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Items: 1 to 50 of 198

1.

Role of the Srs2-Rad51 Interaction Domain in Crossover Control in Saccharomyces cerevisiae.

Jenkins SS, Gore S, Guo X, Liu J, Ede C, Veaute X, Jinks-Robertson S, Kowalczykowski SC, Heyer WD.

Genetics. 2019 Aug;212(4):1133-1145. doi: 10.1534/genetics.119.302337. Epub 2019 May 29.

2.

Independent and Stochastic Action of DNA Polymerases in the Replisome.

Graham JE, Marians KJ, Kowalczykowski SC.

Cell. 2017 Jun 15;169(7):1201-1213.e17. doi: 10.1016/j.cell.2017.05.041.

3.

PHF11 promotes DSB resection, ATR signaling, and HR.

Gong Y, Handa N, Kowalczykowski SC, de Lange T.

Genes Dev. 2017 Jan 1;31(1):46-58. doi: 10.1101/gad.291807.116. Epub 2017 Jan 23.

4.

Direct Fluorescent Imaging of Translocation and Unwinding by Individual DNA Helicases.

Pavankumar TL, Exell JC, Kowalczykowski SC.

Methods Enzymol. 2016;581:1-32. doi: 10.1016/bs.mie.2016.09.010. Epub 2016 Oct 18.

5.

RecA: Regulation and Mechanism of a Molecular Search Engine: (Trends in Biochemical Sciences, June 2016, Vol. 41, No. 6, 491--507).

Bell JC, Kowalczykowski SC.

Trends Biochem Sci. 2016 Jul;41(7):646. doi: 10.1016/j.tibs.2016.05.006. Epub 2016 Jun 6. No abstract available.

PMID:
27283513
6.

RecA: Regulation and Mechanism of a Molecular Search Engine.

Bell JC, Kowalczykowski SC.

Trends Biochem Sci. 2016 Jun;41(6):491-507. doi: 10.1016/j.tibs.2016.04.002. Epub 2016 May 4. Review. Erratum in: Trends Biochem Sci. 2016 Jul;41(7):646.

7.

Mechanics and Single-Molecule Interrogation of DNA Recombination.

Bell JC, Kowalczykowski SC.

Annu Rev Biochem. 2016 Jun 2;85:193-226. doi: 10.1146/annurev-biochem-060614-034352. Epub 2016 Apr 18. Review.

PMID:
27088880
8.

BRCA2 regulates DMC1-mediated recombination through the BRC repeats.

Martinez JS, von Nicolai C, Kim T, Ehlén Å, Mazin AV, Kowalczykowski SC, Carreira A.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3515-20. doi: 10.1073/pnas.1601691113. Epub 2016 Mar 14.

9.

Single-molecule visualization of RecQ helicase reveals DNA melting, nucleation, and assembly are required for processive DNA unwinding.

Rad B, Forget AL, Baskin RJ, Kowalczykowski SC.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):E6852-61. doi: 10.1073/pnas.1518028112. Epub 2015 Nov 4.

10.

An Overview of the Molecular Mechanisms of Recombinational DNA Repair.

Kowalczykowski SC.

Cold Spring Harb Perspect Biol. 2015 Nov 2;7(11). pii: a016410. doi: 10.1101/cshperspect.a016410. Review.

11.

Imaging and energetics of single SSB-ssDNA molecules reveal intramolecular condensation and insight into RecOR function.

Bell JC, Liu B, Kowalczykowski SC.

Elife. 2015 Sep 18;4:e08646. doi: 10.7554/eLife.08646.

12.

A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination.

Wang AT, Kim T, Wagner JE, Conti BA, Lach FP, Huang AL, Molina H, Sanborn EM, Zierhut H, Cornes BK, Abhyankar A, Sougnez C, Gabriel SB, Auerbach AD, Kowalczykowski SC, Smogorzewska A.

Mol Cell. 2015 Aug 6;59(3):478-90. doi: 10.1016/j.molcel.2015.07.009.

13.

MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex.

Lee KY, Im JS, Shibata E, Park J, Handa N, Kowalczykowski SC, Dutta A.

Nat Commun. 2015 Jul 28;6:7744. doi: 10.1038/ncomms8744.

14.

Sae2 promotes DNA damage resistance by removing the Mre11-Rad50-Xrs2 complex from DNA and attenuating Rad53 signaling.

Chen H, Donnianni RA, Handa N, Deng SK, Oh J, Timashev LA, Kowalczykowski SC, Symington LS.

Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):E1880-7. doi: 10.1073/pnas.1503331112. Epub 2015 Mar 23.

15.

Top3-Rmi1 dissolve Rad51-mediated D loops by a topoisomerase-based mechanism.

Fasching CL, Cejka P, Kowalczykowski SC, Heyer WD.

Mol Cell. 2015 Feb 19;57(4):595-606. doi: 10.1016/j.molcel.2015.01.022.

16.

RecQ helicase and RecJ nuclease provide complementary functions to resect DNA for homologous recombination.

Morimatsu K, Kowalczykowski SC.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):E5133-42. doi: 10.1073/pnas.1420009111. Epub 2014 Nov 19.

17.

Structural and mechanistic insight into Holliday-junction dissolution by topoisomerase IIIα and RMI1.

Bocquet N, Bizard AH, Abdulrahman W, Larsen NB, Faty M, Cavadini S, Bunker RD, Kowalczykowski SC, Cejka P, Hickson ID, Thomä NH.

Nat Struct Mol Biol. 2014 Mar;21(3):261-8. doi: 10.1038/nsmb.2775. Epub 2014 Feb 9.

18.

DNA unwinding heterogeneity by RecBCD results from static molecules able to equilibrate.

Liu B, Baskin RJ, Kowalczykowski SC.

Nature. 2013 Aug 22;500(7463):482-5. doi: 10.1038/nature12333. Epub 2013 Jul 14.

19.

Pif1 family helicases suppress genome instability at G-quadruplex motifs.

Paeschke K, Bochman ML, Garcia PD, Cejka P, Friedman KL, Kowalczykowski SC, Zakian VA.

Nature. 2013 May 23;497(7450):458-62. doi: 10.1038/nature12149. Epub 2013 May 8.

20.

Relationship of DNA degradation by Saccharomyces cerevisiae exonuclease 1 and its stimulation by RPA and Mre11-Rad50-Xrs2 to DNA end resection.

Cannavo E, Cejka P, Kowalczykowski SC.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):E1661-8. doi: 10.1073/pnas.1305166110. Epub 2013 Apr 15.

21.

Exploring protein-DNA interactions in 3D using in situ construction, manipulation and visualization of individual DNA dumbbells with optical traps, microfluidics and fluorescence microscopy.

Forget AL, Dombrowski CC, Amitani I, Kowalczykowski SC.

Nat Protoc. 2013 Mar;8(3):525-38. doi: 10.1038/nprot.2013.016. Epub 2013 Feb 14.

22.

BRCA2 is epistatic to the RAD51 paralogs in response to DNA damage.

Jensen RB, Ozes A, Kim T, Estep A, Kowalczykowski SC.

DNA Repair (Amst). 2013 Apr 1;12(4):306-11. doi: 10.1016/j.dnarep.2012.12.007. Epub 2013 Feb 4.

23.

Direct imaging of RecA nucleation and growth on single molecules of SSB-coated ssDNA.

Bell JC, Plank JL, Dombrowski CC, Kowalczykowski SC.

Nature. 2012 Nov 8;491(7423):274-8. doi: 10.1038/nature11598. Epub 2012 Oct 24.

24.

RecFOR proteins target RecA protein to a DNA gap with either DNA or RNA at the 5' terminus: implication for repair of stalled replication forks.

Morimatsu K, Wu Y, Kowalczykowski SC.

J Biol Chem. 2012 Oct 12;287(42):35621-30. doi: 10.1074/jbc.M112.397034. Epub 2012 Aug 17.

25.

Decatenation of DNA by the S. cerevisiae Sgs1-Top3-Rmi1 and RPA complex: a mechanism for disentangling chromosomes.

Cejka P, Plank JL, Dombrowski CC, Kowalczykowski SC.

Mol Cell. 2012 Sep 28;47(6):886-96. doi: 10.1016/j.molcel.2012.06.032. Epub 2012 Aug 9.

26.

Saccharomyces cerevisiae Dmc1 and Rad51 proteins preferentially function with Tid1 and Rad54 proteins, respectively, to promote DNA strand invasion during genetic recombination.

Nimonkar AV, Dombrowski CC, Siino JS, Stasiak AZ, Stasiak A, Kowalczykowski SC.

J Biol Chem. 2012 Aug 17;287(34):28727-37. doi: 10.1074/jbc.M112.373290. Epub 2012 Jun 29.

27.

Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.

Ciccia A, Nimonkar AV, Hu Y, Hajdu I, Achar YJ, Izhar L, Petit SA, Adamson B, Yoon JC, Kowalczykowski SC, Livingston DM, Haracska L, Elledge SJ.

Mol Cell. 2012 Aug 10;47(3):396-409. doi: 10.1016/j.molcel.2012.05.024. Epub 2012 Jun 14.

28.

Molecular determinants responsible for recognition of the single-stranded DNA regulatory sequence, χ, by RecBCD enzyme.

Handa N, Yang L, Dillingham MS, Kobayashi I, Wigley DB, Kowalczykowski SC.

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8901-6. doi: 10.1073/pnas.1206076109. Epub 2012 May 17.

29.

Alteration of χ recognition by RecBCD reveals a regulated molecular latch and suggests a channel-bypass mechanism for biological control.

Yang L, Handa N, Liu B, Dillingham MS, Wigley DB, Kowalczykowski SC.

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8907-12. doi: 10.1073/pnas.1206081109. Epub 2012 May 17.

30.

Translocation of E. coli RecQ helicase on single-stranded DNA.

Rad B, Kowalczykowski SC.

Biochemistry. 2012 Apr 3;51(13):2921-9. doi: 10.1021/bi3000676. Epub 2012 Mar 21.

31.

Single-molecule imaging of DNA pairing by RecA reveals a three-dimensional homology search.

Forget AL, Kowalczykowski SC.

Nature. 2012 Feb 8;482(7385):423-7. doi: 10.1038/nature10782.

32.

Efficient coupling of ATP hydrolysis to translocation by RecQ helicase.

Rad B, Kowalczykowski SC.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1443-8. doi: 10.1073/pnas.1119952109. Epub 2012 Jan 17.

33.

Two classes of BRC repeats in BRCA2 promote RAD51 nucleoprotein filament function by distinct mechanisms.

Carreira A, Kowalczykowski SC.

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10448-53. doi: 10.1073/pnas.1106971108. Epub 2011 Jun 13.

34.

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair.

Nimonkar AV, Genschel J, Kinoshita E, Polaczek P, Campbell JL, Wyman C, Modrich P, Kowalczykowski SC.

Genes Dev. 2011 Feb 15;25(4):350-62. doi: 10.1101/gad.2003811.

35.

Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1-Top3.

Cejka P, Plank JL, Bachrati CZ, Hickson ID, Kowalczykowski SC.

Nat Struct Mol Biol. 2010 Nov;17(11):1377-82. doi: 10.1038/nsmb.1919. Epub 2010 Oct 10.

36.

DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2.

Cejka P, Cannavo E, Polaczek P, Masuda-Sasa T, Pokharel S, Campbell JL, Kowalczykowski SC.

Nature. 2010 Sep 2;467(7311):112-6. doi: 10.1038/nature09355.

37.

Purified human BRCA2 stimulates RAD51-mediated recombination.

Jensen RB, Carreira A, Kowalczykowski SC.

Nature. 2010 Oct 7;467(7316):678-83. doi: 10.1038/nature09399.

38.

Watching individual proteins acting on single molecules of DNA.

Amitani I, Liu B, Dombrowski CC, Baskin RJ, Kowalczykowski SC.

Methods Enzymol. 2010;472:261-91. doi: 10.1016/S0076-6879(10)72007-3.

39.

Single-molecule imaging brings Rad51 nucleoprotein filaments into focus.

Forget AL, Kowalczykowski SC.

Trends Cell Biol. 2010 May;20(5):269-76. doi: 10.1016/j.tcb.2010.02.004. Epub 2010 Mar 17. Review.

40.

The full-length Saccharomyces cerevisiae Sgs1 protein is a vigorous DNA helicase that preferentially unwinds holliday junctions.

Cejka P, Kowalczykowski SC.

J Biol Chem. 2010 Mar 12;285(11):8290-301. doi: 10.1074/jbc.M109.083196. Epub 2010 Jan 19.

41.

An alternative form of replication protein a expressed in normal human tissues supports DNA repair.

Kemp MG, Mason AC, Carreira A, Reardon JT, Haring SJ, Borgstahl GE, Kowalczykowski SC, Sancar A, Wold MS.

J Biol Chem. 2010 Feb 12;285(7):4788-97. doi: 10.1074/jbc.M109.079418. Epub 2009 Dec 7.

42.

Visualizing protein-DNA interactions at the single-molecule level.

Hilario J, Kowalczykowski SC.

Curr Opin Chem Biol. 2010 Feb;14(1):15-22. doi: 10.1016/j.cbpa.2009.10.035. Epub 2009 Nov 27. Review.

43.

BRCA2: Shining light on the regulation of DNA-binding selectivity by RAD51.

Carreira A, Kowalczykowski SC.

Cell Cycle. 2009 Nov 1;8(21):3445-7. Epub 2009 Nov 6. No abstract available.

44.

Second-end DNA capture in double-strand break repair: how to catch a DNA by its tail.

Nimonkar AV, Kowalczykowski SC.

Cell Cycle. 2009 Jun 15;8(12):1816-7. Epub 2009 Jun 6. No abstract available.

45.

Reconstitution of initial steps of dsDNA break repair by the RecF pathway of E. coli.

Handa N, Morimatsu K, Lovett ST, Kowalczykowski SC.

Genes Dev. 2009 May 15;23(10):1234-45. doi: 10.1101/gad.1780709.

46.

Single molecule analysis of a red fluorescent RecA protein reveals a defect in nucleoprotein filament nucleation that relates to its reduced biological functions.

Handa N, Amitani I, Gumlaw N, Sandler SJ, Kowalczykowski SC.

J Biol Chem. 2009 Jul 10;284(28):18664-73. doi: 10.1074/jbc.M109.004895. Epub 2009 May 5.

47.

The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51.

Carreira A, Hilario J, Amitani I, Baskin RJ, Shivji MK, Venkitaraman AR, Kowalczykowski SC.

Cell. 2009 Mar 20;136(6):1032-43. doi: 10.1016/j.cell.2009.02.019.

48.

An archaeal Rad54 protein remodels DNA and stimulates DNA strand exchange by RadA.

Haseltine CA, Kowalczykowski SC.

Nucleic Acids Res. 2009 May;37(8):2757-70. doi: 10.1093/nar/gkp068. Epub 2009 Mar 12.

49.

Rad52 promotes second-end DNA capture in double-stranded break repair to form complement-stabilized joint molecules.

Nimonkar AV, Sica RA, Kowalczykowski SC.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3077-82. doi: 10.1073/pnas.0813247106. Epub 2009 Feb 9.

50.

Direct imaging of human Rad51 nucleoprotein dynamics on individual DNA molecules.

Hilario J, Amitani I, Baskin RJ, Kowalczykowski SC.

Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):361-8. doi: 10.1073/pnas.0811965106. Epub 2009 Jan 2.

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