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Items: 1 to 50 of 54

1.

4-amino-5-aryl-6-arylethynylpyrimidines: structure-activity relationships of non-nucleoside adenosine kinase inhibitors.

Matulenko MA, Paight ES, Frey RR, Gomtsyan A, DiDomenico S Jr, Jiang M, Lee CH, Stewart AO, Yu H, Kohlhaas KL, Alexander KM, McGaraughty S, Mikusa J, Marsh KC, Muchmore SW, Jakob CL, Kowaluk EA, Jarvis MF, Bhagwat SS.

Bioorg Med Chem. 2007 Feb 15;15(4):1586-605. Epub 2006 Dec 20.

PMID:
17197188
2.

Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes.

Muchmore SW, Smith RA, Stewart AO, Cowart MD, Gomtsyan A, Matulenko MA, Yu H, Severin JM, Bhagwat SS, Lee CH, Kowaluk EA, Jarvis MF, Jakob CL.

J Med Chem. 2006 Nov 16;49(23):6726-31.

PMID:
17154503
3.

Adenosine modulation: a novel approach to analgesia and inflammation.

Kowaluk EA.

Expert Opin Investig Drugs. 1998 Apr;7(4):535-43.

PMID:
15991991
4.

5-(3-Bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine: structure-activity relationships of 7-substituted heteroaryl analogs as non-nucleoside adenosine kinase inhibitors.

Matulenko MA, Lee CH, Jiang M, Frey RR, Cowart MD, Bayburt EK, Didomenico S, Gfesser GA, Gomtsyan A, Zheng GZ, McKie JA, Stewart AO, Yu H, Kohlhaas KL, Alexander KM, McGaraughty S, Wismer CT, Mikusa J, Marsh KC, Snyder RD, Diehl MS, Kowaluk EA, Jarvis MF, Bhagwat SS.

Bioorg Med Chem. 2005 Jun 1;13(11):3705-20.

PMID:
15863000
5.

Synthesis and biological evaluation of pteridine and pyrazolopyrimidine based adenosine kinase inhibitors.

Gomtsyan A, Didomenico S, Lee CH, Stewart AO, Bhagwat SS, Kowaluk EA, Jarvis MF.

Bioorg Med Chem Lett. 2004 Aug 16;14(16):4165-8.

PMID:
15261263
6.

5,6,7-trisubstituted 4-aminopyrido[2,3-d]pyrimidines as novel inhibitors of adenosine kinase.

Perner RJ, Gu YG, Lee CH, Bayburt EK, McKie J, Alexander KM, Kohlhaas KL, Wismer CT, Mikusa J, Jarvis MF, Kowaluk EA, Bhagwat SS.

J Med Chem. 2003 Nov 20;46(24):5249-57.

PMID:
14613327
7.

Adenosine kinase inhibitors: polar 7-substitutent of pyridopyrimidine derivatives improving their locomotor selectivity.

Zheng GZ, Mao Y, Lee CH, Pratt JK, Koenig JR, Perner RJ, Cowart MD, Gfesser GA, McGaraughty S, Chu KL, Zhu C, Yu H, Kohlhaas K, Alexander KM, Wismer CT, Mikusa J, Jarvis MF, Kowaluk EA, Stewart AO.

Bioorg Med Chem Lett. 2003 Sep 15;13(18):3041-4.

PMID:
12941329
8.

Synthesis and structure-activity relationships of 5-heteroatom-substituted pyridopyrimidines as adenosine kinase inhibitors.

Gfesser GA, Bayburt EK, Cowart M, DiDomenico S, Gomtsyan A, Lee CH, Stewart AO, Jarvis MF, Kowaluk EA, Bhagwat SS.

Eur J Med Chem. 2003 Mar;38(3):245-52.

PMID:
12667691
9.

Design, synthesis, and structure-activity relationship of 6-alkynylpyrimidines as potent adenosine kinase inhibitors.

Gomtsyan A, Didomenico S, Lee CH, Matulenko MA, Kim K, Kowaluk EA, Wismer CT, Mikusa J, Yu H, Kohlhaas K, Jarvis MF, Bhagwat SS.

J Med Chem. 2002 Aug 15;45(17):3639-48.

PMID:
12166937
10.

Comparison of the ability of adenosine kinase inhibitors and adenosine receptor agonists to attenuate thermal hyperalgesia and reduce motor performance in rats.

Jarvis MF, Mikusa J, Chu KL, Wismer CT, Honore P, Kowaluk EA, McGaraughty S.

Pharmacol Biochem Behav. 2002 Oct;73(3):573-81.

PMID:
12151032
11.

Analgesic and anti-inflammatory effects of A-286501, a novel orally active adenosine kinase inhibitor.

Jarvis MF, Yu H, McGaraughty S, Wismer CT, Mikusa J, Zhu C, Chu K, Kohlhaas K, Cowart M, Lee CH, Stewart AO, Cox BF, Polakowski J, Kowaluk EA.

Pain. 2002 Mar;96(1-2):107-18.

PMID:
11932067
12.

Pyridopyrimidine analogues as novel adenosine kinase inhibitors.

Zheng GZ, Lee C, Pratt JK, Perner RJ, Jiang MQ, Gomtsyan A, Matulenko MA, Mao Y, Koenig JR, Kim KH, Muchmore S, Yu H, Kohlhaas K, Alexander KM, McGaraughty S, Chu KL, Wismer CT, Mikusa J, Jarvis MF, Marsh K, Kowaluk EA, Bhagwat SS, Stewart AO.

Bioorg Med Chem Lett. 2001 Aug 20;11(16):2071-4.

PMID:
11514141
13.

A-134974: a novel adenosine kinase inhibitor, relieves tactile allodynia via spinal sites of action in peripheral nerve injured rats.

Zhu CZ, Mikusa J, Chu KL, Cowart M, Kowaluk EA, Jarvis MF, McGaraughty S.

Brain Res. 2001 Jun 29;905(1-2):104-10.

PMID:
11423084
14.

Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor..

Lee CH, Jiang M, Cowart M, Gfesser G, Perner R, Kim KH, Gu YG, Williams M, Jarvis MF, Kowaluk EA, Stewart AO, Bhagwat SS.

J Med Chem. 2001 Jun 21;44(13):2133-8.

PMID:
11405650
15.
16.

Effects of A-134974, a novel adenosine kinase inhibitor, on carrageenan-induced inflammatory hyperalgesia and locomotor activity in rats: evaluation of the sites of action.

McGaraughty S, Chu KL, Wismer CT, Mikusa J, Zhu CZ, Cowart M, Kowaluk EA, Jarvis MF.

J Pharmacol Exp Ther. 2001 Feb;296(2):501-9.

PMID:
11160637
17.

Anti-inflammatory effects of ABT-702, a novel non-nucleoside adenosine kinase inhibitor, in rat adjuvant arthritis.

Boyle DL, Kowaluk EA, Jarvis MF, Lee CH, Bhagwat SS, Williams M, Firestein GS.

J Pharmacol Exp Ther. 2001 Feb;296(2):495-500.

PMID:
11160636
18.

Modulation of BzATP and formalin induced nociception: attenuation by the P2X receptor antagonist, TNP-ATP and enhancement by the P2X(3) allosteric modulator, cibacron blue.

Jarvis MF, Wismer CT, Schweitzer E, Yu H, van Biesen T, Lynch KJ, Burgard EC, Kowaluk EA.

Br J Pharmacol. 2001 Jan;132(1):259-69.

19.

Structure-activity studies of 5-substituted pyridopyrimidines as adenosine kinase inhibitors.

Cowart M, Lee CH, Gfesser GA, Bayburt EK, Bhagwat SS, Stewart AO, Yu H, Kohlhaas KL, McGaraughty S, Wismer CT, Mikusa J, Zhu C, Alexander KM, Jarvis MF, Kowaluk EA.

Bioorg Med Chem Lett. 2001 Jan 8;11(1):83-6.

PMID:
11140740
20.

Design of adenosine kinase inhibitors from the NMR-based screening of fragments.

Hajduk PJ, Gomtsyan A, Didomenico S, Cowart M, Bayburt EK, Solomon L, Severin J, Smith R, Walter K, Holzman TF, Stewart A, McGaraughty S, Jarvis MF, Kowaluk EA, Fesik SW.

J Med Chem. 2000 Dec 14;43(25):4781-6.

PMID:
11123986
21.

Competitive antagonism of recombinant P2X(2/3) receptors by 2', 3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP).

Burgard EC, Niforatos W, van Biesen T, Lynch KJ, Kage KL, Touma E, Kowaluk EA, Jarvis MF.

Mol Pharmacol. 2000 Dec;58(6):1502-10.

PMID:
11093790
22.

ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties. II. In vivo characterization in the rat.

Kowaluk EA, Mikusa J, Wismer CT, Zhu CZ, Schweitzer E, Lynch JJ, Lee CH, Jiang M, Bhagwat SS, Gomtsyan A, McKie J, Cox BF, Polakowski J, Reinhart G, Williams M, Jarvis MF.

J Pharmacol Exp Ther. 2000 Dec;295(3):1165-74.

PMID:
11082454
24.

Therapeutic potential of adenosine kinase inhibitors.

Kowaluk EA, Jarvis MF.

Expert Opin Investig Drugs. 2000 Mar;9(3):551-64. Review.

PMID:
11060695
25.

ABT-627, an endothelin ET(A) receptor-selective antagonist, attenuates tactile allodynia in a diabetic rat model of neuropathic pain.

Jarvis MF, Wessale JL, Zhu CZ, Lynch JJ, Dayton BD, Calzadilla SV, Padley RJ, Opgenorth TJ, Kowaluk EA.

Eur J Pharmacol. 2000 Jan 24;388(1):29-35.

PMID:
10657544
26.

Molecular and functional characterization of human P2X(2) receptors.

Lynch KJ, Touma E, Niforatos W, Kage KL, Burgard EC, van Biesen T, Kowaluk EA, Jarvis MF.

Mol Pharmacol. 1999 Dec;56(6):1171-81.

PMID:
10570044
27.

Allosteric modulation and accelerated resensitization of human P2X(3) receptors by cibacron blue.

Alexander K, Niforatos W, Bianchi B, Burgard EC, Lynch KJ, Kowaluk EA, Jarvis MF, van Biesen T.

J Pharmacol Exp Ther. 1999 Dec;291(3):1135-42.

PMID:
10565834
28.

P2X receptor-mediated ionic currents in dorsal root ganglion neurons.

Burgard EC, Niforatos W, van Biesen T, Lynch KJ, Touma E, Metzger RE, Kowaluk EA, Jarvis MF.

J Neurophysiol. 1999 Sep;82(3):1590-8.

29.

Site and event specific increase of striatal adenosine release by adenosine kinase inhibition in rats.

Britton DR, Mikusa J, Lee CH, Jarvis MF, Williams M, Kowaluk EA.

Neurosci Lett. 1999 May 7;266(2):93-6.

PMID:
10353335
30.

Characterization of the effects of adenosine kinase inhibitors on acute thermal nociception in mice.

Kowaluk EA, Kohlhaas KL, Bannon A, Gunther K, Lynch JJ 3rd, Jarvis MF.

Pharmacol Biochem Behav. 1999 May;63(1):83-91.

PMID:
10340527
31.

Emerging molecular approaches to pain therapy.

Williams M, Kowaluk EA, Arneric SP.

J Med Chem. 1999 May 6;42(9):1481-500. Review. No abstract available.

PMID:
10229619
32.

Adenosine kinase inhibitors.

Kowaluk EA, Bhagwat SS, Jarvis MF.

Curr Pharm Des. 1998 Oct;4(5):403-16. Review.

PMID:
10197052
33.

An adenosine kinase inhibitor attenuates tactile allodynia in a rat model of diabetic neuropathic pain.

Lynch JJ 3rd, Jarvis MF, Kowaluk EA.

Eur J Pharmacol. 1999 Jan 8;364(2-3):141-6.

PMID:
9932716
34.

Inhibition of adenosine kinase during oxygen-glucose deprivation in rat cortical neuronal cultures.

Lynch JJ 3rd, Alexander KM, Jarvis MF, Kowaluk EA.

Neurosci Lett. 1998 Aug 21;252(3):207-10.

PMID:
9739997
35.

Nitroaromatic amino acids as inhibitors of neuronal nitric oxide synthase.

Cowart M, Kowaluk EA, Daanen JF, Kohlhaas KL, Alexander KM, Wagenaar FL, Kerwin JF Jr.

J Med Chem. 1998 Jul 2;41(14):2636-42.

PMID:
9651169
36.

Cloning and expression of the adenosine kinase gene from rat and human tissues.

McNally T, Helfrich RJ, Cowart M, Dorwin SA, Meuth JL, Idler KB, Klute KA, Simmer RL, Kowaluk EA, Halbert DN.

Biochem Biophys Res Commun. 1997 Feb 24;231(3):645-50.

PMID:
9070863
37.

Adenosine kinase inhibition protects brain against transient focal ischemia in rats.

Jiang N, Kowaluk EA, Lee CH, Mazdiyasni H, Chopp M.

Eur J Pharmacol. 1997 Feb 12;320(2-3):131-7.

PMID:
9059845
38.

Nitrite ion is not an active intermediate in the vascular metabolism of organic nitrates and organic nitrites to nitric oxide.

Kowaluk EA, Chung SJ, Fung HL.

Drug Metab Dispos. 1993 Sep-Oct;21(5):967-9. No abstract available.

PMID:
7902265
39.

Biochemical mechanism of organic nitrate action.

Fung HL, Chung SJ, Bauer JA, Chong S, Kowaluk EA.

Am J Cardiol. 1992 Sep 24;70(8):4B-10B. Review.

PMID:
1529925
40.

Metabolic activation of sodium nitroprusside to nitric oxide in vascular smooth muscle.

Kowaluk EA, Seth P, Fung HL.

J Pharmacol Exp Ther. 1992 Sep;262(3):916-22.

PMID:
1527732
41.

Vascular nitric oxide-generating activities for organic nitrites and organic nitrates are distinct.

Kowaluk EA, Fung HL.

J Pharmacol Exp Ther. 1991 Nov;259(2):519-25.

PMID:
1682477
42.

Prediction of solute sorption by polyvinyl chloride plastic infusion bags.

Roberts MS, Kowaluk EA, Polack AE.

J Pharm Sci. 1991 May;80(5):449-55.

PMID:
1880725
43.
44.
45.

Tolerance to relaxation in rat aorta: comparison of an S-nitrosothiol with nitroglycerin.

Kowaluk EA, Poliszczuk R, Fung HL.

Eur J Pharmacol. 1987 Dec 15;144(3):379-83.

PMID:
3126076
46.

Kinetics of sorption of ionizable solutes by plastic infusion bags.

Kowaluk EA, Roberts MS, Polack AE.

J Pharm Sci. 1986 Jun;75(6):562-70.

PMID:
3735100
47.
48.

Computer education for clinical pharmacy students--a program for use in teaching.

Polack AE, Kowaluk EA, Peterson GM.

J Clin Hosp Pharm. 1984 Dec;9(4):345-8.

PMID:
6396322
49.

Dynamics of clomethiazole edisylate interaction with plastic infusion systems.

Kowaluk EA, Roberts MS, Polack AE.

J Pharm Sci. 1984 Jan;73(1):43-7.

PMID:
6694081
50.

Factors affecting the availability of diazepam stored in plastic bags and administered through intravenous sets.

Kowaluk EA, Roberts MS, Polack AE.

Am J Hosp Pharm. 1983 Mar;40(3):417-23.

PMID:
6846350

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