Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 103


A novel assay to screen siRNA libraries identifies protein kinases required for chromosome transmission.

Liskovykh M, Goncharov NV, Petrov N, Aksenova V, Pegoraro G, Ozbun LL, Reinhold WC, Varma S, Dasso M, Kumeiko V, Masumoto H, Earnshaw WC, Larionov V, Kouprina N.

Genome Res. 2019 Oct;29(10):1719-1732. doi: 10.1101/gr.254276.119. Epub 2019 Sep 12.


TAR Cloning: Perspectives for Functional Genomics, Biomedicine, and Biotechnology.

Kouprina N, Larionov V.

Mol Ther Methods Clin Dev. 2019 May 21;14:16-26. doi: 10.1016/j.omtm.2019.05.006. eCollection 2019 Sep 13. Review.


Novel screen for anti-cancer drugs that elevate chromosome instability (CIN) using human artificial chromosome (HAC).

Kouprina N, Pommier Y, Larionov V.

Oncotarget. 2018 Dec 7;9(96):36833-36835. doi: 10.18632/oncotarget.26406. eCollection 2018 Dec 7.


Transfer of Synthetic Human Chromosome into Human Induced Pluripotent Stem Cells for Biomedical Applications.

Sinenko SA, Skvortsova EV, Liskovykh MA, Ponomartsev SV, Kuzmin AA, Khudiakov AA, Malashicheva AB, Alenina N, Larionov V, Kouprina N, Tomilin AN.

Cells. 2018 Dec 8;7(12). pii: E261. doi: 10.3390/cells7120261.


Systematic Analysis of Compounds Specifically Targeting Telomeres and Telomerase for Clinical Implications in Cancer Therapy.

Lee HS, Carmena M, Liskovykh M, Peat E, Kim JH, Oshimura M, Masumoto H, Teulade-Fichou MP, Pommier Y, Earnshaw WC, Larionov V, Kouprina N.

Cancer Res. 2018 Nov 1;78(21):6282-6296. doi: 10.1158/0008-5472.CAN-18-0894. Epub 2018 Aug 30.


Human Artificial Chromosome with Regulated Centromere: A Tool for Genome and Cancer Studies.

Kouprina N, Petrov N, Molina O, Liskovykh M, Pesenti E, Ohzeki JI, Masumoto H, Earnshaw WC, Larionov V.

ACS Synth Biol. 2018 Sep 21;7(9):1974-1989. doi: 10.1021/acssynbio.8b00230. Epub 2018 Aug 16. Review.


Analysis of the 9p21.3 sequence associated with coronary artery disease reveals a tendency for duplication in a CAD patient.

Kouprina N, Liskovykh M, Lee NCO, Noskov VN, Waterfall JJ, Walker RL, Meltzer PS, Topol EJ, Larionov V.

Oncotarget. 2018 Feb 26;9(20):15275-15291. doi: 10.18632/oncotarget.24567. eCollection 2018 Mar 16.


Generation of a Synthetic Human Chromosome with Two Centromeric Domains for Advanced Epigenetic Engineering Studies.

Pesenti E, Kouprina N, Liskovykh M, Aurich-Costa J, Larionov V, Masumoto H, Earnshaw WC, Molina O.

ACS Synth Biol. 2018 Apr 20;7(4):1116-1130. doi: 10.1021/acssynbio.8b00018. Epub 2018 Mar 29.


Method to Assemble Genomic DNA Fragments or Genes on Human Artificial Chromosome with Regulated Kinetochore Using a Multi-Integrase System.

Lee NCO, Kim JH, Petrov NS, Lee HS, Masumoto H, Earnshaw WC, Larionov V, Kouprina N.

ACS Synth Biol. 2018 Jan 19;7(1):63-74. doi: 10.1021/acssynbio.7b00209. Epub 2017 Aug 24.


Using human artificial chromosomes to study centromere assembly and function.

Molina O, Kouprina N, Masumoto H, Larionov V, Earnshaw WC.

Chromosoma. 2017 Oct;126(5):559-575. doi: 10.1007/s00412-017-0633-x. Epub 2017 Jul 7. Review.


Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance.

Molina O, Vargiu G, Abad MA, Zhiteneva A, Jeyaprakash AA, Masumoto H, Kouprina N, Larionov V, Earnshaw WC.

Nat Commun. 2016 Nov 14;7:13334. doi: 10.1038/ncomms13334.


3D-CLEM Reveals that a Major Portion of Mitotic Chromosomes Is Not Chromatin.

Booth DG, Beckett AJ, Molina O, Samejima I, Masumoto H, Kouprina N, Larionov V, Prior IA, Earnshaw WC.

Mol Cell. 2016 Nov 17;64(4):790-802. doi: 10.1016/j.molcel.2016.10.009. Epub 2016 Nov 10.


Moving toward a higher efficiency of microcell-mediated chromosome transfer.

Liskovykh M, Lee NC, Larionov V, Kouprina N.

Mol Ther Methods Clin Dev. 2016 Jun 22;3:16043. doi: 10.1038/mtm.2016.43. eCollection 2016.


Transformation-associated recombination (TAR) cloning for genomics studies and synthetic biology.

Kouprina N, Larionov V.

Chromosoma. 2016 Sep;125(4):621-32. doi: 10.1007/s00412-016-0588-3. Epub 2016 Apr 26. Review.


Development of a novel HAC-based "gain of signal" quantitative assay for measuring chromosome instability (CIN) in cancer cells.

Kim JH, Lee HS, Lee NC, Goncharov NV, Kumeiko V, Masumoto H, Earnshaw WC, Kouprina N, Larionov V.

Oncotarget. 2016 Mar 22;7(12):14841-56. doi: 10.18632/oncotarget.7854.


Effects of Anticancer Drugs on Chromosome Instability and New Clinical Implications for Tumor-Suppressing Therapies.

Lee HS, Lee NC, Kouprina N, Kim JH, Kagansky A, Bates S, Trepel JB, Pommier Y, Sackett D, Larionov V.

Cancer Res. 2016 Feb 15;76(4):902-11. doi: 10.1158/0008-5472.CAN-15-1617. Epub 2016 Feb 2.


Generation of a conditionally self-eliminating HAC gene delivery vector through incorporation of a tTAVP64 expression cassette.

Kononenko AV, Lee NC, Liskovykh M, Masumoto H, Earnshaw WC, Larionov V, Kouprina N.

Nucleic Acids Res. 2015 May 19;43(9):e57. doi: 10.1093/nar/gkv124. Epub 2015 Feb 20.


Stable maintenance of de novo assembled human artificial chromosomes in embryonic stem cells and their differentiated progeny in mice.

Liskovykh M, Ponomartsev S, Popova E, Bader M, Kouprina N, Larionov V, Alenina N, Tomilin A.

Cell Cycle. 2015;14(8):1268-73. doi: 10.1080/15384101.2015.1014151.


Highly efficient CRISPR/Cas9-mediated TAR cloning of genes and chromosomal loci from complex genomes in yeast.

Lee NC, Larionov V, Kouprina N.

Nucleic Acids Res. 2015 Apr 30;43(8):e55. doi: 10.1093/nar/gkv112. Epub 2015 Feb 17.


Recent advances in chromosome engineering.

Kouprina N, Larionov V.

Chromosome Res. 2015 Feb;23(1):1-5. doi: 10.1007/s10577-015-9469-5. No abstract available.


A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function.

Kononenko AV, Bansal R, Lee NC, Grimes BR, Masumoto H, Earnshaw WC, Larionov V, Kouprina N.

Nucleic Acids Res. 2014 Dec 1;42(21). doi: 10.1093/nar/gku870. Epub 2014 Sep 26.


From selective full-length genes isolation by TAR cloning in yeast to their expression from HAC vectors in human cells.

Kouprina N, Lee NC, Kononenko AV, Samoshkin A, Larionov V.

Methods Mol Biol. 2015;1227:3-26. doi: 10.1007/978-1-4939-1652-8_1.


Replication of alpha-satellite DNA arrays in endogenous human centromeric regions and in human artificial chromosome.

Erliandri I, Fu H, Nakano M, Kim JH, Miga KH, Liskovykh M, Earnshaw WC, Masumoto H, Kouprina N, Aladjem MI, Larionov V.

Nucleic Acids Res. 2014 Oct;42(18):11502-16. doi: 10.1093/nar/gku835. Epub 2014 Sep 16.


Bi-HAC vector system toward gene and cell therapy.

Iida Y, Kazuki Y, Hayashi M, Ueda Y, Hasegawa M, Kouprina N, Larionov V, Oshimura M.

ACS Synth Biol. 2014 Feb 21;3(2):83-90. doi: 10.1021/sb400166j. Epub 2014 Jan 9.


Human artificial chromosome-based gene delivery vectors for biomedicine and biotechnology.

Kouprina N, Tomilin AN, Masumoto H, Earnshaw WC, Larionov V.

Expert Opin Drug Deliv. 2014 Apr;11(4):517-35. doi: 10.1517/17425247.2014.882314. Epub 2014 Jan 30. Review.


A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells.

Lee HS, Lee NC, Grimes BR, Samoshkin A, Kononenko AV, Bansal R, Masumoto H, Earnshaw WC, Kouprina N, Larionov V.

BMC Cancer. 2013 May 22;13:252. doi: 10.1186/1471-2407-13-252.


Protecting a transgene expression from the HAC-based vector by different chromatin insulators.

Lee NC, Kononenko AV, Lee HS, Tolkunova EN, Liskovykh MA, Masumoto H, Earnshaw WC, Tomilin AN, Larionov V, Kouprina N.

Cell Mol Life Sci. 2013 Oct;70(19):3723-37. doi: 10.1007/s00018-013-1362-9. Epub 2013 May 16.


Re-engineering an alphoid(tetO)-HAC-based vector to enable high-throughput analyses of gene function.

Kononenko AV, Lee NC, Earnshaw WC, Kouprina N, Larionov V.

Nucleic Acids Res. 2013 May 1;41(10):e107. doi: 10.1093/nar/gkt205. Epub 2013 Apr 4.


Organization of synthetic alphoid DNA array in human artificial chromosome (HAC) with a conditional centromere.

Kouprina N, Samoshkin A, Erliandri I, Nakano M, Lee HS, Fu H, Iida Y, Aladjem M, Oshimura M, Masumoto H, Earnshaw WC, Larionov V.

ACS Synth Biol. 2012 Dec 21;1(12):590-601.


Division of the intermediate compartment at the onset of mitosis provides a mechanism for Golgi inheritance.

Marie M, Dale HA, Kouprina N, Saraste J.

J Cell Sci. 2012 Nov 15;125(Pt 22):5403-16. doi: 10.1242/jcs.108100. Epub 2012 Sep 3.


A new generation of human artificial chromosomes for functional genomics and gene therapy.

Kouprina N, Earnshaw WC, Masumoto H, Larionov V.

Cell Mol Life Sci. 2013 Apr;70(7):1135-48. doi: 10.1007/s00018-012-1113-3. Epub 2012 Aug 21. Review.


Exclusion of the 750-kb genetically unstable region at Xq27 as a candidate locus for prostate malignancy in HPCX1-linked families.

Kouprina N, Lee NC, Pavlicek A, Samoshkin A, Kim JH, Lee HS, Varma S, Reinhold WC, Otstot J, Solomon G, Davis S, Meltzer PS, Schleutker J, Larionov V.

Genes Chromosomes Cancer. 2012 Oct;51(10):933-48. doi: 10.1002/gcc.21977. Epub 2012 Jun 26.


Breaking the HAC Barrier: histone H3K9 acetyl/methyl balance regulates CENP-A assembly.

Ohzeki J, Bergmann JH, Kouprina N, Noskov VN, Nakano M, Kimura H, Earnshaw WC, Larionov V, Masumoto H.

EMBO J. 2012 May 16;31(10):2391-402. doi: 10.1038/emboj.2012.82. Epub 2012 Apr 3.


Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells.

Kim JH, Kononenko A, Erliandri I, Kim TA, Nakano M, Iida Y, Barrett JC, Oshimura M, Masumoto H, Earnshaw WC, Larionov V, Kouprina N.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20048-53. doi: 10.1073/pnas.1114483108. Epub 2011 Nov 28.


Rapid generation of long tandem DNA repeat arrays by homologous recombination in yeast to study their function in mammalian genomes.

Noskov VN, Lee NC, Larionov V, Kouprina N.

Biol Proced Online. 2011 Oct 7;13(1):8. doi: 10.1186/1480-9222-13-8.


tRNA genes protect a reporter gene from epigenetic silencing in mouse cells.

Ebersole T, Kim JH, Samoshkin A, Kouprina N, Pavlicek A, White RJ, Larionov V.

Cell Cycle. 2011 Aug 15;10(16):2779-91. Epub 2011 Aug 15.


Isolation of circular yeast artificial chromosomes for synthetic biology and functional genomics studies.

Noskov VN, Chuang RY, Gibson DG, Leem SH, Larionov V, Kouprina N.

Nat Protoc. 2011 Jan;6(1):89-96. doi: 10.1038/nprot.2010.174. Epub 2010 Dec 23.


Refined human artificial chromosome vectors for gene therapy and animal transgenesis.

Kazuki Y, Hoshiya H, Takiguchi M, Abe S, Iida Y, Osaki M, Katoh M, Hiratsuka M, Shirayoshi Y, Hiramatsu K, Ueno E, Kajitani N, Yoshino T, Kazuki K, Ishihara C, Takehara S, Tsuji S, Ejima F, Toyoda A, Sakaki Y, Larionov V, Kouprina N, Oshimura M.

Gene Ther. 2011 Apr;18(4):384-93. doi: 10.1038/gt.2010.147. Epub 2010 Nov 18.


Shorter telomeres in luminal B, HER-2 and triple-negative breast cancer subtypes.

Heaphy CM, Subhawong AP, Gross AL, Konishi Y, Kouprina N, Argani P, Visvanathan K, Meeker AK.

Mod Pathol. 2011 Feb;24(2):194-200. doi: 10.1038/modpathol.2010.198. Epub 2010 Nov 5.


Human artificial chromosome with a conditional centromere for gene delivery and gene expression.

Iida Y, Kim JH, Kazuki Y, Hoshiya H, Takiguchi M, Hayashi M, Erliandri I, Lee HS, Samoshkin A, Masumoto H, Earnshaw WC, Kouprina N, Larionov V, Oshimura M.

DNA Res. 2010 Oct;17(5):293-301. doi: 10.1093/dnares/dsq020. Epub 2010 Aug 26.


The alternative lengthening of telomeres phenotype in breast carcinoma is associated with HER-2 overexpression.

Subhawong AP, Heaphy CM, Argani P, Konishi Y, Kouprina N, Nassar H, Vang R, Meeker AK.

Mod Pathol. 2009 Nov;22(11):1423-31. doi: 10.1038/modpathol.2009.125. Epub 2009 Sep 4.


Sperm-derived SPANX-B is a clinically relevant tumor antigen that is expressed in human tumors and readily recognized by human CD4+ and CD8+ T cells.

Almanzar G, Olkhanud PB, Bodogai M, Dell'agnola C, Baatar D, Hewitt SM, Ghimenton C, Tummala MK, Weeraratna AT, Hoek KS, Kouprina N, Larionov V, Biragyn A.

Clin Cancer Res. 2009 Mar 15;15(6):1954-63. doi: 10.1158/1078-0432.CCR-08-1290. Epub 2009 Mar 10.


Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing.

Kim JH, Ebersole T, Kouprina N, Noskov VN, Ohzeki J, Masumoto H, Mravinac B, Sullivan BA, Pavlicek A, Dovat S, Pack SD, Kwon YW, Flanagan PT, Loukinov D, Lobanenkov V, Larionov V.

Genome Res. 2009 Apr;19(4):533-44. doi: 10.1101/gr.086496.108. Epub 2009 Jan 13.


Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9.

Cao D, Polyak K, Halushka MK, Nassar H, Kouprina N, Iacobuzio-Donahue C, Wu X, Sukumar S, Hicks J, De Marzo A, Argani P.

Breast Cancer Res. 2008;10(5):R91. doi: 10.1186/bcr2189. Epub 2008 Oct 27.


Most basal-like breast carcinomas demonstrate the same Rb-/p16+ immunophenotype as the HPV-related poorly differentiated squamous cell carcinomas which they resemble morphologically.

Subhawong AP, Subhawong T, Nassar H, Kouprina N, Begum S, Vang R, Westra WH, Argani P.

Am J Surg Pathol. 2009 Feb;33(2):163-75. doi: 10.1097/PAS.0b013e31817f9790.


Selective isolation of mammalian genes by TAR cloning.

Kouprina N, Larionov V.

Curr Protoc Hum Genet. 2006 May;Chapter 5:Unit 5.17. doi: 10.1002/0471142905.hg0517s49. Review.


The superficial margin of the skin-sparing mastectomy for breast carcinoma: factors predicting involvement and efficacy of additional margin sampling.

Cao D, Tsangaris TN, Kouprina N, Wu LS, Balch CM, Vang R, Argani P.

Ann Surg Oncol. 2008 May;15(5):1330-40. doi: 10.1245/s10434-007-9795-8. Epub 2008 Feb 2.


Evolutionary diversification of SPANX-N sperm protein gene structure and expression.

Kouprina N, Noskov VN, Pavlicek A, Collins NK, Schoppee Bortz PD, Ottolenghi C, Loukinov D, Goldsmith P, Risinger JI, Kim JH, Westbrook VA, Solomon G, Sounders H, Herr JC, Jurka J, Lobanenkov V, Schlessinger D, Larionov V.

PLoS One. 2007 Apr 4;2(4):e359.


Mutational analysis of SPANX genes in families with X-linked prostate cancer.

Kouprina N, Noskov VN, Solomon G, Otstot J, Isaacs W, Xu J, Schleutker J, Larionov V.

Prostate. 2007 Jun 1;67(8):820-8.


Supplemental Content

Loading ...
Support Center