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Items: 20

1.

Vascular Endothelial Growth Factor Receptor 3 Regulates Endothelial Function Through β-Arrestin 1.

Ma Z, Yu YR, Badea CT, Kovacs JJ, Xiong X, Comhair S, Piantadosi CA, Rajagopal S.

Circulation. 2018 Dec 11. doi: 10.1161/CIRCULATIONAHA.118.034961. [Epub ahead of print]

PMID:
30586762
2.

PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy.

Hsu JI, Dayaram T, Tovy A, De Braekeleer E, Jeong M, Wang F, Zhang J, Heffernan TP, Gera S, Kovacs JJ, Marszalek JR, Bristow C, Yan Y, Garcia-Manero G, Kantarjian H, Vassiliou G, Futreal PA, Donehower LA, Takahashi K, Goodell MA.

Cell Stem Cell. 2018 Nov 1;23(5):700-713.e6. doi: 10.1016/j.stem.2018.10.004.

3.

Targeted disruption of β-arrestin 2-mediated signaling pathways by aptamer chimeras leads to inhibition of leukemic cell growth.

Kotula JW, Sun J, Li M, Pratico ED, Fereshteh MP, Ahrens DP, Sullenger BA, Kovacs JJ.

PLoS One. 2014 Apr 15;9(4):e93441. doi: 10.1371/journal.pone.0093441. eCollection 2014.

4.

β-Arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration.

Simard E, Kovacs JJ, Miller WE, Kim J, Grandbois M, Lefkowitz RJ.

PLoS One. 2013 Nov 8;8(11):e80532. doi: 10.1371/journal.pone.0080532. eCollection 2013.

5.

β-Arrestin2 mediates the initiation and progression of myeloid leukemia.

Fereshteh M, Ito T, Kovacs JJ, Zhao C, Kwon HY, Tornini V, Konuma T, Chen M, Lefkowitz RJ, Reya T.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12532-7. doi: 10.1073/pnas.1209815109. Epub 2012 Jul 5.

6.

A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.

Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ.

Nature. 2011 Aug 21;477(7364):349-53. doi: 10.1038/nature10368.

7.

Constitutional telomerase mutations are genetic risk factors for cirrhosis.

Calado RT, Brudno J, Mehta P, Kovacs JJ, Wu C, Zago MA, Chanock SJ, Boyer TD, Young NS.

Hepatology. 2011 May;53(5):1600-7. doi: 10.1002/hep.24173.

8.

β-arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix.

Lovgren AK, Kovacs JJ, Xie T, Potts EN, Li Y, Foster WM, Liang J, Meltzer EB, Jiang D, Lefkowitz RJ, Noble PW.

Sci Transl Med. 2011 Mar 16;3(74):74ra23. doi: 10.1126/scitranslmed.3001564.

9.

Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR).

Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villén J, Haas W, Kovacs JJ, Shukla AK, Hara MR, Hernandez M, Lachmann A, Zhao S, Lin Y, Cheng Y, Mizuno K, Ma'ayan A, Gygi SP, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15299-304. doi: 10.1073/pnas.1008461107. Epub 2010 Aug 4. Erratum in: Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13464.

10.

Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways.

Kovacs JJ, Hara MR, Davenport CL, Kim J, Lefkowitz RJ.

Dev Cell. 2009 Oct;17(4):443-58. doi: 10.1016/j.devcel.2009.09.011. Review.

11.

beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice.

Walters RW, Shukla AK, Kovacs JJ, Violin JD, DeWire SM, Lam CM, Chen JR, Muehlbauer MJ, Whalen EJ, Lefkowitz RJ.

J Clin Invest. 2009 May;119(5):1312-21. doi: 10.1172/JCI36806. Epub 2009 Apr 6.

12.

Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor.

Nelson CD, Kovacs JJ, Nobles KN, Whalen EJ, Lefkowitz RJ.

J Biol Chem. 2008 Jul 25;283(30):21093-101. doi: 10.1074/jbc.M800431200. Epub 2008 Jun 5.

13.

Beta-arrestin-mediated localization of smoothened to the primary cilium.

Kovacs JJ, Whalen EJ, Liu R, Xiao K, Kim J, Chen M, Wang J, Chen W, Lefkowitz RJ.

Science. 2008 Jun 27;320(5884):1777-81. doi: 10.1126/science.1157983. Epub 2008 May 22.

14.

Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin.

Pai MT, Tzeng SR, Kovacs JJ, Keaton MA, Li SS, Yao TP, Zhou P.

J Mol Biol. 2007 Jul 6;370(2):290-302. Epub 2007 Apr 12.

15.

Chaperoning steroid hormone signaling via reversible acetylation.

Kovacs JJ, Cohen TJ, Yao TP.

Nucl Recept Signal. 2005;3:e004. Epub 2005 Oct 21.

16.

Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone.

Murphy PJ, Morishima Y, Kovacs JJ, Yao TP, Pratt WB.

J Biol Chem. 2005 Oct 7;280(40):33792-9. Epub 2005 Aug 8.

17.

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor.

Kovacs JJ, Murphy PJ, Gaillard S, Zhao X, Wu JT, Nicchitta CV, Yoshida M, Toft DO, Pratt WB, Yao TP.

Mol Cell. 2005 May 27;18(5):601-7.

18.

The HDAC complex and cytoskeleton.

Kovacs JJ, Hubbert C, Yao TP.

Novartis Found Symp. 2004;259:170-7; discussion 178-81, 223-5.

PMID:
15171253
19.

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress.

Kawaguchi Y, Kovacs JJ, McLaurin A, Vance JM, Ito A, Yao TP.

Cell. 2003 Dec 12;115(6):727-38.

20.

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation.

Ito A, Kawaguchi Y, Lai CH, Kovacs JJ, Higashimoto Y, Appella E, Yao TP.

EMBO J. 2002 Nov 15;21(22):6236-45.

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