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Items: 1 to 50 of 88

1.

Zanamivir Amidoxime- and N-Hydroxyguanidine-Based Prodrug Approaches to Tackle Poor Oral Bioavailability.

Schade D, Kotthaus J, Riebling L, Kotthaus J, Müller-Fielitz H, Raasch W, Hoffmann A, Schmidtke M, Clement B.

J Pharm Sci. 2015 Sep;104(9):3208-19. doi: 10.1002/jps.24508. Epub 2015 Jun 2.

PMID:
26037932
2.

Energy losses of nanomechanical resonators induced by atomic force microscopy-controlled mechanical impedance mismatching.

Rieger J, Isacsson A, Seitner MJ, Kotthaus JP, Weig EM.

Nat Commun. 2014 Mar 4;5:3345. doi: 10.1038/ncomms4345.

3.

Development of novel potent orally bioavailable oseltamivir derivatives active against resistant influenza A.

Schade D, Kotthaus J, Riebling L, Kotthaus J, Müller-Fielitz H, Raasch W, Koch O, Seidel N, Schmidtke M, Clement B.

J Med Chem. 2014 Feb 13;57(3):759-69. doi: 10.1021/jm401492x. Epub 2014 Feb 3.

PMID:
24422530
4.

Confinement and interaction of single indirect excitons in a voltage-controlled trap formed inside double InGaAs quantum Wells.

Schinner GJ, Repp J, Schubert E, Rai AK, Reuter D, Wieck AD, Govorov AO, Holleitner AW, Kotthaus JP.

Phys Rev Lett. 2013 Mar 22;110(12):127403. Epub 2013 Mar 19.

PMID:
25166847
5.

MS³ fragmentation patterns of monomethylarginine species and the quantification of all methylarginine species in yeast using MRM³.

Lakowski TM, Szeitz A, Pak ML, Thomas D, Vhuiyan MI, Kotthaus J, Clement B, Frankel A.

J Proteomics. 2013 Mar 27;80:43-54. doi: 10.1016/j.jprot.2013.01.003. Epub 2013 Jan 17.

PMID:
23333926
6.

Nonadiabatic dynamics of two strongly coupled nanomechanical resonator modes.

Faust T, Rieger J, Seitner MJ, Krenn P, Kotthaus JP, Weig EM.

Phys Rev Lett. 2012 Jul 20;109(3):037205. Epub 2012 Jul 17.

PMID:
22861892
7.

Microwave cavity-enhanced transduction for plug and play nanomechanics at room temperature.

Faust T, Krenn P, Manus S, Kotthaus JP, Weig EM.

Nat Commun. 2012 Mar 6;3:728. doi: 10.1038/ncomms1723.

8.

Tunable photoemission from an excitonic antitrap.

Kowalik-Seidl K, Vögele XP, Rimpfl BN, Schinner GJ, Schuh D, Wegscheider W, Holleitner AW, Kotthaus JP.

Nano Lett. 2012 Jan 11;12(1):326-30. doi: 10.1021/nl203613k. Epub 2011 Dec 9.

PMID:
22142491
9.

New prodrugs of the antiprotozoal drug pentamidine.

Kotthaus J, Kotthaus J, Schade D, Schwering U, Hungeling H, Müller-Fielitz H, Raasch W, Clement B.

ChemMedChem. 2011 Dec 9;6(12):2233-42. doi: 10.1002/cmdc.201100422. Epub 2011 Oct 7.

PMID:
21984033
10.

Designing modulators of dimethylarginine dimethylaminohydrolase (DDAH): a focus on selectivity over arginase.

Kotthaus J, Schade D, Kotthaus J, Clement B.

J Enzyme Inhib Med Chem. 2012 Feb;27(1):24-8. doi: 10.3109/14756366.2011.573480. Epub 2011 Jul 8.

PMID:
21740101
11.

Prodrug design for the potent cardiovascular agent Nω-hydroxy-L-arginine (NOHA): synthetic approaches and physicochemical characterization.

Schade D, Kotthaus J, Klein N, Kotthaus J, Clement B.

Org Biomol Chem. 2011 Jul 21;9(14):5249-59. doi: 10.1039/c0ob01117g. Epub 2011 May 31.

PMID:
21625725
12.

Synthesis and biological evaluation of L-valine-amidoximeesters as double prodrugs of amidines.

Kotthaus J, Hungeling H, Reeh C, Kotthaus J, Schade D, Wein S, Wolffram S, Clement B.

Bioorg Med Chem. 2011 Mar 15;19(6):1907-14. doi: 10.1016/j.bmc.2011.01.066. Epub 2011 Feb 3.

PMID:
21345682
13.

Reduction of N(ω)-hydroxy-L-arginine by the mitochondrial amidoxime reducing component (mARC).

Kotthaus J, Wahl B, Havemeyer A, Kotthaus J, Schade D, Garbe-Schönberg D, Mendel R, Bittner F, Clement B.

Biochem J. 2011 Jan 15;433(2):383-91. doi: 10.1042/BJ20100960.

PMID:
21029045
14.

Damping of nanomechanical resonators.

Unterreithmeier QP, Faust T, Kotthaus JP.

Phys Rev Lett. 2010 Jul 9;105(2):027205. Epub 2010 Jul 9.

PMID:
20867737
15.

Spatially resolved ballistic optoelectronic transport measured by quantized photocurrent spectroscopy.

Hof KD, Kaiser FJ, Stallhofer M, Schuh D, Wegscheider W, Hänggi P, Kohler S, Kotthaus JP, Holleitner AW.

Nano Lett. 2010 Oct 13;10(10):3836-40. doi: 10.1021/nl102068v.

PMID:
20853822
16.

Analysis of highly potent amidine containing inhibitors of serine proteases and their N-hydroxylated prodrugs (amidoximes).

Kotthaus J, Steinmetzer T, van de Locht A, Clement B.

J Enzyme Inhib Med Chem. 2011 Feb;26(1):115-22. doi: 10.3109/14756361003733647. Epub 2010 Jun 28.

PMID:
20583861
17.

Resonant coupling of a Bose-Einstein condensate to a micromechanical oscillator.

Hunger D, Camerer S, Hänsch TW, König D, Kotthaus JP, Reichel J, Treutlein P.

Phys Rev Lett. 2010 Apr 9;104(14):143002. Epub 2010 Apr 9.

PMID:
20481938
18.

Modulating the NO generating system from a medicinal chemistry perspective: current trends and therapeutic options in cardiovascular disease.

Schade D, Kotthaus J, Clement B.

Pharmacol Ther. 2010 Jun;126(3):279-300. doi: 10.1016/j.pharmthera.2010.02.005. Epub 2010 Mar 10. Review.

PMID:
20226211
19.

On-chip interferometric detection of nanomechanical motion.

Unterreithmeier QP, Faust T, Manus S, Kotthaus JP.

Nano Lett. 2010 Mar 10;10(3):887-90. doi: 10.1021/nl903556s.

PMID:
20131919
20.

Metabolism and distribution of two highly potent and selective peptidomimetic inhibitors of matriptase.

Kotthaus J, Steinmetzer T, Kotthaus J, Schade D, van de Locht A, Clement B.

Xenobiotica. 2010 Feb;40(2):93-101. doi: 10.3109/00498250903402266.

PMID:
20028195
21.

Arylazoamidoximes and related compounds as NO-modulators.

Schröder A, Kotthaus J, Schade D, Clement B, Rehse K.

Arch Pharm (Weinheim). 2010 Jan;343(1):9-16. doi: 10.1002/ardp.200900060.

PMID:
19921683
22.

Density enhanced diffusion of dipolar excitons within a one-dimensional channel.

Vögele XP, Schuh D, Wegscheider W, Kotthaus JP, Holleitner AW.

Phys Rev Lett. 2009 Sep 18;103(12):126402. Epub 2009 Sep 16.

PMID:
19792450
23.

The peptidylglycine alpha-amidating monooxygenase (PAM): a novel prodrug strategy for amidoximes and N-hydroxyguanidines?

Schade D, Kotthaus J, Hungeling H, Kotthaus J, Clement B.

ChemMedChem. 2009 Oct;4(10):1595-9. doi: 10.1002/cmdc.200900233. No abstract available.

PMID:
19693765
24.

Phonon-mediated nonequilibrium interaction between nanoscale devices.

Schinner GJ, Tranitz HP, Wegscheider W, Kotthaus JP, Ludwig S.

Phys Rev Lett. 2009 May 8;102(18):186801. Epub 2009 May 5.

PMID:
19518896
25.

Universal transduction scheme for nanomechanical systems based on dielectric forces.

Unterreithmeier QP, Weig EM, Kotthaus JP.

Nature. 2009 Apr 23;458(7241):1001-4. doi: 10.1038/nature07932.

PMID:
19396140
26.

Incorporation of neutral C-terminal residues in 3-amidinophenylalanine-derived matriptase inhibitors.

Schweinitz A, Dönnecke D, Ludwig A, Steinmetzer P, Schulze A, Kotthaus J, Wein S, Clement B, Steinmetzer T.

Bioorg Med Chem Lett. 2009 Apr 1;19(7):1960-5. doi: 10.1016/j.bmcl.2009.02.047. Epub 2009 Feb 14.

PMID:
19250826
27.

The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs.

Gruenewald S, Wahl B, Bittner F, Hungeling H, Kanzow S, Kotthaus J, Schwering U, Mendel RR, Clement B.

J Med Chem. 2008 Dec 25;51(24):8173-7. doi: 10.1021/jm8010417.

PMID:
19053771
28.

New 1H-pyrazole-4-carboxamides with antiplatelet activity.

Rehse K, Kotthaus J, Khadembashi L.

Arch Pharm (Weinheim). 2009 Jan;342(1):27-33. doi: 10.1002/ardp.200800181.

PMID:
19051198
29.

Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads.

Kotthaus J, Schade D, Muschick N, Beitz E, Clement B.

Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. doi: 10.1016/j.bmc.2008.10.058. Epub 2008 Oct 29.

PMID:
19013076
30.

Ultrasonically driven nanomechanical single-electron shuttle.

Koenig DR, Weig EM, Kotthaus JP.

Nat Nanotechnol. 2008 Aug;3(8):482-5. doi: 10.1038/nnano.2008.178. Epub 2008 Jul 6.

PMID:
18685635
31.

Voltage controlled SAW velocity in GaAs/LiNbO(3)-hybrids.

Rotter M, Ruile W, Wixforth A, Kotthaus JP.

IEEE Trans Ultrason Ferroelectr Freq Control. 1999;46(1):120-5. doi: 10.1109/58.741522.

PMID:
18238405
32.

Synthetic approaches to N(delta)-methylated L-arginine, N(omega)-hydroxy-L-arginine, L-citrulline, and N(delta)-cyano-L-ornithine.

Schade D, Töpker-Lehmann K, Kotthaus J, Clement B.

J Org Chem. 2008 Feb 1;73(3):1025-30. doi: 10.1021/jo702150d. Epub 2008 Jan 8.

PMID:
18179234
33.

N(delta)-Methylated L-arginine derivatives and their effects on the nitric oxide generating system.

Kotthaus J, Schade D, Töpker-Lehmann K, Beitz E, Clement B.

Bioorg Med Chem. 2008 Mar 1;16(5):2305-12. Epub 2007 Nov 29.

PMID:
18083522
34.

Counterflow of electrons in two isolated quantum point contacts.

Khrapai VS, Ludwig S, Kotthaus JP, Tranitz HP, Wegscheider W.

Phys Rev Lett. 2007 Aug 31;99(9):096803. Epub 2007 Aug 31.

PMID:
17931027
35.

Highly potent and selective substrate analogue factor Xa inhibitors containing D-homophenylalanine analogues as P3 residue: part 2.

Stürzebecher A, Dönnecke D, Schweinitz A, Schuster O, Steinmetzer P, Stürzebecher U, Kotthaus J, Clement B, Stürzebecher J, Steinmetzer T.

ChemMedChem. 2007 Jul;2(7):1043-53.

PMID:
17541992
36.

Double-dot quantum ratchet driven by an independently biased quantum point contact.

Khrapai VS, Ludwig S, Kotthaus JP, Tranitz HP, Wegscheider W.

Phys Rev Lett. 2006 Oct 27;97(17):176803. Epub 2006 Oct 26.

PMID:
17155493
37.

Periodic field emission from an isolated nanoscale electron island.

Scheible DV, Weiss C, Kotthaus JP, Blick RH.

Phys Rev Lett. 2004 Oct 29;93(18):186801. Epub 2004 Oct 25.

PMID:
15525190
38.

Single-electron-phonon interaction in a suspended quantum dot phonon cavity.

Weig EM, Blick RH, Brandes T, Kirschbaum J, Wegscheider W, Bichler M, Kotthaus JP.

Phys Rev Lett. 2004 Jan 30;92(4):046804. Epub 2004 Jan 30.

PMID:
14995394
39.

Rectification in mesoscopic systems with broken symmetry: quasiclassical ballistic versus classical transport.

de Haan S, Lorke A, Kotthaus JP, Wegscheider W, Bichler M.

Phys Rev Lett. 2004 Feb 6;92(5):056806. Epub 2004 Feb 6.

PMID:
14995331
40.

Low temperature conductance measurements of self-assembled monolayers of 1,4-phenylene diisocyanide.

Dupraz CJ, Beierlein U, Kotthaus JP.

Chemphyschem. 2003 Nov 14;4(11):1247-52. No abstract available.

PMID:
14653008
41.

Probing and controlling the bonds of an artificial molecule.

Holleitner AW, Blick RH, Huttel AK, Eberl K, Kotthaus JP.

Science. 2002 Jul 5;297(5578):70-2.

42.

Nonlinear charge spreading visualized in voltage-controlled lateral superlattices.

Krauss J, Wixforth A, Kalameitsev AV, Govorov AO, Wegscheider W, Kotthaus JP.

Phys Rev Lett. 2002 Jan 21;88(3):036803. Epub 2002 Jan 3.

PMID:
11801078
43.

Spectroscopy of nanoscopic semiconductor rings.

Lorke A, Luyken RJ, Govorov AO, Kotthaus JP, Garcia JM, Petroff PM.

Phys Rev Lett. 2000 Mar 6;84(10):2223-6.

PMID:
11017249
44.

A Semiconductor-Based Photonic Memory Cell.

Zimmermann S, Wixforth A, Kotthaus JP, Wegscheider W, Bichler M.

Science. 1999 Feb 26;283(5406):1292-1295.

45.

Compressible and incompressible stripes in a narrow electron channel.

Schmerek D, Manus S, Govorov AO, Hansen W, Kotthaus JP, Holland M.

Phys Rev B Condens Matter. 1996 Nov 15;54(19):13816-13819. No abstract available.

PMID:
9985298
46.

Quantum oscillation of the cyclotron mass in two-dimensional electron systems in silicon.

Kaesen KF, Huber A, Lorenz H, Kotthaus JP, Bakker S, Klapwijk TM.

Phys Rev B Condens Matter. 1996 Jul 15;54(3):1514-1517. No abstract available.

PMID:
9985986
47.

Intersubband resonances in InAs/AlSb quantum wells: Selection rules, matrix elements, and the depolarization field.

Warburton RJ, Gauer C, Wixforth A, Kotthaus JP, Brar B, Kroemer H.

Phys Rev B Condens Matter. 1996 Mar 15;53(12):7903-7910. No abstract available.

PMID:
9982243
48.

Local far-infrared spectroscopy of edge states in the quantum Hall regime.

Lorke A, Kotthaus JP, English JH, Gossard AC.

Phys Rev B Condens Matter. 1996 Jan 15;53(3):1054-1057. No abstract available.

PMID:
9983553
49.

Electron effective mass and nonparabolicity in Ga0.47In0.53As/InP quantum wells.

Wetzel C, Winkler R, Drechsler M, Meyer BK, Rössler U, Scriba J, Kotthaus JP, Härle V V, Scholz F.

Phys Rev B Condens Matter. 1996 Jan 15;53(3):1038-1041. No abstract available.

PMID:
9983549
50.

Coulomb-blockade oscillations in a quantum dot strongly coupled to leads.

Heinzel T, Johnson AT, Wharam DA, Kotthaus JP, Böhm G, Klein W, Tränkle G, Weimann G.

Phys Rev B Condens Matter. 1995 Dec 15;52(23):16638-16645. No abstract available.

PMID:
9981067

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