Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 76

1.

Structural aspects of 4-aminoquinolines as reversible inhibitors of human acetylcholinesterase and butyrylcholinesterase.

Bosak A, Opsenica DM, Šinko G, Zlatar M, Kovarik Z.

Chem Biol Interact. 2019 Aug 1;308:101-109. doi: 10.1016/j.cbi.2019.05.024. Epub 2019 May 15.

PMID:
31100281
2.

Assessment of ionizable, zwitterionic oximes as reactivating antidotal agents for organophosphate exposure.

Taylor P, Yan-Jye S, Momper J, Hou W, Camacho-Hernandez GA, Radic' Z, Rosenberg Y, Kovarik Z, Sit R, Sharpless KB.

Chem Biol Interact. 2019 Aug 1;308:194-197. doi: 10.1016/j.cbi.2019.05.015. Epub 2019 May 14. Review.

PMID:
31100277
3.

Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes.

Zorbaz T, Malinak D, Kuca K, Musilek K, Kovarik Z.

Chem Biol Interact. 2019 Jul 1;307:16-20. doi: 10.1016/j.cbi.2019.04.020. Epub 2019 Apr 18.

PMID:
31004594
4.

Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase.

Kovarik Z, Maček Hrvat N, Kalisiak J, Katalinić M, Sit RK, Zorbaz T, Radić Z, Fokin VV, Sharpless KB, Taylor P.

Toxicol Appl Pharmacol. 2019 Jun 1;372:40-46. doi: 10.1016/j.taap.2019.04.007. Epub 2019 Apr 9.

PMID:
30978400
5.

Advice on assistance and protection provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 1. On medical care and treatment of injuries from nerve agents.

Timperley CM, Forman JE, Abdollahi M, Al-Amri AS, Baulig A, Benachour D, Borrett V, Cariño FA, Geist M, Gonzalez D, Kane W, Kovarik Z, Martínez-Álvarez R, Mourão NMF, Neffe S, Raza SK, Rubaylo V, Suárez AG, Takeuchi K, Tang C, Trifirò F, van Straten FM, Vanninen PS, Vučinić S, Zaitsev V, Zafar-Uz-Zaman M, Zina MS, Holen S.

Toxicology. 2019 Mar 1;415:56-69. doi: 10.1016/j.tox.2019.01.004. Epub 2019 Jan 9.

PMID:
30639304
6.

Advice on assistance and protection from the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 2. On preventing and treating health effects from acute, prolonged, and repeated nerve agent exposure, and the identification of medical countermeasures able to reduce or eliminate the longer term health effects of nerve agents.

Timperley CM, Abdollahi M, Al-Amri AS, Baulig A, Benachour D, Borrett V, Cariño FA, Geist M, Gonzalez D, Kane W, Kovarik Z, Martínez-Álvarez R, Fusaro Mourão NM, Neffe S, Raza SK, Rubaylo V, Suárez AG, Takeuchi K, Tang C, Trifirò F, van Straten FM, Vanninen PS, Vučinić S, Zaitsev V, Zafar-Uz-Zaman M, Zina MS, Holen S, Forman JE, Alwan WS, Suri V.

Toxicology. 2019 Feb 1;413:13-23. doi: 10.1016/j.tox.2018.11.009. Epub 2018 Nov 27. Review.

PMID:
30500381
7.

Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase.

Kovarik Z, Kalisiak J, Hrvat NM, Katalinić M, Zorbaz T, Žunec S, Green C, Radić Z, Fokin VV, Sharpless KB, Taylor P.

Chemistry. 2019 Mar 15;25(16):4100-4114. doi: 10.1002/chem.201805051. Epub 2019 Feb 14.

PMID:
30458057
8.

Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents.

Zorbaz T, Malinak D, Maraković N, Maček Hrvat N, Zandona A, Novotny M, Skarka A, Andrys R, Benkova M, Soukup O, Katalinić M, Kuca K, Kovarik Z, Musilek K.

J Med Chem. 2018 Dec 13;61(23):10753-10766. doi: 10.1021/acs.jmedchem.8b01398. Epub 2018 Nov 20.

PMID:
30383374
9.

Design and evaluation of selective butyrylcholinesterase inhibitors based on Cinchona alkaloid scaffold.

Bosak A, Ramić A, Šmidlehner T, Hrenar T, Primožič I, Kovarik Z.

PLoS One. 2018 Oct 5;13(10):e0205193. doi: 10.1371/journal.pone.0205193. eCollection 2018.

10.

Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure.

Sit RK, Kovarik Z, Maček Hrvat N, Žunec S, Green C, Fokin VV, Sharpless KB, Radić Z, Taylor P.

J Pharmacol Exp Ther. 2018 Nov;367(2):363-372. doi: 10.1124/jpet.118.249383. Epub 2018 Sep 6.

11.

Advice on chemical weapons sample stability and storage provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons to increase investigative capabilities worldwide.

Timperley CM, Forman JE, Abdollahi M, Al-Amri AS, Alonso IP, Baulig A, Borrett V, Cariño FA, Curty C, Berrutti DG, Kovarik Z, Martínez-Álvarez R, Mikulak R, Mourão NMF, Ponnadurai R, Neffe S, Raza SK, Rubaylo V, Takeuchi K, Tang C, Trifirò F, van Straten FM, Vanninen PS, Zaitsev V, Waqar F, Zina MS, Blum MM, Gregg H, Fischer E, Sun S, Yang P.

Talanta. 2018 Oct 1;188:808-832. doi: 10.1016/j.talanta.2018.04.022. Epub 2018 Apr 27.

PMID:
30029449
12.

Oxime-assisted reactivation of tabun-inhibited acetylcholinesterase analysed by active site mutations.

Katalinić M, Šinko G, Maček Hrvat N, Zorbaz T, Bosak A, Kovarik Z.

Toxicology. 2018 Aug 1;406-407:104-113. doi: 10.1016/j.tox.2018.05.008. Epub 2018 May 22.

PMID:
29772260
13.

Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration.

Zorbaz T, Braïki A, Maraković N, Renou J, de la Mora E, Maček Hrvat N, Katalinić M, Silman I, Sussman JL, Mercey G, Gomez C, Mougeot R, Pérez B, Baati R, Nachon F, Weik M, Jean L, Kovarik Z, Renard PY.

Chemistry. 2018 Jul 5;24(38):9675-9691. doi: 10.1002/chem.201801394. Epub 2018 Jun 8.

PMID:
29672968
14.

The estimation of oxime efficiency is affected by the experimental design of phosphylated acetylcholinesterase reactivation.

Maček Hrvat N, Zorbaz T, Šinko G, Kovarik Z.

Toxicol Lett. 2018 Sep 1;293:222-228. doi: 10.1016/j.toxlet.2017.11.022. Epub 2017 Nov 24.

PMID:
29180286
15.

New Cinchona Oximes Evaluated as Reactivators of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Organophosphorus Compounds.

Katalinić M, Zandona A, Ramić A, Zorbaz T, Primožič I, Kovarik Z.

Molecules. 2017 Jul 22;22(7). pii: E1234. doi: 10.3390/molecules22071234.

16.

Resorcinol-, catechol- and saligenin-based bronchodilating β2-agonists as inhibitors of human cholinesterase activity.

Bosak A, Knežević A, Gazić Smilović I, Šinko G, Kovarik Z.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):789-797. doi: 10.1080/14756366.2017.1326109.

17.

Pyridoxal oxime derivative potency to reactivate cholinesterases inhibited by organophosphorus compounds.

Bušić V, Katalinić M, Šinko G, Kovarik Z, Gašo-Sokač D.

Toxicol Lett. 2016 Nov 16;262:114-122. doi: 10.1016/j.toxlet.2016.09.015. Epub 2016 Sep 29.

PMID:
27693733
18.

A comprehensive evaluation of novel oximes in creation of butyrylcholinesterase-based nerve agent bioscavengers.

Katalinić M, Maček Hrvat N, Baumann K, Morasi Piperčić S, Makarić S, Tomić S, Jović O, Hrenar T, Miličević A, Jelić D, Žunec S, Primožič I, Kovarik Z.

Toxicol Appl Pharmacol. 2016 Nov 1;310:195-204. doi: 10.1016/j.taap.2016.09.015. Epub 2016 Sep 18.

PMID:
27654152
19.

Design and synthesis of N-substituted-2-hydroxyiminoacetamides and interactions with cholinesterases.

Maraković N, Knežević A, Vinković V, Kovarik Z, Šinko G.

Chem Biol Interact. 2016 Nov 25;259(Pt B):122-132. doi: 10.1016/j.cbi.2016.05.035. Epub 2016 May 26.

PMID:
27238725
20.

HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants.

Maček Hrvat N, Žunec S, Taylor P, Radić Z, Kovarik Z.

Chem Biol Interact. 2016 Nov 25;259(Pt B):148-153. doi: 10.1016/j.cbi.2016.04.023. Epub 2016 Apr 12.

21.

Translation of in vitro to in vivo pyridinium oxime potential in tabun poisoning.

Katalinić M, Maček Hrvat N, Žďárová Karasová J, Misik J, Kovarik Z.

Arh Hig Rada Toksikol. 2015 Dec;66(4):291-8. doi: 10.1515/aiht-2015-66-2740.

PMID:
26751861
22.

Catalytic Soman Scavenging by the Y337A/F338A Acetylcholinesterase Mutant Assisted with Novel Site-Directed Aldoximes.

Kovarik Z, Maček Hrvat N, Katalinić M, Sit RK, Paradyse A, Žunec S, Musilek K, Fokin VV, Taylor P, Radić Z.

Chem Res Toxicol. 2015 May 18;28(5):1036-44. doi: 10.1021/acs.chemrestox.5b00060. Epub 2015 Apr 16.

23.

Peripheral site and acyl pocket define selective inhibition of mouse butyrylcholinesterase by two biscarbamates.

Bosak A, Smilović IG, Stimac A, Vinković V, Sinko G, Kovarik Z.

Arch Biochem Biophys. 2013 Jan 15;529(2):140-5. doi: 10.1016/j.abb.2012.11.012. Epub 2012 Dec 3.

PMID:
23219600
24.

Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes.

Radić Z, Dale T, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radić B, Duggan BM, Ajami D, Rebek J, Taylor P.

Biochem J. 2013 Feb 15;450(1):231-42. doi: 10.1042/BJ20121612.

25.

The cholinergic and non-cholinergic effects of organophosphates and oximes in cultured human myoblasts.

Katalinić M, Miš K, Pirkmajer S, Grubič Z, Kovarik Z, Marš T.

Chem Biol Interact. 2013 Mar 25;203(1):144-8. doi: 10.1016/j.cbi.2012.09.015. Epub 2012 Oct 6.

PMID:
23047024
26.

Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates.

Radić Z, Sit RK, Garcia E, Zhang L, Berend S, Kovarik Z, Amitai G, Fokin VV, Barry Sharpless K, Taylor P.

Chem Biol Interact. 2013 Mar 25;203(1):67-71. doi: 10.1016/j.cbi.2012.08.014. Epub 2012 Sep 4.

27.

Centrally acting oximes in reactivation of tabun-phosphoramidated AChE.

Kovarik Z, Maček N, Sit RK, Radić Z, Fokin VV, Barry Sharpless K, Taylor P.

Chem Biol Interact. 2013 Mar 25;203(1):77-80. doi: 10.1016/j.cbi.2012.08.019. Epub 2012 Sep 7.

28.

Metaproterenol, isoproterenol, and their bisdimethylcarbamate derivatives as human cholinesterase inhibitors.

Bosak A, Gazić Smilović I, Sinko G, Vinković V, Kovarik Z.

J Med Chem. 2012 Aug 9;55(15):6716-23. doi: 10.1021/jm300289k. Epub 2012 Jul 27.

PMID:
22817559
29.

Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases.

Radić Z, Sit RK, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radić B, Fokin VV, Sharpless KB, Taylor P.

J Biol Chem. 2012 Apr 6;287(15):11798-809. doi: 10.1074/jbc.M111.333732. Epub 2012 Feb 16. Erratum in: J Biol Chem. 2012 Jun 1;287(23):19337.

30.

Mechanism of stereoselective interaction between butyrylcholinesterase and ethopropazine enantiomers.

Sinko G, Kovarik Z, Reiner E, Simeon-Rudolf V, Stojan J.

Biochimie. 2011 Oct;93(10):1797-807. doi: 10.1016/j.biochi.2011.06.023. Epub 2011 Jun 29.

PMID:
21740955
31.

Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging.

Cochran R, Kalisiak J, Küçükkilinç T, Radic Z, Garcia E, Zhang L, Ho KY, Amitai G, Kovarik Z, Fokin VV, Sharpless KB, Taylor P.

J Biol Chem. 2011 Aug 26;286(34):29718-24. doi: 10.1074/jbc.M111.264739. Epub 2011 Jul 5.

32.

[Cholinesterases: structure, role, and inhibition].

Bosak A, Katalinić M, Kovarik Z.

Arh Hig Rada Toksikol. 2011 Jun;62(2):175-90. doi: 10.2478/10004-1254-62-2011-2107. Review. Croatian.

PMID:
21705306
33.

A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning.

Lovrić J, Berend S, Lucić Vrdoljak A, Radić B, Katalinić M, Kovarik Z, Želježić D, Kopjar N, Rast S, Mesić M.

Acta Biochim Pol. 2011;58(2):193-8. Epub 2011 Jun 13.

34.

New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases.

Sit RK, Radić Z, Gerardi V, Zhang L, Garcia E, Katalinić M, Amitai G, Kovarik Z, Fokin VV, Sharpless KB, Taylor P.

J Biol Chem. 2011 Jun 3;286(22):19422-30. doi: 10.1074/jbc.M111.230656. Epub 2011 Apr 4.

35.

Increased uric acid and glucose concentrations in vitreous and serum of patients with diabetic macular oedema.

Krizova L, Kalousova M, Kubena A, Benakova H, Zima T, Kovarik Z, Kalvoda J, Kalvodova B.

Ophthalmic Res. 2011;46(2):73-9. doi: 10.1159/000322994. Epub 2011 Jan 14.

PMID:
21242702
36.

[Efficiency of vitrectomy in diabetic macular edema and morphometry of surgically removed of the internal limiting membrane].

Kalvoda J, Dusková J, Kovarík Z, Kubena A, Kalvodová B.

Cesk Slov Oftalmol. 2010 Apr;66(2):76-82. Czech.

PMID:
20925242
37.

Interactions of pyridinium oximes with acetylcholinesterase.

Sinko G, Brglez J, Kovarik Z.

Chem Biol Interact. 2010 Sep 6;187(1-3):172-6. doi: 10.1016/j.cbi.2010.04.017. Epub 2010 Apr 24.

PMID:
20417629
38.

In vivo experimental approach to treatment against tabun poisoning.

Berend S, Katalinić M, Vrdoljak AL, Kovarik Z, Kuca K, Radić B.

J Enzyme Inhib Med Chem. 2010 Aug;25(4):531-6. doi: 10.3109/14756360903357593.

PMID:
20235800
39.

Pseudo-catalytic scavenging: searching for a suitable reactivator of phosphorylated butyrylcholinesterase.

Kovarik Z, Katalinić M, Sinko G, Binder J, Holas O, Jung YS, Musilova L, Jun D, Kuca K.

Chem Biol Interact. 2010 Sep 6;187(1-3):167-71. doi: 10.1016/j.cbi.2010.02.023. Epub 2010 Mar 3.

PMID:
20206154
40.

Synthesis and evaluation of novel analogues of vitamin B6 as reactivators of tabun and paraoxon inhibited acetylcholinesterase.

Gaso-Sokac D, Katalinić M, Kovarik Z, Busić V, Kovac S.

Chem Biol Interact. 2010 Sep 6;187(1-3):234-7. doi: 10.1016/j.cbi.2010.02.004. Epub 2010 Feb 6.

PMID:
20144593
41.

Structural aspects of flavonoids as inhibitors of human butyrylcholinesterase.

Katalinić M, Rusak G, Domaćinović Barović J, Sinko G, Jelić D, Antolović R, Kovarik Z.

Eur J Med Chem. 2010 Jan;45(1):186-92. doi: 10.1016/j.ejmech.2009.09.041. Epub 2009 Oct 6.

PMID:
19879672
42.

[Malignant masquerade syndromes].

Heissigerová J, Ríhová E, Svozílková P, Brichová M, Jenícková D, Kovarík Z, Sach J, Adam P, Spicka I.

Cesk Slov Oftalmol. 2009 Jul;65(4):131-8. Czech.

PMID:
19750830
43.

Evaluation of oxime k203 as antidote in tabun poisoning.

Kovarik Z, Vrdoljak AL, Berend S, Katalinić M, Kuc K, Musilek K, Radić B.

Arh Hig Rada Toksikol. 2009 Mar;60(1):19-26. doi: 10.2478/10004-1254-60-2009-1890.

PMID:
19329372
44.

Stereoselective inhibition of human, mouse, and horse cholinesterases by bambuterol enantiomers.

Bosak A, Gazić I, Vinković V, Kovarik Z.

Chem Biol Interact. 2008 Sep 25;175(1-3):192-5. doi: 10.1016/j.cbi.2008.04.050. Epub 2008 May 21.

PMID:
18582854
45.

Interactions of butane, but-2-ene or xylene-like linked bispyridinium para-aldoximes with native and tabun-inhibited human cholinesterases.

Calić M, Bosak A, Kuca K, Kovarik Z.

Chem Biol Interact. 2008 Sep 25;175(1-3):305-8. doi: 10.1016/j.cbi.2008.04.010. Epub 2008 May 23.

PMID:
18501885
46.

Oximes: Reactivators of phosphorylated acetylcholinesterase and antidotes in therapy against tabun poisoning.

Kovarik Z, Calić M, Sinko G, Bosak A, Berend S, Vrdoljak AL, Radić B.

Chem Biol Interact. 2008 Sep 25;175(1-3):173-9. doi: 10.1016/j.cbi.2008.04.011. Epub 2008 May 23.

PMID:
18501341
47.

Amino acid residues involved in stereoselective inhibition of cholinesterases with bambuterol.

Bosak A, Gazić I, Vinković V, Kovarik Z.

Arch Biochem Biophys. 2008 Mar 1;471(1):72-6. doi: 10.1016/j.abb.2007.12.007. Epub 2007 Dec 23.

PMID:
18167304
48.

Application of recombinant DNA methods for production of cholinesterases as organophosphate antidotes and detectors.

Taylor P, Reiner E, Kovarik Z, Radić Z.

Arh Hig Rada Toksikol. 2007 Sep;58(3):339-45. Review.

PMID:
17913689
49.

Limitation of the Ellman method: cholinesterase activity measurement in the presence of oximes.

Sinko G, Calić M, Bosak A, Kovarik Z.

Anal Biochem. 2007 Nov 15;370(2):223-7. Epub 2007 Aug 1.

PMID:
17716616
50.

Supplemental Content

Loading ...
Support Center