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Single-Shot Sub-microsecond Mid-infrared Spectroscopy on Protein Reactions with Quantum Cascade Laser Frequency Combs.

Klocke JL, Mangold M, Allmendinger P, Hugi A, Geiser M, Jouy P, Faist J, Kottke T.

Anal Chem. 2018 Aug 15. doi: 10.1021/acs.analchem.8b02531. [Epub ahead of print]


A flavin-dependent halogenase from metagenomic analysis prefers bromination over chlorination.

Neubauer PR, Widmann C, Wibberg D, Schröder L, Frese M, Kottke T, Kalinowski J, Niemann HH, Sewald N.

PLoS One. 2018 May 10;13(5):e0196797. doi: 10.1371/journal.pone.0196797. eCollection 2018.


Photoreceptors Take Charge: Emerging Principles for Light Sensing.

Kottke T, Xie A, Larsen DS, Hoff WD.

Annu Rev Biophys. 2018 Mar 14. doi: 10.1146/annurev-biophys-070317-033047. [Epub ahead of print]


Characterization of Robust and Free-Standing 2D-Nanomembranes of UV-Polymerized Diacetylene Lipids.

Hillmann R, Viefhues M, Goett-Zink L, Gilzer D, Hellweg T, Gölzhäuser A, Kottke T, Anselmetti D.

Langmuir. 2018 Mar 13;34(10):3256-3263. doi: 10.1021/acs.langmuir.7b03403. Epub 2018 Mar 2.


Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade.

Samson A, Scott KJ, Taggart D, West EJ, Wilson E, Nuovo GJ, Thomson S, Corns R, Mathew RK, Fuller MJ, Kottke TJ, Thompson JM, Ilett EJ, Cockle JV, van Hille P, Sivakumar G, Polson ES, Turnbull SJ, Appleton ES, Migneco G, Rose AS, Coffey MC, Beirne DA, Collinson FJ, Ralph C, Alan Anthoney D, Twelves CJ, Furness AJ, Quezada SA, Wurdak H, Errington-Mais F, Pandha H, Harrington KJ, Selby PJ, Vile RG, Griffin SD, Stead LF, Short SC, Melcher AA.

Sci Transl Med. 2018 Jan 3;10(422). pii: eaam7577. doi: 10.1126/scitranslmed.aam7577.


Activation of Recombinantly Expressed l-Amino Acid Oxidase from Rhizoctonia solani by Sodium Dodecyl Sulfate.

Hahn K, Hertle Y, Bloess S, Kottke T, Hellweg T, Fischer von Mollard G.

Molecules. 2017 Dec 20;22(12). pii: E2272. doi: 10.3390/molecules22122272.


Access to Affordable Housing Promotes Health and Well-Being and Reduces Hospital Visits.

Kottke T, Abariotes A, Spoonheim JB.

Perm J. 2017;22. doi: 10.7812/TPP/17-079.


Time-Resolved Infrared Spectroscopy on Plant Cryptochrome-Relevance of Proton Transfer and ATP Binding for Signaling.

Schroeder L, Oldemeyer S, Kottke T.

J Phys Chem A. 2018 Jan 11;122(1):140-147. doi: 10.1021/acs.jpca.7b10249. Epub 2017 Dec 20.


Subversion of NK-cell and TNFα Immune Surveillance Drives Tumor Recurrence.

Kottke T, Evgin L, Shim KG, Rommelfanger D, Boisgerault N, Zaidi S, Diaz RM, Thompson J, Ilett E, Coffey M, Selby P, Pandha H, Harrington K, Melcher A, Vile R.

Cancer Immunol Res. 2017 Nov;5(11):1029-1045. doi: 10.1158/2326-6066.CIR-17-0175. Epub 2017 Oct 15.


Synthesis, Molecular Properties Estimations, and Dual Dopamine D2 and D3 Receptor Activities of Benzothiazole-Based Ligands.

Schübler M, Sadek B, Kottke T, Weizel L, Stark H.

Front Chem. 2017 Sep 12;5:64. doi: 10.3389/fchem.2017.00064. eCollection 2017.


An update on aureochromes: Phylogeny - mechanism - function.

Kroth PG, Wilhelm C, Kottke T.

J Plant Physiol. 2017 Oct;217:20-26. doi: 10.1016/j.jplph.2017.06.010. Epub 2017 Jul 11. Review.


The cryptochrome-photolyase protein family in diatoms.

König S, Juhas M, Jäger S, Kottke T, Büchel C.

J Plant Physiol. 2017 Oct;217:15-19. doi: 10.1016/j.jplph.2017.06.015. Epub 2017 Jul 8. Review.


Cryptochrome photoreceptors in green algae: Unexpected versatility of mechanisms and functions.

Kottke T, Oldemeyer S, Wenzel S, Zou Y, Mittag M.

J Plant Physiol. 2017 Oct;217:4-14. doi: 10.1016/j.jplph.2017.05.021. Epub 2017 May 31. Review.


Oncolytic Herpes Simplex Virus Inhibits Pediatric Brain Tumor Migration and Invasion.

Cockle JV, Brüning-Richardson A, Scott KJ, Thompson J, Kottke T, Morrison E, Ismail A, Carcaboso AM, Rose A, Selby P, Conner J, Picton S, Short S, Vile R, Melcher A, Ilett E.

Mol Ther Oncolytics. 2017 May 2;5:75-86. doi: 10.1016/j.omto.2017.04.002. eCollection 2017 Jun 16.


Light-Induced Conformational Changes in the Plant Cryptochrome Photolyase Homology Region Resolved by Selective Isotope Labeling and Infrared Spectroscopy.

Sommer C, Dietz MS, Patschkowski T, Mathes T, Kottke T.

Photochem Photobiol. 2017 May;93(3):881-887. doi: 10.1111/php.12750.


Philanthropy and Beyond: Creating Shared Value to Promote Well-Being for Individuals in Their Communities.

Kottke TE, Pronk N, Zinkel AR, Isham GJ.

Perm J. 2017;21. doi: 10.7812/TPP/16-188.


An Animal-Like Cryptochrome Controls the Chlamydomonas Sexual Cycle.

Zou Y, Wenzel S, Müller N, Prager K, Jung EM, Kothe E, Kottke T, Mittag M.

Plant Physiol. 2017 Jul;174(3):1334-1347. doi: 10.1104/pp.17.00493. Epub 2017 May 3.


Use and Customization of Risk Scores for Predicting Cardiovascular Events Using Electronic Health Record Data.

Wolfson J, Vock DM, Bandyopadhyay S, Kottke T, Vazquez-Benitez G, Johnson P, Adomavicius G, O'Connor PJ.

J Am Heart Assoc. 2017 Apr 24;6(4). pii: e003670. doi: 10.1161/JAHA.116.003670.


Strategies to Prioritize Clinical Options in Primary Care.

O'Connor PJ, Sperl-Hillen JM, Margolis KL, Kottke TE.

Ann Fam Med. 2017 Jan;15(1):10-13. doi: 10.1370/afm.2027. Epub 2017 Jan 6. No abstract available.


Synthesis and biological activity of novel tert-amylphenoxyalkyl (homo)piperidine derivatives as histamine H3R ligands.

Kuder KJ, Łażewska D, Kaleta M, Latacz G, Kottke T, Olejarz A, Karcz T, Fruziński A, Szczepańska K, Karolak-Wojciechowska J, Stark H, Kieć-Kononowicz K.

Bioorg Med Chem. 2017 May 15;25(10):2701-2712. doi: 10.1016/j.bmc.2017.03.031. Epub 2017 Mar 21.


A Plant Cryptochrome Controls Key Features of the Chlamydomonas Circadian Clock and Its Life Cycle.

Müller N, Wenzel S, Zou Y, Künzel S, Sasso S, Weiß D, Prager K, Grossman A, Kottke T, Mittag M.

Plant Physiol. 2017 May;174(1):185-201. doi: 10.1104/pp.17.00349. Epub 2017 Mar 30.


Inhibitory Receptors Induced by VSV Viroimmunotherapy Are Not Necessarily Targets for Improving Treatment Efficacy.

Shim KG, Zaidi S, Thompson J, Kottke T, Evgin L, Rajani KR, Schuelke M, Driscoll CB, Huff A, Pulido JS, Vile RG.

Mol Ther. 2017 Apr 5;25(4):962-975. doi: 10.1016/j.ymthe.2017.01.023. Epub 2017 Feb 22.


Boreal pollen contain ice-nucleating as well as ice-binding 'antifreeze' polysaccharides.

Dreischmeier K, Budke C, Wiehemeier L, Kottke T, Koop T.

Sci Rep. 2017 Feb 3;7:41890. doi: 10.1038/srep41890.


The Grateful Infrared: Sequential Protein Structural Changes Resolved by Infrared Difference Spectroscopy.

Kottke T, Lórenz-Fonfría VA, Heberle J.

J Phys Chem B. 2017 Jan 19;121(2):335-350. doi: 10.1021/acs.jpcb.6b09222. Epub 2016 Dec 1. Review.


Concordance Between Life Satisfaction and Six Elements of Well-Being Among Respondents to a Health Assessment Survey, HealthPartners Employees, Minnesota, 2011.

Pronk NP, Kottke TE, Lowry M, Katz AS, Gallagher JM, Knudson SM, Rauri SJ, Tillema JO.

Prev Chronic Dis. 2016 Dec 22;13:E173. doi: 10.5888/pcd13.160309.


Recombinant expression and characterization of a L-amino acid oxidase from the fungus Rhizoctonia solani.

Hahn K, Neumeister K, Mix A, Kottke T, Gröger H, Fischer von Mollard G.

Appl Microbiol Biotechnol. 2017 Apr;101(7):2853-2864. doi: 10.1007/s00253-016-8054-y. Epub 2016 Dec 16.


Immunogenicity of self tumor associated proteins is enhanced through protein truncation.

Kottke T, Shim KG, Alonso-Camino V, Zaidi S, Maria Diaz R, Pulido J, Thompson J, Rajani KR, Evgin L, Ilett E, Pandha H, Harrington K, Selby P, Melcher A, Vile R.

Mol Ther Oncolytics. 2016 Dec 7;3:16030. eCollection 2016.


Prime-boost using separate oncolytic viruses in combination with checkpoint blockade improves anti-tumour therapy.

Ilett E, Kottke T, Thompson J, Rajani K, Zaidi S, Evgin L, Coffey M, Ralph C, Diaz R, Pandha H, Harrington K, Selby P, Bram R, Melcher A, Vile R.

Gene Ther. 2017 Jan;24(1):21-30. doi: 10.1038/gt.2016.70. Epub 2016 Oct 25.


A blue-light photoreceptor mediates the feedback regulation of photosynthesis.

Petroutsos D, Tokutsu R, Maruyama S, Flori S, Greiner A, Magneschi L, Cusant L, Kottke T, Mittag M, Hegemann P, Finazzi G, Minagawa J.

Nature. 2016 Sep 22;537(7621):563-566. doi: 10.1038/nature19358. Epub 2016 Sep 14.


The financial impact of team-based care on primary care.

Kottke TE, Maciosek MV, Huebsch JA, McGinnis P, Nichols JM, Parker ED, Tillema JO.

Am J Manag Care. 2016 Aug 1;22(8):e283-6.


Proton pump inhibitor use by aspirin-treated coronary artery disease patients is not associated with increased risk of cardiovascular events.

Fortuna LA, Pawloski PA, Parker ED, Trower NK, Kottke TE.

Eur Heart J Cardiovasc Pharmacother. 2016 Jan;2(1):13-9. doi: 10.1093/ehjcvp/pvv036. Epub 2015 Sep 7.


New Summary Measures of Population Health and Well-Being for Implementation by Health Plans and Accountable Care Organizations.

Kottke TE, Gallagher JM, Rauri S, Tillema JO, Pronk NP, Knudson SM.

Prev Chronic Dis. 2016 Jul 7;13:E89. doi: 10.5888/pcd13.160224.


Obesity Treatment at HealthPartners: Adaptation of Clinical Guidelines into Systems for Practice Operations.

Vesely JM, Pronk NP, Kottke TE, Marshall PS.

Curr Obes Rep. 2016 Sep;5(3):312-9. doi: 10.1007/s13679-016-0220-0. Review.


Essential Role of an Unusually Long-lived Tyrosyl Radical in the Response to Red Light of the Animal-like Cryptochrome aCRY.

Oldemeyer S, Franz S, Wenzel S, Essen LO, Mittag M, Kottke T.

J Biol Chem. 2016 Jul 1;291(27):14062-71. doi: 10.1074/jbc.M116.726976. Epub 2016 May 9.


Allosteric communication between DNA-binding and light-responsive domains of diatom class I aureochromes.

Banerjee A, Herman E, Serif M, Maestre-Reyna M, Hepp S, Pokorny R, Kroth PG, Essen LO, Kottke T.

Nucleic Acids Res. 2016 Jul 8;44(12):5957-70. doi: 10.1093/nar/gkw420. Epub 2016 May 13.


Modeled Health and Economic Impact of Team-Based Care for Hypertension.

Dehmer SP, Baker-Goering MM, Maciosek MV, Hong Y, Kottke TE, Margolis KL, Will JC, Flottemesch TJ, LaFrance AB, Martinson BC, Thomas AJ, Roy K.

Am J Prev Med. 2016 May;50(5 Suppl 1):S34-S44. doi: 10.1016/j.amepre.2016.01.027.


"Well-Being in All Policies": Promoting Cross-Sectoral Collaboration to Improve People's Lives.

Kottke TE, Stiefel M, Pronk NP.

Prev Chronic Dis. 2016 Apr 14;13:E52. doi: 10.5888/pcd13.160155. No abstract available.


Evidence for Tautomerisation of Glutamine in BLUF Blue Light Receptors by Vibrational Spectroscopy and Computational Chemistry.

Domratcheva T, Hartmann E, Schlichting I, Kottke T.

Sci Rep. 2016 Mar 7;6:22669. doi: 10.1038/srep22669.


Using Principles of Complex Adaptive Systems to Implement Secondary Prevention of Coronary Heart Disease in Primary Care.

Kottke TE, Huebsch JA, Mcginnis P, Nichols JM, Parker ED, Tillema JO, Maciosek MV.

Perm J. 2016 spring;20(2):17-24. doi: 10.7812/TPP/15-100. Epub 2016 Jan 6.


Structure of a Native-like Aureochrome 1a LOV Domain Dimer from Phaeodactylum tricornutum.

Banerjee A, Herman E, Kottke T, Essen LO.

Structure. 2016 Jan 5;24(1):171-178. doi: 10.1016/j.str.2015.10.022. Epub 2015 Dec 10.


Reducing Medication Costs to Prevent Cardiovascular Disease: A Community Guide Systematic Review.

Njie GJ, Finnie RK, Acharya SD, Jacob V, Proia KK, Hopkins DP, Pronk NP, Goetzel RZ, Kottke TE, Rask KJ, Lackland DT, Braun LT; Community Preventive Services Task Force.

Prev Chronic Dis. 2015 Nov 25;12:E208. doi: 10.5888/pcd12.150242. Review.


Clinical Decision Support Systems and Prevention: A Community Guide Cardiovascular Disease Systematic Review.

Njie GJ, Proia KK, Thota AB, Finnie RKC, Hopkins DP, Banks SM, Callahan DB, Pronk NP, Rask KJ, Lackland DT, Kottke TE; Community Preventive Services Task Force.

Am J Prev Med. 2015 Nov;49(5):784-795. doi: 10.1016/j.amepre.2015.04.006. Review.


Economics of Team-based Care in Controlling Blood Pressure: A Community Guide Systematic Review.

Jacob V, Chattopadhyay SK, Thota AB, Proia KK, Njie G, Hopkins DP, Finnie RKC, Pronk NP, Kottke TE; Community Preventive Services Task Force.

Am J Prev Med. 2015 Nov;49(5):772-783. doi: 10.1016/j.amepre.2015.04.003. Review.


Combination viroimmunotherapy with checkpoint inhibition to treat glioma, based on location-specific tumor profiling.

Cockle JV, Rajani K, Zaidi S, Kottke T, Thompson J, Diaz RM, Shim K, Peterson T, Parney IF, Short S, Selby P, Ilett E, Melcher A, Vile R.

Neuro Oncol. 2016 Apr;18(4):518-27. doi: 10.1093/neuonc/nov173. Epub 2015 Sep 26.


(2-Arylethenyl)-1,3,5-triazin-2-amines as a novel histamine H4 receptor ligands.

Kamińska K, Ziemba J, Ner J, Schwed JS, Łażewska D, Więcek M, Karcz T, Olejarz A, Latacz G, Kuder K, Kottke T, Zygmunt M, Sapa J, Karolak-Wojciechowska J, Stark H, Kieć-Kononowicz K.

Eur J Med Chem. 2015 Oct 20;103:238-51. doi: 10.1016/j.ejmech.2015.08.014. Epub 2015 Aug 10.


Combination Therapy With Reovirus and Anti-PD-1 Blockade Controls Tumor Growth Through Innate and Adaptive Immune Responses.

Rajani K, Parrish C, Kottke T, Thompson J, Zaidi S, Ilett L, Shim KG, Diaz RM, Pandha H, Harrington K, Coffey M, Melcher A, Vile R.

Mol Ther. 2016 Feb;24(1):166-74. doi: 10.1038/mt.2015.156. Epub 2015 Aug 27.


Development of Fluorine-18 Labeled Metabolically Activated Tracers for Imaging of Drug Efflux Transporters with Positron Emission Tomography.

Sander K, Galante E, Gendron T, Yiannaki E, Patel N, Kalber TL, Badar A, Robson M, Johnson SP, Bauer F, Mairinger S, Stanek J, Wanek T, Kuntner C, Kottke T, Weizel L, Dickens D, Erlandsson K, Hutton BF, Lythgoe MF, Stark H, Langer O, Koepp M, Årstad E.

J Med Chem. 2015 Aug 13;58(15):6058-80. doi: 10.1021/acs.jmedchem.5b00652. Epub 2015 Jul 24.


A qualitative study of processes used to implement evidence-based care in a primary care practice.

Huebsch JA, Kottke TE, McGinnis P, Nichols J, Parker ED, Tillema JO, Hanson AM.

Fam Pract. 2015 Oct;32(5):578-83. doi: 10.1093/fampra/cmv045. Epub 2015 Jun 18.


Microsecond Deprotonation of Aspartic Acid and Response of the α/β Subdomain Precede C-Terminal Signaling in the Blue Light Sensor Plant Cryptochrome.

Thöing C, Oldemeyer S, Kottke T.

J Am Chem Soc. 2015 May 13;137(18):5990-9. doi: 10.1021/jacs.5b01404. Epub 2015 May 4.


Persistence of smoking-cessation decision support use in a dental practice.

Kottke TE, Brad Rindal D, Rush WA, Asche SE, Enstad CJ.

Am J Prev Med. 2015 Jun;48(6):722-8. doi: 10.1016/j.amepre.2014.12.017. Epub 2015 Feb 27.


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