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Repeat exposure to polyinosinic:polycytidylic acid induces TLR3 expression via JAK-STAT signaling and synergistically potentiates NFκB-RelA signaling in ARPE-19 cells.

Duncan RS, Rohowetz L, Vogt A, Koulen P.

Cell Signal. 2020 Feb;66:109494. doi: 10.1016/j.cellsig.2019.109494. Epub 2019 Dec 4.


Resveratrol Directly Controls the Activity of Neuronal Ryanodine Receptors at the Single-Channel Level.

Kraus JG, Koulen P.

Mol Neurobiol. 2020 Jan;57(1):422-434. doi: 10.1007/s12035-019-01705-7. Epub 2019 Aug 2.


Manganese(III) tetrakis(1-methyl-4-pyridyl) porphyrin, a superoxide dismutase mimetic, reduces disease severity in in vitro and in vivo models for dry-eye disease.

Žiniauskaitė A, Ragauskas S, Ghosh AK, Thapa R, Roessler AE, Koulen P, Kalesnykas G, Hakkarainen JJ, Kaja S.

Ocul Surf. 2019 Apr;17(2):257-264. doi: 10.1016/j.jtos.2019.02.006. Epub 2019 Feb 23.


Reactive Oxygen Species-Mediated Damage of Retinal Neurons: Drug Development Targets for Therapies of Chronic Neurodegeneration of the Retina.

Rohowetz LJ, Kraus JG, Koulen P.

Int J Mol Sci. 2018 Oct 27;19(11). pii: E3362. doi: 10.3390/ijms19113362. Review.


Contribution of HIV Infection, AIDS, and Antiretroviral Therapy to Exocrine Pathogenesis in Salivary and Lacrimal Glands.

Nizamuddin I, Koulen P, McArthur CP.

Int J Mol Sci. 2018 Sep 13;19(9). pii: E2747. doi: 10.3390/ijms19092747. Review.


Quantification of Changes in Visual Function During Disease Development in a Mouse Model of Pigmentary Glaucoma.

Grillo SL, Montgomery CL, Johnson HM, Koulen P.

J Glaucoma. 2018 Sep;27(9):828-841. doi: 10.1097/IJG.0000000000001024.


Mechanisms Underlying Early-Stage Changes in Visual Performance and Retina Function After Experimental Induction of Sustained Dyslipidemia.

Montgomery CL, Johnson HM, Johnston TP, Koulen P.

Neurochem Res. 2018 Aug;43(8):1500-1510. doi: 10.1007/s11064-018-2563-2. Epub 2018 Jun 2.


Presenilins as Drug Targets for Alzheimer's Disease-Recent Insights from Cell Biology and Electrophysiology as Novel Opportunities in Drug Development.

Duncan RS, Song B, Koulen P.

Int J Mol Sci. 2018 May 31;19(6). pii: E1621. doi: 10.3390/ijms19061621. Review.


Control of Neuronal Ryanodine Receptor-Mediated Calcium Signaling by Calsenilin.

Grillo MA, Grillo SL, Gerdes BC, Kraus JG, Koulen P.

Mol Neurobiol. 2019 Jan;56(1):525-534. doi: 10.1007/s12035-018-1080-2. Epub 2018 May 5.


Distinct Mechanisms Underlying Resveratrol-Mediated Protection from Types of Cellular Stress in C6 Glioma Cells.

Means JC, Gerdes BC, Koulen P.

Int J Mol Sci. 2017 Jul 14;18(7). pii: E1521. doi: 10.3390/ijms18071521.


Quantification of Lactate Dehydrogenase for Cell Viability Testing Using Cell Lines and Primary Cultured Astrocytes.

Kaja S, Payne AJ, Naumchuk Y, Koulen P.

Curr Protoc Toxicol. 2017 May 2;72:2.26.1-2.26.10. doi: 10.1002/cptx.21.


Changes in Retinal N-Acylethanolamines and their Oxylipin Derivatives During the Development of Visual Impairment in a Mouse Model for Glaucoma.

Montgomery CL, Keereetaweep J, Johnson HM, Grillo SL, Chapman KD, Koulen P.

Lipids. 2016 Jul;51(7):857-66. doi: 10.1007/s11745-016-4161-x. Epub 2016 May 24.


Caspase-3-Dependent Proteolytic Cleavage of Tau Causes Neurofibrillary Tangles and Results in Cognitive Impairment During Normal Aging.

Means JC, Gerdes BC, Kaja S, Sumien N, Payne AJ, Stark DA, Borden PK, Price JL, Koulen P.

Neurochem Res. 2016 Sep;41(9):2278-88. doi: 10.1007/s11064-016-1942-9. Epub 2016 May 25.


Differential cerebellar GABAA receptor expression in mice with mutations in CaV2.1 (P/Q-type) calcium channels.

Kaja S, Payne AJ, Nielsen EØ, Thompson CL, van den Maagdenberg AM, Koulen P, Snutch TP.

Neuroscience. 2015 Sep 24;304:198-208. doi: 10.1016/j.neuroscience.2015.07.044. Epub 2015 Jul 21.


The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders.

Prokai L, Nguyen V, Szarka S, Garg P, Sabnis G, Bimonte-Nelson HA, McLaughlin KJ, Talboom JS, Conrad CD, Shughrue PJ, Gould TD, Brodie A, Merchenthaler I, Koulen P, Prokai-Tatrai K.

Sci Transl Med. 2015 Jul 22;7(297):297ra113. doi: 10.1126/scitranslmed.aab1290.


Psychophysical testing in rodent models of glaucomatous optic neuropathy.

Grillo SL, Koulen P.

Exp Eye Res. 2015 Dec;141:154-63. doi: 10.1016/j.exer.2015.06.025. Epub 2015 Jul 2. Review.


Plate reader-based cell viability assays for glioprotection using primary rat optic nerve head astrocytes.

Kaja S, Payne AJ, Naumchuk Y, Levy D, Zaidi DH, Altman AM, Nawazish S, Ghuman JK, Gerdes BC, Moore MA, Koulen P.

Exp Eye Res. 2015 Sep;138:159-66. doi: 10.1016/j.exer.2015.05.023. Epub 2015 Jun 3.


Nampt/PBEF/visfatin serum levels: a new biomarker for retinal blood vessel occlusions.

Kaja S, Shah AA, Haji SA, Patel KB, Naumchuk Y, Zabaneh A, Gerdes BC, Kunjukunju N, Sabates NR, Cassell MA, Lord RK, Pikey KP, Poulose A, Koulen P.

Clin Ophthalmol. 2015 Apr 7;9:611-8. doi: 10.2147/OPTH.S80784. eCollection 2015.


An optimized lactate dehydrogenase release assay for screening of drug candidates in neuroscience.

Kaja S, Payne AJ, Singh T, Ghuman JK, Sieck EG, Koulen P.

J Pharmacol Toxicol Methods. 2015 May-Jun;73:1-6. doi: 10.1016/j.vascn.2015.02.001. Epub 2015 Feb 12.


Regulation of ryanodine receptor-mediated calcium signaling by presenilins.

Payne AJ, Kaja S, Koulen P.

Receptors Clin Investig. 2015;2(1):e449. No abstract available.


Differential subcellular Ca2+ signaling in a highly specialized subpopulation of astrocytes.

Kaja S, Payne AJ, Patel KR, Naumchuk Y, Koulen P.

Exp Neurol. 2015 Mar;265:59-68. doi: 10.1016/j.expneurol.2014.12.014. Epub 2014 Dec 24.


Effects of synthetic alkamides on Arabidopsis fatty acid amide hydrolase activity and plant development.

Faure L, Cavazos R, Khan BR, Petros RA, Koulen P, Blancaflor EB, Chapman KD.

Phytochemistry. 2015 Feb;110:58-71. doi: 10.1016/j.phytochem.2014.11.011. Epub 2014 Dec 6.


Clinical application of optical coherence tomography in combination with functional diagnostics: advantages and limitations for diagnosis and assessment of therapy outcome in central serous chorioretinopathy.

Schliesser JA, Gallimore G, Kunjukunju N, Sabates NR, Koulen P, Sabates FN.

Clin Ophthalmol. 2014 Nov 21;8:2337-45. doi: 10.2147/OPTH.S73119. eCollection 2014.


Loss of Spatial Memory, Learning, and Motor Function During Normal Aging Is Accompanied by Changes in Brain Presenilin 1 and 2 Expression Levels.

Kaja S, Sumien N, Shah VV, Puthawala I, Maynard AN, Khullar N, Payne AJ, Forster MJ, Koulen P.

Mol Neurobiol. 2015 Aug;52(1):545-54. doi: 10.1007/s12035-014-8877-4. Epub 2014 Sep 10.


Resveratrol and calcium signaling: molecular mechanisms and clinical relevance.

McCalley AE, Kaja S, Payne AJ, Koulen P.

Molecules. 2014 Jun 5;19(6):7327-40. doi: 10.3390/molecules19067327. Review.


Synthesis of phenoxyacyl-ethanolamides and their effects on fatty acid amide hydrolase activity.

Faure L, Nagarajan S, Hwang H, Montgomery CL, Khan BR, John G, Koulen P, Blancaflor EB, Chapman KD.

J Biol Chem. 2014 Mar 28;289(13):9340-51. doi: 10.1074/jbc.M113.533315. Epub 2014 Feb 20.


Antioxidant drug therapy approaches for neuroprotection in chronic diseases of the retina.

Payne AJ, Kaja S, Naumchuk Y, Kunjukunju N, Koulen P.

Int J Mol Sci. 2014 Jan 27;15(2):1865-86. doi: 10.3390/ijms15021865. Review.


Insert sequence length determines transfection efficiency and gene expression levels in bicistronic mammalian expression vectors.

Payne AJ, Gerdes BC, Kaja S, Koulen P.

Int J Biochem Mol Biol. 2013 Dec 15;4(4):201-8. eCollection 2013.


A case for neuroprotection in ophthalmology: developments in translational research.

Payne AJ, Kaja S, Sabates NR, Koulen P.

Mo Med. 2013 Sep-Oct;110(5):429-36. Review.


Differential up-regulation of Vesl-1/Homer 1 protein isoforms associated with decline in visual performance in a preclinical glaucoma model.

Kaja S, Naumchuk Y, Grillo SL, Borden PK, Koulen P.

Vision Res. 2014 Jan;94:16-23. doi: 10.1016/j.visres.2013.10.018. Epub 2013 Nov 9.


Presenilins regulate the cellular activity of ryanodine receptors differentially through isotype-specific N-terminal cysteines.

Payne AJ, Gerdes BC, Naumchuk Y, McCalley AE, Kaja S, Koulen P.

Exp Neurol. 2013 Dec;250:143-50. doi: 10.1016/j.expneurol.2013.09.001. Epub 2013 Sep 9.


N-Palmitoylethanolamine depot injection increased its tissue levels and those of other acylethanolamide lipids.

Grillo SL, Keereetaweep J, Grillo MA, Chapman KD, Koulen P.

Drug Des Devel Ther. 2013 Aug 12;7:747-52. doi: 10.2147/DDDT.S48324. eCollection 2013.


17β-estradiol eye drops protect the retinal ganglion cell layer and preserve visual function in an in vivo model of glaucoma.

Prokai-Tatrai K, Xin H, Nguyen V, Szarka S, Blazics B, Prokai L, Koulen P.

Mol Pharm. 2013 Aug 5;10(8):3253-61. doi: 10.1021/mp400313u. Epub 2013 Jul 23.


Detection of novel biomarkers for ovarian cancer with an optical nanotechnology detection system enabling label-free diagnostics.

Kaja S, Hilgenberg JD, Collins JL, Shah AA, Wawro D, Zimmerman S, Magnusson R, Koulen P.

J Biomed Opt. 2012 Aug;17(8):081412-1. doi: 10.1117/1.JBO.17.8.081412.


Homer-1a immediate early gene expression correlates with better cognitive performance in aging.

Kaja S, Sumien N, Borden PK, Khullar N, Iqbal M, Collins JL, Forster MJ, Koulen P.

Age (Dordr). 2013 Oct;35(5):1799-808. doi: 10.1007/s11357-012-9479-6. Epub 2012 Oct 11.


Evaluation of tensile strength of tissue adhesives and sutures for clear corneal incisions using porcine and bovine eyes, with a novel standardized testing platform.

Kaja S, Goad DL, Ali F, Abraham A, Rebenitsch RL, Teymoorian S, Krishna R, Koulen P.

Clin Ophthalmol. 2012;6:305-9. doi: 10.2147/OPTH.S29859. Epub 2012 Feb 28.


Distribution and function of polycystin-2 in mouse retinal ganglion cells.

Kaja S, Mafe OA, Parikh RA, Kandula P, Reddy CA, Gregg EV, Xin H, Mitchell P, Grillo MA, Koulen P.

Neuroscience. 2012 Jan 27;202:99-107. doi: 10.1016/j.neuroscience.2011.11.047. Epub 2011 Dec 2.


Plate reader-based assays for measuring cell viability, neuroprotection and calcium in primary neuronal cultures.

Burroughs SL, Duncan RS, Rayudu P, Kandula P, Payne AJ, Clark JL, Koulen P, Kaja S.

J Neurosci Methods. 2012 Jan 15;203(1):141-5. doi: 10.1016/j.jneumeth.2011.09.007. Epub 2011 Sep 24.


Protection of neurons in the retinal ganglion cell layer against excitotoxicity by the N-acylethanolamine, N-linoleoylethanolamine.

Duncan RS, Xin H, Goad DL, Chapman KD, Koulen P.

Clin Ophthalmol. 2011;5:543-8. doi: 10.2147/OPTH.S18309. Epub 2011 Apr 26.


Polycystin-2 expression and function in adult mouse lacrimal acinar cells.

Kaja S, Hilgenberg JD, Rybalchenko V, Medina-Ortiz WE, Gregg EV, Koulen P.

Invest Ophthalmol Vis Sci. 2011 Jul 29;52(8):5605-11. doi: 10.1167/iovs.10-7114.


Normative data set identifying properties of the macula across age groups: integration of visual function and retinal structure with microperimetry and spectral-domain optical coherence tomography.

Sabates FN, Vincent RD, Koulen P, Sabates NR, Gallimore G.

Retina. 2011 Jul-Aug;31(7):1294-302. doi: 10.1097/IAE.0b013e3182019be2.


Quantification of deficits in spatial visual function of mouse models for glaucoma.

Burroughs SL, Kaja S, Koulen P.

Invest Ophthalmol Vis Sci. 2011 Jun 1;52(6):3654-9. doi: 10.1167/iovs.10-7106.


Lauroylethanolamide and linoleoylethanolamide improve functional outcome in a rodent model for stroke.

Garg P, Duncan RS, Kaja S, Zabaneh A, Chapman KD, Koulen P.

Neurosci Lett. 2011 Apr 4;492(3):134-8. doi: 10.1016/j.neulet.2011.01.073. Epub 2011 Feb 4.


Changes in N-acylethanolamine Pathway Related Metabolites in a Rat Model of Cerebral Ischemia/Reperfusion.

Kilaru A, Tamura P, Garg P, Isaac G, Baxter D, Duncan RS, Welti R, Koulen P, Chapman KD, Venables BJ.

J Glycomics Lipidomics. 2011;1(1). pii: 101.


Novel mechanism of increased Ca2+ release following oxidative stress in neuronal cells involves type 2 inositol-1,4,5-trisphosphate receptors.

Kaja S, Duncan RS, Longoria S, Hilgenberg JD, Payne AJ, Desai NM, Parikh RA, Burroughs SL, Gregg EV, Goad DL, Koulen P.

Neuroscience. 2011 Feb 23;175:281-91. doi: 10.1016/j.neuroscience.2010.11.010. Epub 2010 Nov 11.


Regulator of G-protein signaling 14 protein modulates Ca²+ influx through Cav1 channels.

Martín-Montañez E, Acevedo MJ, López-Téllez JF, Duncan RS, Mateos AG, Pavía J, Koulen P, Khan ZU.

Neuroreport. 2010 Nov 17;21(16):1034-9. doi: 10.1097/WNR.0b013e32833f7b7b.

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