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Items: 6


An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans.

Kurtz CB, Millet YA, Puurunen MK, Perreault M, Charbonneau MR, Isabella VM, Kotula JW, Antipov E, Dagon Y, Denney WS, Wagner DA, West KA, Degar AJ, Brennan AM, Miller PF.

Sci Transl Med. 2019 Jan 16;11(475). pii: eaau7975. doi: 10.1126/scitranslmed.aau7975.


Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation.

Riglar DT, Giessen TW, Baym M, Kerns SJ, Niederhuber MJ, Bronson RT, Kotula JW, Gerber GK, Way JC, Silver PA.

Nat Biotechnol. 2017 Jul;35(7):653-658. doi: 10.1038/nbt.3879. Epub 2017 May 29.


A distributed cell division counter reveals growth dynamics in the gut microbiota.

Myhrvold C, Kotula JW, Hicks WM, Conway NJ, Silver PA.

Nat Commun. 2015 Nov 30;6:10039. doi: 10.1038/ncomms10039.


Targeted disruption of β-arrestin 2-mediated signaling pathways by aptamer chimeras leads to inhibition of leukemic cell growth.

Kotula JW, Sun J, Li M, Pratico ED, Fereshteh MP, Ahrens DP, Sullenger BA, Kovacs JJ.

PLoS One. 2014 Apr 15;9(4):e93441. doi: 10.1371/journal.pone.0093441. eCollection 2014.


Programmable bacteria detect and record an environmental signal in the mammalian gut.

Kotula JW, Kerns SJ, Shaket LA, Siraj L, Collins JJ, Way JC, Silver PA.

Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4838-43. doi: 10.1073/pnas.1321321111. Epub 2014 Mar 17.


Aptamer-mediated delivery of splice-switching oligonucleotides to the nuclei of cancer cells.

Kotula JW, Pratico ED, Ming X, Nakagawa O, Juliano RL, Sullenger BA.

Nucleic Acid Ther. 2012 Jun;22(3):187-95. doi: 10.1089/nat.2012.0347.

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