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Items: 1 to 50 of 75

1.

Feeling the force: formin's role in mechanotransduction.

Zimmermann D, Kovar DR.

Curr Opin Cell Biol. 2019 Feb;56:130-140. doi: 10.1016/j.ceb.2018.12.008. Epub 2019 Jan 11. Review.

PMID:
30639952
2.

Ena/VASP processive elongation is modulated by avidity on actin filaments bundled by the filopodia crosslinker fascin.

Harker AJ, Katkar HH, Bidone TC, Aydin F, Voth GA, Applewhite DA, Kovar DR.

Mol Biol Cell. 2019 Jan 2:mbcE18080500. doi: 10.1091/mbc.E18-08-0500. [Epub ahead of print]

PMID:
30601697
3.

Actin Cross-Linking Toxin Is a Universal Inhibitor of Tandem-Organized and Oligomeric G-Actin Binding Proteins.

Kudryashova E, Heisler DB, Williams B, Harker AJ, Shafer K, Quinlan ME, Kovar DR, Vavylonis D, Kudryashov DS.

Curr Biol. 2018 May 21;28(10):1536-1547.e9. doi: 10.1016/j.cub.2018.03.065. Epub 2018 May 3.

PMID:
29731300
4.

Partitioning and Enhanced Self-Assembly of Actin in Polypeptide Coacervates.

McCall PM, Srivastava S, Perry SL, Kovar DR, Gardel ML, Tirrell MV.

Biophys J. 2018 Apr 10;114(7):1636-1645. doi: 10.1016/j.bpj.2018.02.020.

5.

Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly.

Zimmermann D, Homa KE, Hocky GM, Pollard LW, De La Cruz EM, Voth GA, Trybus KM, Kovar DR.

Nat Commun. 2017 Sep 26;8(1):703. doi: 10.1038/s41467-017-00445-3.

6.

When Is "Enough" Enough?

Suarez C, McCall PM, Gardel ML, Kovar DR.

Cell Syst. 2017 May 24;4(5):480-482. doi: 10.1016/j.cels.2017.05.007.

7.

The bacterial virulence factors VopL and VopF nucleate actin from the pointed end.

Burke TA, Harker AJ, Dominguez R, Kovar DR.

J Cell Biol. 2017 May 1;216(5):1267-1276. doi: 10.1083/jcb.201608104. Epub 2017 Mar 31.

8.

Competition between Tropomyosin, Fimbrin, and ADF/Cofilin drives their sorting to distinct actin filament networks.

Christensen JR, Hocky GM, Homa KE, Morganthaler AN, Hitchcock-DeGregori SE, Voth GA, Kovar DR.

Elife. 2017 Mar 10;6. pii: e23152. doi: 10.7554/eLife.23152.

9.

Internetwork competition for monomers governs actin cytoskeleton organization.

Suarez C, Kovar DR.

Nat Rev Mol Cell Biol. 2016 Dec;17(12):799-810. doi: 10.1038/nrm.2016.106. Epub 2016 Sep 14.

10.

Fascin- and α-Actinin-Bundled Networks Contain Intrinsic Structural Features that Drive Protein Sorting.

Winkelman JD, Suarez C, Hocky GM, Harker AJ, Morganthaler AN, Christensen JR, Voth GA, Bartles JR, Kovar DR.

Curr Biol. 2016 Oct 24;26(20):2697-2706. doi: 10.1016/j.cub.2016.07.080. Epub 2016 Sep 22.

11.

The F-actin bundler α-actinin Ain1 is tailored for ring assembly and constriction during cytokinesis in fission yeast.

Li Y, Christensen JR, Homa KE, Hocky GM, Fok A, Sees JA, Voth GA, Kovar DR.

Mol Biol Cell. 2016 Jun 1;27(11):1821-33. doi: 10.1091/mbc.E16-01-0010. Epub 2016 Apr 13.

12.

Interactions between the Microtubule Binding Protein EB1 and F-Actin.

Alberico EO, Zhu ZC, Wu YO, Gardner MK, Kovar DR, Goodson HV.

J Mol Biol. 2016 Mar 27;428(6):1304-1314. doi: 10.1016/j.jmb.2016.01.032. Epub 2016 Feb 6.

13.

In Vitro Biochemical Characterization of Cytokinesis Actin-Binding Proteins.

Zimmermann D, Morganthaler AN, Kovar DR, Suarez C.

Methods Mol Biol. 2016;1369:151-79. doi: 10.1007/978-1-4939-3145-3_12.

PMID:
26519312
14.

ACTIN-DIRECTED TOXIN. ACD toxin-produced actin oligomers poison formin-controlled actin polymerization.

Heisler DB, Kudryashova E, Grinevich DO, Suarez C, Winkelman JD, Birukov KG, Kotha SR, Parinandi NL, Vavylonis D, Kovar DR, Kudryashov DS.

Science. 2015 Jul 31;349(6247):535-9. doi: 10.1126/science.aab4090.

15.

Actin age orchestrates myosin-5 and myosin-6 run lengths.

Zimmermann D, Santos A, Kovar DR, Rock RS.

Curr Biol. 2015 Aug 3;25(15):2057-62. doi: 10.1016/j.cub.2015.06.033. Epub 2015 Jul 16.

16.

Plasmodium falciparum coronin organizes arrays of parallel actin filaments potentially guiding directional motility in invasive malaria parasites.

Olshina MA, Angrisano F, Marapana DS, Riglar DT, Bane K, Wong W, Catimel B, Yin MX, Holmes AB, Frischknecht F, Kovar DR, Baum J.

Malar J. 2015 Jul 18;14:280. doi: 10.1186/s12936-015-0801-5.

17.

Disassembly activity of actin-depolymerizing factor (ADF) is associated with distinct cellular processes in apicomplexan parasites.

Haase S, Zimmermann D, Olshina MA, Wilkinson M, Fisher F, Tan YH, Stewart RJ, Tonkin CJ, Wong W, Kovar DR, Baum J.

Mol Biol Cell. 2015 Sep 1;26(17):3001-12. doi: 10.1091/mbc.E14-10-1427. Epub 2015 Jul 8.

18.

Cytoskeletal dynamics: a view from the membrane.

Bezanilla M, Gladfelter AS, Kovar DR, Lee WL.

J Cell Biol. 2015 May 11;209(3):329-37. doi: 10.1083/jcb.201502062. Review.

19.

Profilin regulates F-actin network homeostasis by favoring formin over Arp2/3 complex.

Suarez C, Carroll RT, Burke TA, Christensen JR, Bestul AJ, Sees JA, James ML, Sirotkin V, Kovar DR.

Dev Cell. 2015 Jan 12;32(1):43-53. doi: 10.1016/j.devcel.2014.10.027. Epub 2014 Dec 24.

20.

Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways.

Rotty JD, Wu C, Haynes EM, Suarez C, Winkelman JD, Johnson HE, Haugh JM, Kovar DR, Bear JE.

Dev Cell. 2015 Jan 12;32(1):54-67. doi: 10.1016/j.devcel.2014.10.026. Epub 2014 Dec 24.

21.

Fission yeast profilin is tailored to facilitate actin assembly by the cytokinesis formin Cdc12.

Bestul AJ, Christensen JR, Grzegorzewska AP, Burke TA, Sees JA, Carroll RT, Sirotkin V, Keenan RJ, Kovar DR.

Mol Biol Cell. 2015 Jan 15;26(2):283-93. doi: 10.1091/mbc.E13-05-0281. Epub 2014 Nov 12.

22.

High-resolution temporal analysis reveals a functional timeline for the molecular regulation of cytokinesis.

Davies T, Jordan SN, Chand V, Sees JA, Laband K, Carvalho AX, Shirasu-Hiza M, Kovar DR, Dumont J, Canman JC.

Dev Cell. 2014 Jul 28;30(2):209-23. doi: 10.1016/j.devcel.2014.05.009.

23.

HopW1 from Pseudomonas syringae disrupts the actin cytoskeleton to promote virulence in Arabidopsis.

Kang Y, Jelenska J, Cecchini NM, Li Y, Lee MW, Kovar DR, Greenberg JT.

PLoS Pathog. 2014 Jun 26;10(6):e1004232. doi: 10.1371/journal.ppat.1004232. eCollection 2014 Jun.

24.

Ena/VASP Enabled is a highly processive actin polymerase tailored to self-assemble parallel-bundled F-actin networks with Fascin.

Winkelman JD, Bilancia CG, Peifer M, Kovar DR.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4121-6. doi: 10.1073/pnas.1322093111. Epub 2014 Mar 3.

25.

Enabled negatively regulates diaphanous-driven actin dynamics in vitro and in vivo.

Bilancia CG, Winkelman JD, Tsygankov D, Nowotarski SH, Sees JA, Comber K, Evans I, Lakhani V, Wood W, Elston TC, Kovar DR, Peifer M.

Dev Cell. 2014 Feb 24;28(4):394-408. doi: 10.1016/j.devcel.2014.01.015.

26.

Homeostatic actin cytoskeleton networks are regulated by assembly factor competition for monomers.

Burke TA, Christensen JR, Barone E, Suarez C, Sirotkin V, Kovar DR.

Curr Biol. 2014 Mar 3;24(5):579-85. doi: 10.1016/j.cub.2014.01.072. Epub 2014 Feb 20.

27.

A mechanism for actin filament severing by malaria parasite actin depolymerizing factor 1 via a low affinity binding interface.

Wong W, Webb AI, Olshina MA, Infusini G, Tan YH, Hanssen E, Catimel B, Suarez C, Condron M, Angrisano F, Nebi T, Kovar DR, Baum J.

J Biol Chem. 2014 Feb 14;289(7):4043-54. doi: 10.1074/jbc.M113.523365. Epub 2013 Dec 26.

28.

In vitro reconstitution of an mRNA-transport complex reveals mechanisms of assembly and motor activation.

Heym RG, Zimmermann D, Edelmann FT, Israel L, Ökten Z, Kovar DR, Niessing D.

J Cell Biol. 2013 Dec 23;203(6):971-84. doi: 10.1083/jcb.201302095.

29.

Formin-based control of the actin cytoskeleton during cytokinesis.

Bohnert KA, Willet AH, Kovar DR, Gould KL.

Biochem Soc Trans. 2013 Dec;41(6):1750-4. doi: 10.1042/BST20130208. Review.

30.

The formins Cdc12 and For3 cooperate during contractile ring assembly in cytokinesis.

Coffman VC, Sees JA, Kovar DR, Wu JQ.

J Cell Biol. 2013 Oct 14;203(1):101-14. doi: 10.1083/jcb.201305022.

31.

SIN-dependent phosphoinhibition of formin multimerization controls fission yeast cytokinesis.

Bohnert KA, Grzegorzewska AP, Willet AH, Vander Kooi CW, Kovar DR, Gould KL.

Genes Dev. 2013 Oct 1;27(19):2164-77. doi: 10.1101/gad.224154.113.

32.

Rickettsia Sca2 has evolved formin-like activity through a different molecular mechanism.

Madasu Y, Suarez C, Kast DJ, Kovar DR, Dominguez R.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):E2677-86. doi: 10.1073/pnas.1307235110. Epub 2013 Jul 1.

33.

Actin assembly factors regulate the gelation kinetics and architecture of F-actin networks.

Falzone TT, Oakes PW, Sees J, Kovar DR, Gardel ML.

Biophys J. 2013 Apr 16;104(8):1709-19. doi: 10.1016/j.bpj.2013.01.017.

34.

Assembly kinetics determine the architecture of α-actinin crosslinked F-actin networks.

Falzone TT, Lenz M, Kovar DR, Gardel ML.

Nat Commun. 2012 May 29;3:861. doi: 10.1038/ncomms1862.

35.

Mechanism of actin filament nucleation by Vibrio VopL and implications for tandem W domain nucleation.

Namgoong S, Boczkowska M, Glista MJ, Winkelman JD, Rebowski G, Kovar DR, Dominguez R.

Nat Struct Mol Biol. 2011 Aug 28;18(9):1060-7. doi: 10.1038/nsmb.2109.

36.

The functionally distinct fission yeast formins have specific actin-assembly properties.

Scott BJ, Neidt EM, Kovar DR.

Mol Biol Cell. 2011 Oct;22(20):3826-39. doi: 10.1091/mbc.E11-06-0492. Epub 2011 Aug 24.

37.

Actin filament bundling by fimbrin is important for endocytosis, cytokinesis, and polarization in fission yeast.

Skau CT, Courson DS, Bestul AJ, Winkelman JD, Rock RS, Sirotkin V, Kovar DR.

J Biol Chem. 2011 Jul 29;286(30):26964-77. doi: 10.1074/jbc.M111.239004. Epub 2011 Jun 3.

38.

Minimal requirements for actin filament disassembly revealed by structural analysis of malaria parasite actin-depolymerizing factor 1.

Wong W, Skau CT, Marapana DS, Hanssen E, Taylor NL, Riglar DT, Zuccala ES, Angrisano F, Lewis H, Catimel B, Clarke OB, Kershaw NJ, Perugini MA, Kovar DR, Gulbis JM, Baum J.

Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9869-74. doi: 10.1073/pnas.1018927108. Epub 2011 May 31.

39.

Three's company: the fission yeast actin cytoskeleton.

Kovar DR, Sirotkin V, Lord M.

Trends Cell Biol. 2011 Mar;21(3):177-87. doi: 10.1016/j.tcb.2010.11.001. Epub 2010 Dec 7. Review.

40.

Rickettsia Sca2 is a bacterial formin-like mediator of actin-based motility.

Haglund CM, Choe JE, Skau CT, Kovar DR, Welch MD.

Nat Cell Biol. 2010 Nov;12(11):1057-63. doi: 10.1038/ncb2109. Epub 2010 Oct 24.

41.

Fimbrin and tropomyosin competition regulates endocytosis and cytokinesis kinetics in fission yeast.

Skau CT, Kovar DR.

Curr Biol. 2010 Aug 24;20(16):1415-22. doi: 10.1016/j.cub.2010.06.020. Epub 2010 Aug 12.

42.

Rationally simplified bistramide analog reversibly targets actin polymerization and inhibits cancer progression in vitro and in vivo.

Rizvi SA, Liu S, Chen Z, Skau C, Pytynia M, Kovar DR, Chmura SJ, Kozmin SA.

J Am Chem Soc. 2010 Jun 2;132(21):7288-90. doi: 10.1021/ja101811x.

PMID:
20455580
43.

Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly.

Rizvi SA, Neidt EM, Cui J, Feiger Z, Skau CT, Gardel ML, Kozmin SA, Kovar DR.

Chem Biol. 2009 Nov 25;16(11):1158-68. doi: 10.1016/j.chembiol.2009.10.006.

44.

Role of tropomyosin in formin-mediated contractile ring assembly in fission yeast.

Skau CT, Neidt EM, Kovar DR.

Mol Biol Cell. 2009 Apr;20(8):2160-73. doi: 10.1091/mbc.E08-12-1201. Epub 2009 Feb 25.

45.

Incompatibility with formin Cdc12p prevents human profilin from substituting for fission yeast profilin: insights from crystal structures of fission yeast profilin.

Ezezika OC, Younger NS, Lu J, Kaiser DA, Corbin ZA, Nolen BJ, Kovar DR, Pollard TD.

J Biol Chem. 2009 Jan 23;284(4):2088-97. doi: 10.1074/jbc.M807073200. Epub 2008 Nov 20.

46.

Formin differentially utilizes profilin isoforms to rapidly assemble actin filaments.

Neidt EM, Scott BJ, Kovar DR.

J Biol Chem. 2009 Jan 2;284(1):673-84. doi: 10.1074/jbc.M804201200. Epub 2008 Oct 31.

47.

The cytokinesis formins from the nematode worm and fission yeast differentially mediate actin filament assembly.

Neidt EM, Skau CT, Kovar DR.

J Biol Chem. 2008 Aug 29;283(35):23872-83. doi: 10.1074/jbc.M803734200. Epub 2008 Jun 23.

48.
49.

Attachment conditions control actin filament buckling and the production of forces.

Berro J, Michelot A, Blanchoin L, Kovar DR, Martiel JL.

Biophys J. 2007 Apr 1;92(7):2546-58. Epub 2007 Jan 5.

50.

Arp2/3 ATP hydrolysis: to branch or to debranch?

Kovar DR.

Nat Cell Biol. 2006 Aug;8(8):783-5. No abstract available.

PMID:
16880808

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