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Items: 1 to 50 of 394

1.

Resolvins: Emerging Players in Autoimmune and Inflammatory Diseases.

Abdolmaleki F, Kovanen PT, Mardani R, Gheibi-Hayat SM, Bo S, Sahebkar A.

Clin Rev Allergy Immunol. 2019 Jul 2. doi: 10.1007/s12016-019-08754-9. [Epub ahead of print] Review.

PMID:
31267470
2.

Mast cell tryptase - Marker and maker of cardiovascular diseases.

Mohajeri M, Kovanen PT, Bianconi V, Pirro M, Cicero AFG, Sahebkar A.

Pharmacol Ther. 2019 Jul;199:91-110. doi: 10.1016/j.pharmthera.2019.03.008. Epub 2019 Mar 12. Review.

PMID:
30877022
3.

Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities.

Bäck M, Yurdagul A Jr, Tabas I, Öörni K, Kovanen PT.

Nat Rev Cardiol. 2019 Jul;16(7):389-406. doi: 10.1038/s41569-019-0169-2. Review.

PMID:
30846875
4.

Lipoprotein(a) as a risk factor for calcific aortic valvulopathy in heterozygous familial hypercholesterolemia.

Vuorio A, Watts GF, Kovanen PT.

Atherosclerosis. 2019 Feb;281:25-30. doi: 10.1016/j.atherosclerosis.2018.11.040. Epub 2018 Dec 7. Review.

PMID:
30616181
5.

USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages.

Ruuth M, Soronen J, Kaiharju E, Merikanto K, Perttilä J, Metso J, Lee-Rueckert M, Taskinen MR, Kovanen PT, Öörni K, Olkkonen VM, Jauhiainen MS, Laurila PP.

Lipids Health Dis. 2018 Dec 13;17(1):285. doi: 10.1186/s12944-018-0930-2.

6.

Decreasing the Cholesterol Burden in Heterozygous Familial Hypercholesterolemia Children by Dietary Plant Stanol Esters.

Vuorio A, Kovanen PT.

Nutrients. 2018 Dec 1;10(12). pii: E1842. doi: 10.3390/nu10121842. Review.

7.

IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice.

Wang J, Cheng X, Xiang MX, Alanne-Kinnunen M, Wang JA, Chen H, He A, Sun X, Lin Y, Tang TT, Tu X, Sjöberg S, Sukhova GK, Liao YH, Conrad DH, Yu L, Kawakami T, Kovanen PT, Libby P, Shi GP.

J Clin Invest. 2018 Nov 1;128(11):5184. doi: 10.1172/JCI124107. Epub 2018 Nov 1. No abstract available.

8.

Macrophage Infiltration in the Saccular Intracranial Aneurysm Wall as a Response to Locally Lysed Erythrocytes That Promote Degeneration.

Ollikainen E, Tulamo R, Kaitainen S, Honkanen P, Lehti S, Liimatainen T, Hernesniemi J, Niemelä M, Kovanen PT, Frösen J.

J Neuropathol Exp Neurol. 2018 Oct 1;77(10):890-903. doi: 10.1093/jnen/nly068.

PMID:
30113655
9.

Morphology and histology of silent and symptom-causing atherosclerotic carotid plaques - Rationale and design of the Helsinki Carotid Endarterectomy Study 2 (the HeCES2).

Nuotio K, Ijäs P, Heikkilä HM, Koskinen SM, Saksi J, Vikatmaa P, Sorto P, Mäkitie L, Eriksson H, Kasari S, Silvennoinen H, Valanne L, Mäyränpää MI, Kovanen PT, Soinne L, Lindsberg PJ.

Ann Med. 2018 Sep;50(6):501-510. doi: 10.1080/07853890.2018.1494851. Epub 2018 Oct 1.

PMID:
30010425
10.

Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, is modifiable, and associates with future cardiovascular deaths.

Ruuth M, Nguyen SD, Vihervaara T, Hilvo M, Laajala TD, Kondadi PK, Gisterå A, Lähteenmäki H, Kittilä T, Huusko J, Uusitupa M, Schwab U, Savolainen MJ, Sinisalo J, Lokki ML, Nieminen MS, Jula A, Perola M, Ylä-Herttula S, Rudel L, Öörni A, Baumann M, Baruch A, Laaksonen R, Ketelhuth DFJ, Aittokallio T, Jauhiainen M, Käkelä R, Borén J, Williams KJ, Kovanen PT, Öörni K.

Eur Heart J. 2018 Jul 14;39(27):2562-2573. doi: 10.1093/eurheartj/ehy319.

11.

Triglyceride-Rich Lipoproteins as a Source of Proinflammatory Lipids in the Arterial Wall.

Öörni K, Lehti S, Sjövall P, Kovanen PT.

Curr Med Chem. 2019;26(9):1701-1710. doi: 10.2174/0929867325666180530094819. Review.

PMID:
29848270
12.

Myeloperoxidase Associates With Degenerative Remodeling and Rupture of the Saccular Intracranial Aneurysm Wall.

Ollikainen E, Tulamo R, Lehti S, Hernesniemi J, Niemelä M, Kovanen PT, Frösen J.

J Neuropathol Exp Neurol. 2018 Jun 1;77(6):461-468. doi: 10.1093/jnen/nly028.

PMID:
29718300
13.

Human mast cell neutral proteases generate modified LDL particles with increased proteoglycan binding.

Maaninka K, Nguyen SD, Mäyränpää MI, Plihtari R, Rajamäki K, Lindsberg PJ, Kovanen PT, Öörni K.

Atherosclerosis. 2018 Aug;275:390-399. doi: 10.1016/j.atherosclerosis.2018.04.016. Epub 2018 Apr 13.

PMID:
29703634
14.

Chymase released from hypoxia-activated cardiac mast cells cleaves human apoA-I at Tyr192 and compromises its cardioprotective activity.

Kareinen I, Baumann M, Nguyen SD, Maaninka K, Anisimov A, Tozuka M, Jauhiainen M, Lee-Rueckert M, Kovanen PT.

J Lipid Res. 2018 Jun;59(6):945-957. doi: 10.1194/jlr.M077503. Epub 2018 Mar 26.

15.

Efferocytosis in atherosclerotic lesions: Malfunctioning regulatory pathways and control mechanisms.

Tajbakhsh A, Rezaee M, Kovanen PT, Sahebkar A.

Pharmacol Ther. 2018 Aug;188:12-25. doi: 10.1016/j.pharmthera.2018.02.003. Epub 2018 Feb 11. Review.

PMID:
29444453
16.

Altered HDL Remodeling and Functionality in Familial Hypercholesterolemia.

Cedó L, Plana N, Metso J, Lee-Rueckert M, Sanchez-Quesada JL, Kovanen PT, Jauhiainen M, Masana L, Escolà-Gil JC, Blanco-Vaca F.

J Am Coll Cardiol. 2018 Jan 30;71(4):466-468. doi: 10.1016/j.jacc.2017.11.035. No abstract available.

17.

Effects of orlistat on blood pressure: a systematic review and meta-analysis of 27 randomized controlled clinical trials.

Sahebkar A, Simental-Mendía LE, Kovanen PT, Pedone C, Simental-Mendía M, Cicero AFG.

J Am Soc Hypertens. 2018 Feb;12(2):80-96. doi: 10.1016/j.jash.2017.12.002. Epub 2017 Dec 14.

PMID:
29275922
18.

Extracellular Lipids Accumulate in Human Carotid Arteries as Distinct Three-Dimensional Structures and Have Proinflammatory Properties.

Lehti S, Nguyen SD, Belevich I, Vihinen H, Heikkilä HM, Soliymani R, Käkelä R, Saksi J, Jauhiainen M, Grabowski GA, Kummu O, Hörkkö S, Baumann M, Lindsberg PJ, Jokitalo E, Kovanen PT, Öörni K.

Am J Pathol. 2018 Feb;188(2):525-538. doi: 10.1016/j.ajpath.2017.09.019. Epub 2017 Nov 14.

PMID:
29154769
19.

Mast cells in atherosclerotic cardiovascular disease - Activators and actions.

Kovanen PT, Bot I.

Eur J Pharmacol. 2017 Dec 5;816:37-46. doi: 10.1016/j.ejphar.2017.10.013. Epub 2017 Oct 12. Review.

PMID:
29032103
20.

Depicting new pharmacological strategies for familial hypercholesterolaemia involving lipoprotein (a).

Vuorio A, Watts GF, Kovanen PT.

Eur Heart J. 2017 Dec 21;38(48):3555-3559. doi: 10.1093/eurheartj/ehx546.

PMID:
29029165
21.

HDL functionality in familial hypercholesterolemia: effects of treatment modalities and pharmacological interventions.

Ganjali S, Momtazi-Borojeni AA, Banach M, Kovanen PT, Gotto AM Jr, Sahebkar A.

Drug Discov Today. 2018 Jan;23(1):171-180. doi: 10.1016/j.drudis.2017.09.014. Epub 2017 Oct 3. Review.

PMID:
28986138
22.

Statins for children with familial hypercholesterolemia.

Vuorio A, Kuoppala J, Kovanen PT, Humphries SE, Tonstad S, Wiegman A, Drogari E, Ramaswami U.

Cochrane Database Syst Rev. 2017 Jul 7;7:CD006401. doi: 10.1002/14651858.CD006401.pub4. Review.

23.

Statistical vs clinical significance: A matter of debate for orlistat treatment.

Sahebkar A, Simental-Mendía LE, Reiner Ž, Kovanen PT, Simental-Mendía M, Bianconi V, Pirro M.

Pharmacol Res. 2017 Oct;124:158-159. doi: 10.1016/j.phrs.2017.06.011. Epub 2017 Jun 23. No abstract available.

PMID:
28652221
24.

Effect of orlistat on plasma lipids and body weight: A systematic review and meta-analysis of 33 randomized controlled trials.

Sahebkar A, Simental-Mendía LE, Reiner Ž, Kovanen PT, Simental-Mendía M, Bianconi V, Pirro M.

Pharmacol Res. 2017 Aug;122:53-65. doi: 10.1016/j.phrs.2017.05.022. Epub 2017 May 27. Review.

PMID:
28559211
25.

HDL abnormalities in familial hypercholesterolemia: Focus on biological functions.

Ganjali S, Momtazi AA, Banach M, Kovanen PT, Stein EA, Sahebkar A.

Prog Lipid Res. 2017 Jul;67:16-26. doi: 10.1016/j.plipres.2017.05.001. Epub 2017 May 12. Review.

PMID:
28506805
26.

Attitudes and actions: A survey to assess statin use among Finnish patients with increased risk for cardiovascular events.

Silvennoinen R, Turunen JH, Kovanen PT, Syvänne M, Tikkanen MJ.

J Clin Lipidol. 2017 Mar - Apr;11(2):485-494. doi: 10.1016/j.jacl.2017.02.013. Epub 2017 Mar 9.

PMID:
28502506
27.

Phytosterol-mediated inhibition of intestinal cholesterol absorption in mice is independent of liver X receptor.

Cedó L, Santos D, Ludwig IA, Silvennoinen R, García-León A, Kaipiainen L, Carbó JM, Valledor AF, Gylling H, Motilva MJ, Kovanen PT, Lee-Rueckert M, Blanco-Vaca F, Escolà-Gil JC.

Mol Nutr Food Res. 2017 Sep;61(9). doi: 10.1002/mnfr.201700055. Epub 2017 Apr 5.

PMID:
28296229
28.

Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future.

Valent P, Akin C, Hartmann K, Nilsson G, Reiter A, Hermine O, Sotlar K, Sperr WR, Escribano L, George TI, Kluin-Nelemans HC, Ustun C, Triggiani M, Brockow K, Gotlib J, Orfao A, Schwartz LB, Broesby-Olsen S, Bindslev-Jensen C, Kovanen PT, Galli SJ, Austen KF, Arber DA, Horny HP, Arock M, Metcalfe DD.

Cancer Res. 2017 Mar 15;77(6):1261-1270. doi: 10.1158/0008-5472.CAN-16-2234. Epub 2017 Mar 2. Review.

29.

Congestive heart failure: more common as well as an important cardiovascular outcome: reply.

Hartman O, Sinisalo J, Kovanen PT, Lehtonen J, Eklund KK.

Eur Heart J Cardiovasc Pharmacother. 2017 Apr 1;3(2):99. doi: 10.1093/ehjcvp/pvw050. No abstract available.

PMID:
28069608
30.

Reply: The complexity of substance P-mediated mast cell activation.

Shi GP, Bot I, Kovanen PT.

Nat Rev Cardiol. 2017 Feb;14(2):124. doi: 10.1038/nrcardio.2016.213. Epub 2017 Jan 5. No abstract available.

PMID:
28054578
31.

Hydroxychloroquine for the prevention of recurrent cardiovascular events in myocardial infarction patients: rationale and design of the OXI trial.

Hartman O, Kovanen PT, Lehtonen J, Eklund KK, Sinisalo J.

Eur Heart J Cardiovasc Pharmacother. 2017 Apr 1;3(2):92-97. doi: 10.1093/ehjcvp/pvw035.

PMID:
28025216
32.

Rescue therapy with PCSK9 inhibitors for patients with delayed diagnosis of heterozygous familial hypercholesterolemia: Redressing the balance of missed opportunities.

Vuorio A, Watts GF, Kovanen PT.

J Clin Lipidol. 2016 Sep-Oct;10(5):1278-9. doi: 10.1016/j.jacl.2016.07.003. Epub 2016 Jul 20. No abstract available.

PMID:
27678448
33.

Hemin and Cobalt Protoporphyrin Inhibit NLRP3 Inflammasome Activation by Enhancing Autophagy: A Novel Mechanism of Inflammasome Regulation.

Nurmi K, Kareinen I, Virkanen J, Rajamäki K, Kouri VP, Vaali K, Levonen AL, Fyhrquist N, Matikainen S, Kovanen PT, Eklund KK.

J Innate Immun. 2017;9(1):65-82. doi: 10.1159/000448894. Epub 2016 Sep 22.

34.

Prompt impact of first prospective statin mega-trials on postoperative lipid management of CABG patients: a 20-year follow-up in a single hospital.

Palomäki A, Hällberg V, Ala-Korpela M, Kovanen PT, Malminiemi K.

Lipids Health Dis. 2016 Jul 26;15(1):124. doi: 10.1186/s12944-016-0292-6.

35.

Response to Dr. Gerald M Reaven: good news for patients with familial hypercholesterolaemia: statins are not diabetogenic in this disease.

Vuorio A, Strandberg TE, Schneider WJ, Kovanen PT.

J Intern Med. 2016 Oct;280(4):419-20. doi: 10.1111/joim.12536. Epub 2016 Jul 25. No abstract available.

36.

p38δ MAPK: A Novel Regulator of NLRP3 Inflammasome Activation With Increased Expression in Coronary Atherogenesis.

Rajamäki K, Mäyränpää MI, Risco A, Tuimala J, Nurmi K, Cuenda A, Eklund KK, Öörni K, Kovanen PT.

Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1937-46. doi: 10.1161/ATVBAHA.115.307312. Epub 2016 Jul 14.

PMID:
27417584
37.

Smooth Muscle Cell Foam Cell Formation, Apolipoproteins, and ABCA1 in Intracranial Aneurysms: Implications for Lipid Accumulation as a Promoter of Aneurysm Wall Rupture.

Ollikainen E, Tulamo R, Lehti S, Lee-Rueckert M, Hernesniemi J, Niemelä M, Ylä-Herttuala S, Kovanen PT, Frösen J.

J Neuropathol Exp Neurol. 2016 Jul;75(7):689-99. doi: 10.1093/jnen/nlw041. Epub 2016 Jun 9.

38.

Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation.

da Silva RF, Lappalainen J, Lee-Rueckert M, Kovanen PT.

Atherosclerosis. 2016 May;248:170-8. doi: 10.1016/j.atherosclerosis.2016.03.012. Epub 2016 Mar 10.

PMID:
27038418
39.

HDL functionality in reverse cholesterol transport--Challenges in translating data emerging from mouse models to human disease.

Lee-Rueckert M, Escola-Gil JC, Kovanen PT.

Biochim Biophys Acta. 2016 Jul;1861(7):566-83. doi: 10.1016/j.bbalip.2016.03.004. Epub 2016 Mar 9. Review.

PMID:
26968096
40.

Initiation of PCSK9 inhibition in patients with heterozygous familial hypercholesterolaemia entering adulthood: a new design for living with a high-risk condition?

Vuorio A, Watts GF, Kovanen PT.

Eur Heart J. 2016 May 1;37(17):1353-6. doi: 10.1093/eurheartj/ehw010. Epub 2016 Feb 6. Review. No abstract available.

PMID:
26851704
41.

USF1 deficiency activates brown adipose tissue and improves cardiometabolic health.

Laurila PP, Soronen J, Kooijman S, Forsström S, Boon MR, Surakka I, Kaiharju E, Coomans CP, Van Den Berg SA, Autio A, Sarin AP, Kettunen J, Tikkanen E, Manninen T, Metso J, Silvennoinen R, Merikanto K, Ruuth M, Perttilä J, Mäkelä A, Isomi A, Tuomainen AM, Tikka A, Ramadan UA, Seppälä I, Lehtimäki T, Eriksson J, Havulinna A, Jula A, Karhunen PJ, Salomaa V, Perola M, Ehnholm C, Lee-Rueckert M, Van Eck M, Roivainen A, Taskinen MR, Peltonen L, Mervaala E, Jalanko A, Hohtola E, Olkkonen VM, Ripatti S, Kovanen PT, Rensen PC, Suomalainen A, Jauhiainen M.

Sci Transl Med. 2016 Jan 27;8(323):323ra13. doi: 10.1126/scitranslmed.aad0015.

PMID:
26819196
42.

Carboxyl-Terminal Cleavage of Apolipoprotein A-I by Human Mast Cell Chymase Impairs Its Anti-Inflammatory Properties.

Nguyen SD, Maaninka K, Lappalainen J, Nurmi K, Metso J, Öörni K, Navab M, Fogelman AM, Jauhiainen M, Lee-Rueckert M, Kovanen PT.

Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):274-84. doi: 10.1161/ATVBAHA.115.306827. Epub 2015 Dec 17.

43.

Novel 6p21.3 Risk Haplotype Predisposes to Acute Coronary Syndrome.

Sinisalo J, Vlachopoulou E, Marchesani M, Nokelainen J, Mäyränpää MI, Lappalainen J, Paakkanen R, Wennerström A, Salli K, Niemi HJ, Männistö S, Salo P, Junttila J, Eskola M, Nikus K, Arstila TP, Perola M, Huikuri H, Karhunen PJ, Kovanen PT, Palotie A, Havulinna AS, Lluis-Ganella C, Marrugat J, Elosua R, Salomaa V, Nieminen MS, Lokki ML.

Circ Cardiovasc Genet. 2016 Feb;9(1):55-63. doi: 10.1161/CIRCGENETICS.115.001226. Epub 2015 Dec 17.

PMID:
26679868
44.

The mast cell as a pluripotent HDL-modifying effector in atherogenesis: from in vitro to in vivo significance.

Lee-Rueckert M, Kovanen PT.

Curr Opin Lipidol. 2015 Oct;26(5):362-8. doi: 10.1097/MOL.0000000000000224. Review.

PMID:
26339766
45.

Electronegative LDL induces priming and inflammasome activation leading to IL-1β release in human monocytes and macrophages.

Estruch M, Rajamäki K, Sanchez-Quesada JL, Kovanen PT, Öörni K, Benitez S, Ordoñez-Llanos J.

Biochim Biophys Acta. 2015 Nov;1851(11):1442-9. doi: 10.1016/j.bbalip.2015.08.009. Epub 2015 Aug 29.

PMID:
26327597
46.

Life-threatening coronary disease is prevalent in patients with stenosing carotid artery disease.

Nuotio K, Soinne L, Hänninen H, Saksi J, Tuimala J, Jula A, Kovanen PT, Kaste M, Ijäs P, Lindsberg PJ.

Int J Stroke. 2015 Dec;10(8):1217-23. doi: 10.1111/ijs.12590. Epub 2015 Aug 26.

PMID:
26311319
47.

Statins and new-onset diabetes mellitus - a risk lacking in familial hypercholesterolaemia.

Vuorio A, Strandberg TE, Schneider WJ, Kovanen PT.

J Intern Med. 2016 Apr;279(4):358-61. doi: 10.1111/joim.12405. Epub 2015 Aug 11. No abstract available.

48.

Mast cells in human and experimental cardiometabolic diseases.

Shi GP, Bot I, Kovanen PT.

Nat Rev Cardiol. 2015 Nov;12(11):643-58. doi: 10.1038/nrcardio.2015.117. Epub 2015 Aug 11. Review.

PMID:
26259935
49.

MicroRNA-125b and chemokine CCL4 expression are associated with calcific aortic valve disease.

Ohukainen P, Syväranta S, Näpänkangas J, Rajamäki K, Taskinen P, Peltonen T, Helske-Suihko S, Kovanen PT, Ruskoaho H, Rysä J.

Ann Med. 2015;47(5):423-9. doi: 10.3109/07853890.2015.1059955. Epub 2015 Jul 30.

PMID:
26203686
50.

Lipid droplets in activated mast cells - a significant source of triglyceride-derived arachidonic acid for eicosanoid production.

Dichlberger A, Schlager S, Kovanen PT, Schneider WJ.

Eur J Pharmacol. 2016 Aug 15;785:59-69. doi: 10.1016/j.ejphar.2015.07.020. Epub 2015 Jul 9. Review.

PMID:
26164793

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