radiotherapy.

Gao C, Kozlowska A, Nechaev S, Li H, Zhang Q, Hossain DM, Kowolik CM, Chu P, Swiderski P, Diamond DJ, Pal SK, Raubitschek A, Kortylewski M.

Cancer Res. 2013 Dec 15;73(24):7211-21. doi: 10.1158/0008-5472.CAN-13-1314. Epub 2013 Oct 23.


Intracellular processing of immunostimulatory CpG-siRNA: Toll-like receptor 9 facilitates siRNA dicing and endosomal escape.

Nechaev S, Gao C, Moreira D, Swiderski P, Jozwiak A, Kowolik CM, Zhou J, Armstrong B, Raubitschek A, Rossi JJ, Kortylewski M.

J Control Release. 2013 Sep 28;170(3):307-15. doi: 10.1016/j.jconrel.2013.06.007. Epub 2013 Jun 15.


Co-evolution of breast-to-brain metastasis and neural progenitor cells.

Neman J, Choy C, Kowolik CM, Anderson A, Duenas VJ, Waliany S, Chen BT, Chen MY, Jandial R.

Clin Exp Metastasis. 2013 Aug;30(6):753-68. doi: 10.1007/s10585-013-9576-7. Epub 2013 Feb 28.


Lineage mapping and characterization of the native progenitor population in cellular allograft.

Neman J, Duenas V, Kowolik C, Hambrecht A, Chen M, Jandial R.

Spine J. 2013 Feb;13(2):162-174. doi: 10.1016/j.spinee.2012.11.017. Epub 2013 Jan 8.


TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells in vivo.

Zhang Q, Hossain DM, Nechaev S, Kozlowska A, Zhang W, Liu Y, Kowolik CM, Swiderski P, Rossi JJ, Forman S, Pal S, Bhatia R, Raubitschek A, Yu H, Kortylewski M.

Blood. 2013 Feb 21;121(8):1304-15. doi: 10.1182/blood-2012-07-442590. Epub 2013 Jan 3.


Sequential posttranslational modifications program FEN1 degradation during cell-cycle progression.

Guo Z, Kanjanapangka J, Liu N, Liu S, Liu C, Wu Z, Wang Y, Loh T, Kowolik C, Jamsen J, Zhou M, Truong K, Chen Y, Zheng L, Shen B.

Mol Cell. 2012 Aug 10;47(3):444-56. doi: 10.1016/j.molcel.2012.05.042. Epub 2012 Jun 30.


S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma.

Liu Y, Deng J, Wang L, Lee H, Armstrong B, Scuto A, Kowolik C, Weiss LM, Forman S, Yu H.

Blood. 2012 Aug 16;120(7):1458-65. doi: 10.1182/blood-2011-12-399030. Epub 2012 Jun 28.


Identification of a natural compound by cell-based screening that enhances interferon regulatory factor-1 activity and causes tumor suppression.

Gao J, Wang Y, Xing Q, Yan J, Senthil M, Akmal Y, Kowolik CM, Kang J, Lu DM, Zhao M, Lin Z, Cheng CH, Yip ML, Yim JH.

Mol Cancer Ther. 2011 Oct;10(10):1774-83. doi: 10.1158/1535-7163.MCT-11-0304. Epub 2011 Aug 4.


Humanized Lewis-Y specific antibody based delivery of STAT3 siRNA.

Ma Y, Kowolik CM, Swiderski PM, Kortylewski M, Yu H, Horne DA, Jove R, Caballero OL, Simpson AJ, Lee FT, Pillay V, Scott AM.

ACS Chem Biol. 2011 Sep 16;6(9):962-70. doi: 10.1021/cb200176v. Epub 2011 Jul 26.


Differential expression patterns of capping protein, protein phosphatase 1, and casein kinase 1 may serve as diagnostic markers for malignant melanoma.

Sun D, Zhou M, Kowolik CM, Trisal V, Huang Q, Kernstine KH, Lian F, Shen B.

Melanoma Res. 2011 Aug;21(4):335-43. doi: 10.1097/CMR.0b013e328346b715.


STAT3 inhibition is a therapeutic strategy for ABC-like diffuse large B-cell lymphoma.

Scuto A, Kujawski M, Kowolik C, Krymskaya L, Wang L, Weiss LM, Digiusto D, Yu H, Forman S, Jove R.

Cancer Res. 2011 May 1;71(9):3182-8. doi: 10.1158/0008-5472.CAN-10-2380. Epub 2011 Apr 26.


Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels.

Kretzner L, Scuto A, Dino PM, Kowolik CM, Wu J, Ventura P, Jove R, Forman SJ, Yen Y, Kirschbaum MH.

Cancer Res. 2011 Jun 1;71(11):3912-20. doi: 10.1158/0008-5472.CAN-10-2259. Epub 2011 Apr 18.


The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival.

Scuto A, Krejci P, Popplewell L, Wu J, Wang Y, Kujawski M, Kowolik C, Xin H, Chen L, Wang Y, Kretzner L, Yu H, Wilcox WR, Yen Y, Forman S, Jove R.

Leukemia. 2011 Mar;25(3):538-50. doi: 10.1038/leu.2010.289. Epub 2010 Dec 17.


Targeting Stat3 in the myeloid compartment drastically improves the in vivo antitumor functions of adoptively transferred T cells.

Herrmann A, Kortylewski M, Kujawski M, Zhang C, Reckamp K, Armstrong B, Wang L, Kowolik C, Deng J, Figlin R, Yu H.

Cancer Res. 2010 Oct 1;70(19):7455-64. doi: 10.1158/0008-5472.CAN-10-0736. Epub 2010 Sep 14.


The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors.

Hedvat M, Huszar D, Herrmann A, Gozgit JM, Schroeder A, Sheehy A, Buettner R, Proia D, Kowolik CM, Xin H, Armstrong B, Bebernitz G, Weng S, Wang L, Ye M, McEachern K, Chen H, Morosini D, Bell K, Alimzhanov M, Ioannidis S, McCoon P, Cao ZA, Yu H, Jove R, Zinda M.

Cancer Cell. 2009 Dec 8;16(6):487-97. doi: 10.1016/j.ccr.2009.10.015.


In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses.

Kortylewski M, Swiderski P, Herrmann A, Wang L, Kowolik C, Kujawski M, Lee H, Scuto A, Liu Y, Yang C, Deng J, Soifer HS, Raubitschek A, Forman S, Rossi JJ, Pardoll DM, Jove R, Yu H.

Nat Biotechnol. 2009 Oct;27(10):925-32. doi: 10.1038/nbt.1564. Epub 2009 Sep 13.


Stat3 activity is required for gap junctional permeability in normal rat liver epithelial cells.

Geletu M, Chaize C, Arulanandam R, Vultur A, Kowolik C, Anagnostopoulou A, Jove R, Raptis L.

DNA Cell Biol. 2009 Jul;28(7):319-27. doi: 10.1089/dna.2008.0833.


Sorafenib inhibits signal transducer and activator of transcription 3 signaling associated with growth arrest and apoptosis of medulloblastomas.

Yang F, Van Meter TE, Buettner R, Hedvat M, Liang W, Kowolik CM, Mepani N, Mirosevich J, Nam S, Chen MY, Tye G, Kirschbaum M, Jove R.

Mol Cancer Ther. 2008 Nov;7(11):3519-26. doi: 10.1158/1535-7163.MCT-08-0138.


SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells.

Vultur A, Buettner R, Kowolik C, Liang W, Smith D, Boschelli F, Jove R.

Mol Cancer Ther. 2008 May;7(5):1185-94. doi: 10.1158/1535-7163.MCT-08-0126.


The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells.

Scuto A, Kirschbaum M, Kowolik C, Kretzner L, Juhasz A, Atadja P, Pullarkat V, Bhatia R, Forman S, Yen Y, Jove R.

Blood. 2008 May 15;111(10):5093-100. doi: 10.1182/blood-2007-10-117762. Epub 2008 Mar 18.


CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells.

Kowolik CM, Topp MS, Gonzalez S, Pfeiffer T, Olivares S, Gonzalez N, Smith DD, Forman SJ, Jensen MC, Cooper LJ.

Cancer Res. 2006 Nov 15;66(22):10995-1004.


Characterization of an artificial antigen-presenting cell to propagate cytolytic CD19-specific T cells.

Numbenjapon T, Serrano LM, Singh H, Kowolik CM, Olivares S, Gonzalez N, Chang WC, Forman SJ, Jensen MC, Cooper LJ.

Leukemia. 2006 Oct;20(10):1889-92. No abstract available.


Cre-mediated reversible immortalization of human renal proximal tubular epithelial cells.

Kowolik CM, Liang S, Yu Y, Yee JK.

Oncogene. 2004 Aug 5;23(35):5950-7.


HIV vector production mediated by Rev protein transduction.

Kowolik CM, Yam P, Yu Y, Yee JK.

Mol Ther. 2003 Aug;8(2):324-31.


15N and 1H NMR study of histidine containing protein (HPr) from Staphylococcus carnosus at high pressure.

Kalbitzer HR, Görler A, Li H, Dubovskii PV, Hengstenberg W, Kowolik C, Yamada H, Akasaka K.

Protein Sci. 2000 Apr;9(4):693-703.

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