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Items: 38

1.

Preparation of Viscosity-Sensitive Isoxazoline/Isoxazolyl-Based Molecular Rotors and Directly Linked BODIPY-Fulleroisoxazoline from the Stable meso-(Nitrile Oxide)-Substituted BODIPY.

Zatsikha YV, Didukh NO, Swedin RK, Yakubovskyi VP, Blesener TS, Healy AT, Herbert DE, Blank DA, Nemykin VN, Kovtun YP.

Org Lett. 2019 Jul 19;21(14):5713-5718. doi: 10.1021/acs.orglett.9b02082. Epub 2019 Jul 8.

PMID:
31283252
2.

Solvatochromic Near-Infrared Probe for Polarity Mapping of Biomembranes and Lipid Droplets in Cells under Stress.

Ashoka AH, Ashokkumar P, Kovtun YP, Klymchenko AS.

J Phys Chem Lett. 2019 May 16;10(10):2414-2421. doi: 10.1021/acs.jpclett.9b00668. Epub 2019 Apr 30.

PMID:
31021640
3.

Synthesis, Characterization, and Electron-Transfer Properties of Ferrocene-BODIPY-Fullerene Near-Infrared-Absorbing Triads: Are Catecholopyrrolidine-Linked Fullerenes a Good Architecture to Facilitate Electron-Transfer?

Zatsikha YV, Swedin RK, Healy AT, Goff PC, Didukh NO, Blesener TS, Kayser M, Kovtun YP, Blank DA, Nemykin VN.

Chemistry. 2019 Jun 21;25(35):8401-8414. doi: 10.1002/chem.201901225. Epub 2019 May 24.

PMID:
31001860
4.

Flexible BODIPY Platform That Offers an Unexpected Regioselective Heterocyclization Reaction toward Preparation of 2-Pyridone[ a]-Fused BODIPYs.

Didukh NO, Yakubovskyi VP, Zatsikha YV, Rohde GT, Nemykin VN, Kovtun YP.

J Org Chem. 2019 Feb 15;84(4):2133-2147. doi: 10.1021/acs.joc.8b03119. Epub 2019 Feb 4.

PMID:
30693775
5.

CD123 expression patterns and selective targeting with a CD123-targeted antibody-drug conjugate (IMGN632) in acute lymphoblastic leukemia.

Angelova E, Audette C, Kovtun Y, Daver N, Wang SA, Pierce S, Konoplev SN, Khogeer H, Jorgensen JL, Konopleva M, Zweidler-McKay PA, Medeiros LJ, Kantarjian HM, Jabbour EJ, Khoury JD.

Haematologica. 2019 Apr;104(4):749-755. doi: 10.3324/haematol.2018.205252. Epub 2018 Oct 25.

6.

A CD123-targeting antibody-drug conjugate, IMGN632, designed to eradicate AML while sparing normal bone marrow cells.

Kovtun Y, Jones GE, Adams S, Harvey L, Audette CA, Wilhelm A, Bai C, Rui L, Laleau R, Liu F, Ab O, Setiady Y, Yoder NC, Goldmacher VS, Chari RVJ, Pinkas J, Chittenden T.

Blood Adv. 2018 Apr 24;2(8):848-858. doi: 10.1182/bloodadvances.2018017517.

7.

IMGN779, a Novel CD33-Targeting Antibody-Drug Conjugate with DNA-Alkylating Activity, Exhibits Potent Antitumor Activity in Models of AML.

Kovtun Y, Noordhuis P, Whiteman KR, Watkins K, Jones GE, Harvey L, Lai KC, Portwood S, Adams S, Sloss CM, Schuurhuis GJ, Ossenkoppele G, Wang ES, Pinkas J.

Mol Cancer Ther. 2018 Jun;17(6):1271-1279. doi: 10.1158/1535-7163.MCT-17-1077. Epub 2018 Mar 27.

8.

A DNA-Interacting Payload Designed to Eliminate Cross-Linking Improves the Therapeutic Index of Antibody-Drug Conjugates (ADCs).

Miller ML, Shizuka M, Wilhelm A, Salomon P, Reid EE, Lanieri L, Sikka S, Maloney EK, Harvey L, Qiu Q, Archer KE, Bai C, Vitharana D, Harris L, Singh R, Ponte JF, Yoder NC, Kovtun Y, Lai KC, Ab O, Pinkas J, Keating TA, Chari RVJ.

Mol Cancer Ther. 2018 Mar;17(3):650-660. doi: 10.1158/1535-7163.MCT-17-0940. Epub 2018 Feb 13.

9.

Ferrocene-BODIPYmerocyanine dyads: new NIR absorbing platforms with optical properties susceptible to protonation.

Zatsikha YV, Didukh NO, Nemez D, Schlachter AC, Karsenti PL, Kovtun YP, Harvey PD, Nemykin VN.

Chem Commun (Camb). 2017 Jul 4;53(54):7612-7615. doi: 10.1039/c7cc03332j.

PMID:
28639661
10.

Push-pull dioxaborine as fluorescent molecular rotor: far-red fluorogenic probe for ligand-receptor interactions.

Karpenko IA, Niko Y, Yakubovskyi VP, Gerasov AO, Bonnet D, Kovtun YP, Klymchenko AS.

J Mater Chem C Mater. 2016 Apr 14;4(14):3002-3009. doi: 10.1039/C5TC03411F. Epub 2015 Dec 7.

11.

NIR absorbing diferrocene-containing meso-cyano-BODIPY with a UV-Vis-NIR spectrum remarkably close to that of magnesium tetracyanotetraferrocenyltetraazaporphyrin.

Didukh NO, Zatsikha YV, Rohde GT, Blesener TS, Yakubovskyi VP, Kovtun YP, Nemykin VN.

Chem Commun (Camb). 2016 Oct 4;52(77):11563-6. doi: 10.1039/c6cc06344f. Epub 2016 Sep 6.

PMID:
27602790
12.

A New Class of Antibody-Drug Conjugates with Potent DNA Alkylating Activity.

Miller ML, Fishkin NE, Li W, Whiteman KR, Kovtun Y, Reid EE, Archer KE, Maloney EK, Audette CA, Mayo MF, Wilhelm A, Modafferi HA, Singh R, Pinkas J, Goldmacher V, Lambert JM, Chari RV.

Mol Cancer Ther. 2016 Aug;15(8):1870-8. doi: 10.1158/1535-7163.MCT-16-0184. Epub 2016 May 23.

13.

A New Triglycyl Peptide Linker for Antibody-Drug Conjugates (ADCs) with Improved Targeted Killing of Cancer Cells.

Singh R, Setiady YY, Ponte J, Kovtun YV, Lai KC, Hong EE, Fishkin N, Dong L, Jones GE, Coccia JA, Lanieri L, Veale K, Costoplus JA, Skaletskaya A, Gabriel R, Salomon P, Wu R, Qiu Q, Erickson HK, Lambert JM, Chari RV, Widdison WC.

Mol Cancer Ther. 2016 Jun;15(6):1311-20. doi: 10.1158/1535-7163.MCT-16-0021. Epub 2016 Mar 29.

14.

A sensing mechanism for the detection of carbon nanotubes using selective photoluminescent probes based on ionic complexes with organic dyes.

Lutsyk P, Arif R, Hruby J, Bukivskyi A, Vinijchuk O, Shandura M, Yakubovskyi V, Kovtun Y, Rance GA, Fay M, Piryatinski Y, Kachkovsky O, Verbitsky A, Rozhin A.

Light Sci Appl. 2016 Feb 12;5(2):e16028. doi: 10.1038/lsa.2016.28. eCollection 2016 Feb.

15.

Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolites in Cancer Cells and Induce High Levels of Bystander Killing.

Widdison WC, Ponte JF, Coccia JA, Lanieri L, Setiady Y, Dong L, Skaletskaya A, Hong EE, Wu R, Qiu Q, Singh R, Salomon P, Fishkin N, Harris L, Maloney EK, Kovtun Y, Veale K, Wilhelm SD, Audette CA, Costoplus JA, Chari RV.

Bioconjug Chem. 2015 Nov 18;26(11):2261-78. doi: 10.1021/acs.bioconjchem.5b00430. Epub 2015 Sep 30.

PMID:
26355774
16.

Tuning Electronic Structure, Redox, and Photophysical Properties in Asymmetric NIR-Absorbing Organometallic BODIPYs.

Zatsikha YV, Maligaspe E, Purchel AA, Didukh NO, Wang Y, Kovtun YP, Blank DA, Nemykin VN.

Inorg Chem. 2015 Aug 17;54(16):7915-28. doi: 10.1021/acs.inorgchem.5b00992. Epub 2015 Jul 29.

PMID:
26220063
17.

Design of Coltuximab Ravtansine, a CD19-Targeting Antibody-Drug Conjugate (ADC) for the Treatment of B-Cell Malignancies: Structure-Activity Relationships and Preclinical Evaluation.

Hong EE, Erickson H, Lutz RJ, Whiteman KR, Jones G, Kovtun Y, Blanc V, Lambert JM.

Mol Pharm. 2015 Jun 1;12(6):1703-16. doi: 10.1021/acs.molpharmaceut.5b00175. Epub 2015 Apr 27.

PMID:
25856201
18.

Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies.

Widdison W, Wilhelm S, Veale K, Costoplus J, Jones G, Audette C, Leece B, Bartle L, Kovtun Y, Chari R.

Mol Pharm. 2015 Jun 1;12(6):1762-73. doi: 10.1021/mp5007757. Epub 2015 Apr 8.

PMID:
25826705
19.

High-affinity accumulation of a maytansinoid in cells via weak tubulin interaction.

Goldmacher VS, Audette CA, Guan Y, Sidhom EH, Shah JV, Whiteman KR, Kovtun YV.

PLoS One. 2015 Feb 11;10(2):e0117523. doi: 10.1371/journal.pone.0117523. eCollection 2015.

20.

3,5-Bis(acetaldehyde) substituted BODIPY.

Shandura MP, Yakubovskyi VP, Kovtun YP.

Org Biomol Chem. 2013 Feb 7;11(5):835-41. doi: 10.1039/c2ob27004h. Epub 2012 Dec 12.

PMID:
23235924
21.

Two-Photon Absorption Spectrum of a Single Crystal Cyanine-like Dye.

Hu H, Fishman DA, Gerasov AO, Przhonska OV, Webster S, Padilha LA, Peceli D, Shandura M, Kovtun YP, Kachkovski AD, Nayyar IH, Masunov AE, Tongwa P, Timofeeva TV, Hagan DJ, Van Stryland EW.

J Phys Chem Lett. 2012 May 3;3(9):1222-8. doi: 10.1021/jz300222h. Epub 2012 Apr 23.

PMID:
26288058
22.

Fluorescent labeling of proteins with amine-specific 1,3,2-(2H)-dioxaborine polymethine dye.

Gerasov A, Shandura M, Kovtun Y, Losytskyy M, Negrutska V, Dubey I.

Anal Biochem. 2012 Jan 15;420(2):115-20. doi: 10.1016/j.ab.2011.09.018. Epub 2011 Oct 1.

PMID:
22005321
23.

Synthesis and evaluation of hydrophilic linkers for antibody-maytansinoid conjugates.

Zhao RY, Wilhelm SD, Audette C, Jones G, Leece BA, Lazar AC, Goldmacher VS, Singh R, Kovtun Y, Widdison WC, Lambert JM, Chari RV.

J Med Chem. 2011 May 26;54(10):3606-23. doi: 10.1021/jm2002958. Epub 2011 May 4.

PMID:
21517041
24.

Disulfide-linked antibody-maytansinoid conjugates: optimization of in vivo activity by varying the steric hindrance at carbon atoms adjacent to the disulfide linkage.

Kellogg BA, Garrett L, Kovtun Y, Lai KC, Leece B, Miller M, Payne G, Steeves R, Whiteman KR, Widdison W, Xie H, Singh R, Chari RV, Lambert JM, Lutz RJ.

Bioconjug Chem. 2011 Apr 20;22(4):717-27. doi: 10.1021/bc100480a. Epub 2011 Mar 22.

PMID:
21425776
25.

Antibody-drug conjugates: using monoclonal antibodies for delivery of cytotoxic payloads to cancer cells.

Goldmacher VS, Kovtun YV.

Ther Deliv. 2011 Mar;2(3):397-416. Review.

PMID:
22834009
26.

Maytansinoid-antibody conjugates induce mitotic arrest by suppressing microtubule dynamic instability.

Oroudjev E, Lopus M, Wilson L, Audette C, Provenzano C, Erickson H, Kovtun Y, Chari R, Jordan MA.

Mol Cancer Ther. 2010 Oct;9(10):2700-13. doi: 10.1158/1535-7163.MCT-10-0645.

27.

Efficient two-photon absorbing acceptor-pi-acceptor polymethine dyes.

Padilha LA, Webster S, Przhonska OV, Hu H, Peceli D, Ensley TR, Bondar MV, Gerasov AO, Kovtun YP, Shandura MP, Kachkovski AD, Hagan DJ, Van Stryland EW.

J Phys Chem A. 2010 Jun 17;114(23):6493-501. doi: 10.1021/jp100963e.

PMID:
20486673
28.

Antibody-maytansinoid conjugates designed to bypass multidrug resistance.

Kovtun YV, Audette CA, Mayo MF, Jones GE, Doherty H, Maloney EK, Erickson HK, Sun X, Wilhelm S, Ab O, Lai KC, Widdison WC, Kellogg B, Johnson H, Pinkas J, Lutz RJ, Singh R, Goldmacher VS, Chari RV.

Cancer Res. 2010 Mar 15;70(6):2528-37. doi: 10.1158/0008-5472.CAN-09-3546. Epub 2010 Mar 2.

29.

Cell killing by antibody-drug conjugates.

Kovtun YV, Goldmacher VS.

Cancer Lett. 2007 Oct 8;255(2):232-40. Epub 2007 Jun 5. Review.

PMID:
17553616
30.

Semisynthetic maytansine analogues for the targeted treatment of cancer.

Widdison WC, Wilhelm SD, Cavanagh EE, Whiteman KR, Leece BA, Kovtun Y, Goldmacher VS, Xie H, Steeves RM, Lutz RJ, Zhao R, Wang L, Blättler WA, Chari RV.

J Med Chem. 2006 Jul 13;49(14):4392-408.

PMID:
16821799
31.

Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing.

Erickson HK, Park PU, Widdison WC, Kovtun YV, Garrett LM, Hoffman K, Lutz RJ, Goldmacher VS, Blättler WA.

Cancer Res. 2006 Apr 15;66(8):4426-33.

32.

Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen.

Kovtun YV, Audette CA, Ye Y, Xie H, Ruberti MF, Phinney SJ, Leece BA, Chittenden T, Blättler WA, Goldmacher VS.

Cancer Res. 2006 Mar 15;66(6):3214-21.

33.

Fumonisin B1-induced cell death in arabidopsis protoplasts requires jasmonate-, ethylene-, and salicylate-dependent signaling pathways.

Asai T, Stone JM, Heard JE, Kovtun Y, Yorgey P, Sheen J, Ausubel FM.

Plant Cell. 2000 Oct;12(10):1823-36.

34.

Functional analysis of oxidative stress-activated mitogen-activated protein kinase cascade in plants.

Kovtun Y, Chiu WL, Tena G, Sheen J.

Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2940-5.

35.

Suppression of auxin signal transduction by a MAPK cascade in higher plants.

Kovtun Y, Chiu WL, Zeng W, Sheen J.

Nature. 1998 Oct 15;395(6703):716-20.

PMID:
9790195
37.

A new middle repetitive sequence of Nicotiana plumbaginifolia genome.

Kovtun YV, Komarnitsky IK, Gleba YYu.

Plant Mol Biol. 1993 Oct;23(2):435-8.

PMID:
8219078
38.

Amplification of repetitive DNA from Nicotiana plumbaginifolia in asymmetric somatic hybrids between Nicotiana sylvestris and Nicotiana plumbaginifolia.

Kovtun YV, Korostash MA, Butsko YV, Gleba YY.

Theor Appl Genet. 1993 Apr;86(2-3):221-8. doi: 10.1007/BF00222082.

PMID:
24193463

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