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LDH-A regulates the tumor microenvironment via HIF-signaling and modulates the immune response.

Serganova I, Cohen IJ, Vemuri K, Shindo M, Maeda M, Mane M, Moroz E, Khanin R, Satagopan J, Koutcher JA, Blasberg R.

PLoS One. 2018 Sep 24;13(9):e0203965. doi: 10.1371/journal.pone.0203965. eCollection 2018.


Iron deposition is associated with differential macrophage infiltration and therapeutic response to iron chelation in prostate cancer.

Leftin A, Zhao H, Turkekul M, de Stanchina E, Manova K, Koutcher JA.

Sci Rep. 2017 Sep 14;7(1):11632. doi: 10.1038/s41598-017-11899-2.


Iron imaging reveals tumor and metastasis macrophage hemosiderin deposits in breast cancer.

Leftin A, Ben-Chetrit N, Klemm F, Joyce JA, Koutcher JA.

PLoS One. 2017 Sep 12;12(9):e0184765. doi: 10.1371/journal.pone.0184765. eCollection 2017.


Automation of pattern recognition analysis of dynamic contrast-enhanced MRI data to characterize intratumoral vascular heterogeneity.

Han S, Stoyanova R, Lee H, Carlin SD, Koutcher JA, Cho H, Ackerstaff E.

Magn Reson Med. 2018 Mar;79(3):1736-1744. doi: 10.1002/mrm.26822. Epub 2017 Jul 20.


The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma.

Nargund AM, Pham CG, Dong Y, Wang PI, Osmangeyoglu HU, Xie Y, Aras O, Han S, Oyama T, Takeda S, Ray CE, Dong Z, Berge M, Hakimi AA, Monette S, Lekaye CL, Koutcher JA, Leslie CS, Creighton CJ, Weinhold N, Lee W, Tickoo SK, Wang Z, Cheng EH, Hsieh JJ.

Cell Rep. 2017 Mar 21;18(12):2893-2906. doi: 10.1016/j.celrep.2017.02.074.


Inhibition of prostate cancer proliferation by Deferiprone.

Simões RV, Veeraperumal S, Serganova IS, Kruchevsky N, Varshavsky J, Blasberg RG, Ackerstaff E, Koutcher JA.

NMR Biomed. 2017 Jun;30(6). doi: 10.1002/nbm.3712. Epub 2017 Mar 8.


Tumor stroma interaction is mediated by monocarboxylate metabolism.

Patel BB, Ackerstaff E, Serganova IS, Kerrigan JE, Blasberg RG, Koutcher JA, Banerjee D.

Exp Cell Res. 2017 Mar 1;352(1):20-33. doi: 10.1016/j.yexcr.2017.01.013. Epub 2017 Jan 26.


Corrigendum to "Noninvasive Multimodality Imaging of the Tumor Microenvironment: Registered Dynamic Magnetic Resonance Imaging and Positron Emission Tomography Studies of a Preclinical Tumor Model of Tumor Hypoxia" [Neoplasia 11 (2009) 247-259].

Cho H, Ackerstaff E, Carlin S, Lupu ME, Wang Y, Rizwan A, O'Donoghue J, Ling CC, Humm JL, Zanzonico PB, Koutcher JA.

Neoplasia. 2016 Dec;18(12):811. doi: 10.1016/j.neo.2016.10.008. No abstract available.


Visualizing the antivascular effect of bortezomib on the hypoxic tumor microenvironment.

Sun X, Ackerstaff E, He F, Xing L, Hsiao HT, Koutcher JA, Ling CC, Li GC.

Oncotarget. 2015 Oct 27;6(33):34732-44. doi: 10.18632/oncotarget.5300.


Metabolic plasticity of metastatic breast cancer cells: adaptation to changes in the microenvironment.

Simões RV, Serganova IS, Kruchevsky N, Leftin A, Shestov AA, Thaler HT, Sukenick G, Locasale JW, Blasberg RG, Koutcher JA, Ackerstaff E.

Neoplasia. 2015 Aug;17(8):671-84. doi: 10.1016/j.neo.2015.08.005.


Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer.

Viola-Villegas NT, Carlin SD, Ackerstaff E, Sevak KK, Divilov V, Serganova I, Kruchevsky N, Anderson M, Blasberg RG, Andreev OA, Engelman DM, Koutcher JA, Reshetnyak YK, Lewis JS.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7254-9. doi: 10.1073/pnas.1405240111. Epub 2014 May 1.


High-field small animal magnetic resonance oncology studies.

Bokacheva L, Ackerstaff E, LeKaye HC, Zakian K, Koutcher JA.

Phys Med Biol. 2014 Jan 20;59(2):R65-R127. doi: 10.1088/0031-9155/59/2/R65. Epub 2013 Dec 30. Review.


Anatomic segmentation improves prostate cancer detection with artificial neural networks analysis of 1H magnetic resonance spectroscopic imaging.

Matulewicz L, Jansen JF, Bokacheva L, Vargas HA, Akin O, Fine SW, Shukla-Dave A, Eastham JA, Hricak H, Koutcher JA, Zakian KL.

J Magn Reson Imaging. 2014 Dec;40(6):1414-21. doi: 10.1002/jmri.24487. Epub 2013 Nov 15.


Noninvasive phosphorus magnetic resonance spectroscopic imaging predicts outcome to first-line chemotherapy in newly diagnosed patients with diffuse large B-cell lymphoma.

Arias-Mendoza F, Payne GS, Zakian K, Stubbs M, O'Connor OA, Mojahed H, Smith MR, Schwarz AJ, Shukla-Dave A, Howe F, Poptani H, Lee SC, Pettengel R, Schuster SJ, Cunningham D, Heerschap A, Glickson JD, Griffiths JR, Koutcher JA, Leach MO, Brown TR.

Acad Radiol. 2013 Sep;20(9):1122-9. doi: 10.1016/j.acra.2013.04.013.


ETV4 promotes metastasis in response to activation of PI3-kinase and Ras signaling in a mouse model of advanced prostate cancer.

Aytes A, Mitrofanova A, Kinkade CW, Lefebvre C, Lei M, Phelan V, LeKaye HC, Koutcher JA, Cardiff RD, Califano A, Shen MM, Abate-Shen C.

Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):E3506-15. doi: 10.1073/pnas.1303558110. Epub 2013 Aug 5.


Native fluorescence spectroscopy reveals spectral differences among prostate cancer cell lines with different risk levels.

Pu Y, Xue J, Wang W, Xu B, Gu Y, Tang R, Ackerstaff E, Koutcher JA, Achilefu S, Alfano RR.

J Biomed Opt. 2013 Aug;18(8):87002. doi: 10.1117/1.JBO.18.8.087002.


Relationships between LDH-A, lactate, and metastases in 4T1 breast tumors.

Rizwan A, Serganova I, Khanin R, Karabeber H, Ni X, Thakur S, Zakian KL, Blasberg R, Koutcher JA.

Clin Cancer Res. 2013 Sep 15;19(18):5158-69. doi: 10.1158/1078-0432.CCR-12-3300. Epub 2013 Jul 5.


A triple suicide gene strategy that improves therapeutic effects and incorporates multimodality molecular imaging for monitoring gene functions.

Xing L, Sun X, Deng X, Kotedia K, Zanzonico PB, Ackerstaff E, Koutcher JA, Ling CC, Li GC.

Cancer Gene Ther. 2013 Jun;20(6):358-65. doi: 10.1038/cgt.2013.28. Epub 2013 May 31.


Gaussian mixture model-based classification of dynamic contrast enhanced MRI data for identifying diverse tumor microenvironments: preliminary results.

Han SH, Ackerstaff E, Stoyanova R, Carlin S, Huang W, Koutcher JA, Kim JK, Cho G, Jang G, Cho H.

NMR Biomed. 2013 May;26(5):519-32. doi: 10.1002/nbm.2888. Epub 2013 Feb 25.


β4 Integrin signaling induces expansion of prostate tumor progenitors.

Yoshioka T, Otero J, Chen Y, Kim YM, Koutcher JA, Satagopan J, Reuter V, Carver B, de Stanchina E, Enomoto K, Greenberg NM, Scardino PT, Scher HI, Sawyers CL, Giancotti FG.

J Clin Invest. 2013 Feb;123(2):682-99. doi: 10.1172/JCI60720. Epub 2013 Jan 25.


Mapping Tumor Hypoxia In Vivo Using Pattern Recognition of Dynamic Contrast-enhanced MRI Data.

Stoyanova R, Huang K, Sandler K, Cho H, Carlin S, Zanzonico PB, Koutcher JA, Ackerstaff E.

Transl Oncol. 2012 Dec;5(6):437-47. Epub 2012 Dec 1.


Serial measurement of hepatic lipids during chemotherapy in patients with colorectal cancer: a 1 H MRS study.

Qi J, Fong Y, Saltz L, D'Angelica MI, Kemeny NE, Gonen M, Shia J, Shukla-Dave A, Jarnagin WR, Do RK, Schwartz LH, Koutcher JA, Zakian KL.

NMR Biomed. 2013 Feb;26(2):204-12. doi: 10.1002/nbm.2837. Epub 2012 Sep 7. Erratum in: NMR Biomed. 2014 Feb;27(2):235. Jarnagin, William M [corrected to Jarnagin, William R].


Hypoxia targeted bifunctional suicide gene expression enhances radiotherapy in vitro and in vivo.

Sun X, Xing L, Deng X, Hsiao HT, Manami A, Koutcher JA, Clifton Ling C, Li GC.

Radiother Oncol. 2012 Oct;105(1):57-63. doi: 10.1016/j.radonc.2012.07.011. Epub 2012 Aug 29.


Extension of the intravoxel incoherent motion model to non-gaussian diffusion in head and neck cancer.

Lu Y, Jansen JF, Mazaheri Y, Stambuk HE, Koutcher JA, Shukla-Dave A.

J Magn Reson Imaging. 2012 Nov;36(5):1088-96. doi: 10.1002/jmri.23770. Epub 2012 Jul 23.


Response of HT29 colorectal xenograft model to cediranib assessed with 18 F-fluoromisonidazole positron emission tomography, dynamic contrast-enhanced and diffusion-weighted MRI.

Bokacheva L, Kotedia K, Reese M, Ricketts SA, Halliday J, Le CH, Koutcher JA, Carlin S.

NMR Biomed. 2013 Feb;26(2):151-63. doi: 10.1002/nbm.2830. Epub 2012 Jul 8.


Radiation impairs perineural invasion by modulating the nerve microenvironment.

Bakst RL, Lee N, He S, Chernichenko N, Chen CH, Linkov G, Le HC, Koutcher J, Vakiani E, Wong RJ.

PLoS One. 2012;7(6):e39925. doi: 10.1371/journal.pone.0039925. Epub 2012 Jun 29.


Temporal/spatial resolution improvement of in vivo DCE-MRI with compressed sensing-optimized FLASH.

Han S, Paulsen JL, Zhu G, Song Y, Chun S, Cho G, Ackerstaff E, Koutcher JA, Cho H.

Magn Reson Imaging. 2012 Jul;30(6):741-52. doi: 10.1016/j.mri.2012.02.001. Epub 2012 Mar 31.


Disruption of Abi1/Hssh3bp1 expression induces prostatic intraepithelial neoplasia in the conditional Abi1/Hssh3bp1 KO mice.

Xiong X, Chorzalska A, Dubielecka PM, White JR, Vedvyas Y, Hedvat CV, Haimovitz-Friedman A, Koutcher JA, Reimand J, Bader GD, Sawicki JA, Kotula L.

Oncogenesis. 2012 Sep 3;1:e26. doi: 10.1038/oncsis.2012.28.


Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment.

Rattigan YI, Patel BB, Ackerstaff E, Sukenick G, Koutcher JA, Glod JW, Banerjee D.

Exp Cell Res. 2012 Feb 15;318(4):326-35. doi: 10.1016/j.yexcr.2011.11.014. Epub 2011 Dec 8.


Preclinical study of treatment response in HCT-116 cells and xenografts with (1) H-decoupled (31) P MRS.

Darpolor MM, Kennealey PT, Le HC, Zakian KL, Ackerstaff E, Rizwan A, Chen JH, Sambol EB, Schwartz GK, Singer S, Koutcher JA.

NMR Biomed. 2011 Nov;24(9):1159-68. doi: 10.1002/nbm.1674. Epub 2011 Mar 24.


Metabolic imaging: a link between lactate dehydrogenase A, lactate, and tumor phenotype.

Serganova I, Rizwan A, Ni X, Thakur SB, Vider J, Russell J, Blasberg R, Koutcher JA.

Clin Cancer Res. 2011 Oct 1;17(19):6250-6261. doi: 10.1158/1078-0432.CCR-11-0397. Epub 2011 Aug 15.


Discrimination of benign and malignant breast lesions by using shutter-speed dynamic contrast-enhanced MR imaging.

Huang W, Tudorica LA, Li X, Thakur SB, Chen Y, Morris EA, Tagge IJ, Korenblit ME, Rooney WD, Koutcher JA, Springer CS Jr.

Radiology. 2011 Nov;261(2):394-403. doi: 10.1148/radiol.11102413. Epub 2011 Aug 9.


Imaging of alkaline phosphatase activity in bone tissue.

Gade TP, Motley MW, Beattie BJ, Bhakta R, Boskey AL, Koutcher JA, Mayer-Kuckuk P.

PLoS One. 2011;6(7):e22608. doi: 10.1371/journal.pone.0022608. Epub 2011 Jul 25.


31P MR spectroscopic imaging detects regenerative changes in human liver stimulated by portal vein embolization.

Qi J, Shukla-Dave A, Fong Y, Gönen M, Schwartz LH, Jarnagin WM, Koutcher JA, Zakian KL.

J Magn Reson Imaging. 2011 Aug;34(2):336-44. doi: 10.1002/jmri.22616.


Lactate MRSI and DCE MRI as surrogate markers of prostate tumor aggressiveness.

Yaligar J, Thakur SB, Bokacheva L, Carlin S, Thaler HT, Rizwan A, Lupu ME, Wang Y, Matei CC, Zakian KL, Koutcher JA.

NMR Biomed. 2012 Jan;25(1):113-122. doi: 10.1002/nbm.1723. Epub 2011 May 25.


Dynamic contrast-enhanced magnetic resonance imaging as a predictor of outcome in head-and-neck squamous cell carcinoma patients with nodal metastases.

Shukla-Dave A, Lee NY, Jansen JF, Thaler HT, Stambuk HE, Fury MG, Patel SG, Moreira AL, Sherman E, Karimi S, Wang Y, Kraus D, Shah JP, Pfister DG, Koutcher JA.

Int J Radiat Oncol Biol Phys. 2012 Apr 1;82(5):1837-44. doi: 10.1016/j.ijrobp.2011.03.006. Epub 2011 May 19.


Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer.

Carver BS, Chapinski C, Wongvipat J, Hieronymus H, Chen Y, Chandarlapaty S, Arora VK, Le C, Koutcher J, Scher H, Scardino PT, Rosen N, Sawyers CL.

Cancer Cell. 2011 May 17;19(5):575-86. doi: 10.1016/j.ccr.2011.04.008.


Diagnostic usefulness of water-to-fat ratio and choline concentration in malignant and benign breast lesions and normal breast parenchyma: an in vivo (1) H MRS study.

Thakur SB, Brennan SB, Ishill NM, Morris EA, Liberman L, Dershaw DD, Bartella L, Koutcher JA, Huang W.

J Magn Reson Imaging. 2011 Apr;33(4):855-63. doi: 10.1002/jmri.22493.


Radiosynthesis of the tumor hypoxia marker [18F]TFMISO via O-[18F]trifluoroethylation reveals a striking difference between trifluoroethyl tosylate and iodide in regiochemical reactivity toward oxygen nucleophiles.

Suehiro M, Yang G, Torchon G, Ackerstaff E, Humm J, Koutcher J, Ouerfelli O.

Bioorg Med Chem. 2011 Apr 1;19(7):2287-97. doi: 10.1016/j.bmc.2011.02.026. Epub 2011 Feb 18.


Tumor metabolism and perfusion in head and neck squamous cell carcinoma: pretreatment multimodality imaging with 1H magnetic resonance spectroscopy, dynamic contrast-enhanced MRI, and [18F]FDG-PET.

Jansen JF, Schöder H, Lee NY, Stambuk HE, Wang Y, Fury MG, Patel SG, Pfister DG, Shah JP, Koutcher JA, Shukla-Dave A.

Int J Radiat Oncol Biol Phys. 2012 Jan 1;82(1):299-307. doi: 10.1016/j.ijrobp.2010.11.022. Epub 2011 Jan 13.


Semi-automatic deformable registration of prostate MR images to pathological slices.

Mazaheri Y, Bokacheva L, Kroon DJ, Akin O, Hricak H, Chamudot D, Fine S, Koutcher JA.

J Magn Reson Imaging. 2010 Nov;32(5):1149-57. doi: 10.1002/jmri.22347.


An exploratory study of endorectal magnetic resonance imaging and spectroscopy of the prostate as preoperative predictive biomarkers of biochemical relapse after radical prostatectomy.

Zakian KL, Hricak H, Ishill N, Reuter VE, Eberhardt S, Moskowitz CS, Shukla-Dave A, Wang L, Scardino PT, Eastham JA, Koutcher JA.

J Urol. 2010 Dec;184(6):2320-7. doi: 10.1016/j.juro.2010.07.037. Epub 2010 Oct 16.


Non-invasive imaging of angiogenesis in head and neck squamous cell carcinoma.

Jansen JF, Koutcher JA, Shukla-Dave A.

Angiogenesis. 2010 Jun;13(2):149-60. doi: 10.1007/s10456-010-9167-z. Epub 2010 Apr 11. Review.


Fat-free MRI based on magnetization exchange.

Chen JH, Le HC, Koutcher JA, Singer S.

Magn Reson Med. 2010 Mar;63(3):713-8. doi: 10.1002/mrm.22208.


Non-gaussian analysis of diffusion-weighted MR imaging in head and neck squamous cell carcinoma: A feasibility study.

Jansen JF, Stambuk HE, Koutcher JA, Shukla-Dave A.

AJNR Am J Neuroradiol. 2010 Apr;31(4):741-8. doi: 10.3174/ajnr.A1919. Epub 2009 Dec 24.


Phase I study of intravenous vascular endothelial growth factor trap, aflibercept, in patients with advanced solid tumors.

Lockhart AC, Rothenberg ML, Dupont J, Cooper W, Chevalier P, Sternas L, Buzenet G, Koehler E, Sosman JA, Schwartz LH, Gultekin DH, Koutcher JA, Donnelly EF, Andal R, Dancy I, Spriggs DR, Tew WP.

J Clin Oncol. 2010 Jan 10;28(2):207-14. doi: 10.1200/JCO.2009.22.9237. Epub 2009 Nov 30.


Noninvasive assessment of tumor microenvironment using dynamic contrast-enhanced magnetic resonance imaging and 18F-fluoromisonidazole positron emission tomography imaging in neck nodal metastases.

Jansen JF, Schöder H, Lee NY, Wang Y, Pfister DG, Fury MG, Stambuk HE, Humm JL, Koutcher JA, Shukla-Dave A.

Int J Radiat Oncol Biol Phys. 2010 Aug 1;77(5):1403-10. doi: 10.1016/j.ijrobp.2009.07.009. Epub 2009 Nov 10.


Proton MRS detects metabolic changes in hormone sensitive and resistant human prostate cancer models CWR22 and CWR22r.

Le HC, Lupu M, Kotedia K, Rosen N, Solit D, Koutcher JA.

Magn Reson Med. 2009 Nov;62(5):1112-9. doi: 10.1002/mrm.22137.


Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer.

Regales L, Gong Y, Shen R, de Stanchina E, Vivanco I, Goel A, Koutcher JA, Spassova M, Ouerfelli O, Mellinghoff IK, Zakowski MF, Politi KA, Pao W.

J Clin Invest. 2009 Oct;119(10):3000-10. doi: 10.1172/JCI38746. Epub 2009 Sep 14.


Atrasentan (ABT-627) enhances perfusion and reduces hypoxia in a human tumor xenograft model.

Yang KM, Russell J, Lupu ME, Cho H, Li XF, Koutcher JA, Ling CC.

Cancer Biol Ther. 2009 Oct;8(20):1940-6. Epub 2009 Oct 22.

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