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Items: 1 to 50 of 188

1.

Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells.

Samudyata, Amaral PP, Engström PG, Robson SC, Nielsen ML, Kouzarides T, Castelo-Branco G.

Exp Cell Res. 2019 Aug 1;381(1):129-138. doi: 10.1016/j.yexcr.2019.05.006. Epub 2019 May 9.

PMID:
31077711
2.

METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation.

Pandolfini L, Barbieri I, Bannister AJ, Hendrick A, Andrews B, Webster N, Murat P, Mach P, Brandi R, Robson SC, Migliori V, Alendar A, d'Onofrio M, Balasubramanian S, Kouzarides T.

Mol Cell. 2019 Jun 20;74(6):1278-1290.e9. doi: 10.1016/j.molcel.2019.03.040. Epub 2019 Apr 25.

3.

Citrullination of HP1γ chromodomain affects association with chromatin.

Wiese M, Bannister AJ, Basu S, Boucher W, Wohlfahrt K, Christophorou MA, Nielsen ML, Klenerman D, Laue ED, Kouzarides T.

Epigenetics Chromatin. 2019 Apr 2;12(1):21. doi: 10.1186/s13072-019-0265-x.

4.

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.

Tzelepis K, De Braekeleer E, Aspris D, Barbieri I, Vijayabaskar MS, Liu WH, Gozdecka M, Metzakopian E, Toop HD, Dudek M, Robson SC, Hermida-Prado F, Yang YH, Babaei-Jadidi R, Garyfallos DA, Ponstingl H, Dias JML, Gallipoli P, Seiler M, Buonamici S, Vick B, Bannister AJ, Rad R, Prinjha RK, Marioni JC, Huntly B, Batson J, Morris JC, Pina C, Bradley A, Jeremias I, Bates DO, Yusa K, Kouzarides T, Vassiliou GS.

Nat Commun. 2018 Dec 19;9(1):5378. doi: 10.1038/s41467-018-07620-0.

5.

Phosphorylation of Histone H4T80 Triggers DNA Damage Checkpoint Recovery.

Millan-Zambrano G, Santos-Rosa H, Puddu F, Robson SC, Jackson SP, Kouzarides T.

Mol Cell. 2018 Nov 15;72(4):625-635.e4. doi: 10.1016/j.molcel.2018.09.023. Epub 2018 Oct 25.

6.

Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway.

Larrieu D, Viré E, Robson S, Breusegem SY, Kouzarides T, Jackson SP.

Sci Signal. 2018 Jul 3;11(537). pii: eaar5401. doi: 10.1126/scisignal.aar5401.

7.

Methylation of Histone H3 K4 Mediates Association of the Isw1p ATPase with Chromatin.

Santos-Rosa H, Schneider R, Bernstein BE, Karabetsou N, Morillon A, Weise C, Schreiber SL, Mellor J, Kouzarides T.

Mol Cell. 2018 Jun 7;70(5):983. doi: 10.1016/j.molcel.2018.05.012. Epub 2018 Jun 7. No abstract available.

8.

DDX3X RNA helicase affects breast cancer cell cycle progression by regulating expression of KLF4.

Cannizzaro E, Bannister AJ, Han N, Alendar A, Kouzarides T.

FEBS Lett. 2018 Jul;592(13):2308-2322. doi: 10.1002/1873-3468.13106. Epub 2018 Jun 21.

9.

Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci.

Amaral PP, Leonardi T, Han N, Viré E, Gascoigne DK, Arias-Carrasco R, Büscher M, Pandolfini L, Zhang A, Pluchino S, Maracaja-Coutinho V, Nakaya HI, Hemberg M, Shiekhattar R, Enright AJ, Kouzarides T.

Genome Biol. 2018 Mar 15;19(1):32. doi: 10.1186/s13059-018-1405-5.

10.

Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control.

Barbieri I, Tzelepis K, Pandolfini L, Shi J, Millán-Zambrano G, Robson SC, Aspris D, Migliori V, Bannister AJ, Han N, De Braekeleer E, Ponstingl H, Hendrick A, Vakoc CR, Vassiliou GS, Kouzarides T.

Nature. 2017 Dec 7;552(7683):126-131. doi: 10.1038/nature24678. Epub 2017 Nov 27.

11.

A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation.

Li MA, Amaral PP, Cheung P, Bergmann JH, Kinoshita M, Kalkan T, Ralser M, Robson S, von Meyenn F, Paramor M, Yang F, Chen C, Nichols J, Spector DL, Kouzarides T, He L, Smith A.

Elife. 2017 Aug 18;6. pii: e23468. doi: 10.7554/eLife.23468.

12.

RNA Binding by Histone Methyltransferases Set1 and Set2.

Sayou C, Millán-Zambrano G, Santos-Rosa H, Petfalski E, Robson S, Houseley J, Kouzarides T, Tollervey D.

Mol Cell Biol. 2017 Jun 29;37(14). pii: e00165-17. doi: 10.1128/MCB.00165-17. Print 2017 Jul 15.

13.

A Chemical Probe for the ATAD2 Bromodomain.

Bamborough P, Chung CW, Demont EH, Furze RC, Bannister AJ, Che KH, Diallo H, Douault C, Grandi P, Kouzarides T, Michon AM, Mitchell DJ, Prinjha RK, Rau C, Robson S, Sheppard RJ, Upton R, Watson RJ.

Angew Chem Int Ed Engl. 2016 Sep 12;55(38):11382-6. doi: 10.1002/anie.201603928. Epub 2016 Aug 17.

PMID:
27530368
14.

Functional interdependence of BRD4 and DOT1L in MLL leukemia.

Gilan O, Lam EY, Becher I, Lugo D, Cannizzaro E, Joberty G, Ward A, Wiese M, Fong CY, Ftouni S, Tyler D, Stanley K, MacPherson L, Weng CF, Chan YC, Ghisi M, Smil D, Carpenter C, Brown P, Garton N, Blewitt ME, Bannister AJ, Kouzarides T, Huntly BJ, Johnstone RW, Drewes G, Dawson SJ, Arrowsmith CH, Grandi P, Prinjha RK, Dawson MA.

Nat Struct Mol Biol. 2016 Jul;23(7):673-81. doi: 10.1038/nsmb.3249. Epub 2016 Jun 13.

PMID:
27294782
15.

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy.

Picaud S, Fedorov O, Thanasopoulou A, Leonards K, Jones K, Meier J, Olzscha H, Monteiro O, Martin S, Philpott M, Tumber A, Filippakopoulos P, Yapp C, Wells C, Che KH, Bannister A, Robson S, Kumar U, Parr N, Lee K, Lugo D, Jeffrey P, Taylor S, Vecellio ML, Bountra C, Brennan PE, O'Mahony A, Velichko S, Müller S, Hay D, Daniels DL, Urh M, La Thangue NB, Kouzarides T, Prinjha R, Schwaller J, Knapp S.

Cancer Res. 2015 Dec 1;75(23):5106-5119. doi: 10.1158/0008-5472.CAN-15-0236. Epub 2015 Nov 9.

16.

Post transcriptional control of the epigenetic stem cell regulator PLZF by sirtuin and HDAC deacetylases.

McConnell MJ, Durand L, Langley E, Coste-Sarguet L, Zelent A, Chomienne C, Kouzarides T, Licht JD, Guidez F.

Epigenetics Chromatin. 2015 Sep 24;8:38. doi: 10.1186/s13072-015-0030-8. eCollection 2015.

17.

BET inhibitor resistance emerges from leukaemia stem cells.

Fong CY, Gilan O, Lam EY, Rubin AF, Ftouni S, Tyler D, Stanley K, Sinha D, Yeh P, Morison J, Giotopoulos G, Lugo D, Jeffrey P, Lee SC, Carpenter C, Gregory R, Ramsay RG, Lane SW, Abdel-Wahab O, Kouzarides T, Johnstone RW, Dawson SJ, Huntly BJ, Prinjha RK, Papenfuss AT, Dawson MA.

Nature. 2015 Sep 24;525(7570):538-42. doi: 10.1038/nature14888. Epub 2015 Sep 14.

18.

Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition.

Theodoulou NH, Bamborough P, Bannister AJ, Becher I, Bit RA, Che KH, Chung CW, Dittmann A, Drewes G, Drewry DH, Gordon L, Grandi P, Leveridge M, Lindon M, Michon AM, Molnar J, Robson SC, Tomkinson NC, Kouzarides T, Prinjha RK, Humphreys PG.

J Med Chem. 2016 Feb 25;59(4):1425-39. doi: 10.1021/acs.jmedchem.5b00256. Epub 2015 Apr 30.

19.

Histone core modifications regulating nucleosome structure and dynamics.

Tessarz P, Kouzarides T.

Nat Rev Mol Cell Biol. 2014 Nov;15(11):703-8. doi: 10.1038/nrm3890. Epub 2014 Oct 15. Review.

PMID:
25315270
20.

Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells.

Xu H, Xian J, Vire E, McKinney S, Wei V, Wong J, Tong R, Kouzarides T, Caldas C, Aparicio S.

J Pathol. 2014 Nov;234(3):386-97. doi: 10.1002/path.4404. Epub 2014 Aug 28.

21.

The Breast Cancer Oncogene EMSY Represses Transcription of Antimetastatic microRNA miR-31.

Viré E, Curtis C, Davalos V, Git A, Robson S, Villanueva A, Vidal A, Barbieri I, Aparicio S, Esteller M, Caldas C, Kouzarides T.

Mol Cell. 2014 Apr 10;54(1):203. doi: 10.1016/j.molcel.2014.03.041. Epub 2014 Apr 10. No abstract available.

22.

The breast cancer oncogene EMSY represses transcription of antimetastatic microRNA miR-31.

Viré E, Curtis C, Davalos V, Git A, Robson S, Villanueva A, Vidal A, Barbieri I, Aparicio S, Esteller M, Caldas C, Kouzarides T.

Mol Cell. 2014 Mar 6;53(5):806-18. doi: 10.1016/j.molcel.2014.01.029. Epub 2014 Feb 27. Erratum in: Mol Cell. 2014 Apr 10;54(1):203. Barbieri, Isaia [added].

23.

Citrullination regulates pluripotency and histone H1 binding to chromatin.

Christophorou MA, Castelo-Branco G, Halley-Stott RP, Oliveira CS, Loos R, Radzisheuskaya A, Mowen KA, Bertone P, Silva JC, Zernicka-Goetz M, Nielsen ML, Gurdon JB, Kouzarides T.

Nature. 2014 Mar 6;507(7490):104-8. doi: 10.1038/nature12942. Epub 2014 Jan 26.

24.

Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification.

Tessarz P, Santos-Rosa H, Robson SC, Sylvestersen KB, Nelson CJ, Nielsen ML, Kouzarides T.

Nature. 2014 Jan 23;505(7484):564-8. doi: 10.1038/nature12819. Epub 2013 Dec 18.

25.

Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia.

Dawson MA, Gudgin EJ, Horton SJ, Giotopoulos G, Meduri E, Robson S, Cannizzaro E, Osaki H, Wiese M, Putwain S, Fong CY, Grove C, Craig J, Dittmann A, Lugo D, Jeffrey P, Drewes G, Lee K, Bullinger L, Prinjha RK, Kouzarides T, Vassiliou GS, Huntly BJ.

Leukemia. 2014 Feb;28(2):311-20. doi: 10.1038/leu.2013.338. Epub 2013 Nov 13.

26.

The non-coding snRNA 7SK controls transcriptional termination, poising, and bidirectionality in embryonic stem cells.

Castelo-Branco G, Amaral PP, Engström PG, Robson SC, Marques SC, Bertone P, Kouzarides T.

Genome Biol. 2013;14(9):R98.

27.

BET protein inhibition shows efficacy against JAK2V617F-driven neoplasms.

Wyspiańska BS, Bannister AJ, Barbieri I, Nangalia J, Godfrey A, Calero-Nieto FJ, Robson S, Rioja I, Li J, Wiese M, Cannizzaro E, Dawson MA, Huntly B, Prinjha RK, Green AR, Gottgens B, Kouzarides T.

Leukemia. 2014 Jan;28(1):88-97. doi: 10.1038/leu.2013.234. Epub 2013 Aug 9.

PMID:
23929215
28.

S6 kinase 2 is bound to chromatin-nuclear matrix cellular fractions and is able to phosphorylate histone H3 at threonine 45 in vitro and in vivo.

Ismail HM, Hurd PJ, Khalil MI, Kouzarides T, Bannister A, Gout I.

J Cell Biochem. 2014 Jun;115(6):1048-62. doi: 10.1002/jcb.24566.

PMID:
23564320
29.

Human RNA methyltransferase BCDIN3D regulates microRNA processing.

Xhemalce B, Robson SC, Kouzarides T.

Cell. 2012 Oct 12;151(2):278-88. doi: 10.1016/j.cell.2012.08.041.

30.

Three distinct patterns of histone H3Y41 phosphorylation mark active genes.

Dawson MA, Foster SD, Bannister AJ, Robson SC, Hannah R, Wang X, Xhemalce B, Wood AD, Green AR, Göttgens B, Kouzarides T.

Cell Rep. 2012 Sep 27;2(3):470-7. doi: 10.1016/j.celrep.2012.08.016. Epub 2012 Sep 20.

31.

ALKBH1 is a histone H2A dioxygenase involved in neural differentiation.

Ougland R, Lando D, Jonson I, Dahl JA, Moen MN, Nordstrand LM, Rognes T, Lee JT, Klungland A, Kouzarides T, Larsen E.

Stem Cells. 2012 Dec;30(12):2672-82. doi: 10.1002/stem.1228.

32.

Targeting epigenetic readers in cancer.

Dawson MA, Kouzarides T, Huntly BJ.

N Engl J Med. 2012 Aug 16;367(7):647-57. doi: 10.1056/NEJMra1112635. Review. No abstract available.

PMID:
22894577
33.

Cancer epigenetics: from mechanism to therapy.

Dawson MA, Kouzarides T.

Cell. 2012 Jul 6;150(1):12-27. doi: 10.1016/j.cell.2012.06.013. Review.

34.

The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4.

Watson AA, Mahajan P, Mertens HD, Deery MJ, Zhang W, Pham P, Du X, Bartke T, Zhang W, Edlich C, Berridge G, Chen Y, Burgess-Brown NA, Kouzarides T, Wiechens N, Owen-Hughes T, Svergun DI, Gileadi O, Laue ED.

J Mol Biol. 2012 Sep 7;422(1):3-17. doi: 10.1016/j.jmb.2012.04.031. Epub 2012 May 7.

35.

The S. pombe histone H2A dioxygenase Ofd2 regulates gene expression during hypoxia.

Lando D, Balmer J, Laue ED, Kouzarides T.

PLoS One. 2012;7(1):e29765. doi: 10.1371/journal.pone.0029765. Epub 2012 Jan 3.

36.

Nuclear JAK2.

Dawson MA, Bannister AJ, Saunders L, Wahab OA, Liu F, Nimer SD, Levine RL, Göttgens B, Kouzarides T, Green AR.

Blood. 2011 Dec 22;118(26):6987-8. doi: 10.1182/blood-2011-10-385278. No abstract available.

37.

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.

Dawson MA, Prinjha RK, Dittmann A, Giotopoulos G, Bantscheff M, Chan WI, Robson SC, Chung CW, Hopf C, Savitski MM, Huthmacher C, Gudgin E, Lugo D, Beinke S, Chapman TD, Roberts EJ, Soden PE, Auger KR, Mirguet O, Doehner K, Delwel R, Burnett AK, Jeffrey P, Drewes G, Lee K, Huntly BJ, Kouzarides T.

Nature. 2011 Oct 2;478(7370):529-33. doi: 10.1038/nature10509.

38.

Regulation of chromatin by histone modifications.

Bannister AJ, Kouzarides T.

Cell Res. 2011 Mar;21(3):381-95. doi: 10.1038/cr.2011.22. Epub 2011 Feb 15. Review.

39.

Decoding the chromatin modification landscape.

Bartke T, Kouzarides T.

Cell Cycle. 2011 Jan 15;10(2):182. Epub 2011 Jan 15. No abstract available.

PMID:
21224725
40.

LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease.

Griffiths DS, Li J, Dawson MA, Trotter MW, Cheng YH, Smith AM, Mansfield W, Liu P, Kouzarides T, Nichols J, Bannister AJ, Green AR, Göttgens B.

Nat Cell Biol. 2011 Jan;13(1):13-21. doi: 10.1038/ncb2135. Epub 2010 Dec 12.

41.

Nucleosome-interacting proteins regulated by DNA and histone methylation.

Bartke T, Vermeulen M, Xhemalce B, Robson SC, Mann M, Kouzarides T.

Cell. 2010 Oct 29;143(3):470-84. doi: 10.1016/j.cell.2010.10.012.

42.

A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly.

Xhemalce B, Kouzarides T.

Genes Dev. 2010 Apr 1;24(7):647-52. doi: 10.1101/gad.1881710. Epub 2010 Mar 18.

43.

Histone H3 lysine 4 methylation is associated with the transcriptional reprogramming efficiency of somatic nuclei by oocytes.

Murata K, Kouzarides T, Bannister AJ, Gurdon JB.

Epigenetics Chromatin. 2010 Feb 4;3(1):4. doi: 10.1186/1756-8935-3-4.

44.

JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin.

Dawson MA, Bannister AJ, Göttgens B, Foster SD, Bartke T, Green AR, Kouzarides T.

Nature. 2009 Oct 8;461(7265):819-22. doi: 10.1038/nature08448. Epub 2009 Sep 27.

45.

Phosphorylation of histone H3 Thr-45 is linked to apoptosis.

Hurd PJ, Bannister AJ, Halls K, Dawson MA, Vermeulen M, Olsen JV, Ismail H, Somers J, Mann M, Owen-Hughes T, Gout I, Kouzarides T.

J Biol Chem. 2009 Jun 12;284(24):16575-83. doi: 10.1074/jbc.M109.005421. Epub 2009 Apr 10.

46.

An operational definition of epigenetics.

Berger SL, Kouzarides T, Shiekhattar R, Shilatifard A.

Genes Dev. 2009 Apr 1;23(7):781-3. doi: 10.1101/gad.1787609.

47.

Distinct transcriptional outputs associated with mono- and dimethylated histone H3 arginine 2.

Kirmizis A, Santos-Rosa H, Penkett CJ, Singer MA, Green RD, Kouzarides T.

Nat Struct Mol Biol. 2009 Apr;16(4):449-51. doi: 10.1038/nsmb.1569. Epub 2009 Mar 8.

48.

Histone H3 tail clipping regulates gene expression.

Santos-Rosa H, Kirmizis A, Nelson C, Bartke T, Saksouk N, Cote J, Kouzarides T.

Nat Struct Mol Biol. 2009 Jan;16(1):17-22. doi: 10.1038/nsmb.1534. Epub 2008 Dec 14.

49.

Heritable gene repression through the action of a directed DNA methyltransferase at a chromosomal locus.

Smith AE, Hurd PJ, Bannister AJ, Kouzarides T, Ford KG.

J Biol Chem. 2008 Apr 11;283(15):9878-85. doi: 10.1074/jbc.M710393200. Epub 2008 Feb 13.

50.

SnapShot: Histone-modifying enzymes.

Kouzarides T.

Cell. 2007 Nov 16;131(4):822. No abstract available.

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