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Items: 1 to 50 of 65

1.

Gene Silencing With Small Interfering RNA: A New Therapeutic Option During Ex Vivo Machine Liver Perfusion Preservation.

Thijssen MF, Brüggenwirth IMA, Gillooly A, Khvorova A, Kowalik TF, Martins PN.

Liver Transpl. 2019 Jan;25(1):140-151. doi: 10.1002/lt.25383. Review.

PMID:
30561891
2.

A Comparative Study of Single and Dual Perfusion During End-ischemic Subnormothermic Liver Machine Preservation.

Brüggenwirth IMA, Moore C, Mahboub P, Thijssen MF, E X, Leuvenink HGD, Mandrekar P, Wang X, Kowalik TF, Porte RJ, Martins PN.

Transplant Direct. 2018 Oct 23;4(11):e400. doi: 10.1097/TXD.0000000000000840. eCollection 2018 Nov.

3.

Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody.

Prachanronarong KL, Canale AS, Liu P, Somasundaran M, Hou S, Poh YP, Han T, Zhu Q, Renzette N, Zeldovich KB, Kowalik TF, Kurt-Yilmaz N, Jensen JD, Bolon DNA, Marasco WA, Finberg RW, Schiffer CA, Wang JP.

J Virol. 2019 Jan 4;93(2). pii: e01639-18. doi: 10.1128/JVI.01639-18. Print 2019 Jan 15.

PMID:
30381484
4.

Synonymous Mutations at the Beginning of the Influenza A Virus Hemagglutinin Gene Impact Experimental Fitness.

Canale AS, Venev SV, Whitfield TW, Caffrey DR, Marasco WA, Schiffer CA, Kowalik TF, Jensen JD, Finberg RW, Zeldovich KB, Wang JP, Bolon DNA.

J Mol Biol. 2018 Apr 13;430(8):1098-1115. doi: 10.1016/j.jmb.2018.02.009. Epub 2018 Feb 18.

PMID:
29466705
5.

On the Demographic and Selective Forces Shaping Patterns of Human Cytomegalovirus Variation within Hosts.

Sackman AM, Pfeifer SP, Kowalik TF, Jensen JD.

Pathogens. 2018 Jan 28;7(1). pii: E16. doi: 10.3390/pathogens7010016. Review.

6.

Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope.

Avnir Y, Prachanronarong KL, Zhang Z, Hou S, Peterson EC, Sui J, Zayed H, Kurella VB, McGuire AT, Stamatatos L, Hilbert BJ, Bohn MF, Kowalik TF, Jensen JD, Finberg RW, Wang JP, Goodall M, Jefferis R, Zhu Q, Kurt Yilmaz N, Schiffer CA, Marasco WA.

Cell Rep. 2017 Dec 12;21(11):3243-3255. doi: 10.1016/j.celrep.2017.11.056.

7.

The Combined Effect of Oseltamivir and Favipiravir on Influenza A Virus Evolution.

Ormond L, Liu P, Matuszewski S, Renzette N, Bank C, Zeldovich K, Bolon DN, Kowalik TF, Finberg RW, Jensen JD, Wang JP.

Genome Biol Evol. 2017 Jul 1;9(7):1913-1924. doi: 10.1093/gbe/evx138.

8.

Antiviral drug resistance as an adaptive process.

Irwin KK, Renzette N, Kowalik TF, Jensen JD.

Virus Evol. 2016 Jun 10;2(1):vew014. doi: 10.1093/ve/vew014. eCollection 2016 Jan. Review.

9.

Characterizing human cytomegalovirus reinfection in congenitally infected infants: an evolutionary perspective.

Pokalyuk C, Renzette N, Irwin KK, Pfeifer SP, Gibson L, Britt WJ, Yamamoto AY, Mussi-Pinhata MM, Kowalik TF, Jensen JD.

Mol Ecol. 2017 Apr;26(7):1980-1990. doi: 10.1111/mec.13953. Epub 2017 Feb 8.

PMID:
27988973
10.

On the Analysis of Intrahost and Interhost Viral Populations: Human Cytomegalovirus as a Case Study of Pitfalls and Expectations.

Renzette N, Pfeifer SP, Matuszewski S, Kowalik TF, Jensen JD.

J Virol. 2017 Feb 14;91(5). pii: e01976-16. doi: 10.1128/JVI.01976-16. Print 2017 Mar 1.

11.

Molecular Basis for Differential Patterns of Drug Resistance in Influenza N1 and N2 Neuraminidase.

Prachanronarong KL, Özen A, Thayer KM, Yilmaz LS, Zeldovich KB, Bolon DN, Kowalik TF, Jensen JD, Finberg RW, Wang JP, Kurt-Yilmaz N, Schiffer CA.

J Chem Theory Comput. 2016 Dec 13;12(12):6098-6108. Epub 2016 Nov 17.

PMID:
27951676
12.

An experimental evaluation of drug-induced mutational meltdown as an antiviral treatment strategy.

Bank C, Renzette N, Liu P, Matuszewski S, Shim H, Foll M, Bolon DN, Zeldovich KB, Kowalik TF, Finberg RW, Wang JP, Jensen JD.

Evolution. 2016 Nov;70(11):2470-2484. doi: 10.1111/evo.13041. Epub 2016 Sep 13.

PMID:
27566611
13.

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.

Savidis G, McDougall WM, Meraner P, Perreira JM, Portmann JM, Trincucci G, John SP, Aker AM, Renzette N, Robbins DR, Guo Z, Green S, Kowalik TF, Brass AL.

Cell Rep. 2016 Jun 28;16(1):232-246. doi: 10.1016/j.celrep.2016.06.028. Epub 2016 Jun 21.

14.

A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance.

Jiang L, Liu P, Bank C, Renzette N, Prachanronarong K, Yilmaz LS, Caffrey DR, Zeldovich KB, Schiffer CA, Kowalik TF, Jensen JD, Finberg RW, Wang JP, Bolon DNA.

J Mol Biol. 2016 Feb 13;428(3):538-553. doi: 10.1016/j.jmb.2015.11.027. Epub 2015 Dec 4.

PMID:
26656922
15.

On the relative roles of background selection and genetic hitchhiking in shaping human cytomegalovirus genetic diversity.

Renzette N, Kowalik TF, Jensen JD.

Mol Ecol. 2016 Jan;25(1):403-13. doi: 10.1111/mec.13331. Epub 2015 Sep 3.

16.

Limits and patterns of cytomegalovirus genomic diversity in humans.

Renzette N, Pokalyuk C, Gibson L, Bhattacharjee B, Schleiss MR, Hamprecht K, Yamamoto AY, Mussi-Pinhata MM, Britt WJ, Jensen JD, Kowalik TF.

Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4120-8. doi: 10.1073/pnas.1501880112. Epub 2015 Jul 6.

17.

Positive Selection Drives Preferred Segment Combinations during Influenza Virus Reassortment.

Zeldovich KB, Liu P, Renzette N, Foll M, Pham ST, Venev SV, Gallagher GR, Bolon DN, Kurt-Jones EA, Jensen JD, Caffrey DR, Schiffer CA, Kowalik TF, Wang JP, Finberg RW.

Mol Biol Evol. 2015 Jun;32(6):1519-32. doi: 10.1093/molbev/msv044. Epub 2015 Feb 23.

18.

Human cytomegalovirus intrahost evolution-a new avenue for understanding and controlling herpesvirus infections.

Renzette N, Gibson L, Jensen JD, Kowalik TF.

Curr Opin Virol. 2014 Oct;8:109-15. doi: 10.1016/j.coviro.2014.08.001. Epub 2014 Aug 25. Review.

19.

The DNA damage response induced by infection with human cytomegalovirus and other viruses.

Xiaofei E, Kowalik TF.

Viruses. 2014 May 23;6(5):2155-85. doi: 10.3390/v6052155. Review.

20.

Influenza virus drug resistance: a time-sampled population genetics perspective.

Foll M, Poh YP, Renzette N, Ferrer-Admetlla A, Bank C, Shim H, Malaspinas AS, Ewing G, Liu P, Wegmann D, Caffrey DR, Zeldovich KB, Bolon DN, Wang JP, Kowalik TF, Schiffer CA, Finberg RW, Jensen JD.

PLoS Genet. 2014 Feb 27;10(2):e1004185. doi: 10.1371/journal.pgen.1004185. eCollection 2014 Feb.

21.

Epstein-Barr virus latent membrane protein 1 genetic variability in peripheral blood B cells and oropharyngeal fluids.

Renzette N, Somasundaran M, Brewster F, Coderre J, Weiss ER, McManus M, Greenough T, Tabak B, Garber M, Kowalik TF, Luzuriaga K.

J Virol. 2014 Apr;88(7):3744-55. doi: 10.1128/JVI.03378-13. Epub 2014 Jan 15.

22.

A novel DDB2-ATM feedback loop regulates human cytomegalovirus replication.

E X, Savidis G, Chin CR, Wang S, Lu S, Brass AL, Kowalik TF.

J Virol. 2014 Feb;88(4):2279-90. doi: 10.1128/JVI.03423-13. Epub 2013 Dec 11.

23.

Evolution of the influenza A virus genome during development of oseltamivir resistance in vitro.

Renzette N, Caffrey DR, Zeldovich KB, Liu P, Gallagher GR, Aiello D, Porter AJ, Kurt-Jones EA, Bolon DN, Poh YP, Jensen JD, Schiffer CA, Kowalik TF, Finberg RW, Wang JP.

J Virol. 2014 Jan;88(1):272-81. doi: 10.1128/JVI.01067-13. Epub 2013 Oct 23.

24.

Rapid intrahost evolution of human cytomegalovirus is shaped by demography and positive selection.

Renzette N, Gibson L, Bhattacharjee B, Fisher D, Schleiss MR, Jensen JD, Kowalik TF.

PLoS Genet. 2013;9(9):e1003735. doi: 10.1371/journal.pgen.1003735. Epub 2013 Sep 26.

25.

Genetic analysis of cytomegalovirus in malignant gliomas.

Bhattacharjee B, Renzette N, Kowalik TF.

J Virol. 2012 Jun;86(12):6815-24. doi: 10.1128/JVI.00015-12. Epub 2012 Apr 11.

26.

RNA interference-mediated targeting of human cytomegalovirus immediate-early or early gene products inhibits viral replication with differential effects on cellular functions.

Xiaofei E, Stadler BM, Debatis M, Wang S, Lu S, Kowalik TF.

J Virol. 2012 May;86(10):5660-73. doi: 10.1128/JVI.06338-11. Epub 2012 Mar 21.

27.

Extensive genome-wide variability of human cytomegalovirus in congenitally infected infants.

Renzette N, Bhattacharjee B, Jensen JD, Gibson L, Kowalik TF.

PLoS Pathog. 2011 May;7(5):e1001344. doi: 10.1371/journal.ppat.1001344. Epub 2011 May 19.

28.

An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus.

E X, Pickering MT, Debatis M, Castillo J, Lagadinos A, Wang S, Lu S, Kowalik TF.

PLoS Pathog. 2011 May;7(5):e1001342. doi: 10.1371/journal.ppat.1001342. Epub 2011 May 12.

29.

Viral Bcl-2-mediated evasion of autophagy aids chronic infection of gammaherpesvirus 68.

E X, Hwang S, Oh S, Lee JS, Jeong JH, Gwack Y, Kowalik TF, Sun R, Jung JU, Liang C.

PLoS Pathog. 2009 Oct;5(10):e1000609. doi: 10.1371/journal.ppat.1000609. Epub 2009 Oct 9.

30.

miR-17 and miR-20a temper an E2F1-induced G1 checkpoint to regulate cell cycle progression.

Pickering MT, Stadler BM, Kowalik TF.

Oncogene. 2009 Jan 8;28(1):140-5. doi: 10.1038/onc.2008.372. Epub 2008 Oct 6.

31.

Activated checkpoint kinase 2 provides a survival signal for tumor cells.

Ghosh JC, Dohi T, Raskett CM, Kowalik TF, Altieri DC.

Cancer Res. 2006 Dec 15;66(24):11576-9.

32.

Deregulation of DNA damage signal transduction by herpesvirus latency-associated M2.

Liang X, Pickering MT, Cho NH, Chang H, Volkert MR, Kowalik TF, Jung JU.

J Virol. 2006 Jun;80(12):5862-74.

33.

Inhibition of the ATM/p53 signal transduction pathway by Kaposi's sarcoma-associated herpesvirus interferon regulatory factor 1.

Shin YC, Nakamura H, Liang X, Feng P, Chang H, Kowalik TF, Jung JU.

J Virol. 2006 Mar;80(5):2257-66.

34.

E2F1 induces MRN foci formation and a cell cycle checkpoint response in human fibroblasts.

Frame FM, Rogoff HA, Pickering MT, Cress WD, Kowalik TF.

Oncogene. 2006 Jun 1;25(23):3258-66. Epub 2006 Jan 23.

PMID:
16434972
35.

Gene silencing in the endocrine pancreas mediated by short-interfering RNA.

Bradley SP, Rastellini C, da Costa MA, Kowalik TF, Bloomenthal AB, Brown M, Cicalese L, Basadonna GP, Uknis ME.

Pancreas. 2005 Nov;31(4):373-9.

PMID:
16258373
36.

Rb inactivation leads to E2F1-mediated DNA double-strand break accumulation.

Pickering MT, Kowalik TF.

Oncogene. 2006 Feb 2;25(5):746-55.

PMID:
16186801
37.

Human cytomegalovirus IE1-72 activates ataxia telangiectasia mutated kinase and a p53/p21-mediated growth arrest response.

Castillo JP, Frame FM, Rogoff HA, Pickering MT, Yurochko AD, Kowalik TF.

J Virol. 2005 Sep;79(17):11467-75.

38.

Successful incorporation of short-interfering RNA into islet cells by in situ perfusion.

Bradley SP, Kowalik TF, Rastellini C, da Costa MA, Bloomenthal AB, Cicalese L, Basadonna GP, Uknis ME.

Transplant Proc. 2005 Jan-Feb;37(1):233-6.

PMID:
15808605
39.

Life, death and E2F: linking proliferation control and DNA damage signaling via E2F1.

Rogoff HA, Kowalik TF.

Cell Cycle. 2004 Jul;3(7):845-6. Epub 2004 Jul 14. Review.

PMID:
15190206
40.

Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2.

Rogoff HA, Pickering MT, Frame FM, Debatis ME, Sanchez Y, Jones S, Kowalik TF.

Mol Cell Biol. 2004 Apr;24(7):2968-77.

41.

HCMV infection: modulating the cell cycle and cell death.

Castillo JP, Kowalik TF.

Int Rev Immunol. 2004 Jan-Apr;23(1-2):113-39. Review.

PMID:
14690857
42.
43.

E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis.

Rogoff HA, Pickering MT, Debatis ME, Jones S, Kowalik TF.

Mol Cell Biol. 2002 Aug;22(15):5308-18.

44.

Human cytomegalovirus immediate early proteins and cell growth control.

Castillo JP, Kowalik TF.

Gene. 2002 May 15;290(1-2):19-34. Review.

PMID:
12062798
45.

Active RB elicits late G1/S inhibition.

Angus SP, Fribourg AF, Markey MP, Williams SL, Horn HF, DeGregori J, Kowalik TF, Fukasawa K, Knudsen ES.

Exp Cell Res. 2002 Jun 10;276(2):201-13.

PMID:
12027450
46.

Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling.

Strobeck MW, Reisman DN, Gunawardena RW, Betz BL, Angus SP, Knudsen KE, Kowalik TF, Weissman BE, Knudsen ES.

J Biol Chem. 2002 Feb 15;277(7):4782-9. Epub 2001 Nov 21.

47.

Role of human cytomegalovirus immediate-early proteins in cell growth control.

Castillo JP, Yurochko AD, Kowalik TF.

J Virol. 2000 Sep;74(17):8028-37.

48.

Myosin V plays an essential role in the thyroid hormone-dependent endocytosis of type II iodothyronine 5'-deiodinase.

Stachelek SJ, Kowalik TF, Farwell AP, Leonard JL.

J Biol Chem. 2000 Oct 13;275(41):31701-7.

49.

Cloning, expression, and functional characterization of the substrate binding subunit of rat type II iodothyronine 5'-deiodinase.

Leonard DM, Stachelek SJ, Safran M, Farwell AP, Kowalik TF, Leonard JL.

J Biol Chem. 2000 Aug 18;275(33):25194-201.

50.

E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2.

Kowalik TF, DeGregori J, Leone G, Jakoi L, Nevins JR.

Cell Growth Differ. 1998 Feb;9(2):113-8.

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