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Items: 31


Structurally conserved binding motifs of transcriptional regulators to notch nuclear effector CSL.

Hall DP, Kovall RA.

Exp Biol Med (Maywood). 2019 Sep 22:1535370219877818. doi: 10.1177/1535370219877818. [Epub ahead of print] No abstract available.


Structural and Functional Studies of the RBPJ-SHARP Complex Reveal a Conserved Corepressor Binding Site.

Yuan Z, VanderWielen BD, Giaimo BD, Pan L, Collins CE, Turkiewicz A, Hein K, Oswald F, Borggrefe T, Kovall RA.

Cell Rep. 2019 Jan 22;26(4):845-854.e6. doi: 10.1016/j.celrep.2018.12.097.


CSL-Associated Corepressor and Coactivator Complexes.

Oswald F, Kovall RA.

Adv Exp Med Biol. 2018;1066:279-295. doi: 10.1007/978-3-319-89512-3_14. Review.


Rbpj direct regulation of Atoh7 transcription in the embryonic mouse retina.

Miesfeld JB, Moon MS, Riesenberg AN, Contreras AN, Kovall RA, Brown NL.

Sci Rep. 2018 Jul 5;8(1):10195. doi: 10.1038/s41598-018-28420-y.


RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1.

Xu T, Park SS, Giaimo BD, Hall D, Ferrante F, Ho DM, Hori K, Anhezini L, Ertl I, Bartkuhn M, Zhang H, Milon E, Ha K, Conlon KP, Kuick R, Govindarajoo B, Zhang Y, Sun Y, Dou Y, Basrur V, Elenitoba-Johnson KS, Nesvizhskii AI, Ceron J, Lee CY, Borggrefe T, Kovall RA, Rual JF.

EMBO J. 2017 Nov 2;36(21):3232-3249. doi: 10.15252/embj.201796525. Epub 2017 Oct 13.


Phosphorylation of Suppressor of Hairless impedes its DNA-binding activity.

Nagel AC, Auer JS, Schulz A, Pfannstiel J, Yuan Z, Collins CE, Kovall RA, Preiss A.

Sci Rep. 2017 Sep 19;7(1):11820. doi: 10.1038/s41598-017-11952-0.


Structure-function analysis of RBP-J-interacting and tubulin-associated (RITA) reveals regions critical for repression of Notch target genes.

Tabaja N, Yuan Z, Oswald F, Kovall RA.

J Biol Chem. 2017 Jun 23;292(25):10549-10563. doi: 10.1074/jbc.M117.791707. Epub 2017 May 9.


The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force.

Kovall RA, Gebelein B, Sprinzak D, Kopan R.

Dev Cell. 2017 May 8;41(3):228-241. doi: 10.1016/j.devcel.2017.04.001. Review.


Structure and Function of the Su(H)-Hairless Repressor Complex, the Major Antagonist of Notch Signaling in Drosophila melanogaster.

Yuan Z, Praxenthaler H, Tabaja N, Torella R, Preiss A, Maier D, Kovall RA.

PLoS Biol. 2016 Jul 12;14(7):e1002509. doi: 10.1371/journal.pbio.1002509. eCollection 2016 Jul.


A phospho-dependent mechanism involving NCoR and KMT2D controls a permissive chromatin state at Notch target genes.

Oswald F, Rodriguez P, Giaimo BD, Antonello ZA, Mira L, Mittler G, Thiel VN, Collins KJ, Tabaja N, Cizelsky W, Rothe M, Kühl SJ, Kühl M, Ferrante F, Hein K, Kovall RA, Dominguez M, Borggrefe T.

Nucleic Acids Res. 2016 Jun 2;44(10):4703-20. doi: 10.1093/nar/gkw105. Epub 2016 Feb 23.


Thermodynamic binding analysis of Notch transcription complexes from Drosophila melanogaster.

Contreras AN, Yuan Z, Kovall RA.

Protein Sci. 2015 May;24(5):812-22. doi: 10.1002/pro.2652. Epub 2015 Mar 16.


A combination of computational and experimental approaches identifies DNA sequence constraints associated with target site binding specificity of the transcription factor CSL.

Torella R, Li J, Kinrade E, Cerda-Moya G, Contreras AN, Foy R, Stojnic R, Glen RC, Kovall RA, Adryan B, Bray SJ.

Nucleic Acids Res. 2014;42(16):10550-63. doi: 10.1093/nar/gku730. Epub 2014 Aug 11.


Catalase (KatA) plays a role in protection against anaerobic nitric oxide in Pseudomonas aeruginosa.

Su S, Panmanee W, Wilson JJ, Mahtani HK, Li Q, Vanderwielen BD, Makris TM, Rogers M, McDaniel C, Lipscomb JD, Irvin RT, Schurr MJ, Lancaster JR Jr, Kovall RA, Hassett DJ.

PLoS One. 2014 Mar 24;9(3):e91813. doi: 10.1371/journal.pone.0091813. eCollection 2014.


Structure and function of the CSL-KyoT2 corepressor complex: a negative regulator of Notch signaling.

Collins KJ, Yuan Z, Kovall RA.

Structure. 2014 Jan 7;22(1):70-81. doi: 10.1016/j.str.2013.10.010. Epub 2013 Nov 27.


Characterization of CSL (CBF-1, Su(H), Lag-1) mutants reveals differences in signaling mediated by Notch1 and Notch2.

Yuan Z, Friedmann DR, VanderWielen BD, Collins KJ, Kovall RA.

J Biol Chem. 2012 Oct 12;287(42):34904-16. doi: 10.1074/jbc.M112.403287. Epub 2012 Aug 22.


In notch, one ANK repeat is not like the other.

Kovall RA.

Structure. 2012 Feb 8;20(2):202-4. doi: 10.1016/j.str.2012.01.017.


Molecular analysis of the notch repressor-complex in Drosophila: characterization of potential hairless binding sites on suppressor of hairless.

Kurth P, Preiss A, Kovall RA, Maier D.

PLoS One. 2011;6(11):e27986. doi: 10.1371/journal.pone.0027986. Epub 2011 Nov 18.


Structural and functional analysis of the repressor complex in the Notch signaling pathway of Drosophila melanogaster.

Maier D, Kurth P, Schulz A, Russell A, Yuan Z, Gruber K, Kovall RA, Preiss A.

Mol Biol Cell. 2011 Sep;22(17):3242-52. doi: 10.1091/mbc.E11-05-0420. Epub 2011 Jul 7.


Transcriptional repression in the Notch pathway: thermodynamic characterization of CSL-MINT (Msx2-interacting nuclear target protein) complexes.

VanderWielen BD, Yuan Z, Friedmann DR, Kovall RA.

J Biol Chem. 2011 Apr 29;286(17):14892-902. doi: 10.1074/jbc.M110.181156. Epub 2011 Mar 3.


A human cancer-predisposing polymorphism in Cdc25A is embryonic lethal in the mouse and promotes ASK-1 mediated apoptosis.

Bahassi el M, Yin M, Robbins SB, Li YQ, Conrady DG, Yuan Z, Kovall RA, Herr AB, Stambrook PJ.

Cell Div. 2011 Feb 10;6(1):4. doi: 10.1186/1747-1028-6-4.


Molecular basis of differential B-pentamer stability of Shiga toxins 1 and 2.

Conrady DG, Flagler MJ, Friedmann DR, Vander Wielen BD, Kovall RA, Weiss AA, Herr AB.

PLoS One. 2010 Dec 28;5(12):e15153. doi: 10.1371/journal.pone.0015153.


Mechanistic insights into Notch receptor signaling from structural and biochemical studies.

Kovall RA, Blacklow SC.

Curr Top Dev Biol. 2010;92:31-71. doi: 10.1016/S0070-2153(10)92002-4. Review.


Thermodynamic and structural insights into CSL-DNA complexes.

Friedmann DR, Kovall RA.

Protein Sci. 2010 Jan;19(1):34-46. doi: 10.1002/pro.280.


More complicated than it looks: assembly of Notch pathway transcription complexes.

Kovall RA.

Oncogene. 2008 Sep 1;27(38):5099-109. doi: 10.1038/onc.2008.223. Review.


RAM-induced allostery facilitates assembly of a notch pathway active transcription complex.

Friedmann DR, Wilson JJ, Kovall RA.

J Biol Chem. 2008 May 23;283(21):14781-91. doi: 10.1074/jbc.M709501200. Epub 2008 Apr 1.


Structures of CSL, Notch and Mastermind proteins: piecing together an active transcription complex.

Kovall RA.

Curr Opin Struct Biol. 2007 Feb;17(1):117-27. Epub 2006 Dec 6. Review.


Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA.

Wilson JJ, Kovall RA.

Cell. 2006 Mar 10;124(5):985-96.


Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA.

Kovall RA, Hendrickson WA.

EMBO J. 2004 Sep 1;23(17):3441-51. Epub 2004 Aug 5.


Crystal structure of human alpha-tocopherol transfer protein bound to its ligand: implications for ataxia with vitamin E deficiency.

Min KC, Kovall RA, Hendrickson WA.

Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14713-8. Epub 2003 Dec 1.


Type II restriction endonucleases: structural, functional and evolutionary relationships.

Kovall RA, Matthews BW.

Curr Opin Chem Biol. 1999 Oct;3(5):578-83. Review.


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