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Items: 1 to 50 of 91

1.

RUNX transcription factors: orchestrators of development.

Mevel R, Draper JE, Lie-A-Ling M, Kouskoff V, Lacaud G.

Development. 2019 Sep 5;146(17). pii: dev148296. doi: 10.1242/dev.148296. Review.

2.

Transcriptional control of blood cell emergence.

Menegatti S, de Kruijf M, Garcia-Alegria E, Lacaud G, Kouskoff V.

FEBS Lett. 2019 Aug 21. doi: 10.1002/1873-3468.13585. [Epub ahead of print] Review.

PMID:
31432499
3.

Early Human Hemogenic Endothelium Generates Primitive and Definitive Hematopoiesis In Vitro.

Garcia-Alegria E, Menegatti S, Fadlullah MZH, Menendez P, Lacaud G, Kouskoff V.

Stem Cell Reports. 2018 Nov 13;11(5):1061-1074. doi: 10.1016/j.stemcr.2018.09.013. Epub 2018 Oct 25.

4.

Single-cell transcriptomics reveal the dynamic of haematopoietic stem cell production in the aorta.

Baron CS, Kester L, Klaus A, Boisset JC, Thambyrajah R, Yvernogeau L, Kouskoff V, Lacaud G, van Oudenaarden A, Robin C.

Nat Commun. 2018 Jun 28;9(1):2517. doi: 10.1038/s41467-018-04893-3.

5.

HDAC1 and HDAC2 Modulate TGF-β Signaling during Endothelial-to-Hematopoietic Transition.

Thambyrajah R, Fadlullah MZH, Proffitt M, Patel R, Cowley SM, Kouskoff V, Lacaud G.

Stem Cell Reports. 2018 Apr 10;10(4):1369-1383. doi: 10.1016/j.stemcr.2018.03.011.

6.

Regulation of RUNX1 dosage is crucial for efficient blood formation from hemogenic endothelium.

Lie-A-Ling M, Marinopoulou E, Lilly AJ, Challinor M, Patel R, Lancrin C, Kouskoff V, Lacaud G.

Development. 2018 Mar 12;145(5). pii: dev149419. doi: 10.1242/dev.149419.

7.

HOXB4 Promotes Hemogenic Endothelium Formation without Perturbing Endothelial Cell Development.

Teichweyde N, Kasperidus L, Carotta S, Kouskoff V, Lacaud G, Horn PA, Heinrichs S, Klump H.

Stem Cell Reports. 2018 Mar 13;10(3):875-889. doi: 10.1016/j.stemcr.2018.01.009. Epub 2018 Feb 15.

8.

A novel prospective isolation of murine fetal liver progenitors to study in utero hematopoietic defects.

Draper JE, Sroczynska P, Fadlullah MZH, Patel R, Newton G, Breitwieser W, Kouskoff V, Lacaud G.

PLoS Genet. 2018 Jan 4;14(1):e1007127. doi: 10.1371/journal.pgen.1007127. eCollection 2018 Jan.

9.

Primitive erythrocytes are generated from hemogenic endothelial cells.

Stefanska M, Batta K, Patel R, Florkowska M, Kouskoff V, Lacaud G.

Sci Rep. 2017 Jul 25;7(1):6401. doi: 10.1038/s41598-017-06627-9.

10.

SOX7 expression is critically required in FLK1-expressing cells for vasculogenesis and angiogenesis during mouse embryonic development.

Lilly AJ, Mazan A, Scott DA, Lacaud G, Kouskoff V.

Mech Dev. 2017 Aug;146:31-41. doi: 10.1016/j.mod.2017.05.004. Epub 2017 May 31.

11.

Mouse RUNX1C regulates premegakaryocytic/erythroid output and maintains survival of megakaryocyte progenitors.

Draper JE, Sroczynska P, Leong HS, Fadlullah MZH, Miller C, Kouskoff V, Lacaud G.

Blood. 2017 Jul 20;130(3):271-284. doi: 10.1182/blood-2016-06-723635. Epub 2017 May 10.

12.

TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells.

Diamantopoulou Z, White G, Fadlullah MZH, Dreger M, Pickering K, Maltas J, Ashton G, MacLeod R, Baillie GS, Kouskoff V, Lacaud G, Murray GI, Sansom OJ, Hurlstone AFL, Malliri A.

Cancer Cell. 2017 May 8;31(5):621-634.e6. doi: 10.1016/j.ccell.2017.03.007. Epub 2017 Apr 13.

13.

Runx1 Structure and Function in Blood Cell Development.

Bonifer C, Levantini E, Kouskoff V, Lacaud G.

Adv Exp Med Biol. 2017;962:65-81. doi: 10.1007/978-981-10-3233-2_5. Review.

PMID:
28299651
14.

Hemangioblast, hemogenic endothelium, and primitive versus definitive hematopoiesis.

Lacaud G, Kouskoff V.

Exp Hematol. 2017 May;49:19-24. doi: 10.1016/j.exphem.2016.12.009. Epub 2016 Dec 30. Review.

PMID:
28043822
15.

Interplay between SOX7 and RUNX1 regulates hemogenic endothelial fate in the yolk sac.

Lilly AJ, Costa G, Largeot A, Fadlullah MZ, Lie-A-Ling M, Lacaud G, Kouskoff V.

Development. 2016 Dec 1;143(23):4341-4351. Epub 2016 Oct 17.

16.

Cooperative binding of AP-1 and TEAD4 modulates the balance between vascular smooth muscle and hemogenic cell fate.

Obier N, Cauchy P, Assi SA, Gilmour J, Lie-A-Ling M, Lichtinger M, Hoogenkamp M, Noailles L, Cockerill PN, Lacaud G, Kouskoff V, Bonifer C.

Development. 2016 Dec 1;143(23):4324-4340. Epub 2016 Oct 17.

17.

Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes.

Nasrallah R, Fast EM, Solaimani P, Knezevic K, Eliades A, Patel R, Thambyrajah R, Unnikrishnan A, Thoms J, Beck D, Vink CS, Smith A, Wong J, Shepherd M, Kent D, Roychoudhuri R, Paul F, Klippert J, Hammes A, Willnow T, Göttgens B, Dzierzak E, Zon LI, Lacaud G, Kouskoff V, Pimanda JE.

Blood. 2016 Oct 13;128(15):1928-1939. Epub 2016 Aug 23. Erratum in: Blood. 2017 Nov 16;130(20):2234.

18.

SOXF transcription factors in cardiovascular development.

Lilly AJ, Lacaud G, Kouskoff V.

Semin Cell Dev Biol. 2017 Mar;63:50-57. doi: 10.1016/j.semcdb.2016.07.021. Epub 2016 Jul 25. Review.

PMID:
27470491
19.

SOX7-enforced expression promotes the expansion of adult blood progenitors and blocks B-cell development.

Cuvertino S, Lacaud G, Kouskoff V.

Open Biol. 2016 Jul;6(7). pii: 160070. doi: 10.1098/rsob.160070.

20.

Emerging concepts for the in vitro derivation of murine haematopoietic stem and progenitor cells.

Garcia-Alegria E, Menegatti S, Batta K, Cuvertino S, Florkowska M, Kouskoff V.

FEBS Lett. 2016 Nov;590(22):4116-4125. doi: 10.1002/1873-3468.12300. Epub 2016 Jul 28. Review.

21.

New insights into the regulation by RUNX1 and GFI1(s) proteins of the endothelial to hematopoietic transition generating primordial hematopoietic cells.

Thambyrajah R, Patel R, Mazan M, Lie-A-Ling M, Lilly A, Eliades A, Menegatti S, Garcia-Alegria E, Florkowska M, Batta K, Kouskoff V, Lacaud G.

Cell Cycle. 2016 Aug 17;15(16):2108-2114. Epub 2016 Jul 11.

22.

Concise Review: Recent Advances in the In Vitro Derivation of Blood Cell Populations.

Batta K, Menegatti S, Garcia-Alegria E, Florkowska M, Lacaud G, Kouskoff V.

Stem Cells Transl Med. 2016 Oct;5(10):1330-1337. Epub 2016 Jul 7. Review.

23.

SOX7 promotes the maintenance and proliferation of B cell precursor acute lymphoblastic cells.

Cuvertino S, Filiciotto G, Masurekar A, Saha V, Lacaud G, Kouskoff V.

Oncotarget. 2016 Jul 7;8(39):64974-64983. doi: 10.18632/oncotarget.10472. eCollection 2017 Sep 12.

24.

Corrigendum: Graphene Oxide promotes embryonic stem cell differentiation to haematopoietic lineage.

Garcia-Alegria E, Iliut M, Stefanska M, Silva C, Heeg S, Kimber SJ, Kouskoff V, Lacaud G, Vijayaraghavan A, Batta K.

Sci Rep. 2016 Jul 4;6:28723. doi: 10.1038/srep28723. No abstract available.

25.

The Hemogenic Competence of Endothelial Progenitors Is Restricted by Runx1 Silencing during Embryonic Development.

Eliades A, Wareing S, Marinopoulou E, Fadlullah MZH, Patel R, Grabarek JB, Plusa B, Lacaud G, Kouskoff V.

Cell Rep. 2016 Jun 7;15(10):2185-2199. doi: 10.1016/j.celrep.2016.05.001. Epub 2016 May 26.

26.

Correction: RUNX1B Expression Is Highly Heterogeneous and Distinguishes Megakaryocytic and Erythroid Lineage Fate in Adult Mouse Hematopoiesis.

Draper JE, Sroczynska P, Tsoulaki O, Leong HS, Fadlullah MZ, Miller C, Kouskoff V, Lacaud G.

PLoS Genet. 2016 May 20;12(5):e1006084. doi: 10.1371/journal.pgen.1006084. eCollection 2016 May.

27.

Graphene Oxide promotes embryonic stem cell differentiation to haematopoietic lineage.

Garcia-Alegria E, Iliut M, Stefanska M, Silva C, Heeg S, Kimber SJ, Kouskoff V, Lacaud G, Vijayaraghavan A, Batta K.

Sci Rep. 2016 May 20;6:25917. doi: 10.1038/srep25917. Erratum in: Sci Rep. 2016 Jul 04;6:28723.

28.

Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation.

Goode DK, Obier N, Vijayabaskar MS, Lie-A-Ling M, Lilly AJ, Hannah R, Lichtinger M, Batta K, Florkowska M, Patel R, Challinor M, Wallace K, Gilmour J, Assi SA, Cauchy P, Hoogenkamp M, Westhead DR, Lacaud G, Kouskoff V, Göttgens B, Bonifer C.

Dev Cell. 2016 Mar 7;36(5):572-87. doi: 10.1016/j.devcel.2016.01.024. Epub 2016 Feb 25.

29.

Expression of the MOZ-TIF2 oncoprotein in mice represses senescence.

Largeot A, Perez-Campo FM, Marinopoulou E, Lie-a-Ling M, Kouskoff V, Lacaud G.

Exp Hematol. 2016 Apr;44(4):231-7.e4. doi: 10.1016/j.exphem.2015.12.006. Epub 2016 Feb 5.

30.

RUNX1B Expression Is Highly Heterogeneous and Distinguishes Megakaryocytic and Erythroid Lineage Fate in Adult Mouse Hematopoiesis.

Draper JE, Sroczynska P, Tsoulaki O, Leong HS, Fadlullah MZ, Miller C, Kouskoff V, Lacaud G.

PLoS Genet. 2016 Jan 25;12(1):e1005814. doi: 10.1371/journal.pgen.1005814. eCollection 2016 Jan. Erratum in: PLoS Genet. 2016 May;12(5):e1006084.

31.

GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1.

Thambyrajah R, Mazan M, Patel R, Moignard V, Stefanska M, Marinopoulou E, Li Y, Lancrin C, Clapes T, Möröy T, Robin C, Miller C, Cowley S, Göttgens B, Kouskoff V, Lacaud G.

Nat Cell Biol. 2016 Jan;18(1):21-32. doi: 10.1038/ncb3276. Epub 2015 Nov 30.

PMID:
26619147
32.

FOXF1 inhibits hematopoietic lineage commitment during early mesoderm specification.

Fleury M, Eliades A, Carlsson P, Lacaud G, Kouskoff V.

Development. 2015 Oct 1;142(19):3307-20. doi: 10.1242/dev.124685. Epub 2015 Aug 20.

33.

Endoglin potentiates nitric oxide synthesis to enhance definitive hematopoiesis.

Nasrallah R, Knezevic K, Thai T, Thomas SR, Göttgens B, Lacaud G, Kouskoff V, Pimanda JE.

Biol Open. 2015 May 15;4(7):819-29. doi: 10.1242/bio.011494.

34.

Quantitative phosphoproteome analysis of embryonic stem cell differentiation toward blood.

Piazzi M, Williamson A, Lee CF, Pearson S, Lacaud G, Kouskoff V, McCubrey JA, Cocco L, Whetton AD.

Oncotarget. 2015 May 10;6(13):10924-39.

35.

Decoding the regulatory network of early blood development from single-cell gene expression measurements.

Moignard V, Woodhouse S, Haghverdi L, Lilly AJ, Tanaka Y, Wilkinson AC, Buettner F, Macaulay IC, Jawaid W, Diamanti E, Nishikawa SI, Piterman N, Kouskoff V, Theis FJ, Fisher J, Göttgens B.

Nat Biotechnol. 2015 Mar;33(3):269-276. doi: 10.1038/nbt.3154. Epub 2015 Feb 9.

36.

In vivo repopulating activity emerges at the onset of hematopoietic specification during embryonic stem cell differentiation.

Pearson S, Cuvertino S, Fleury M, Lacaud G, Kouskoff V.

Stem Cell Reports. 2015 Mar 10;4(3):431-44. doi: 10.1016/j.stemcr.2015.01.003. Epub 2015 Feb 5.

37.

Direct reprogramming of murine fibroblasts to hematopoietic progenitor cells.

Batta K, Florkowska M, Kouskoff V, Lacaud G.

Cell Rep. 2014 Dec 11;9(5):1871-1884. doi: 10.1016/j.celrep.2014.11.002. Epub 2014 Nov 26.

38.

RUNX1 positively regulates a cell adhesion and migration program in murine hemogenic endothelium prior to blood emergence.

Lie-A-Ling M, Marinopoulou E, Li Y, Patel R, Stefanska M, Bonifer C, Miller C, Kouskoff V, Lacaud G.

Blood. 2014 Sep 11;124(11):e11-20. doi: 10.1182/blood-2014-04-572958. Epub 2014 Jul 31.

PMID:
25082880
39.

MOZ-mediated repression of p16(INK) (4) (a) is critical for the self-renewal of neural and hematopoietic stem cells.

Perez-Campo FM, Costa G, Lie-A-Ling M, Stifani S, Kouskoff V, Lacaud G.

Stem Cells. 2014 Jun;32(6):1591-601. doi: 10.1002/stem.1606.

40.

Smooth muscle cells largely develop independently of functional hemogenic endothelium.

Stefanska M, Costa G, Lie-A-Ling M, Kouskoff V, Lacaud G.

Stem Cell Res. 2014 Jan;12(1):222-32. doi: 10.1016/j.scr.2013.10.009. Epub 2013 Nov 5.

41.

The MYSTerious MOZ, a histone acetyltransferase with a key role in haematopoiesis.

Perez-Campo FM, Costa G, Lie-a-Ling M, Kouskoff V, Lacaud G.

Immunology. 2013 Jun;139(2):161-5. doi: 10.1111/imm.12072. Review.

42.

RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis.

Lichtinger M, Ingram R, Hannah R, Müller D, Clarke D, Assi SA, Lie-A-Ling M, Noailles L, Vijayabaskar MS, Wu M, Tenen DG, Westhead DR, Kouskoff V, Lacaud G, Göttgens B, Bonifer C.

EMBO J. 2012 Nov 14;31(22):4318-33. doi: 10.1038/emboj.2012.275. Epub 2012 Oct 12.

43.

ETV2 expression marks blood and endothelium precursors, including hemogenic endothelium, at the onset of blood development.

Wareing S, Eliades A, Lacaud G, Kouskoff V.

Dev Dyn. 2012 Sep;241(9):1454-64. doi: 10.1002/dvdy.23825. Epub 2012 Jul 16.

44.

GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment.

Lancrin C, Mazan M, Stefanska M, Patel R, Lichtinger M, Costa G, Vargel O, Wilson NK, Möröy T, Bonifer C, Göttgens B, Kouskoff V, Lacaud G.

Blood. 2012 Jul 12;120(2):314-22. doi: 10.1182/blood-2011-10-386094. Epub 2012 Jun 5.

PMID:
22668850
45.

The Flk1-Cre-mediated deletion of ETV2 defines its narrow temporal requirement during embryonic hematopoietic development.

Wareing S, Mazan A, Pearson S, Göttgens B, Lacaud G, Kouskoff V.

Stem Cells. 2012 Jul;30(7):1521-31. doi: 10.1002/stem.1115.

46.

SOX7 regulates the expression of VE-cadherin in the haemogenic endothelium at the onset of haematopoietic development.

Costa G, Mazan A, Gandillet A, Pearson S, Lacaud G, Kouskoff V.

Development. 2012 May;139(9):1587-98. doi: 10.1242/dev.071282.

47.

Origin of blood cells and HSC production in the embryo.

Costa G, Kouskoff V, Lacaud G.

Trends Immunol. 2012 May;33(5):215-23. doi: 10.1016/j.it.2012.01.012. Epub 2012 Feb 23. Review.

PMID:
22365572
48.

The transcription factor Mxd4 controls the proliferation of the first blood precursors at the onset of hematopoietic development in vitro.

Boros K, Lacaud G, Kouskoff V.

Exp Hematol. 2011 Nov;39(11):1090-100. doi: 10.1016/j.exphem.2011.07.007. Epub 2011 Jul 23.

PMID:
21782766
49.

Identification and characterization of a novel transcriptional target of RUNX1/AML1 at the onset of hematopoietic development.

Ferreras C, Lancrin C, Lie-A-Ling M, Kouskoff V, Lacaud G.

Blood. 2011 Jul 21;118(3):594-7. doi: 10.1182/blood-2010-06-294124. Epub 2011 Apr 15.

PMID:
21498670
50.

Influencing hematopoietic differentiation of mouse embryonic stem cells using soluble heparin and heparan sulfate saccharides.

Holley RJ, Pickford CE, Rushton G, Lacaud G, Gallagher JT, Kouskoff V, Merry CL.

J Biol Chem. 2011 Feb 25;286(8):6241-52. doi: 10.1074/jbc.M110.178483. Epub 2010 Dec 10.

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