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Items: 1 to 50 of 90

1.

Antiretroviral penetration across three preclinical animal models and humans in eight putative HIV viral reservoirs.

Devanathan AS, Pirone JR, Akkina R, Remling-Mulder L, Luciw P, Adamson L, Garcia JV, Kovarova M, White NR, Schauer AP, Blake K, Sykes C, Burgunder EM, Srinivas N, Rosen EP, Kashuba ADM.

Antimicrob Agents Chemother. 2019 Oct 14. pii: AAC.01639-19. doi: 10.1128/AAC.01639-19. [Epub ahead of print]

PMID:
31611355
2.

Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery.

Benhabbour SR, Kovarova M, Jones C, Copeland DJ, Shrivastava R, Swanson MD, Sykes C, Ho PT, Cottrell ML, Sridharan A, Fix SM, Thayer O, Long JM, Hazuda DJ, Dayton PA, Mumper RJ, Kashuba ADM, Victor Garcia J.

Nat Commun. 2019 Sep 20;10(1):4324. doi: 10.1038/s41467-019-12141-5.

3.

Patients with rheumatoid arthritis facing sick leave or work disability meet varying regulations: a study among rheumatologists and patients from 44 European countries.

Putrik P, Ramiro S, Guillemin F, Péntek M, Sivera F, Sokka T, de Wit M, Woolf AD, Zink A, Andersone D, Berghea F, Butrimiene I, Brouwer S, Cassar K, Charalambous P, Caporali R, Deseatnicova E, Damjanov NS, Finckh A, FitzGerald O, Gröndal G, Gobejishjvili N, Gluszko P, Hirsch M, Jovanovic I, Vencovský J, Janssens X, Keszei AP, Kovarova M, Kull M, Cunha Miranda L, Mayer M, Misevska-Percinkova S, Inanc N, Nadashkevich O, Petersson IF, Puolakka K, Rojkovich B, Radner H, Szabados F, Slobodin G, Shirinsky I, Soroka N, Sidiropoulos P, Shumnalieva R, Sokolovic S, Shukurova S, Tafaj A, Tomšič M, Uhlig T, Verstappen SMM, Boonen A.

Ann Rheum Dis. 2019 Nov;78(11):1472-1479. doi: 10.1136/annrheumdis-2019-215294. Epub 2019 Aug 19.

PMID:
31427438
4.

Heterogeneous antiretroviral drug distribution and HIV/SHIV detection in the gut of three species.

Thompson CG, Rosen EP, Prince HMA, White N, Sykes C, de la Cruz G, Mathews M, Deleage C, Estes JD, Charlins P, Mulder LR, Kovarova M, Adamson L, Arora S, Dellon ES, Peery AF, Shaheen NJ, Gay C, Muddiman DC, Akkina R, Garcia JV, Luciw P, Kashuba ADM.

Sci Transl Med. 2019 Jul 3;11(499). pii: eaap8758. doi: 10.1126/scitranslmed.aap8758.

PMID:
31270274
5.

Antiretroviral Drug Concentrations in Lymph Nodes: A Cross-Species Comparison of the Effect of Drug Transporter Expression, Viral Infection, and Sex in Humanized Mice, Nonhuman Primates, and Humans.

Burgunder E, Fallon JK, White N, Schauer AP, Sykes C, Remling-Mulder L, Kovarova M, Adamson L, Luciw P, Garcia JV, Akkina R, Smith PC, Kashuba ADM.

J Pharmacol Exp Ther. 2019 Sep;370(3):360-368. doi: 10.1124/jpet.119.259150. Epub 2019 Jun 24.

PMID:
31235531
6.

Glucose Responsiveness of β-Cells Depends on Fatty Acids.

Gerst F, Singer C, Noack K, Graf D, Kaiser G, Panse M, Kovarova M, Schleicher E, Häring HU, Drews G, Ullrich S.

Exp Clin Endocrinol Diabetes. 2019 Apr 15. doi: 10.1055/a-0884-2919. [Epub ahead of print]

PMID:
30986881
7.

The Gly385(388)Arg Polymorphism of the FGFR4 Receptor Regulates Hepatic Lipogenesis Under Healthy Diet.

Lutz SZ, Hennige AM, Peter A, Kovarova M, Totsikas C, Machann J, Kröber SM, Sperl B, Schleicher E, Schick F, Heni M, Ullrich A, Häring HU, Stefan N.

J Clin Endocrinol Metab. 2019 Jun 1;104(6):2041-2053. doi: 10.1210/jc.2018-01573.

PMID:
30541128
8.

Antiretroviral concentrations and surrogate measures of efficacy in the brain tissue and CSF of preclinical species.

Srinivas N, Rosen EP, Gilliland WM Jr, Kovarova M, Remling-Mulder L, De La Cruz G, White N, Adamson L, Schauer AP, Sykes C, Luciw P, Garcia JV, Akkina R, Kashuba ADM.

Xenobiotica. 2019 Oct;49(10):1192-1201. doi: 10.1080/00498254.2018.1539278. Epub 2018 Dec 17.

PMID:
30346892
9.

Ultra-long-acting removable drug delivery system for HIV treatment and prevention.

Kovarova M, Benhabbour SR, Massud I, Spagnuolo RA, Skinner B, Baker CE, Sykes C, Mollan KR, Kashuba ADM, García-Lerma JG, Mumper RJ, Garcia JV.

Nat Commun. 2018 Oct 8;9(1):4156. doi: 10.1038/s41467-018-06490-w.

10.

Dissociation of Fatty Liver and Insulin Resistance in I148M PNPLA3 Carriers: Differences in Diacylglycerol (DAG) FA18:1 Lipid Species as a Possible Explanation.

Franko A, Merkel D, Kovarova M, Hoene M, Jaghutriz BA, Heni M, Königsrainer A, Papan C, Lehr S, Häring HU, Peter A.

Nutrients. 2018 Sep 17;10(9). pii: E1314. doi: 10.3390/nu10091314.

11.

cGMP-dependent protein kinase I (cGKI) modulates human hepatic stellate cell activation.

Franko A, Kovarova M, Feil S, Feil R, Wagner R, Heni M, Königsrainer A, Ruoß M, Nüssler AK, Weigert C, Häring HU, Lutz SZ, Peter A.

Metabolism. 2018 Nov;88:22-30. doi: 10.1016/j.metabol.2018.09.001. Epub 2018 Sep 6.

12.

Why is the hydrolytic activity of acetylcholinesterase pH dependent? Kinetic study of acetylcholine and acetylthiocholine hydrolysis catalyzed by acetylcholinesterase from electric eel.

Komersová A, Kovářová M, Komers K, Lochař V, Čegan A.

Z Naturforsch C. 2018 Sep 25;73(9-10):345-351. doi: 10.1515/znc-2017-0134. No abstract available.

PMID:
29936491
13.

BMI-Independent Effects of Gestational Diabetes on Human Placenta.

Stirm L, Kovárová M, Perschbacher S, Michlmaier R, Fritsche L, Siegel-Axel D, Schleicher E, Peter A, Pauluschke-Fröhlich J, Brucker S, Abele H, Wallwiener D, Preissl H, Wadsack C, Häring HU, Fritsche A, Ensenauer R, Desoye G, Staiger H.

J Clin Endocrinol Metab. 2018 Sep 1;103(9):3299-3309. doi: 10.1210/jc.2018-00397.

PMID:
29931171
14.

The hepatokines fetuin-A and fetuin-B are upregulated in the state of hepatic steatosis and may differently impact on glucose homeostasis in humans.

Peter A, Kovarova M, Staiger H, Machann J, Schick F, Königsrainer A, Königsrainer I, Schleicher E, Fritsche A, Häring HU, Stefan N.

Am J Physiol Endocrinol Metab. 2018 Mar 1;314(3):E266-E273. doi: 10.1152/ajpendo.00262.2017. Epub 2017 Nov 14.

15.

Prevalence and Distribution of Diabetes Mellitus in a Maximum Care Hospital: Urgent Need for HbA1c-Screening.

Kufeldt J, Kovarova M, Adolph M, Staiger H, Bamberg M, Häring HU, Fritsche A, Peter A.

Exp Clin Endocrinol Diabetes. 2018 Feb;126(2):123-129. doi: 10.1055/s-0043-112653. Epub 2017 Jul 27.

PMID:
28750430
16.

Multimodal analysis of drug transporter expression in gastrointestinal tissue.

Thompson CG, Fallon JK, Mathews M, Charlins P, Remling-Mulder L, Kovarova M, Adamson L, Srinivas N, Schauer A, Sykes C, Luciw P, Garcia JV, Akkina R, Smith PC, Kashuba ADM.

AIDS. 2017 Jul 31;31(12):1669-1678. doi: 10.1097/QAD.0000000000001554.

17.

Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice.

Franko A, Neschen S, Rozman J, Rathkolb B, Aichler M, Feuchtinger A, Brachthäuser L, Neff F, Kovarova M, Wolf E, Fuchs H, Häring HU, Peter A, Hrabě de Angelis M.

Mol Metab. 2017 Jan 6;6(3):256-266. doi: 10.1016/j.molmet.2016.12.007. eCollection 2017 Mar.

18.

Medium-chain fatty acids modulate myocardial function via a cardiac odorant receptor.

Jovancevic N, Dendorfer A, Matzkies M, Kovarova M, Heckmann JC, Osterloh M, Boehm M, Weber L, Nguemo F, Semmler J, Hescheler J, Milting H, Schleicher E, Gelis L, Hatt H.

Basic Res Cardiol. 2017 Mar;112(2):13. doi: 10.1007/s00395-017-0600-y. Epub 2017 Jan 23.

19.

An NLRP3 Mutation Causes Arthropathy and Osteoporosis in Humanized Mice.

Snouwaert JN, Nguyen M, Repenning PW, Dye R, Livingston EW, Kovarova M, Moy SS, Brigman BE, Bateman TA, Ting JP, Koller BH.

Cell Rep. 2016 Dec 13;17(11):3077-3088. doi: 10.1016/j.celrep.2016.11.052.

20.

The use of Zymosan A and bacteria anchored to tumor cells for effective cancer immunotherapy: B16-F10 murine melanoma model.

Waldmannová E, Caisová V, Fáberová J, Sváčková P, Kovářová M, Sváčková D, Kumžáková Z, Jačková A, Vácová N, Nedbalová P, Horká M, Kopecký J, Ženka J.

Int Immunopharmacol. 2016 Oct;39:295-306. doi: 10.1016/j.intimp.2016.08.004. Epub 2016 Aug 6.

PMID:
27505858
21.

HIV pre-exposure prophylaxis for women and infants prevents vaginal and oral HIV transmission in a preclinical model of HIV infection.

Kovarova M, Shanmugasundaram U, Baker CE, Spagnuolo RA, De C, Nixon CC, Wahl A, Garcia JV.

J Antimicrob Chemother. 2016 Nov;71(11):3185-3194. Epub 2016 Aug 1.

22.

Efficient Inhibition of HIV Replication in the Gastrointestinal and Female Reproductive Tracts of Humanized BLT Mice by EFdA.

Shanmugasundaram U, Kovarova M, Ho PT, Schramm N, Wahl A, Parniak MA, Garcia JV.

PLoS One. 2016 Jul 20;11(7):e0159517. doi: 10.1371/journal.pone.0159517. eCollection 2016.

23.

A long-acting formulation of the integrase inhibitor raltegravir protects humanized BLT mice from repeated high-dose vaginal HIV challenges.

Kovarova M, Swanson MD, Sanchez RI, Baker CE, Steve J, Spagnuolo RA, Howell BJ, Hazuda DJ, Garcia JV.

J Antimicrob Chemother. 2016 Jun;71(6):1586-96. doi: 10.1093/jac/dkw042. Epub 2016 Mar 21.

24.

ART influences HIV persistence in the female reproductive tract and cervicovaginal secretions.

Olesen R, Swanson MD, Kovarova M, Nochi T, Chateau M, Honeycutt JB, Long JM, Denton PW, Hudgens MG, Richardson A, Tolstrup M, Østergaard L, Wahl A, Garcia JV.

J Clin Invest. 2016 Mar 1;126(3):892-904. doi: 10.1172/JCI64212. Epub 2016 Feb 8.

25.

Thyroid-stimulating hormone concentration as an independent risk factor of venous thromboembolism regardless of thyroid function.

Kovářová M, Koller T, Štvrtinová V, Payer J.

Endokrynol Pol. 2015;66(6):474-9. doi: 10.5603/EP.2015.0058.

26.

Correction: Nanoformulations of Rilpivirine for Topical Pericoital and Systemic Coitus-Independent Administration Efficiently Prevent HIV Transmission.

Kovarova M, Council OD, Date AA, Long JM, Nochi T, Belshan M, Shibata A, Vincent H, Baker CE, Thayer WO, Kraus G, Lachaud-Durand S, Williams P, Destache CJ, Garcia JV.

PLoS Pathog. 2015 Oct 16;11(10):e1005170. doi: 10.1371/journal.ppat.1005170. eCollection 2015 Oct. No abstract available.

27.

The Genetic Variant I148M in PNPLA3 Is Associated With Increased Hepatic Retinyl-Palmitate Storage in Humans.

Kovarova M, Königsrainer I, Königsrainer A, Machicao F, Häring HU, Schleicher E, Peter A.

J Clin Endocrinol Metab. 2015 Dec;100(12):E1568-74. doi: 10.1210/jc.2015-2978. Epub 2015 Oct 6.

PMID:
26439088
28.

Nanoformulations of Rilpivirine for Topical Pericoital and Systemic Coitus-Independent Administration Efficiently Prevent HIV Transmission.

Kovarova M, Council OD, Date AA, Long JM, Nochi T, Belshan M, Shibata A, Vincent H, Baker CE, Thayer WO, Kraus G, Lachaud-Durand S, Williams P, Destache CJ, Garcia JV.

PLoS Pathog. 2015 Aug 13;11(8):e1005075. doi: 10.1371/journal.ppat.1005075. eCollection 2015 Aug. Erratum in: PLoS Pathog. 2015 Oct;11(10):e1005170. Nochii, Tomonori [corrected to Nochi, Tomonori].

29.

PGE₂ promotes apoptosis induced by cytokine deprivation through EP3 receptor and induces Bim in mouse mast cells.

Kovarova M, Koller BH.

PLoS One. 2014 Jul 23;9(7):e102948. doi: 10.1371/journal.pone.0102948. eCollection 2014.

30.

PNPLA3 variant I148M is associated with altered hepatic lipid composition in humans.

Peter A, Kovarova M, Nadalin S, Cermak T, Königsrainer A, Machicao F, Stefan N, Häring HU, Schleicher E.

Diabetologia. 2014 Oct;57(10):2103-7. doi: 10.1007/s00125-014-3310-0. Epub 2014 Jun 29.

PMID:
24972532
31.

Mice lacking three Loci encoding 14 glutathione transferase genes: a novel tool for assigning function to the GSTP, GSTM, and GSTT families.

Xiang Z, Snouwaert JN, Kovarova M, Nguyen M, Repenning PW, Latour AM, Cyphert JM, Koller BH.

Drug Metab Dispos. 2014 Jun;42(6):1074-83. doi: 10.1124/dmd.113.056481. Epub 2014 Mar 21.

32.

Isolation and characterization of mast cells in mouse models of allergic diseases.

Kovarova M.

Methods Mol Biol. 2013;1032:109-19. doi: 10.1007/978-1-62703-496-8_8.

PMID:
23943447
33.

New method for the determination of the half inhibition concentration (IC50) of cholinesterase inhibitors.

Kovárová M, Komers K, Stepánková S, Parík P, Cegan A.

Z Naturforsch C. 2013 Mar-Apr;68(3-4):133-8.

PMID:
23819309
34.

Genetic loss of murine pyrin, the Familial Mediterranean Fever protein, increases interleukin-1β levels.

Hesker PR, Nguyen M, Kovarova M, Ting JP, Koller BH.

PLoS One. 2012;7(11):e51105. doi: 10.1371/journal.pone.0051105. Epub 2012 Nov 30.

35.

High hepatic SCD1 activity is associated with low liver fat content in healthy subjects under a lipogenic diet.

Silbernagel G, Kovarova M, Cegan A, Machann J, Schick F, Lehmann R, Häring HU, Stefan N, Schleicher E, Fritsche A, Peter A.

J Clin Endocrinol Metab. 2012 Dec;97(12):E2288-92. doi: 10.1210/jc.2012-2152. Epub 2012 Sep 26.

PMID:
23015656
36.

NLRP1-dependent pyroptosis leads to acute lung injury and morbidity in mice.

Kovarova M, Hesker PR, Jania L, Nguyen M, Snouwaert JN, Xiang Z, Lommatzsch SE, Huang MT, Ting JP, Koller BH.

J Immunol. 2012 Aug 15;189(4):2006-16. doi: 10.4049/jimmunol.1201065. Epub 2012 Jun 29.

37.

Differentiation of mast cells from embryonic stem cells.

Kovarova M, Koller B.

Curr Protoc Immunol. 2012 Apr;Chapter 22:Unit 22F.10.1-16. doi: 10.1002/0471142735.im22f10s97.

PMID:
22470136
38.

PGE2 through the EP4 receptor controls smooth muscle gene expression patterns in the ductus arteriosus critical for remodeling at birth.

Gruzdev A, Nguyen M, Kovarova M, Koller BH.

Prostaglandins Other Lipid Mediat. 2012 Mar;97(3-4):109-19. doi: 10.1016/j.prostaglandins.2012.02.001. Epub 2012 Feb 11.

39.

ONZIN deficiency attenuates contact hypersensitivity responses in mice.

Ledford JG, Kovarova M, Jania LA, Nguyen M, Koller BH.

Immunol Cell Biol. 2012 Aug;90(7):733-42. doi: 10.1038/icb.2011.107. Epub 2012 Jan 17.

40.

Effect of clone selection, nitrogen supply, leaf damage and mycorrhizal fungi on stilbene and emodin production in knotweed.

Kovářová M, Frantík T, Koblihová H, Bartůňková K, Nývltová Z, Vosátka M.

BMC Plant Biol. 2011 May 30;11:98. doi: 10.1186/1471-2229-11-98.

41.

Unique populations of lung mast cells are required for antigen-mediated bronchoconstriction.

Cyphert JM, Kovarova M, Koller BH.

Clin Exp Allergy. 2011 Feb;41(2):260-9. doi: 10.1111/j.1365-2222.2010.03583.x. Epub 2010 Aug 16.

42.

Inhibition of acetylcholinesterase by 14 achiral and five chiral imidazole derivates.

Kovárová M, Komers K, Stepánková S, Cegan A.

Bioresour Technol. 2010 Aug;101(15):6281-3. doi: 10.1016/j.biortech.2010.03.017. Epub 2010 Mar 23.

PMID:
20335028
43.

Human embryonic stem cells: a source of mast cells for the study of allergic and inflammatory diseases.

Kovarova M, Latour AM, Chason KD, Tilley SL, Koller BH.

Blood. 2010 May 6;115(18):3695-703. doi: 10.1182/blood-2009-08-237206. Epub 2010 Mar 3.

44.

Factors influencing the production of stilbenes by the knotweed, Reynoutria x bohemica.

Kovárová M, Bartůnková K, Frantík T, Koblihová H, Prchalová K, Vosátka M.

BMC Plant Biol. 2010 Jan 29;10:19. doi: 10.1186/1471-2229-10-19.

45.

Cooperation between mast cells and neurons is essential for antigen-mediated bronchoconstriction.

Cyphert JM, Kovarova M, Allen IC, Hartney JM, Murphy DL, Wess J, Koller BH.

J Immunol. 2009 Jun 15;182(12):7430-9. doi: 10.4049/jimmunol.0900039.

46.

Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells.

Iwaki S, Spicka J, Tkaczyk C, Jensen BM, Furumoto Y, Charles N, Kovarova M, Rivera J, Horejsi V, Metcalfe DD, Gilfillan AM.

Cell Signal. 2008 Jan;20(1):195-205. Epub 2007 Oct 16.

47.

cPGES/p23 is required for glucocorticoid receptor function and embryonic growth but not prostaglandin E2 synthesis.

Lovgren AK, Kovarova M, Koller BH.

Mol Cell Biol. 2007 Jun;27(12):4416-30. Epub 2007 Apr 16.

48.

Impaired host defense in mice lacking ONZIN.

Ledford JG, Kovarova M, Koller BH.

J Immunol. 2007 Apr 15;178(8):5132-43.

49.

Death in consequence of late failure of endoscopic third ventriculostomy.

Lipina R, Palecek T, Reguli S, Kovarova M.

Childs Nerv Syst. 2007 Jul;23(7):815-9. Epub 2007 Mar 27.

PMID:
17387490
50.

Enhanced mast cell activation in mice deficient in the A2b adenosine receptor.

Hua X, Kovarova M, Chason KD, Nguyen M, Koller BH, Tilley SL.

J Exp Med. 2007 Jan 22;204(1):117-28. Epub 2007 Jan 2. Erratum in: J Exp Med. 2007 Apr 16;204(4):963.

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