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Tumor intrinsic efficacy by SHP2 and RTK inhibitors in KRAS mutant cancers.

Hao HX, Wang H, Liu C, Kovats S, Velazquez R, Lu H, Pant B, Shirley M, Meyer MJ, Pu M, Lim J, Fleming M, Alexander L, Farsidjani A, LaMarche MJ, Moody S, Silver SJ, Caponigro G, Stuart DD, Abrams TJ, Hammerman PS, Williams J, Engelman JA, Goldoni S, Mohseni M.

Mol Cancer Ther. 2019 Aug 22. pii: molcanther.0170.2019. doi: 10.1158/1535-7163.MCT-19-0170. [Epub ahead of print]


Coastal flooding and frontline health care services: challenges for flood risk resilience in the English health care system.

Landeg O, Whitman G, Walker-Springett K, Butler C, Bone A, Kovats S.

J Health Serv Res Policy. 2019 Oct;24(4):219-228. doi: 10.1177/1355819619840672. Epub 2019 Jul 23. No abstract available.


IRF4-dependent dendritic cells regulate CD8+ T-cell differentiation and memory responses in influenza infection.

Ainsua-Enrich E, Hatipoglu I, Kadel S, Turner S, Paul J, Singh S, Bagavant H, Kovats S.

Mucosal Immunol. 2019 Jul;12(4):1025-1037. doi: 10.1038/s41385-019-0173-1. Epub 2019 May 15.


Seasonality and the effects of weather on Campylobacter infections.

Djennad A, Lo Iacono G, Sarran C, Lane C, Elson R, Höser C, Lake IR, Colón-González FJ, Kovats S, Semenza JC, Bailey TC, Kessel A, Fleming LE, Nichols GL.

BMC Infect Dis. 2019 Mar 13;19(1):255. doi: 10.1186/s12879-019-3840-7.


Bacillus anthracis Edema Toxin Inhibits Efferocytosis in Human Macrophages and Alters Efferocytic Receptor Signaling.

Pan Z, Dumas EK, Lawrence C, Pate L, Longobardi S, Wang X, James JA, Kovats S, Farris AD.

Int J Mol Sci. 2019 Mar 7;20(5). pii: E1167. doi: 10.3390/ijms20051167.


Health protection planning for extreme weather events and natural disasters.

Papadakis G, Chalabi Z, Khare S, Bone A, Hajat S, Kovats S.

Am J Disaster Med. 2018 Fall;13(4):227-236. doi: 10.5055/ajdm.2018.0303.


The potent and selective cyclin-dependent kinases 4 and 6 inhibitor ribociclib (LEE011) is a versatile combination partner in preclinical cancer models.

Kim S, Tiedt R, Loo A, Horn T, Delach S, Kovats S, Haas K, Engstler BS, Cao A, Pinzon-Ortiz M, Mulford I, Acker MG, Chopra R, Brain C, di Tomaso E, Sellers WR, Caponigro G.

Oncotarget. 2018 Oct 16;9(81):35226-35240. doi: 10.18632/oncotarget.26215. eCollection 2018 Oct 16.


Sex Hormones Regulate Innate Immune Cells and Promote Sex Differences in Respiratory Virus Infection.

Kadel S, Kovats S.

Front Immunol. 2018 Jul 20;9:1653. doi: 10.3389/fimmu.2018.01653. eCollection 2018. Review.


Greenhouse gas emissions reduction in different economic sectors: Mitigation measures, health co-benefits, knowledge gaps, and policy implications.

Gao J, Hou H, Zhai Y, Woodward A, Vardoulakis S, Kovats S, Wilkinson P, Li L, Song X, Xu L, Meng B, Liu X, Wang J, Zhao J, Liu Q.

Environ Pollut. 2018 Sep;240:683-698. doi: 10.1016/j.envpol.2018.05.011. Epub 2018 May 26. Review.


A Major Population of Functional KLRG1- ILC2s in Female Lungs Contributes to a Sex Bias in ILC2 Numbers.

Kadel S, Ainsua-Enrich E, Hatipoglu I, Turner S, Singh S, Khan S, Kovats S.

Immunohorizons. 2018 Feb;2(2):74-86. doi: 10.4049/immunohorizons.1800008.


The English National Cohort Study of Flooding and Health: the change in the prevalence of psychological morbidity at year two.

Jermacane D, Waite TD, Beck CR, Bone A, Amlôt R, Reacher M, Kovats S, Armstrong B, Leonardi G, James Rubin G, Oliver I.

BMC Public Health. 2018 Mar 7;18(1):330. doi: 10.1186/s12889-018-5236-9.


Public health co-benefits of greenhouse gas emissions reduction: A systematic review.

Gao J, Kovats S, Vardoulakis S, Wilkinson P, Woodward A, Li J, Gu S, Liu X, Wu H, Wang J, Song X, Zhai Y, Zhao J, Liu Q.

Sci Total Environ. 2018 Jun 15;627:388-402. doi: 10.1016/j.scitotenv.2018.01.193. Epub 2018 Feb 3. Review.


The use of climate information to estimate future mortality from high ambient temperature: A systematic literature review.

Sanderson M, Arbuthnott K, Kovats S, Hajat S, Falloon P.

PLoS One. 2017 Jul 7;12(7):e0180369. doi: 10.1371/journal.pone.0180369. eCollection 2017. Review.


Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons.

Li H, Reksten TR, Ice JA, Kelly JA, Adrianto I, Rasmussen A, Wang S, He B, Grundahl KM, Glenn SB, Miceli-Richard C, Bowman S, Lester S, Eriksson P, Eloranta ML, Brun JG, Gøransson LG, Harboe E, Guthridge JM, Kaufman KM, Kvarnström M, Cunninghame Graham DS, Patel K, Adler AJ, Farris AD, Brennan MT, Chodosh J, Gopalakrishnan R, Weisman MH, Venuturupalli S, Wallace DJ, Hefner KS, Houston GD, Huang AJW, Hughes PJ, Lewis DM, Radfar L, Vista ES, Edgar CE, Rohrer MD, Stone DU, Vyse TJ, Harley JB, Gaffney PM, James JA, Turner S, Alevizos I, Anaya JM, Rhodus NL, Segal BM, Montgomery CG, Scofield RH, Kovats S, Mariette X, Rönnblom L, Witte T, Rischmueller M, Wahren-Herlenius M, Omdal R, Jonsson R, Ng WF; for UK Primary Sjögren's Syndrome Registry, Nordmark G, Lessard CJ, Sivils KL.

PLoS Genet. 2017 Jun 22;13(6):e1006820. doi: 10.1371/journal.pgen.1006820. eCollection 2017 Jun.


Challenges in developing methods for quantifying the effects of weather and climate on water-associated diseases: A systematic review.

Lo Iacono G, Armstrong B, Fleming LE, Elson R, Kovats S, Vardoulakis S, Nichols GL.

PLoS Negl Trop Dis. 2017 Jun 12;11(6):e0005659. doi: 10.1371/journal.pntd.0005659. eCollection 2017 Jun. Review.


Socioenvironmental factors associated with heat and cold-related mortality in Vadu HDSS, western India: a population-based case-crossover study.

Ingole V, Kovats S, Schumann B, Hajat S, Rocklöv J, Juvekar S, Armstrong B.

Int J Biometeorol. 2017 Oct;61(10):1797-1804. doi: 10.1007/s00484-017-1363-8. Epub 2017 May 19.


Perceptions of Health Co-Benefits in Relation to Greenhouse Gas Emission Reductions: A Survey among Urban Residents in Three Chinese Cities.

Gao J, Xu G, Ma W, Zhang Y, Woodward A, Vardoulakis S, Kovats S, Wilkinson P, He T, Lin H, Liu T, Gu S, Wang J, Li J, Yang J, Liu X, Li J, Wu H, Liu Q.

Int J Environ Res Public Health. 2017 Mar 13;14(3). pii: E298. doi: 10.3390/ijerph14030298.


Profibrotic Infrapatellar Fat Pad Remodeling Without M1 Macrophage Polarization Precedes Knee Osteoarthritis in Mice With Diet-Induced Obesity.

Barboza E, Hudson J, Chang WP, Kovats S, Towner RA, Silasi-Mansat R, Lupu F, Kent C, Griffin TM.

Arthritis Rheumatol. 2017 Jun;69(6):1221-1232. doi: 10.1002/art.40056. Epub 2017 Apr 28.


The English national cohort study of flooding and health: cross-sectional analysis of mental health outcomes at year one.

Waite TD, Chaintarli K, Beck CR, Bone A, Amlôt R, Kovats S, Reacher M, Armstrong B, Leonardi G, Rubin GJ, Oliver I.

BMC Public Health. 2017 Jan 28;17(1):129. doi: 10.1186/s12889-016-4000-2.


Transcriptional Classification and Functional Characterization of Human Airway Macrophage and Dendritic Cell Subsets.

Patel VI, Booth JL, Duggan ES, Cate S, White VL, Hutchings D, Kovats S, Burian DM, Dozmorov M, Metcalf JP.

J Immunol. 2017 Feb 1;198(3):1183-1201. doi: 10.4049/jimmunol.1600777. Epub 2016 Dec 28.


The Lancet Countdown: tracking progress on health and climate change.

Watts N, Adger WN, Ayeb-Karlsson S, Bai Y, Byass P, Campbell-Lendrum D, Colbourn T, Cox P, Davies M, Depledge M, Depoux A, Dominguez-Salas P, Drummond P, Ekins P, Flahault A, Grace D, Graham H, Haines A, Hamilton I, Johnson A, Kelman I, Kovats S, Liang L, Lott M, Lowe R, Luo Y, Mace G, Maslin M, Morrissey K, Murray K, Neville T, Nilsson M, Oreszczyn T, Parthemore C, Pencheon D, Robinson E, Schütte S, Shumake-Guillemot J, Vineis P, Wilkinson P, Wheeler N, Xu B, Yang J, Yin Y, Yu C, Gong P, Montgomery H, Costello A.

Lancet. 2017 Mar 18;389(10074):1151-1164. doi: 10.1016/S0140-6736(16)32124-9. Epub 2016 Nov 14. Review.


Haze, public health and mitigation measures in China: A review of the current evidence for further policy response.

Gao J, Woodward A, Vardoulakis S, Kovats S, Wilkinson P, Li L, Xu L, Li J, Yang J, Li J, Cao L, Liu X, Wu H, Liu Q.

Sci Total Environ. 2017 Feb 1;578:148-157. doi: 10.1016/j.scitotenv.2016.10.231. Epub 2016 Nov 11. Review.


Update on Gender Equity in Immunology, 2001 to 2016.

Shapiro VS, Kovats S, Parent MA, Gaffen SL, Hedrick CC, Jain P, Denzin LK, Raghavan M, Stephens R.

J Immunol. 2016 Nov 15;197(10):3751-3753. Epub 2016 Oct 17.


West Nile virus-infected human dendritic cells fail to fully activate invariant natural killer T cells.

Kovats S, Turner S, Simmons A, Powe T, Chakravarty E, Alberola-Ila J.

Clin Exp Immunol. 2016 Nov;186(2):214-226. doi: 10.1111/cei.12850. Epub 2016 Sep 22.


Promoting protection against a threat that evokes positive affect: The case of heat waves in the United Kingdom.

Bruine de Bruin W, Lefevre CE, Taylor AL, Dessai S, Fischhoff B, Kovats S.

J Exp Psychol Appl. 2016 Sep;22(3):261-71. doi: 10.1037/xap0000083. Epub 2016 Jun 6.


Estimating the burden of heat illness in England during the 2013 summer heatwave using syndromic surveillance.

Smith S, Elliot AJ, Hajat S, Bone A, Smith GE, Kovats S.

J Epidemiol Community Health. 2016 May;70(5):459-65. doi: 10.1136/jech-2015-206079. Epub 2016 Feb 12.


Impact of high ambient temperature on unintentional injuries in high-income countries: a narrative systematic literature review.

Otte im Kampe E, Kovats S, Hajat S.

BMJ Open. 2016 Feb 11;6(2):e010399. doi: 10.1136/bmjopen-2015-010399. Review.


The impact of climate on the abundance of Musca sorbens, the vector of trachoma.

Ramesh A, Bristow J, Kovats S, Lindsay SW, Haslam D, Schmidt E, Gilbert C.

Parasit Vectors. 2016 Jan 27;9:48. doi: 10.1186/s13071-016-1330-y. Review.


The Impact of Heatwaves on Community Morbidity and Healthcare Usage: A Retrospective Observational Study Using Real-Time Syndromic Surveillance.

Smith S, Elliot AJ, Hajat S, Bone A, Bates C, Smith GE, Kovats S.

Int J Environ Res Public Health. 2016 Jan 16;13(1). pii: E132. doi: 10.3390/ijerph13010132.


IRF4 and IRF8 Act in CD11c+ Cells To Regulate Terminal Differentiation of Lung Tissue Dendritic Cells.

Bajaña S, Turner S, Paul J, Ainsua-Enrich E, Kovats S.

J Immunol. 2016 Feb 15;196(4):1666-77. doi: 10.4049/jimmunol.1501870. Epub 2016 Jan 8.


Heat protection behaviour in the UK: results of an online survey after the 2013 heatwave.

Khare S, Hajat S, Kovats S, Lefevre CE, de Bruin WB, Dessai S, Bone A.

BMC Public Health. 2015 Sep 10;15:878. doi: 10.1186/s12889-015-2181-8.


Estrogen receptors regulate innate immune cells and signaling pathways.

Kovats S.

Cell Immunol. 2015 Apr;294(2):63-9. doi: 10.1016/j.cellimm.2015.01.018. Epub 2015 Feb 7. Review.


Heat protection behaviors and positive affect about heat during the 2013 heat wave in the United Kingdom.

Lefevre CE, Bruine de Bruin W, Taylor AL, Dessai S, Kovats S, Fischhoff B.

Soc Sci Med. 2015 Mar;128:282-9. doi: 10.1016/j.socscimed.2015.01.029. Epub 2015 Jan 20.


Excess winter deaths in Europe: a multi-country descriptive analysis.

Fowler T, Southgate RJ, Waite T, Harrell R, Kovats S, Bone A, Doyle Y, Murray V.

Eur J Public Health. 2015 Apr;25(2):339-45. doi: 10.1093/eurpub/cku073. Epub 2014 Jun 11.


Impact of climate change on global malaria distribution.

Caminade C, Kovats S, Rocklov J, Tompkins AM, Morse AP, Colón-González FJ, Stenlund H, Martens P, Lloyd SJ.

Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3286-91. doi: 10.1073/pnas.1302089111. Epub 2014 Feb 3.


The health implications of fracking.

Kovats S, Depledge M, Haines A, Fleming LE, Wilkinson P, Shonkoff SB, Scovronick N.

Lancet. 2014 Mar 1;383(9919):757-8. doi: 10.1016/S0140-6736(13)62700-2. No abstract available.


Girl power: estrogen promotes HSC self-renewal.

Carreras E, Kovats S.

Cell Stem Cell. 2014 Feb 6;14(2):137-8. doi: 10.1016/j.stem.2014.01.016.


Pharmacological and genomic profiling identifies NF-κB-targeted treatment strategies for mantle cell lymphoma.

Rahal R, Frick M, Romero R, Korn JM, Kridel R, Chan FC, Meissner B, Bhang HE, Ruddy D, Kauffmann A, Farsidjani A, Derti A, Rakiec D, Naylor T, Pfister E, Kovats S, Kim S, Dietze K, Dörken B, Steidl C, Tzankov A, Hummel M, Monahan J, Morrissey MP, Fritsch C, Sellers WR, Cooke VG, Gascoyne RD, Lenz G, Stegmeier F.

Nat Med. 2014 Jan;20(1):87-92. doi: 10.1038/nm.3435. Epub 2013 Dec 22.


The impact of climatic risk factors on the prevalence, distribution, and severity of acute and chronic trachoma.

Ramesh A, Kovats S, Haslam D, Schmidt E, Gilbert CE.

PLoS Negl Trop Dis. 2013 Nov 7;7(11):e2513. doi: 10.1371/journal.pntd.0002513. eCollection 2013 Nov. Review.


Increased level of E protein activity during invariant NKT development promotes differentiation of invariant NKT2 and invariant NKT17 subsets.

Hu T, Wang H, Simmons A, Bajaña S, Zhao Y, Kovats S, Sun XH, Alberola-Ila J.

J Immunol. 2013 Nov 15;191(10):5065-73. doi: 10.4049/jimmunol.1301546. Epub 2013 Oct 11.


An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide).

Korpal M, Korn JM, Gao X, Rakiec DP, Ruddy DA, Doshi S, Yuan J, Kovats SG, Kim S, Cooke VG, Monahan JE, Stegmeier F, Roberts TM, Sellers WR, Zhou W, Zhu P.

Cancer Discov. 2013 Sep;3(9):1030-43. doi: 10.1158/2159-8290.CD-13-0142. Epub 2013 Jul 10.


Time-series analysis of weather and mortality patterns in Nairobi's informal settlements.

Egondi T, Kyobutungi C, Kovats S, Muindi K, Ettarh R, Rocklöv J.

Glob Health Action. 2012 Nov 23;5:23-32. doi: 10.3402/gha.v5i0.19065.


Climate change: how can epidemiology best inform policy?

Armstrong B, Hajat S, Kovats S, Lloyd S, Scovronick N, Wilkinson P.

Epidemiology. 2012 Nov;23(6):780-4. doi: 10.1097/EDE.0b013e31826d0d13. No abstract available.


IRF4 promotes cutaneous dendritic cell migration to lymph nodes during homeostasis and inflammation.

Bajaña S, Roach K, Turner S, Paul J, Kovats S.

J Immunol. 2012 Oct 1;189(7):3368-77. Epub 2012 Aug 29.


Health protection and heatwaves: The need for systematic reviews.

Kovats S, Bickler G.

Cochrane Database Syst Rev. 2012 Jul 11;(8):ED000044. doi: 10.1002/14651858.ED000044. No abstract available.


Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors.

Cho YS, Angove H, Brain C, Chen CH, Cheng H, Cheng R, Chopra R, Chung K, Congreve M, Dagostin C, Davis DJ, Feltell R, Giraldes J, Hiscock SD, Kim S, Kovats S, Lagu B, Lewry K, Loo A, Lu Y, Luzzio M, Maniara W, McMenamin R, Mortenson PN, Benning R, O'Reilly M, Rees DC, Shen J, Smith T, Wang Y, Williams G, Woolford AJ, Wrona W, Xu M, Yang F, Howard S.

ACS Med Chem Lett. 2012 May 17;3(6):445-9. doi: 10.1021/ml200241a. eCollection 2012 Jun 14.


Estrogen receptors regulate an inflammatory pathway of dendritic cell differentiation: mechanisms and implications for immunity.

Kovats S.

Horm Behav. 2012 Aug;62(3):254-62. doi: 10.1016/j.yhbeh.2012.04.011. Epub 2012 Apr 25. Review.


Differential contribution of dendritic cell CD1d to NKT cell-enhanced humoral immunity and CD8+ T cell activation.

Joshi SK, Lang GA, Devera TS, Johnson AM, Kovats S, Lang ML.

J Leukoc Biol. 2012 May;91(5):783-90. doi: 10.1189/jlb.1111559. Epub 2012 Feb 13.


Climate change, crop yields, and undernutrition, with Sari Kovats by Ashley Ahearn.

Kovats S.

Environ Health Perspect. 2011 Dec;119(12): No abstract available.


Drinking Water Salinity and Maternal Health in Coastal Bangladesh: Implications of Climate Change.

Khan AE, Ireson A, Kovats S, Mojumder SK, Khusru A, Rahman A, Vineis P.

Environ Health Perspect. 2011 Apr 12. [Epub ahead of print]

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