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Items: 1 to 50 of 307

1.

Characterization of Pneumocystis murina Bgl2, an Endo-β-1,3-Glucanase and Glucanosyltransferase.

Kutty G, Davis AS, Schuck K, Masterson M, Wang H, Liu Y, Kovacs JA.

J Infect Dis. 2019 Apr 18. pii: jiz172. doi: 10.1093/infdis/jiz172. [Epub ahead of print]

PMID:
31100118
2.

Formation of a Reactive, Alkyl Thiolate-Ligated FeIII-Superoxo Intermediate Derived from Dioxygen.

Blakely MN, Dedushko MA, Yan Poon PC, Villar-Acevedo G, Kovacs JA.

J Am Chem Soc. 2019 Feb 6;141(5):1867-1870. doi: 10.1021/jacs.8b12670. Epub 2019 Jan 24.

PMID:
30661357
3.

Accurate flexible refinement of atomic models against medium-resolution cryo-EM maps using damped dynamics.

Kovacs JA, Galkin VE, Wriggers W.

BMC Struct Biol. 2018 Sep 15;18(1):12. doi: 10.1186/s12900-018-0089-0.

4.

Genetic diversity of Pneumocystis jirovecii from a cluster of cases of pneumonia in renal transplant patients: Cross-sectional study.

Ricci G, Santos DW, Kovacs JA, Nishikaku AS, de Sandes-Freitas TV, Rodrigues AM, Kutty G, Affonso R, Silva HT, Medina-Pestana JO, de Franco MF, Colombo AL.

Mycoses. 2018 Nov;61(11):845-852. doi: 10.1111/myc.12823. Epub 2018 Jul 27.

PMID:
29992629
5.

A Molecular Window into the Biology and Epidemiology of Pneumocystis spp.

Ma L, Cissé OH, Kovacs JA.

Clin Microbiol Rev. 2018 Jun 13;31(3). pii: e00009-18. doi: 10.1128/CMR.00009-18. Print 2018 Jul. Review.

6.

Inability to Culture Pneumocystis jirovecii.

Liu Y, Fahle GA, Kovacs JA.

MBio. 2018 Jun 12;9(3). pii: e00939-18. doi: 10.1128/mBio.00939-18. No abstract available.

7.

The Major Surface Glycoprotein of Pneumocystis murina Does Not Activate Dendritic Cells.

Sassi M, Kutty G, Ferreyra GA, Bishop LR, Liu Y, Qiu J, Huang DW, Kovacs JA.

J Infect Dis. 2018 Oct 5;218(10):1631-1640. doi: 10.1093/infdis/jiy342.

PMID:
29868908
8.

Comparative Population Genomics Analysis of the Mammalian Fungal Pathogen Pneumocystis.

Cissé OH, Ma L, Wei Huang D, Khil PP, Dekker JP, Kutty G, Bishop L, Liu Y, Deng X, Hauser PM, Pagni M, Hirsch V, Lempicki RA, Stajich JE, Cuomo CA, Kovacs JA.

MBio. 2018 May 8;9(3). pii: e00381-18. doi: 10.1128/mBio.00381-18.

9.

Tracing Actin Filament Bundles in Three-Dimensional Electron Tomography Density Maps of Hair Cell Stereocilia.

Sazzed S, Song J, Kovacs JA, Wriggers W, Auer M, He J.

Molecules. 2018 Apr 11;23(4). pii: E882. doi: 10.3390/molecules23040882.

10.

Characterization of p57, a Stage-Specific Antigen of Pneumocystis murina.

Bishop LR, Davis AS, Bradshaw K, Gamez M, Cisse OH, Wang H, Ma L, Kovacs JA.

J Infect Dis. 2018 Jun 20;218(2):282-290. doi: 10.1093/infdis/jiy099.

11.

Cytokine-Mediated Systemic Adverse Drug Reactions in a Drug-Drug Interaction Study of Dolutegravir With Once-Weekly Isoniazid and Rifapentine.

Brooks KM, George JM, Pau AK, Rupert A, Mehaffy C, De P, Dobos KM, Kellogg A, McLaughlin M, McManus M, Alfaro RM, Hadigan C, Kovacs JA, Kumar P.

Clin Infect Dis. 2018 Jul 2;67(2):193-201. doi: 10.1093/cid/ciy082.

12.

How Do Ring Size and π-Donating Thiolate Ligands Affect Redox-Active, α-Imino-N-heterocycle Ligand Activation?

Leipzig BK, Rees JA, Kowalska JK, Theisen RM, Kavčič M, Poon PCY, Kaminsky W, DeBeer S, Bill E, Kovacs JA.

Inorg Chem. 2018 Feb 19;57(4):1935-1949. doi: 10.1021/acs.inorgchem.7b02748. Epub 2018 Feb 7.

PMID:
29411979
13.

Iron L2,3-Edge X-ray Absorption and X-ray Magnetic Circular Dichroism Studies of Molecular Iron Complexes with Relevance to the FeMoco and FeVco Active Sites of Nitrogenase.

Kowalska JK, Nayyar B, Rees JA, Schiewer CE, Lee SC, Kovacs JA, Meyer F, Weyhermüller T, Otero E, DeBeer S.

Inorg Chem. 2017 Jul 17;56(14):8147-8158. doi: 10.1021/acs.inorgchem.7b00852. Epub 2017 Jun 27.

14.

A Balanced Approach to Adaptive Probability Density Estimation.

Kovacs JA, Helmick C, Wriggers W.

Front Mol Biosci. 2017 Apr 25;4:25. doi: 10.3389/fmolb.2017.00025. eCollection 2017.

15.

Computing Spatiotemporal Heat Maps of Lipid Electropore Formation: A Statistical Approach.

Wriggers W, Castellani F, Kovacs JA, Vernier PT.

Front Mol Biosci. 2017 Apr 25;4:22. doi: 10.3389/fmolb.2017.00022. eCollection 2017.

16.

Magnetic Resonance Elastography Shear Wave Velocity Correlates with Liver Fibrosis and Hepatic Venous Pressure Gradient in Adults with Advanced Liver Disease.

Gharib AM, Han MAT, Meissner EG, Kleiner DE, Zhao X, McLaughlin M, Matthews L, Rizvi B, Abd-Elmoniem KZ, Sinkus R, Levy E, Koh C, Myers RP, Subramanian GM, Kottilil S, Heller T, Kovacs JA, Morse CG.

Biomed Res Int. 2017;2017:2067479. doi: 10.1155/2017/2067479. Epub 2017 Apr 5.

17.

Pulmonary Interleukin-17-Positive Lymphocytes Increase during Pneumocystis murina Infection but Are Not Required for Clearance of Pneumocystis.

Ripamonti C, Bishop LR, Kovacs JA.

Infect Immun. 2017 Jun 20;85(7). pii: e00434-16. doi: 10.1128/IAI.00434-16. Print 2017 Jul.

18.

Adverse effects of antiretroviral therapy on liver hepatocytes and endothelium in HIV patients: An ultrastructural perspective.

Chwiki S, Campos MM, McLaughlin ME, Kleiner DE, Kovacs JA, Morse CG, Abu-Asab MS.

Ultrastruct Pathol. 2017 Mar-Apr;41(2):186-195. doi: 10.1080/01913123.2017.1282066. Epub 2017 Feb 28.

19.

Pneumocystis colonization in asthmatic patients not receiving oral corticosteroid therapy.

Davey EL, Colombo RE, Fiorentino C, Fahle G, Davey RT Jr, Olivier KN, Kovacs JA.

J Investig Med. 2017 Apr;65(4):800-802. doi: 10.1136/jim-2016-000381. Epub 2017 Feb 13.

20.

Comparative electronic structures of nitrogenase FeMoco and FeVco.

Rees JA, Bjornsson R, Kowalska JK, Lima FA, Schlesier J, Sippel D, Weyhermüller T, Einsle O, Kovacs JA, DeBeer S.

Dalton Trans. 2017 Feb 21;46(8):2445-2455. doi: 10.1039/c7dt00128b.

21.

Metal-Assisted Oxo Atom Addition to an Fe(III) Thiolate.

Villar-Acevedo G, Lugo-Mas P, Blakely MN, Rees JA, Ganas AS, Hanada EM, Kaminsky W, Kovacs JA.

J Am Chem Soc. 2017 Jan 11;139(1):119-129. doi: 10.1021/jacs.6b03512. Epub 2016 Dec 29.

22.

T-cell Activation and E-selectin Are Associated With Coronary Plaque in HIV-infected Young Adults.

Mattingly AS, Unsal AB, Purdy JB, Gharib AM, Rupert A, Kovacs JA, McAreavey D, Hazra R, Abd-Elmoniem KZ, Hadigan C.

Pediatr Infect Dis J. 2017 Jan;36(1):63-65.

23.

β-Glucans Are Masked but Contribute to Pulmonary Inflammation During Pneumocystis Pneumonia.

Kutty G, Davis AS, Ferreyra GA, Qiu J, Huang da W, Sassi M, Bishop L, Handley G, Sherman B, Lempicki R, Kovacs JA.

J Infect Dis. 2016 Sep 1;214(5):782-91. doi: 10.1093/infdis/jiw249. Epub 2016 Jun 19.

24.

Simtuzumab treatment of advanced liver fibrosis in HIV and HCV-infected adults: results of a 6-month open-label safety trial.

Meissner EG, McLaughlin M, Matthews L, Gharib AM, Wood BJ, Levy E, Sinkus R, Virtaneva K, Sturdevant D, Martens C, Porcella SF, Goodman ZD, Kanwar B, Myers RP, Subramanian M, Hadigan C, Masur H, Kleiner DE, Heller T, Kottilil S, Kovacs JA, Morse CG.

Liver Int. 2016 Dec;36(12):1783-1792. doi: 10.1111/liv.13177. Epub 2016 Jul 6.

25.

Spatial Heat Maps from Fast Information Matching of Fast and Slow Degrees of Freedom: Application to Molecular Dynamics Simulations.

Kovacs JA, Wriggers W.

J Phys Chem B. 2016 Aug 25;120(33):8473-84. doi: 10.1021/acs.jpcb.6b02136. Epub 2016 May 31.

26.

Distinguishing highly similar gene isoforms with a clustering-based bioinformatics analysis of PacBio single-molecule long reads.

Liang M, Raley C, Zheng X, Kutty G, Gogineni E, Sherman BT, Sun Q, Chen X, Skelly T, Jones K, Stephens R, Zhou B, Lau W, Johnson C, Imamichi T, Jiang M, Dewar R, Lempicki RA, Tran B, Kovacs JA, Huang DW.

BioData Min. 2016 Apr 5;9:13. doi: 10.1186/s13040-016-0090-8. eCollection 2016.

27.

Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.

Ma L, Chen Z, Huang da W, Kutty G, Ishihara M, Wang H, Abouelleil A, Bishop L, Davey E, Deng R, Deng X, Fan L, Fantoni G, Fitzgerald M, Gogineni E, Goldberg JM, Handley G, Hu X, Huber C, Jiao X, Jones K, Levin JZ, Liu Y, Macdonald P, Melnikov A, Raley C, Sassi M, Sherman BT, Song X, Sykes S, Tran B, Walsh L, Xia Y, Yang J, Young S, Zeng Q, Zheng X, Stephens R, Nusbaum C, Birren BW, Azadi P, Lempicki RA, Cuomo CA, Kovacs JA.

Nat Commun. 2016 Feb 22;7:10740. doi: 10.1038/ncomms10740.

28.

Lack of an Effect of Ritonavir Alone and Lopinavir-Ritonavir on the Pharmacokinetics of Fenofibric Acid in Healthy Volunteers.

Gordon LA, Malati CY, Hadigan C, McLaughlin M, Alfaro RM, Calderón MM, Kovacs JA, Penzak SR.

Pharmacotherapy. 2016 Jan;36(1):49-56. doi: 10.1002/phar.1682.

29.

Efavirenz but Not Atazanavir/Ritonavir Significantly Reduces Atovaquone Concentrations in HIV-Infected Subjects.

Calderón MM, Penzak SR, Pau AK, Kumar P, McManus M, Alfaro RM, Kovacs JA.

Clin Infect Dis. 2016 Apr 15;62(8):1036-1042. doi: 10.1093/cid/ciw028. Epub 2016 Jan 20.

30.

Lack of Evidence for Molecular Mimicry in HIV-Infected Subjects.

Burbelo PD, Klimavicz JS, Deeks SG, Kovacs JA, Ragheb JA.

PLoS One. 2015 Nov 23;10(11):e0127662. doi: 10.1371/journal.pone.0127662. eCollection 2015.

31.

Transient elastography for the detection of hepatic fibrosis in HIV-monoinfected adults with elevated aminotransferases on antiretroviral therapy.

Morse CG, McLaughlin M, Proschan M, Koh C, Kleiner DE, Heller T, Kovacs JA.

AIDS. 2015 Nov;29(17):2297-302. doi: 10.1097/QAD.0000000000000841.

32.

Serological diagnosis of pulmonary Mycobacterium tuberculosis infection by LIPS using a multiple antigen mixture.

Burbelo PD, Keller J, Wagner J, Klimavicz JS, Bayat A, Rhodes CS, Diarra B, Chetchotisakd P, Suputtamongkol Y, Kiertiburanakul S, Holland SM, Browne SK, Siddiqui S, Kovacs JA.

BMC Microbiol. 2015 Oct 8;15:205. doi: 10.1186/s12866-015-0545-y.

33.

Tuning the Relative Stability and Reactivity of Manganese Dioxygen and Peroxo Intermediates via Systematic Ligand Modification.

Kovacs JA.

Acc Chem Res. 2015 Oct 20;48(10):2744-53. doi: 10.1021/acs.accounts.5b00260. Epub 2015 Sep 3.

34.

Pioglitazone for Hepatic Steatosis in HIV/Hepatitis C Virus Coinfection.

Matthews L, Kleiner DE, Chairez C, McManus M, Nettles MJ, Zemanick K, Morse CG, Benator D, Kovacs JA, Hadigan C.

AIDS Res Hum Retroviruses. 2015 Oct;31(10):961-6. doi: 10.1089/AID.2015.0093. Epub 2015 Aug 24.

35.

X-ray Absorption and Emission Study of Dioxygen Activation by a Small-Molecule Manganese Complex.

Rees JA, Martin-Diaconescu V, Kovacs JA, DeBeer S.

Inorg Chem. 2015 Jul 6;54(13):6410-22. doi: 10.1021/acs.inorgchem.5b00699. Epub 2015 Jun 10.

36.

Characterization of chemokine and chemokine receptor expression during Pneumocystis infection in healthy and immunodeficient mice.

Bishop LR, Lionakis MS, Sassi M, Murphy PM, Hu X, Huang da W, Sherman B, Qiu J, Yang J, Lempicki RA, Kovacs JA.

Microbes Infect. 2015 Sep;17(9):638-50. doi: 10.1016/j.micinf.2015.05.008. Epub 2015 Jun 5.

37.

Nonalcoholic Steatohepatitis and Hepatic Fibrosis in HIV-1-Monoinfected Adults With Elevated Aminotransferase Levels on Antiretroviral Therapy.

Morse CG, McLaughlin M, Matthews L, Proschan M, Thomas F, Gharib AM, Abu-Asab M, Orenstein A, Engle RE, Hu X, Lempicki R, Hadigan C, Kleiner DE, Heller T, Kovacs JA.

Clin Infect Dis. 2015 May 15;60(10):1569-78. doi: 10.1093/cid/civ101. Epub 2015 Feb 13.

38.

Water-soluble Fe(II)-H2O complex with a weak O-H bond transfers a hydrogen atom via an observable monomeric Fe(III)-OH.

Brines LM, Coggins MK, Poon PC, Toledo S, Kaminsky W, Kirk ML, Kovacs JA.

J Am Chem Soc. 2015 Feb 18;137(6):2253-64. doi: 10.1021/ja5068405. Epub 2015 Feb 3.

39.

Pneumocystis encodes a functional endo-β-1,3-glucanase that is expressed exclusively in cysts.

Kutty G, Davis AS, Ma L, Taubenberger JK, Kovacs JA.

J Infect Dis. 2015 Mar 1;211(5):719-28. doi: 10.1093/infdis/jiu517. Epub 2014 Sep 17.

40.

Influence of Panax ginseng on the steady state pharmacokinetic profile of lopinavir-ritonavir in healthy volunteers.

Calderón MM, Chairez CL, Gordon LA, Alfaro RM, Kovacs JA, Penzak SR.

Pharmacotherapy. 2014 Nov;34(11):1151-8. doi: 10.1002/phar.1473. Epub 2014 Aug 20.

41.

Mutational analysis of Pneumocystis jirovecii dihydropteroate synthase and dihydrofolate reductase genes in HIV-infected patients in China.

Deng X, Zhuo L, Lan Y, Dai Z, Chen WS, Cai W, Kovacs JA, Ma L, Tang X.

J Clin Microbiol. 2014 Nov;52(11):4017-9. doi: 10.1128/JCM.01848-14. Epub 2014 Aug 13.

42.

Clearance of Pneumocystis murina infection is not dependent on MyD88.

Ripamonti C, Bishop LR, Yang J, Lempicki RA, Kovacs JA.

Microbes Infect. 2014 Jun;16(6):522-7. doi: 10.1016/j.micinf.2014.03.005. Epub 2014 Mar 25.

43.

CXCR4/IgG-expressing plasma cells are associated with human gastrointestinal tissue inflammation.

Buckner CM, Moir S, Kardava L, Ho J, Santich BH, Kim LJ, Funk EK, Nelson AK, Winckler B, Chairez CL, Theobald-Whiting NL, Anaya-O'Brien S, Alimchandani M, Quezado MM, Yao MD, Kovacs JA, Chun TW, Fauci AS, Malech HL, De Ravin SS.

J Allergy Clin Immunol. 2014 Jun;133(6):1676-85.e5. doi: 10.1016/j.jaci.2013.10.050. Epub 2013 Dec 25.

44.

Altered antibody profiles against common infectious agents in chronic disease.

Burbelo PD, Ching KH, Morse CG, Alevizos I, Bayat A, Cohen JI, Ali MA, Kapoor A, Browne SK, Holland SM, Kovacs JA, Iadarola MJ.

PLoS One. 2013 Dec 2;8(12):e81635. doi: 10.1371/journal.pone.0081635. eCollection 2013.

45.

HIV antibody characterization as a method to quantify reservoir size during curative interventions.

Burbelo PD, Bayat A, Rhodes CS, Hoh R, Martin JN, Fromentin R, Chomont N, Hütter G, Kovacs JA, Deeks SG.

J Infect Dis. 2014 May 15;209(10):1613-7. doi: 10.1093/infdis/jit667. Epub 2013 Nov 28.

46.

Isolation and characterization of a dihydroxo-bridged iron(III,III)(μ-OH)2 diamond core derived from dioxygen.

Coggins MK, Toledo S, Kovacs JA.

Inorg Chem. 2013 Dec 2;52(23):13325-31. doi: 10.1021/ic4010906. Epub 2013 Nov 14.

47.

A Benchmark Study on Error Assessment and Quality Control of CCS Reads Derived from the PacBio RS.

Jiao X, Zheng X, Ma L, Kutty G, Gogineni E, Sun Q, Sherman BT, Hu X, Jones K, Raley C, Tran B, Munroe DJ, Stephens R, Liang D, Imamichi T, Kovacs JA, Lempicki RA, Huang DW.

J Data Mining Genomics Proteomics. 2013 Jul 31;4(3). pii: 16008.

48.

Synthesis and structural characterization of a series of Mn(III)OR complexes, including a water-soluble Mn(III)OH that promotes aerobic hydrogen-atom transfer.

Coggins MK, Brines LM, Kovacs JA.

Inorg Chem. 2013 Nov 4;52(21):12383-93. doi: 10.1021/ic401234t. Epub 2013 Oct 24.

49.

Outbreak of pneumocystis pneumonia in renal and liver transplant patients caused by genotypically distinct strains of Pneumocystis jirovecii.

Rostved AA, Sassi M, Kurtzhals JA, Sørensen SS, Rasmussen A, Ross C, Gogineni E, Huber C, Kutty G, Kovacs JA, Helweg-Larsen J.

Transplantation. 2013 Nov 15;96(9):834-42. doi: 10.1097/TP.0b013e3182a1618c.

50.

Characterization of pneumocystis major surface glycoprotein gene (msg) promoter activity in Saccharomyces cerevisiae.

Kutty G, Shroff R, Kovacs JA.

Eukaryot Cell. 2013 Oct;12(10):1349-55. doi: 10.1128/EC.00122-13. Epub 2013 Jul 26.

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