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Beyond HbA1c : using continuous glucose monitoring metrics to enhance interpretation of treatment effect and improve clinical decision-making.

Brown SA, Basu A, Kovatchev BP.

Diabet Med. 2019 Mar 8. doi: 10.1111/dme.13944. [Epub ahead of print]


The International Diabetes Closed-Loop Study: Testing Artificial Pancreas Component Interoperability.

Anderson SM, Dassau E, Raghinaru D, Lum J, Brown SA, Pinsker JE, Church MM, Levy C, Lam D, Kudva YC, Buckingham B, Forlenza GP, Wadwa RP, Laffel L, Doyle FJ 3rd, DeVries JH, Renard E, Cobelli C, Boscari F, Del Favero S, Kovatchev BP.

Diabetes Technol Ther. 2019 Feb;21(2):73-80. doi: 10.1089/dia.2018.0308. Epub 2019 Jan 16.


Continuous Glucose Monitoring and Insulin Informed Advisory System with Automated Titration and Dosing of Insulin Reduces Glucose Variability in Type 1 Diabetes Mellitus.

Breton MD, Patek SD, Lv D, Schertz E, Robic J, Pinnata J, Kollar L, Barnett C, Wakeman C, Oliveri M, Fabris C, Chernavvsky D, Kovatchev BP, Anderson SM.

Diabetes Technol Ther. 2018 Aug;20(8):531-540. doi: 10.1089/dia.2018.0079. Epub 2018 Jul 6.


Investigation of the Accuracy of 18 Marketed Blood Glucose Monitors.

Klonoff DC, Parkes JL, Kovatchev BP, Kerr D, Bevier WC, Brazg RL, Christiansen M, Bailey TS, Nichols JH, Kohn MA.

Diabetes Care. 2018 Aug;41(8):1681-1688. doi: 10.2337/dc17-1960. Epub 2018 Jun 13.


The UVA/Padova Type 1 Diabetes Simulator Goes From Single Meal to Single Day.

Visentin R, Campos-Náñez E, Schiavon M, Lv D, Vettoretti M, Breton M, Kovatchev BP, Dalla Man C, Cobelli C.

J Diabetes Sci Technol. 2018 Mar;12(2):273-281. doi: 10.1177/1932296818757747. Epub 2018 Feb 16.


Recent Exposure to Hypoglycemia Increases Glucose Variability Following a Hyper/Hypoglycemic Metabolic Challenge in T1D.

Fabris C, Farhy LS, Anderson SM, Nass RM, Kovatchev BP, Breton MD.

J Diabetes Sci Technol. 2018 Mar;12(2):311-317. doi: 10.1177/1932296817729392. Epub 2017 Sep 25.


Closed-Loop Control During Intense Prolonged Outdoor Exercise in Adolescents With Type 1 Diabetes: The Artificial Pancreas Ski Study.

Breton MD, Cherñavvsky DR, Forlenza GP, DeBoer MD, Robic J, Wadwa RP, Messer LH, Kovatchev BP, Maahs DM.

Diabetes Care. 2017 Dec;40(12):1644-1650. doi: 10.2337/dc17-0883. Epub 2017 Aug 30.


Overnight Closed-Loop Control Improves Glycemic Control in a Multicenter Study of Adults With Type 1 Diabetes.

Brown SA, Breton MD, Anderson SM, Kollar L, Keith-Hynes P, Levy CJ, Lam DW, Levister C, Baysal N, Kudva YC, Basu A, Dadlani V, Hinshaw L, McCrady-Spitzer S, Bruttomesso D, Visentin R, Galasso S, Del Favero S, Leal Y, Boscari F, Avogaro A, Cobelli C, Kovatchev BP.

J Clin Endocrinol Metab. 2017 Oct 1;102(10):3674-3682. doi: 10.1210/jc.2017-00556.


Performance of an Artificial Pancreas System for Young Children with Type 1 Diabetes.

DeBoer MD, Breton MD, Wakeman C, Schertz EM, Emory EG, Robic JL, Kollar LL, Kovatchev BP, Cherñavvsky DR.

Diabetes Technol Ther. 2017 May;19(5):293-298. doi: 10.1089/dia.2016.0424. Epub 2017 Apr 20.


Metrics for glycaemic control - from HbA1c to continuous glucose monitoring.

Kovatchev BP.

Nat Rev Endocrinol. 2017 Jul;13(7):425-436. doi: 10.1038/nrendo.2017.3. Epub 2017 Mar 17. Review.


Impact of Meal Constituents on Artificial Pancreas Algorithms.

Campos-Náñez E, Kovatchev BP.

Diabetes Technol Ther. 2016 Oct;18(10):607-609. No abstract available.


Heart rate informed artificial pancreas system enhances glycemic control during exercise in adolescents with T1D.

DeBoer MD, Cherñavvsky DR, Topchyan K, Kovatchev BP, Francis GL, Breton MD.

Pediatr Diabetes. 2017 Nov;18(7):540-546. doi: 10.1111/pedi.12454. Epub 2016 Oct 13.


Accuracy of Continuous Glucose Monitoring in Patients After Total Pancreatectomy with Islet Autotransplantation.

Forlenza GP, Nathan BM, Moran A, Dunn TB, Beilman GJ, Pruett TL, Kovatchev BP, Bellin MD.

Diabetes Technol Ther. 2016 Aug;18(8):455-63. doi: 10.1089/dia.2015.0405. Epub 2016 Apr 22.


Hemoglobin A1c and Self-Monitored Average Glucose: Validation of the Dynamical Tracking eA1c Algorithm in Type 1 Diabetes.

Kovatchev BP, Breton MD.

J Diabetes Sci Technol. 2015 Nov 9;10(2):330-5. doi: 10.1177/1932296815608870.


2 month evening and night closed-loop glucose control in patients with type 1 diabetes under free-living conditions: a randomised crossover trial.

Kropff J, Del Favero S, Place J, Toffanin C, Visentin R, Monaro M, Messori M, Di Palma F, Lanzola G, Farret A, Boscari F, Galasso S, Magni P, Avogaro A, Keith-Hynes P, Kovatchev BP, Bruttomesso D, Cobelli C, DeVries JH, Renard E, Magni L; AP@home consortium.

Lancet Diabetes Endocrinol. 2015 Dec;3(12):939-47. doi: 10.1016/S2213-8587(15)00335-6. Epub 2015 Sep 30.


Measures of Risk and Glucose Variability in Adults Versus Youths.

Kovatchev BP.

Diabetes Technol Ther. 2015 Nov;17(11):766-9. doi: 10.1089/dia.2015.0276. Epub 2015 Sep 8. No abstract available.


Sensitivity of the Predictive Hypoglycemia Minimizer System to the Algorithm Aggressiveness Factor.

Finan DA, Dassau E, Breton MD, Patek SD, McCann TW Jr, Kovatchev BP, Doyle FJ 3rd, Levy BL, Venugopalan R.

J Diabetes Sci Technol. 2015 Jun 30;10(1):104-10. doi: 10.1177/1932296815593292.


Hypoglycemia Reduction and Accuracy of Continuous Glucose Monitoring.

Kovatchev BP.

Diabetes Technol Ther. 2015 Aug;17(8):530-3. doi: 10.1089/dia.2015.0144. Epub 2015 May 15. No abstract available.


Pharmacokinetic Model of the Transport of Fast-Acting Insulin From the Subcutaneous and Intradermal Spaces to Blood.

Lv D, Kulkarni SD, Chan A, Keith S, Pettis R, Kovatchev BP, Farhi LS, Breton MD.

J Diabetes Sci Technol. 2015 Jul;9(4):831-40. doi: 10.1177/1932296815573864. Epub 2015 Mar 9.


Multinight "bedside" closed-loop control for patients with type 1 diabetes.

Brown SA, Kovatchev BP, Breton MD, Anderson SM, Keith-Hynes P, Patek SD, Jiang B, Ben Brahim N, Vereshchetin P, Bruttomesso D, Avogaro A, Del Favero S, Boscari F, Galasso S, Visentin R, Monaro M, Cobelli C.

Diabetes Technol Ther. 2015 Mar;17(3):203-9. doi: 10.1089/dia.2014.0259. Epub 2015 Jan 16.


Computing the surveillance error grid analysis: procedure and examples.

Kovatchev BP, Wakeman CA, Breton MD, Kost GJ, Louie RF, Tran NK, Klonoff DC.

J Diabetes Sci Technol. 2014 Jul;8(4):673-84. doi: 10.1177/1932296814539590. Epub 2014 Jun 13.


Assessing sensor accuracy for non-adjunct use of continuous glucose monitoring.

Kovatchev BP, Patek SD, Ortiz EA, Breton MD.

Diabetes Technol Ther. 2015 Mar;17(3):177-86. doi: 10.1089/dia.2014.0272. Epub 2014 Dec 1.


Use of an artificial pancreas among adolescents for a missed snack bolus and an underestimated meal bolus.

Cherñavvsky DR, DeBoer MD, Keith-Hynes P, Mize B, McElwee M, Demartini S, Dunsmore SF, Wakeman C, Kovatchev BP, Breton MD.

Pediatr Diabetes. 2016 Feb;17(1):28-35. doi: 10.1111/pedi.12230. Epub 2014 Oct 27.


Safety of outpatient closed-loop control: first randomized crossover trials of a wearable artificial pancreas.

Kovatchev BP, Renard E, Cobelli C, Zisser HC, Keith-Hynes P, Anderson SM, Brown SA, Chernavvsky DR, Breton MD, Mize LB, Farret A, Place J, Bruttomesso D, Del Favero S, Boscari F, Galasso S, Avogaro A, Magni L, Di Palma F, Toffanin C, Messori M, Dassau E, Doyle FJ 3rd.

Diabetes Care. 2014 Jul;37(7):1789-96. doi: 10.2337/dc13-2076. Epub 2014 Jun 14.


Overnight glucose control with an automated, unified safety system in children and adolescents with type 1 diabetes at diabetes camp.

Ly TT, Breton MD, Keith-Hynes P, De Salvo D, Clinton P, Benassi K, Mize B, Chernavvsky D, Place J, Wilson DM, Kovatchev BP, Buckingham BA.

Diabetes Care. 2014 Aug;37(8):2310-6. doi: 10.2337/dc14-0147. Epub 2014 May 30.


Closed-Loop Control Performance of the Hypoglycemia-Hyperglycemia Minimizer (HHM) System in a Feasibility Study.

Finan DA, McCann TW Jr, Mackowiak L, Dassau E, Patek SD, Kovatchev BP, Doyle FJ 3rd, Zisser H, Anhalt H, Venugopalan R.

J Diabetes Sci Technol. 2014 Jan;8(1):35-42. Epub 2014 Jan 1.


Effect of algorithm aggressiveness on the performance of the Hypoglycemia-Hyperglycemia Minimizer (HHM) System.

Finan DA, McCann TW Jr, Rhein K, Dassau E, Breton MD, Patek SD, Anhalt H, Kovatchev BP, Doyle FJ 3rd, Anderson SM, Zisser H, Venugopalan R.

J Diabetes Sci Technol. 2014 Jul;8(4):685-90. doi: 10.1177/1932296814534589. Epub 2014 May 18.


First use of model predictive control in outpatient wearable artificial pancreas.

Del Favero S, Bruttomesso D, Di Palma F, Lanzola G, Visentin R, Filippi A, Scotton R, Toffanin C, Messori M, Scarpellini S, Keith-Hynes P, Kovatchev BP, Devries JH, Renard E, Magni L, Avogaro A, Cobelli C; AP@home Consortium.

Diabetes Care. 2014;37(5):1212-5. doi: 10.2337/dc13-1631.


Adding heart rate signal to a control-to-range artificial pancreas system improves the protection against hypoglycemia during exercise in type 1 diabetes.

Breton MD, Brown SA, Karvetski CH, Kollar L, Topchyan KA, Anderson SM, Kovatchev BP.

Diabetes Technol Ther. 2014 Aug;16(8):506-11. doi: 10.1089/dia.2013.0333. Epub 2014 Apr 4.


DiAs user interface: a patient-centric interface for mobile artificial pancreas systems.

Keith-Hynes P, Guerlain S, Mize B, Hughes-Karvetski C, Khan M, McElwee-Malloy M, Kovatchev BP.

J Diabetes Sci Technol. 2013 Nov 1;7(6):1416-26.


Artificial pancreas goes outpatient: a new diabetes ecosystem.

Renard E, Cobelli C, Zisser HC, Kovatchev BP.

J Diabetes Sci Technol. 2013 Nov 1;7(6):1411-5. No abstract available.


Accuracy and robustness of dynamical tracking of average glycemia (A1c) to provide real-time estimation of hemoglobin A1c using routine self-monitored blood glucose data.

Kovatchev BP, Flacke F, Sieber J, Breton MD.

Diabetes Technol Ther. 2014 May;16(5):303-9. doi: 10.1089/dia.2013.0224. Epub 2013 Dec 3.


Closed loop developments to improve glucose control at home.

Renard E, Cobelli C, Kovatchev BP.

Diabetes Res Clin Pract. 2013 Nov;102(2):79-85. doi: 10.1016/j.diabres.2013.09.009. Epub 2013 Sep 28. Review.


Feasibility of outpatient fully integrated closed-loop control: first studies of wearable artificial pancreas.

Kovatchev BP, Renard E, Cobelli C, Zisser HC, Keith-Hynes P, Anderson SM, Brown SA, Chernavvsky DR, Breton MD, Farret A, Pelletier MJ, Place J, Bruttomesso D, Del Favero S, Visentin R, Filippi A, Scotton R, Avogaro A, Doyle FJ 3rd.

Diabetes Care. 2013 Jul;36(7):1851-8. doi: 10.2337/dc12-1965.


Pilot studies of wearable outpatient artificial pancreas in type 1 diabetes.

Cobelli C, Renard E, Kovatchev BP, Keith-Hynes P, Ben Brahim N, Place J, Del Favero S, Breton M, Farret A, Bruttomesso D, Dassau E, Zisser H, Doyle FJ 3rd, Patek SD, Avogaro A.

Diabetes Care. 2012 Sep;35(9):e65-7. doi: 10.2337/dc12-0660. No abstract available.


Modular closed-loop control of diabetes.

Patek SD, Magni L, Dassau E, Karvetski C, Toffanin C, De Nicolao G, Del Favero S, Breton M, Man CD, Renard E, Zisser H, Doyle FJ 3rd, Cobelli C, Kovatchev BP; International Artificial Pancreas (iAP) Study Group.

IEEE Trans Biomed Eng. 2012 Nov;59(11):2986-99. doi: 10.1109/TBME.2012.2192930. Epub 2012 Apr 3.


Association of Basal hyperglucagonemia with impaired glucagon counterregulation in type 1 diabetes.

Farhy LS, Chan A, Breton MD, Anderson SM, Kovatchev BP, McCall AL.

Front Physiol. 2012 Feb 28;3:40. doi: 10.3389/fphys.2012.00040. eCollection 2012.


Historical data enhances safety supervision system performance in T1DM insulin therapy risk management.

Hughes-Karvetski C, Patek SD, Breton MD, Kovatchev BP.

Comput Methods Programs Biomed. 2013 Feb;109(2):220-5. doi: 10.1016/j.cmpb.2011.12.016. Epub 2012 Feb 17.


Diabetes technology: markers, monitoring, assessment, and control of blood glucose fluctuations in diabetes.

Kovatchev BP.

Scientifica (Cairo). 2012;2012:283821. doi: 10.6064/2012/283821. Epub 2012 Oct 17. Review.


Muscle microvascular recruitment predicts insulin sensitivity in middle-aged patients with type 1 diabetes mellitus.

Chan A, Barrett EJ, Anderson SM, Kovatchev BP, Breton MD.

Diabetologia. 2012 Mar;55(3):729-36. doi: 10.1007/s00125-011-2402-3. Epub 2011 Dec 14.


Cardiovascular oscillations at the bedside: early diagnosis of neonatal sepsis using heart rate characteristics monitoring.

Moorman JR, Delos JB, Flower AA, Cao H, Kovatchev BP, Richman JS, Lake DE.

Physiol Meas. 2011 Nov;32(11):1821-32. doi: 10.1088/0967-3334/32/11/S08. Epub 2011 Oct 25.


Effect of automated bio-behavioral feedback on the control of type 1 diabetes.

Kovatchev BP, Mendosa P, Anderson S, Hawley JS, Ritterband LM, Gonder-Frederick L.

Diabetes Care. 2011 Feb;34(2):302-7. doi: 10.2337/dc10-1366. Epub 2011 Jan 7.


Fetal risk assessment in pregnancies complicated by diabetes mellitus.

Zisser HC, Biersmith MA, Jovanovič LB, Yogev Y, Hod M, Kovatchev BP.

J Diabetes Sci Technol. 2010 Nov 1;4(6):1368-73.


Neurocognitive Differences Between Drivers with Type 1 Diabetes with and without a Recent History of Recurrent Driving Mishaps.

Campbell LK, Gonder-Frederick LA, Broshek DK, Kovatchev BP, Anderson S, Clarke WL, Cox DJ.

Int J Diabetes Mellit. 2010 Aug 1;2(2):73-77.


Metabolic Demand of Driving Among Adults with Type 1 Diabetes Mellitus (T1DM).

Cox DJ, Singh H, Clarke WL, Anderson SM, Kovatchev BP, Gonder-Frederick LA.

Ann Adv Automot Med. 2010;54:367-72.


Type 1 diabetic drivers with and without a history of recurrent hypoglycemia-related driving mishaps: physiological and performance differences during euglycemia and the induction of hypoglycemia.

Cox DJ, Kovatchev BP, Anderson SM, Clarke WL, Gonder-Frederick LA.

Diabetes Care. 2010 Nov;33(11):2430-5. doi: 10.2337/dc09-2130. Epub 2010 Aug 10.


Nonlinear metabolic effect of insulin across the blood glucose range in patients with type 1 diabetes mellitus.

Chan A, Heinemann L, Anderson SM, Breton MD, Kovatchev BP.

J Diabetes Sci Technol. 2010 Jul 1;4(4):873-81.


Anticipating the next meal using meal behavioral profiles: a hybrid model-based stochastic predictive control algorithm for T1DM.

Hughes CS, Patek SD, Breton M, Kovatchev BP.

Comput Methods Programs Biomed. 2011 May;102(2):138-48. doi: 10.1016/j.cmpb.2010.04.011. Epub 2010 Jun 19.

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