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Items: 1 to 50 of 64

1.

Human Colonoid Monolayers to Study Interactions Between Pathogens, Commensals, and Host Intestinal Epithelium.

In JG, Foulke-Abel J, Clarke E, Kovbasnjuk O.

J Vis Exp. 2019 Apr 9;(146). doi: 10.3791/59357.

PMID:
31033964
2.

Enterohemorrhagic E. coli (EHEC)-Secreted Serine Protease EspP Stimulates Electrogenic Ion Transport in Human Colonoid Monolayers.

Tse CM, In JG, Yin J, Donowitz M, Doucet M, Foulke-Abel J, Ruiz-Perez F, Nataro JP, Zachos NC, Kaper JB, Kovbasnjuk O.

Toxins (Basel). 2018 Sep 1;10(9). pii: E351. doi: 10.3390/toxins10090351.

3.

xMD-miRNA-seq to generate near in vivo miRNA expression estimates in colon epithelial cells.

Rosenberg AZ, Wright C, Fox-Talbot K, Rajpurohit A, Williams C, Porter C, Kovbasnjuk O, McCall MN, Shin JH, Halushka MK.

Sci Rep. 2018 Jun 28;8(1):9783. doi: 10.1038/s41598-018-28198-z.

4.

Both NHERF3 and NHERF2 are necessary for multiple aspects of acute regulation of NHE3 by elevated Ca2+, cGMP, and lysophosphatidic acid.

Avula LR, Chen T, Kovbasnjuk O, Donowitz M.

Am J Physiol Gastrointest Liver Physiol. 2018 Jan 1;314(1):G81-G90. doi: 10.1152/ajpgi.00140.2017. Epub 2017 Sep 7.

5.

Gastrointestinal microphysiological systems.

Blutt SE, Broughman JR, Zou W, Zeng XL, Karandikar UC, In J, Zachos NC, Kovbasnjuk O, Donowitz M, Estes MK.

Exp Biol Med (Maywood). 2017 Oct;242(16):1633-1642. doi: 10.1177/1535370217710638. Epub 2017 May 23. Review.

6.

Phosphorylation of NHE3-S719 regulates NHE3 activity through the formation of multiple signaling complexes.

Sarker R, Cha B, Kovbasnjuk O, Cole R, Gabelli S, Tse CM, Donowitz M.

Mol Biol Cell. 2017 Jul 1;28(13):1754-1767. doi: 10.1091/mbc.E16-12-0862. Epub 2017 May 11.

7.

Erratum: A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions.

Noel G, Baetz NW, Staab JF, Donowitz M, Kovbasnjuk O, Pasetti MF, Zachos NC.

Sci Rep. 2017 May 3;7:46790. doi: 10.1038/srep46790. No abstract available.

8.

A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions.

Noel G, Baetz NW, Staab JF, Donowitz M, Kovbasnjuk O, Pasetti MF, Zachos NC.

Sci Rep. 2017 Mar 27;7:45270. doi: 10.1038/srep45270. Erratum in: Sci Rep. 2017 May 03;7:46790.

9.

Corrigendum: Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle.

Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL.

Sci Rep. 2017 Mar 16;7:44517. doi: 10.1038/srep44517. No abstract available.

10.

The Contributions of Human Mini-Intestines to the Study of Intestinal Physiology and Pathophysiology.

Yu H, Hasan NM, In JG, Estes MK, Kovbasnjuk O, Zachos NC, Donowitz M.

Annu Rev Physiol. 2017 Feb 10;79:291-312. doi: 10.1146/annurev-physiol-021115-105211. Review.

11.

Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle.

Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL.

Sci Rep. 2017 Feb 8;7:42296. doi: 10.1038/srep42296. Erratum in: Sci Rep. 2017 Mar 16;7:44517.

12.

Secretome analysis of diarrhea-inducing strains of Escherichia coli.

Nirujogi RS, Muthusamy B, Kim MS, Sathe GJ, Lakshmi PT, Kovbasnjuk ON, Prasad TS, Wade M, Jabbour RE.

Proteomics. 2017 Mar;17(6). doi: 10.1002/pmic.201600299. Epub 2017 Mar 6.

13.

A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection.

Saxena K, Simon LM, Zeng XL, Blutt SE, Crawford SE, Sastri NP, Karandikar UC, Ajami NJ, Zachos NC, Kovbasnjuk O, Donowitz M, Conner ME, Shaw CA, Estes MK.

Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E570-E579. doi: 10.1073/pnas.1615422114. Epub 2017 Jan 9.

14.

Human mini-guts: new insights into intestinal physiology and host-pathogen interactions.

In JG, Foulke-Abel J, Estes MK, Zachos NC, Kovbasnjuk O, Donowitz M.

Nat Rev Gastroenterol Hepatol. 2016 Nov;13(11):633-642. doi: 10.1038/nrgastro.2016.142. Epub 2016 Sep 28. Review.

15.

Enterohemorrhagic Escherichia coli reduce mucus and intermicrovillar bridges in human stem cell-derived colonoids.

In J, Foulke-Abel J, Zachos NC, Hansen AM, Kaper JB, Bernstein HD, Halushka M, Blutt S, Estes MK, Donowitz M, Kovbasnjuk O.

Cell Mol Gastroenterol Hepatol. 2016 Jan 1;2(1):48-62.e3.

16.

Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology.

Foulke-Abel J, In J, Yin J, Zachos NC, Kovbasnjuk O, Estes MK, de Jonge H, Donowitz M.

Gastroenterology. 2016 Mar;150(3):638-649.e8. doi: 10.1053/j.gastro.2015.11.047. Epub 2015 Dec 8.

17.

Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology.

Zachos NC, Kovbasnjuk O, Foulke-Abel J, In J, Blutt SE, de Jonge HR, Estes MK, Donowitz M.

J Biol Chem. 2016 Feb 19;291(8):3759-66. doi: 10.1074/jbc.R114.635995. Epub 2015 Dec 16. Review.

18.

Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology.

Saxena K, Blutt SE, Ettayebi K, Zeng XL, Broughman JR, Crawford SE, Karandikar UC, Sastri NP, Conner ME, Opekun AR, Graham DY, Qureshi W, Sherman V, Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Donowitz M, Estes MK.

J Virol. 2015 Oct 7;90(1):43-56. doi: 10.1128/JVI.01930-15. Print 2016 Jan 1.

19.

Lysophosphatidic acid stimulation of NHE3 exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK-PLC-PKCδ signaling.

Cha B, Chen T, Sarker R, Yang J, Raben D, Tse CM, Kovbasnjuk O, Donowitz M.

Am J Physiol Cell Physiol. 2014 Jul 1;307(1):C55-65. doi: 10.1152/ajpcell.00045.2014. Epub 2014 Apr 23.

20.

Microfluidics platform for measurement of volume changes in immobilized intestinal enteroids.

Jin BJ, Battula S, Zachos N, Kovbasnjuk O, Fawlke-Abel J, In J, Donowitz M, Verkman AS.

Biomicrofluidics. 2014 Apr 1;8(2):024106. doi: 10.1063/1.4870400. eCollection 2014 Mar.

21.

Human enteroids as an ex-vivo model of host-pathogen interactions in the gastrointestinal tract.

Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Ettayebi K, Blutt SE, Hyser JM, Zeng XL, Crawford SE, Broughman JR, Estes MK, Donowitz M.

Exp Biol Med (Maywood). 2014 Sep;239(9):1124-34. doi: 10.1177/1535370214529398. Epub 2014 Apr 9. Review.

22.

Carbachol-mediated endocytosis of NHE3 involves a clathrin-independent mechanism requiring lipid rafts and Cdc42.

Zachos NC, Alamelumangpuram B, Lee LJ, Wang P, Kovbasnjuk O.

Cell Physiol Biochem. 2014;33(3):869-81. doi: 10.1159/000358659. Epub 2014 Mar 28.

23.

Human enteroids: preclinical models of non-inflammatory diarrhea.

Kovbasnjuk O, Zachos NC, In J, Foulke-Abel J, Ettayebi K, Hyser JM, Broughman JR, Zeng XL, Middendorp S, de Jonge HR, Estes MK, Donowitz M.

Stem Cell Res Ther. 2013;4 Suppl 1:S3. doi: 10.1186/scrt364. Epub 2013 Dec 20. Review.

24.

Strengthening the skin with topical delivery of keratinocyte growth factor-1 using a novel DNA plasmid.

Dou C, Lay F, Ansari AM, Rees DJ, Ahmed AK, Kovbasnjuk O, Matsangos AE, Du J, Hosseini SM, Steenbergen C, Fox-Talbot K, Tabor AT, Williams JA, Liu L, Marti GP, Harmon JW.

Mol Ther. 2014 Apr;22(4):752-61. doi: 10.1038/mt.2014.2. Epub 2014 Jan 17.

25.

Translating molecular physiology of intestinal transport into pharmacologic treatment of diarrhea: stimulation of Na+ absorption.

Singh V, Yang J, Chen TE, Zachos NC, Kovbasnjuk O, Verkman AS, Donowitz M.

Clin Gastroenterol Hepatol. 2014 Jan;12(1):27-31. doi: 10.1016/j.cgh.2013.10.020. Epub 2013 Oct 31. Review.

26.

Serine protease EspP from enterohemorrhagic Escherichia coli is sufficient to induce shiga toxin macropinocytosis in intestinal epithelium.

In J, Lukyanenko V, Foulke-Abel J, Hubbard AL, Delannoy M, Hansen AM, Kaper JB, Boisen N, Nataro JP, Zhu C, Boedeker EC, Girón JA, Kovbasnjuk O.

PLoS One. 2013 Jul 18;8(7):e69196. doi: 10.1371/journal.pone.0069196. Print 2013.

27.

PLC-γ directly binds activated c-Src, which is necessary for carbachol-mediated inhibition of NHE3 activity in Caco-2/BBe cells.

Zachos NC, Lee LJ, Kovbasnjuk O, Li X, Donowitz M.

Am J Physiol Cell Physiol. 2013 Aug 1;305(3):C266-75. doi: 10.1152/ajpcell.00277.2012. Epub 2013 May 22.

28.

NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells.

Yang J, Singh V, Cha B, Chen TE, Sarker R, Murtazina R, Jin S, Zachos NC, Patterson GH, Tse CM, Kovbasnjuk O, Li X, Donowitz M.

J Biol Chem. 2013 Jun 7;288(23):16960-74. doi: 10.1074/jbc.M113.470799. Epub 2013 Apr 23.

29.

Insulin-like growth factor 1 (IGF-1) enhances the protein expression of CFTR.

Lee HW, Cheng J, Kovbasnjuk O, Donowitz M, Guggino WB.

PLoS One. 2013;8(3):e59992. doi: 10.1371/journal.pone.0059992. Epub 2013 Mar 28.

30.

Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia.

Schiffhauer ES, Vij N, Kovbasnjuk O, Kang PW, Walker D, Lee S, Zeitlin PL.

Am J Physiol Lung Cell Mol Physiol. 2013 Mar 1;304(5):L324-31. doi: 10.1152/ajplung.00277.2012. Epub 2013 Jan 11.

31.

Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na+/H+ exchanger 3 (NHE3) by a NHERF2 protein-dependent process.

Zizak M, Chen T, Bartonicek D, Sarker R, Zachos NC, Cha B, Kovbasnjuk O, Korac J, Mohan S, Cole R, Chen Y, Tse CM, Donowitz M.

J Biol Chem. 2012 Apr 13;287(16):13442-56. doi: 10.1074/jbc.M111.307256. Epub 2012 Feb 27.

32.

Enterohemorrhagic Escherichia coli infection stimulates Shiga toxin 1 macropinocytosis and transcytosis across intestinal epithelial cells.

Lukyanenko V, Malyukova I, Hubbard A, Delannoy M, Boedeker E, Zhu C, Cebotaru L, Kovbasnjuk O.

Am J Physiol Cell Physiol. 2011 Nov;301(5):C1140-9. doi: 10.1152/ajpcell.00036.2011. Epub 2011 Aug 10.

33.

Elevated calcium acutely regulates dynamic interactions of NHERF2 and NHE3 proteins in opossum kidney (OK) cell microvilli.

Zhu X, Cha B, Zachos NC, Sarker R, Chakraborty M, Chen TE, Kovbasnjuk O, Donowitz M.

J Biol Chem. 2011 Oct 7;286(40):34486-96. doi: 10.1074/jbc.M111.230219. Epub 2011 Jul 28.

34.

NHERF2 is necessary for basal activity, second messenger inhibition, and LPA stimulation of NHE3 in mouse distal ileum.

Murtazina R, Kovbasnjuk O, Chen TE, Zachos NC, Chen Y, Kocinsky HS, Hogema BM, Seidler U, de Jonge HR, Donowitz M.

Am J Physiol Cell Physiol. 2011 Jul;301(1):C126-36. doi: 10.1152/ajpcell.00311.2010. Epub 2011 Mar 23.

35.

Alterations in the proteome of the NHERF2 knockout mouse jejunal brush border membrane vesicles.

Donowitz M, Singh S, Singh P, Chakraborty M, Chen Y, Murtazina R, Gucek M, Cole RN, Zachos NC, Salahuddin FF, Kovbasnjuk O, Broere N, Smalley-Freed WG, Reynolds AB, Hubbard AL, Seidler U, Weinman E, de Jonge HR, Hogema BM, Li X.

Physiol Genomics. 2011 Jun 15;43(11):674-84. doi: 10.1152/physiolgenomics.00258.2010. Epub 2011 Mar 22.

36.

D-glucose acts via sodium/glucose cotransporter 1 to increase NHE3 in mouse jejunal brush border by a Na+/H+ exchange regulatory factor 2-dependent process.

Lin R, Murtazina R, Cha B, Chakraborty M, Sarker R, Chen TE, Lin Z, Hogema BM, de Jonge HR, Seidler U, Turner JR, Li X, Kovbasnjuk O, Donowitz M.

Gastroenterology. 2011 Feb;140(2):560-71. doi: 10.1053/j.gastro.2010.10.042. Epub 2010 Oct 23.

37.

Alterations in the proteome of the NHERF1 knockout mouse jejunal brush border membrane vesicles.

Donowitz M, Singh S, Singh P, Salahuddin FF, Chen Y, Chakraborty M, Murtazina R, Gucek M, Cole RN, Zachos NC, Kovbasnjuk O, Broere N, Smalley-Freed WG, Reynolds AB, Hubbard AL, Seidler U, Weinman E, de Jonge HR, Hogema BM, Li X.

Physiol Genomics. 2010 Nov 15;42A(3):200-10. doi: 10.1152/physiolgenomics.00001.2010. Epub 2010 Aug 24.

38.

NHE3 mobility in brush borders increases upon NHERF2-dependent stimulation by lyophosphatidic acid.

Cha B, Zhu XC, Chen W, Jones M, Ryoo S, Zachos NC, Chen TE, Lin R, Sarker R, Kenworthy AK, Tse M, Kovbasnjuk O, Donowitz M.

J Cell Sci. 2010 Jul 15;123(Pt 14):2434-43. doi: 10.1242/jcs.056713. Epub 2010 Jun 22.

39.

Shiga toxin is transported into the nucleoli of intestinal epithelial cells via a carrier-dependent process.

Baibakov B, Murtazina R, Elowsky C, Giardiello FM, Kovbasnjuk O.

Toxins (Basel). 2010 Jun;2(6):1318-35. doi: 10.3390/toxins2061318. Epub 2010 Jun 7.

40.

PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP.

Weinman EJ, Steplock D, Cha B, Kovbasnjuk O, Frost NA, Cunningham R, Shenolikar S, Blanpied TA, Donowitz M.

Am J Physiol Renal Physiol. 2009 Dec;297(6):F1560-5. doi: 10.1152/ajprenal.90657.2008. Epub 2009 Sep 30.

41.

Shiga toxin 1 interaction with enterocytes causes apical protein mistargeting through the depletion of intracellular galectin-3.

Laiko M, Murtazina R, Malyukova I, Zhu C, Boedeker EC, Gutsal O, O'Malley R, Cole RN, Tarr PI, Murray KF, Kane A, Donowitz M, Kovbasnjuk O.

Exp Cell Res. 2010 Feb 15;316(4):657-66. doi: 10.1016/j.yexcr.2009.09.002. Epub 2009 Sep 8.

42.

Regulation of intestinal electroneutral sodium absorption and the brush border Na+/H+ exchanger by intracellular calcium.

Zachos NC, Kovbasnjuk O, Donowitz M.

Ann N Y Acad Sci. 2009 May;1165:240-8. doi: 10.1111/j.1749-6632.2009.04055.x. Review.

43.

NHERF3 (PDZK1) contributes to basal and calcium inhibition of NHE3 activity in Caco-2BBe cells.

Zachos NC, Li X, Kovbasnjuk O, Hogema B, Sarker R, Lee LJ, Li M, de Jonge H, Donowitz M.

J Biol Chem. 2009 Aug 28;284(35):23708-18. doi: 10.1074/jbc.M109.012641. Epub 2009 Jun 17.

44.

Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanism.

Zachos NC, Hodson C, Kovbasnjuk O, Li X, Thelin WR, Cha B, Milgram S, Donowitz M.

Cell Physiol Biochem. 2008;22(5-6):693-704. doi: 10.1159/000185553. Epub 2008 Dec 9.

45.

Macropinocytosis in Shiga toxin 1 uptake by human intestinal epithelial cells and transcellular transcytosis.

Malyukova I, Murray KF, Zhu C, Boedeker E, Kane A, Patterson K, Peterson JR, Donowitz M, Kovbasnjuk O.

Am J Physiol Gastrointest Liver Physiol. 2009 Jan;296(1):G78-92. doi: 10.1152/ajpgi.90347.2008. Epub 2008 Oct 30.

46.

Latrunculin B facilitates Shiga toxin 1 transcellular transcytosis across T84 intestinal epithelial cells.

Maluykova I, Gutsal O, Laiko M, Kane A, Donowitz M, Kovbasnjuk O.

Biochim Biophys Acta. 2008 Jun;1782(6):370-7. doi: 10.1016/j.bbadis.2008.01.010. Epub 2008 Feb 20.

47.

Proteome of murine jejunal brush border membrane vesicles.

Donowitz M, Singh S, Salahuddin FF, Hogema BM, Chen Y, Gucek M, Cole RN, Ham A, Zachos NC, Kovbasnjuk O, Lapierre LA, Broere N, Goldenring J, deJonge H, Li X.

J Proteome Res. 2007 Oct;6(10):4068-79. Epub 2007 Sep 11. Erratum in: J Proteome Res. 2008 Jan;7(1):456. Ham, Amy [added].

PMID:
17845021
48.

Tissue-specific regulation of sodium/proton exchanger isoform 3 activity in Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) null mice. cAMP inhibition is differentially dependent on NHERF1 and exchange protein directly activated by cAMP in ileum versus proximal tubule.

Murtazina R, Kovbasnjuk O, Zachos NC, Li X, Chen Y, Hubbard A, Hogema BM, Steplock D, Seidler U, Hoque KM, Tse CM, De Jonge HR, Weinman EJ, Donowitz M.

J Biol Chem. 2007 Aug 24;282(34):25141-51. Epub 2007 Jun 19.

49.

Na+/H+ exchanger NHE3 activity and trafficking are lipid Raft-dependent.

Murtazina R, Kovbasnjuk O, Donowitz M, Li X.

J Biol Chem. 2006 Jun 30;281(26):17845-55. Epub 2006 Apr 27.

50.

Entry of Trypanosoma brucei gambiense into microvascular endothelial cells of the human blood-brain barrier.

Nikolskaia OV, Kim YV, Kovbasnjuk O, Kim KJ, Grab DJ.

Int J Parasitol. 2006 May 1;36(5):513-9. Epub 2006 Mar 6.

PMID:
16620822

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