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Items: 20

1.

Circumventing senescence is associated with stem cell properties and metformin sensitivity.

Deschênes-Simard X, Parisotto M, Rowell MC, Le Calvé B, Igelmann S, Moineau-Vallée K, Saint-Germain E, Kalegari P, Bourdeau V, Kottakis F, Bardeesy N, Ferbeyre G.

Aging Cell. 2019 Apr;18(2):e12889. doi: 10.1111/acel.12889. Epub 2019 Jan 6.

2.

LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.

Kottakis F, Nicolay BN, Roumane A, Karnik R, Gu H, Nagle JM, Boukhali M, Hayward MC, Li YY, Chen T, Liesa M, Hammerman PS, Wong KK, Hayes DN, Shirihai OS, Dyson NJ, Haas W, Meissner A, Bardeesy N.

Nature. 2016 Nov 17;539(7629):390-395. doi: 10.1038/nature20132. Epub 2016 Oct 31.

3.

NRF2: Translating the Redox Code.

Tummala KS, Kottakis F, Bardeesy N.

Trends Mol Med. 2016 Oct;22(10):829-831. doi: 10.1016/j.molmed.2016.08.002. Epub 2016 Aug 20.

4.

Gene signatures from pancreatic cancer tumor and stromal cells predict disease outcome.

Kottakis F, Bardeesy N.

Nat Genet. 2015 Oct;47(10):1102-3. doi: 10.1038/ng.3408.

PMID:
26417858
5.

Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation.

Nicolay BN, Danielian PS, Kottakis F, Lapek JD Jr, Sanidas I, Miles WO, Dehnad M, Tschöp K, Gierut JJ, Manning AL, Morris R, Haigis K, Bardeesy N, Lees JA, Haas W, Dyson NJ.

Genes Dev. 2015 Sep 1;29(17):1875-89. doi: 10.1101/gad.264127.115. Epub 2015 Aug 27.

6.

YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression.

Fitamant J, Kottakis F, Benhamouche S, Tian HS, Chuvin N, Parachoniak CA, Nagle JM, Perera RM, Lapouge M, Deshpande V, Zhu AX, Lai A, Min B, Hoshida Y, Avruch J, Sia D, Campreciós G, McClatchey AI, Llovet JM, Morrissey D, Raj L, Bardeesy N.

Cell Rep. 2015 Mar 17;10(10):1692-1707. doi: 10.1016/j.celrep.2015.02.027. Epub 2015 Mar 12.

7.

NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells.

Kottakis F, Foltopoulou P, Sanidas I, Keller P, Wronski A, Dake BT, Ezell SA, Shen Z, Naber SP, Hinds PW, McNiel E, Kuperwasser C, Tsichlis PN.

Cancer Res. 2014 Jul 15;74(14):3935-46. doi: 10.1158/0008-5472.CAN-13-2733. Epub 2014 May 22.

8.

The downregulation of GFI1 by the EZH2-NDY1/KDM2B-JARID2 axis and by human cytomegalovirus (HCMV) associated factors allows the activation of the HCMV major IE promoter and the transition to productive infection.

Sourvinos G, Morou A, Sanidas I, Codruta I, Ezell SA, Doxaki C, Kampranis SC, Kottakis F, Tsichlis PN.

PLoS Pathog. 2014 May 15;10(5):e1004136. doi: 10.1371/journal.ppat.1004136. eCollection 2014 May.

9.

Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer.

Sanidas I, Polytarchou C, Hatziapostolou M, Ezell SA, Kottakis F, Hu L, Guo A, Xie J, Comb MJ, Iliopoulos D, Tsichlis PN.

Mol Cell. 2014 Feb 20;53(4):577-90. doi: 10.1016/j.molcel.2013.12.018. Epub 2014 Jan 23.

10.

ERKs in cancer: friends or foes?

Deschênes-Simard X, Kottakis F, Meloche S, Ferbeyre G.

Cancer Res. 2014 Jan 15;74(2):412-9. doi: 10.1158/0008-5472.CAN-13-2381. Epub 2014 Jan 9. Review.

11.

LKB1-AMPK axis revisited.

Kottakis F, Bardeesy N.

Cell Res. 2012 Dec;22(12):1617-20. doi: 10.1038/cr.2012.108. Epub 2012 Jul 17.

12.

Tumor progression locus 2 mediates signal-induced increases in cytoplasmic calcium and cell migration.

Hatziapostolou M, Koukos G, Polytarchou C, Kottakis F, Serebrennikova O, Kuliopulos A, Tsichlis PN.

Sci Signal. 2011 Aug 23;4(187):ra55. doi: 10.1126/scisignal.2002006.

13.

FGF-2 regulates cell proliferation, migration, and angiogenesis through an NDY1/KDM2B-miR-101-EZH2 pathway.

Kottakis F, Polytarchou C, Foltopoulou P, Sanidas I, Kampranis SC, Tsichlis PN.

Mol Cell. 2011 Jul 22;43(2):285-98. doi: 10.1016/j.molcel.2011.06.020.

14.

Helicobacter pylori neutrophil activating protein as target for new drugs against H. pylori inflammation.

Choli-Papadopoulou T, Kottakis F, Papadopoulos G, Pendas S.

World J Gastroenterol. 2011 Jun 7;17(21):2585-91. doi: 10.3748/wjg.v17.i21.2585.

15.

Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation.

Polytarchou C, Iliopoulos D, Hatziapostolou M, Kottakis F, Maroulakou I, Struhl K, Tsichlis PN.

Cancer Res. 2011 Jul 1;71(13):4720-31. doi: 10.1158/0008-5472.CAN-11-0365. Epub 2011 May 9.

16.

MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells.

Iliopoulos D, Polytarchou C, Hatziapostolou M, Kottakis F, Maroulakou IG, Struhl K, Tsichlis PN.

Sci Signal. 2009 Oct 13;2(92):ra62. doi: 10.1126/scisignal.2000356.

17.

The C-terminal region of HPNAP activates neutrophils and promotes their adhesion to endothelial cells.

Kottakis F, Befani C, Asiminas A, Kontou M, Koliakos G, Choli-Papadopoulou T.

Helicobacter. 2009 Jun;14(3):177-9. doi: 10.1111/j.1523-5378.2009.00678.x.

PMID:
19702847
18.

Effects of mastic gum Pistacia lentiscus var. Chia on innate cellular immune effectors.

Kottakis F, Kouzi-Koliakou K, Pendas S, Kountouras J, Choli-Papadopoulou T.

Eur J Gastroenterol Hepatol. 2009 Feb;21(2):143-9. doi: 10.1097/MEG.0b013e32831c50c9.

PMID:
19212203
20.

Arabino-galactan proteins from Pistacia lentiscus var. chia: isolation, characterization and biological function.

Kottakis F, Lamari F, Matragkou Ch, Zachariadis G, Karamanos N, Choli-Papadopoulou T.

Amino Acids. 2008 Apr;34(3):413-20. Epub 2007 May 21.

PMID:
17514491

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