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Compounds from the marine sponge Cribrochalina vasculum offer a way to target IGF-1R mediated signaling in tumor cells.

Zovko A, Novak M, Hååg P, Kovalerchick D, Holmlund T, Färnegårdh K, Ilan M, Carmeli S, Lewensohn R, Viktorsson K.

Oncotarget. 2016 Aug 2;7(31):50258-50276. doi: 10.18632/oncotarget.10361.


Identification and characterization of haemofungin, a novel antifungal compound that inhibits the final step of haem biosynthesis.

Ben Yaakov D, Rivkin A, Mircus G, Albert N, Dietl AM, Kovalerchick D, Carmeli S, Haas H, Kontoyiannis DP, Osherov N.

J Antimicrob Chemother. 2016 Apr;71(4):946-52. doi: 10.1093/jac/dkv446. Epub 2016 Jan 7.


Marine sponge Cribrochalina vasculum compounds activate intrinsic apoptotic signaling and inhibit growth factor signaling cascades in non-small cell lung carcinoma.

Zovko A, Viktorsson K, Hååg P, Kovalerchick D, Färnegårdh K, Alimonti A, Ilan M, Carmeli S, Lewensohn R.

Mol Cancer Ther. 2014 Dec;13(12):2941-54. doi: 10.1158/1535-7163.MCT-14-0329. Epub 2014 Oct 15.

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