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Items: 17

1.

Reelin protects against amyloid β toxicity in vivo.

Lane-Donovan C, Philips GT, Wasser CR, Durakoglugil MS, Masiulis I, Upadhaya A, Pohlkamp T, Coskun C, Kotti T, Steller L, Hammer RE, Frotscher M, Bock HH, Herz J.

Sci Signal. 2015 Jul 7;8(384):ra67. doi: 10.1126/scisignal.aaa6674.

2.

Metabolic adaptation allows Amacr-deficient mice to remain symptom-free despite low levels of mature bile acids.

Selkälä EM, Kuusisto SM, Salonurmi T, Savolainen MJ, Jauhiainen M, Pirilä PL, Kvist AP, Conzelmann E, Schmitz W, Alexson SE, Kotti TJ, Hiltunen JK, Autio KJ.

Biochim Biophys Acta. 2013 Aug;1831(8):1335-43. doi: 10.1016/j.bbalip.2013.05.002. Epub 2013 May 13.

PMID:
23680781
3.

Discovery of a proneurogenic, neuroprotective chemical.

Pieper AA, Xie S, Capota E, Estill SJ, Zhong J, Long JM, Becker GL, Huntington P, Goldman SE, Shen CH, Capota M, Britt JK, Kotti T, Ure K, Brat DJ, Williams NS, MacMillan KS, Naidoo J, Melito L, Hsieh J, De Brabander J, Ready JM, McKnight SL.

Cell. 2010 Jul 9;142(1):39-51. doi: 10.1016/j.cell.2010.06.018.

4.

Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain.

Russell DW, Halford RW, Ramirez DM, Shah R, Kotti T.

Annu Rev Biochem. 2009;78:1017-40. doi: 10.1146/annurev.biochem.78.072407.103859. Review.

5.

Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation.

Kotti T, Head DD, McKenna CE, Russell DW.

Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11394-9. doi: 10.1073/pnas.0805556105. Epub 2008 Aug 6.

6.

Brain cholesterol turnover required for geranylgeraniol production and learning in mice.

Kotti TJ, Ramirez DM, Pfeiffer BE, Huber KM, Russell DW.

Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3869-74. Epub 2006 Feb 27.

7.

Alpha-methylacyl-CoA racemase from Mycobacterium tuberculosis. Mutational and structural characterization of the active site and the fold.

Savolainen K, Bhaumik P, Schmitz W, Kotti TJ, Conzelmann E, Wierenga RK, Hiltunen JK.

J Biol Chem. 2005 Apr 1;280(13):12611-20. Epub 2005 Jan 4.

8.

A mouse model for alpha-methylacyl-CoA racemase deficiency: adjustment of bile acid synthesis and intolerance to dietary methyl-branched lipids.

Savolainen K, Kotti TJ, Schmitz W, Savolainen TI, Sormunen RT, Ilves M, Vainio SJ, Conzelmann E, Hiltunen JK.

Hum Mol Genet. 2004 May 1;13(9):955-65. Epub 2004 Mar 11.

PMID:
15016763
9.

Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover.

Lund EG, Xie C, Kotti T, Turley SD, Dietschy JM, Russell DW.

J Biol Chem. 2003 Jun 20;278(25):22980-8. Epub 2003 Apr 9.

10.

In mouse alpha -methylacyl-CoA racemase, the same gene product is simultaneously located in mitochondria and peroxisomes.

Kotti TJ, Savolainen K, Helander HM, Yagi A, Novikov DK, Kalkkinen N, Conzelmann E, Hiltunen JK, Schmitz W.

J Biol Chem. 2000 Jul 7;275(27):20887-95.

11.

Hippocampal damage after injection of kainic acid into the rat entorhinal cortex.

Miettinen R, Kotti T, Tuunanen J, Toppinen A, Riekkinen P Sr, Halonen T.

Brain Res. 1998 Nov 30;813(1):9-17.

PMID:
9824657
13.

Characterization of target cells for aberrant mossy fiber collaterals in the dentate gyrus of epileptic rat.

Kotti T, Riekkinen PJ Sr, Miettinen R.

Exp Neurol. 1997 Aug;146(2):323-30.

PMID:
9270041
15.

Alpha 2-adrenoceptor agonist, dexmedetomidine, protects against kainic acid-induced convulsions and neuronal damage.

Halonen T, Kotti T, Tuunanen J, Toppinen A, Miettinen R, Riekkinen PJ.

Brain Res. 1995 Sep 25;693(1-2):217-24.

PMID:
8653412
16.

NADPH diaphorase-containing nonpyramidal cells in the rat hippocampus exhibit differential sensitivity to kainic acid.

Miettinen R, Kotti T, Halonen T, Riekkinen P Sr.

Eur J Neurosci. 1995 Aug 1;7(8):1822-5.

PMID:
7582134
17.

Vigabatrin protects against kainic acid-induced neuronal damage in the rat hippocampus.

Halonen T, Miettinen R, Toppinen A, Tuunanen J, Kotti T, Riekkinen PJ Sr.

Neurosci Lett. 1995 Jul 28;195(1):13-6.

PMID:
7478243

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